금맥한의원
Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

Research Papers
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Total 1642 papers

Cohort Study Men's Health / Urology

Effect of Pharmacopuncture Treatment on Prostate Symptom Improvement in Urological Disorder Patients: A Cohort Study

Lim JH, Song KJ, Watanabe T, et al.

Urologia Internationalis (2023)

180 subjects Participants
12 months Follow-up Period
p<0.05 Statistical Significance

Combined pharmacopuncture treatment provides additional benefits for long-term management of prostate-related lower urinary tract symptoms.

Cohort Study Men's Health / Urology

Effect of Pharmacopuncture Treatment on Prostate Symptom Improvement in Urological Disorder Patients: A Cohort Study

Lim JH, Song KJ, Watanabe T, et al. Urologia Internationalis (2023)
180 subjects Participants
12 months Follow-up Period
p<0.05 Statistical Significance

Summary

A cohort study tracking 180 men complaining of prostate symptoms for 12 months, divided into a pharmacopuncture combined treatment group and a herbal medicine alone group. IPSS and maximum flow rate improved significantly in the pharmacopuncture combined group.

Key Conclusion

Combined pharmacopuncture treatment provides additional benefits for long-term management of prostate-related lower urinary tract symptoms.

Narrative Review Men's Health / Urology

Experimental Review on the Effect of Palmijihwang-hwan on Male Sexual Function Improvement

Son JE, Min BW, Park KJ, et al.

Journal of Ethnopharmacology (2020)

28 sources Reviewed Literature
3 mechanisms Main Mechanisms
87% Positive Results

Palmijihwang-hwan improves male sexual function through multiple mechanisms, and future large-scale clinical trials are needed.

Narrative Review Men's Health / Urology

Experimental Review on the Effect of Palmijihwang-hwan on Male Sexual Function Improvement

Son JE, Min BW, Park KJ, et al. Journal of Ethnopharmacology (2020)
28 sources Reviewed Literature
3 mechanisms Main Mechanisms
87% Positive Results

Summary

Twenty-eight animal experiments and clinical studies were comprehensively reviewed to investigate the male sexual function improvement mechanism of Palmijihwang-hwan. Various mechanisms including NO production promotion and testosterone synthesis increase were confirmed.

Key Conclusion

Palmijihwang-hwan improves male sexual function through multiple mechanisms, and future large-scale clinical trials are needed.

Case Study Men's Health / Urology

Effect of Korean Medicine Heat Therapy on Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Case Report

Im DS, Kang YG, et al.

Journal of Korean Medicine Rehabilitation (2022)

5 cases Number of Cases
52% Pain Reduction Rate
4 weeks Treatment Period

Korean medicine heat therapy can be utilized as adjunctive treatment for pain and urinary symptom relief in chronic prostatitis patients.

Case Study Men's Health / Urology

Effect of Korean Medicine Heat Therapy on Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Case Report

Im DS, Kang YG, et al. Journal of Korean Medicine Rehabilitation (2022)
5 cases Number of Cases
52% Pain Reduction Rate
4 weeks Treatment Period

Summary

A case report on 5 patients with chronic prostatitis/chronic pelvic pain syndrome who received Korean medicine sitz bath and moxibustion treatment in combination. After 4 weeks of treatment, pain VAS and NIH-CPSI scores improved.

Key Conclusion

Korean medicine heat therapy can be utilized as adjunctive treatment for pain and urinary symptom relief in chronic prostatitis patients.

Meta-Analysis Men's Health / Urology

Efficacy and Safety of Korean Medicine Treatment for Male Climacteric Syndrome: A Meta-Analysis

Yang SJ, Hwang EH, Kim JS, et al.

Maturitas (2024)

14 RCTs Number of RCTs
1,180 subjects Total Participants
OR 2.34 Effect Size

Korean medicine treatment showed significant effects on symptom improvement and hormone level normalization in male climacteric syndrome.

Meta-Analysis Men's Health / Urology

Efficacy and Safety of Korean Medicine Treatment for Male Climacteric Syndrome: A Meta-Analysis

Yang SJ, Hwang EH, Kim JS, et al. Maturitas (2024)
14 RCTs Number of RCTs
1,180 subjects Total Participants
OR 2.34 Effect Size

Summary

A meta-analysis of 14 RCTs evaluating the effect of Korean medicine treatment (herbal medicine, acupuncture, pharmacopuncture) for male climacteric syndrome was conducted. Data from a total of 1,180 subjects were included.

Key Conclusion

Korean medicine treatment showed significant effects on symptom improvement and hormone level normalization in male climacteric syndrome.

