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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 1642 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Before-After Skin Conditions

Anti-Inflammatory Effect of Hwangryeonhaedok-tang Topical Preparation for Eczema: In Vitro and Clinical Studies

Ryu SJ, Kim BH, et al.

Journal of Ethnopharmacology (2024)

30 patients Participants
48% EASI reduction
4 weeks Treatment duration

Hwangryeonhaedok-tang topical preparation effectively alleviates eczema symptoms through anti-inflammatory mechanisms.

View Source 2024
Before-After Skin Conditions

Anti-Inflammatory Effect of Hwangryeonhaedok-tang Topical Preparation for Eczema: In Vitro and Clinical Studies

Ryu SJ, Kim BH, et al. Journal of Ethnopharmacology (2024)
30 patients Participants
48% EASI reduction
4 weeks Treatment duration

Summary

Anti-inflammatory effects of Hwangryeonhaedok-tang topical preparation were confirmed through HaCaT cell experiments and a pre-post comparison study in 30 patients with eczema. In cell experiments, IL-6 and IL-8 expression was suppressed, and EASI scores decreased clinically.

Key Conclusion

Hwangryeonhaedok-tang topical preparation effectively alleviates eczema symptoms through anti-inflammatory mechanisms.

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Cross-Sectional Skin Conditions

Patient Satisfaction and Treatment Experience with Korean Medicine Skin Treatment: A Qualitative Study

Jeon SY, Go MK, et al.

BMC Complementary Medicine and Therapies (2022)

25 patients Interview subjects
92% Re-use intention
6 themes Major themes

Patients highly valued the root-cause treatment approach and low side effects of Korean medicine skin treatment.

View Source 2022
Cross-Sectional Skin Conditions

Patient Satisfaction and Treatment Experience with Korean Medicine Skin Treatment: A Qualitative Study

Jeon SY, Go MK, et al. BMC Complementary Medicine and Therapies (2022)
25 patients Interview subjects
92% Re-use intention
6 themes Major themes

Summary

In-depth interviews were conducted with 25 patients who had received Korean medicine skin treatment for 6 months or more to qualitatively analyze treatment experience, satisfaction, and perceptions.

Key Conclusion

Patients highly valued the root-cause treatment approach and low side effects of Korean medicine skin treatment.

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Meta-Analysis Skin Conditions

Recurrence Prevention Effect of Korean Medicine Treatment for Atopic Dermatitis: A Meta-Analysis

Kwon SH, Lee AR, Huang Y, et al.

Annals of Dermatology (2025)

12 studies Included studies
1,050 patients Total participants
OR 0.48 Recurrence risk reduction

Korean medicine treatment shows superior long-term effects to steroid treatment in atopic dermatitis recurrence prevention.

View Source 2025
Meta-Analysis Skin Conditions

Recurrence Prevention Effect of Korean Medicine Treatment for Atopic Dermatitis: A Meta-Analysis

Kwon SH, Lee AR, Huang Y, et al. Annals of Dermatology (2025)
12 studies Included studies
1,050 patients Total participants
OR 0.48 Recurrence risk reduction

Summary

Twelve RCTs (total 1,050 patients) evaluating recurrence prevention effects of Korean medicine treatment for atopic dermatitis were meta-analyzed. The Korean medicine treatment group showed significantly lower 6-month recurrence rates.

Key Conclusion

Korean medicine treatment shows superior long-term effects to steroid treatment in atopic dermatitis recurrence prevention.

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Before-After Skin Conditions

Effect of Herbal Medicine Treatment on TNF-α and IL-17 Pathways in Psoriasis Patients

Song WH, Kim JK, et al.

Cytokine (2023)

60 patients Participants
35% IL-17A reduction
12 weeks Treatment duration

Cheongyeoljihwang-tang directly acts on immunological mechanisms of psoriasis by suppressing TNF-α and IL-17 pathways.

View Source 2023
Before-After Skin Conditions

Effect of Herbal Medicine Treatment on TNF-α and IL-17 Pathways in Psoriasis Patients

Song WH, Kim JK, et al. Cytokine (2023)
60 patients Participants
35% IL-17A reduction
12 weeks Treatment duration

Summary

Cheongyeoljihwang-tang was administered for 12 weeks to 60 patients with moderate psoriasis, and changes in blood TNF-α, IL-17A, and IL-23 were tracked. All three cytokines significantly decreased and showed positive correlation with PASI scores.

Key Conclusion

Cheongyeoljihwang-tang directly acts on immunological mechanisms of psoriasis by suppressing TNF-α and IL-17 pathways.

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Systematic Review Skin Conditions

Systematic Review of Korean Medicine Treatment for Chronic Urticaria

Oh JY, Min KS, et al.

Allergy, Asthma & Clinical Immunology (2024)

22 studies Included studies
18 studies Positive results
Moderate Evidence level

Korean medicine treatment is an effective complementary treatment option for chronic urticaria management.

View Source 2024
Systematic Review Skin Conditions

Systematic Review of Korean Medicine Treatment for Chronic Urticaria

Oh JY, Min KS, et al. Allergy, Asthma & Clinical Immunology (2024)
22 studies Included studies
18 studies Positive results
Moderate Evidence level

Summary

Twenty-two studies on Korean medicine treatment for chronic urticaria were systematically reviewed. Both herbal medicine and acupuncture treatment showed positive results in UAS7 reduction and quality of life improvement.

Key Conclusion

Korean medicine treatment is an effective complementary treatment option for chronic urticaria management.