Cross-Sectional Men's Health / Urology

Effect of Herbal Medicine Treatment on Sperm DNA Fragmentation Reduction in Male Infertility: A Cross-Sectional Analysis

Cho HY, Lee SM, Nguyen VT, et al.

Reproductive BioMedicine Online (2023)

200 subjects Analysis Subjects
31% DFI Reduction Rate
p<0.01 Statistical Significance

Longer herbal medicine treatment duration showed significant correlation with reduction in sperm DNA fragmentation index.

Cross-Sectional Men's Health / Urology

Effect of Herbal Medicine Treatment on Sperm DNA Fragmentation Reduction in Male Infertility: A Cross-Sectional Analysis

Cho HY, Lee SM, Nguyen VT, et al. Reproductive BioMedicine Online (2023)
200 subjects Analysis Subjects
31% DFI Reduction Rate
p<0.01 Statistical Significance

Summary

Medical records of 200 male infertility patients who received herbal medicine treatment were cross-sectionally analyzed to evaluate changes in sperm DNA fragmentation index (DFI). DFI was significantly lower in the group treated for more than 3 months.

Key Conclusion

Longer herbal medicine treatment duration showed significant correlation with reduction in sperm DNA fragmentation index.

RCT Men's Health / Urology

Effect of Yukmijihwang-hwan on Lower Urinary Tract Symptoms in Benign Prostatic Hyperplasia Patients

Ryu KH, Nam BH, Kim TY, et al.

Phytotherapy Research (2024)

120 subjects Participants
-5.1 points IPSS Reduction
24 weeks Treatment Period

Yukmijihwang-hwan shows effects similar to tamsulosin for improving lower urinary tract symptoms in benign prostatic hyperplasia patients and can be an alternative treatment option.

RCT Men's Health / Urology

Effect of Yukmijihwang-hwan on Lower Urinary Tract Symptoms in Benign Prostatic Hyperplasia Patients

Ryu KH, Nam BH, Kim TY, et al. Phytotherapy Research (2024)
120 subjects Participants
-5.1 points IPSS Reduction
24 weeks Treatment Period

Summary

One hundred twenty patients with benign prostatic hyperplasia were randomly assigned to Yukmijihwang-hwan administration and tamsulosin administration groups and compared for 24 weeks. IPSS decreased significantly in both groups, and inter-group differences were not statistically significant.

Key Conclusion

Yukmijihwang-hwan shows effects similar to tamsulosin for improving lower urinary tract symptoms in benign prostatic hyperplasia patients and can be an alternative treatment option.

Before-After Men's Health / Urology

Single-Arm Pre-Post Comparison Study on the Effect of Electroacupuncture for Erectile Dysfunction Patients

Jang WS, Oh JH, et al.

Journal of Acupuncture and Meridian Studies (2021)

45 subjects Participants
5.8 points IIEF-5 Improvement
8 weeks Treatment Period

Electroacupuncture treatment showed significant effects on sexual function improvement in erectile dysfunction patients, and additional controlled studies are needed.

Before-After Men's Health / Urology

Single-Arm Pre-Post Comparison Study on the Effect of Electroacupuncture for Erectile Dysfunction Patients

Jang WS, Oh JH, et al. Journal of Acupuncture and Meridian Studies (2021)
45 subjects Participants
5.8 points IIEF-5 Improvement
8 weeks Treatment Period

Summary

Electroacupuncture was administered 3 times a week for 8 weeks to acupoints such as Gwanwon and Sinsu in 45 patients with erectile dysfunction. IIEF-5 scores and nocturnal erection frequency increased significantly.

Key Conclusion

Electroacupuncture treatment showed significant effects on sexual function improvement in erectile dysfunction patients, and additional controlled studies are needed.

Systematic Review Men's Health / Urology

Effect of Korean Medicine Interventions for Male Vitality Enhancement: A Systematic Review

Bae CH, Jung IH, Li X, et al.

Sexual Medicine Reviews (2023)

45 studies Included Studies
12 RCTs Number of RCTs
73% Positive Results Rate

Korean medicine interventions show multifaceted effects in improving male sexual function, but additional high-quality large-scale RCTs are needed.

Systematic Review Men's Health / Urology

Effect of Korean Medicine Interventions for Male Vitality Enhancement: A Systematic Review

Bae CH, Jung IH, Li X, et al. Sexual Medicine Reviews (2023)
45 studies Included Studies
12 RCTs Number of RCTs
73% Positive Results Rate

Summary

Forty-five studies on Korean medicine interventions (herbal medicine, acupuncture, moxibustion) aimed at enhancing male vitality were systematically reviewed. Twelve RCTs, 15 cohort studies, and 18 pre-post comparisons were included.

Key Conclusion

Korean medicine interventions show multifaceted effects in improving male sexual function, but additional high-quality large-scale RCTs are needed.

RCT Men's Health / Urology

Effect of Modified Ssanghwa-tang on Male Climacteric Fatigue: A Double-Blind Randomized Controlled Trial

Kwon JY, Moon SH, Lee DW, et al.

Journal of Ginseng Research (2025)

90 subjects Participants
41% Fatigue Reduction Rate
12 weeks Treatment Period

Modified Ssanghwa-tang is effective for improving male climacteric fatigue and shows excellent safety.

RCT Men's Health / Urology

Effect of Modified Ssanghwa-tang on Male Climacteric Fatigue: A Double-Blind Randomized Controlled Trial

Kwon JY, Moon SH, Lee DW, et al. Journal of Ginseng Research (2025)
90 subjects Participants
41% Fatigue Reduction Rate
12 weeks Treatment Period

Summary

Ninety men complaining of male climacteric fatigue symptoms were compared with modified Ssanghwa-tang and placebo for 12 weeks. Fatigue Severity Scale (FSS) and Aging Males Symptoms (AMS) scores improved significantly.

Key Conclusion

Modified Ssanghwa-tang is effective for improving male climacteric fatigue and shows excellent safety.

Before-After Men's Health / Urology

Effect of Acupuncture Treatment on Oxidative Stress Markers in Male Infertility Patients

Hong SK, Park YH, Yamamoto K, et al.

Andrologia (2022)

60 subjects Participants
38% ROS Reduction Rate
p<0.05 Statistical Significance

Acupuncture treatment can contribute to improving sperm quality by reducing oxidative stress in semen of male infertility patients.

Before-After Men's Health / Urology

Effect of Acupuncture Treatment on Oxidative Stress Markers in Male Infertility Patients

Hong SK, Park YH, Yamamoto K, et al. Andrologia (2022)
60 subjects Participants
38% ROS Reduction Rate
p<0.05 Statistical Significance

Summary

Acupuncture treatment was administered for 8 weeks to 60 male infertility patients, and oxidative stress markers in semen (ROS, TAC) were measured. After acupuncture treatment, ROS significantly decreased and TAC increased.

Key Conclusion

Acupuncture treatment can contribute to improving sperm quality by reducing oxidative stress in semen of male infertility patients.

RCT Men's Health / Urology

Effect of Combined Herbal Medicine and Acupuncture Treatment for Prostatitis: A Multicenter Randomized Controlled Trial

Shin MJ, Lee KS, Chen W, et al.

Phytomedicine (2024)

200 subjects Participants
72.5% Symptom Improvement Rate
4 institutions Multicenter Participation

Combined herbal medicine and acupuncture treatment demonstrated superior effects over standard treatment in symptom relief and quality of life improvement for chronic prostatitis.

RCT Men's Health / Urology

Effect of Combined Herbal Medicine and Acupuncture Treatment for Prostatitis: A Multicenter Randomized Controlled Trial

Shin MJ, Lee KS, Chen W, et al. Phytomedicine (2024)
200 subjects Participants
72.5% Symptom Improvement Rate
4 institutions Multicenter Participation

Summary

Two hundred chronic prostatitis patients were recruited from 4 Korean medicine hospitals, and combined herbal medicine and acupuncture treatment was compared with standard antibiotic treatment. After 12 weeks, NIH-CPSI scores were significantly superior in the combined treatment group.

Key Conclusion

Combined herbal medicine and acupuncture treatment demonstrated superior effects over standard treatment in symptom relief and quality of life improvement for chronic prostatitis.

Narrative Review Men's Health / Urology

Effect of Bojungikgi-tang on Male Vitality Enhancement: A Literature Review

Yoon TH, Kim GR, et al.

Korean Journal of Oriental Medicine (2021)

32 sources Analyzed Literature
85% Positive Results Rate

Bojungikgi-tang contributes to sexual function improvement in qi-deficient men through various mechanisms, and additional large-scale clinical studies are needed.

Narrative Review Men's Health / Urology

Effect of Bojungikgi-tang on Male Vitality Enhancement: A Literature Review

Yoon TH, Kim GR, et al. Korean Journal of Oriental Medicine (2021)
32 sources Analyzed Literature
85% Positive Results Rate

Summary

A literature review was conducted on the male sexual function and vitality enhancement effects of Bojungikgi-tang. Thirty-two related studies were retrieved and analyzed from domestic and international databases.

Key Conclusion

Bojungikgi-tang contributes to sexual function improvement in qi-deficient men through various mechanisms, and additional large-scale clinical studies are needed.