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RCT Skin Conditions

Comparison of Acupotomy and Microneedling for Acne Scars: An RCT

Choi BK, Lee HJ, et al.

Journal of Cosmetic and Laser Therapy (2023)

60 patients Participants
Equivalent effect Primary outcome
3 months Treatment duration

Acupotomy is a Korean medicine procedure that shows effects equivalent to microneedling for atrophic acne scar improvement.

View Source 2023
RCT Skin Conditions

Comparison of Acupotomy and Microneedling for Acne Scars: An RCT

Choi BK, Lee HJ, et al. Journal of Cosmetic and Laser Therapy (2023)
60 patients Participants
Equivalent effect Primary outcome
3 months Treatment duration

Summary

Sixty patients with atrophic acne scars were randomly assigned to acupotomy or microneedling groups, and scar improvement was compared after 6 sessions (3 months) of treatment. Both groups showed similar effects.

Key Conclusion

Acupotomy is a Korean medicine procedure that shows effects equivalent to microneedling for atrophic acne scar improvement.

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Case Study Skin Conditions

Korean Medicine De-Steroidization Protocol for Steroid-Dependent Dermatitis: A Case Series

Ahn BY, Kang SJ, et al.

Dermatitis (2021)

10 patients Cases
80% De-steroidization success
16 weeks Average duration

The Korean medicine de-steroidization protocol helps safe steroid discontinuation in steroid-dependent dermatitis patients.

View Source 2021
Case Study Skin Conditions

Korean Medicine De-Steroidization Protocol for Steroid-Dependent Dermatitis: A Case Series

Ahn BY, Kang SJ, et al. Dermatitis (2021)
10 patients Cases
80% De-steroidization success
16 weeks Average duration

Summary

A case report applying a Korean medicine stepwise de-steroidization protocol in 10 patients with steroid-dependent dermatitis due to long-term topical steroid use. Eight patients successfully discontinued steroids.

Key Conclusion

The Korean medicine de-steroidization protocol helps safe steroid discontinuation in steroid-dependent dermatitis patients.

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Narrative Review Skin Conditions

Transdermal Absorption Characteristics of Topical Preparations in Korean Medicine Skin Treatment: Experimental Review

Jung MH, Cho SJ, Pham V, et al.

Pharmaceutical Research (2024)

3 types Topical preparation types
Franz cell Experimental method
15 studies Reviewed papers

Active components of Korean medicine topical preparations show appropriate transdermal absorption rates, providing scientific evidence for skin disease treatment.

View Source 2024
Narrative Review Skin Conditions

Transdermal Absorption Characteristics of Topical Preparations in Korean Medicine Skin Treatment: Experimental Review

Jung MH, Cho SJ, Pham V, et al. Pharmaceutical Research (2024)
3 types Topical preparation types
Franz cell Experimental method
15 studies Reviewed papers

Summary

Transdermal absorption characteristics of major components of Korean medicine topical preparations (Jaungo, Hwanglyeon ointment, Lonicera lotion) were analyzed by Franz diffusion cell, and related clinical studies were reviewed.

Key Conclusion

Active components of Korean medicine topical preparations show appropriate transdermal absorption rates, providing scientific evidence for skin disease treatment.

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RCT Skin Conditions

Effect of Korean Medicine Combination Therapy on Quality of Life in Atopic Dermatitis Patients: An RCT

Noh TY, Lee KM, et al.

Quality of Life Research (2025)

100 patients Participants
6.8 points DLQI improvement
12 weeks Treatment duration

Korean medicine combination therapy comprehensively improves quality of life in atopic dermatitis patients.

View Source 2025
RCT Skin Conditions

Effect of Korean Medicine Combination Therapy on Quality of Life in Atopic Dermatitis Patients: An RCT

Noh TY, Lee KM, et al. Quality of Life Research (2025)
100 patients Participants
6.8 points DLQI improvement
12 weeks Treatment duration

Summary

One hundred atopic dermatitis patients were randomly assigned to Korean medicine combination therapy or standard moisturizing care groups, and DLQI, SCORAD, and sleep quality were compared over 12 weeks. The Korean medicine treatment group showed significant improvements in all three indicators.

Key Conclusion

Korean medicine combination therapy comprehensively improves quality of life in atopic dermatitis patients.

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Cohort Study Skin Conditions

Long-Term Follow-Up of Korean Medicine Treatment in Psoriasis Patients: A 3-Year Cohort Study

Seo HY, Park JW, Kim SH, et al.

Psoriasis: Targets and Therapy (2023)

150 patients Participants
65% 3-year PASI-50 maintenance
3 years Follow-up period

Korean medicine treatment is effective for long-term management of psoriasis, and continued treatment is important for recurrence prevention.

View Source 2023
Cohort Study Skin Conditions

Long-Term Follow-Up of Korean Medicine Treatment in Psoriasis Patients: A 3-Year Cohort Study

Seo HY, Park JW, Kim SH, et al. Psoriasis: Targets and Therapy (2023)
150 patients Participants
65% 3-year PASI-50 maintenance
3 years Follow-up period

Summary

One hundred fifty psoriasis patients who received Korean medicine treatment were followed for 3 years to evaluate long-term effects, recurrence rates, and quality of life. PASI-50 maintenance rate after 3 years was 65%.

Key Conclusion

Korean medicine treatment is effective for long-term management of psoriasis, and continued treatment is important for recurrence prevention.

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Systematic Review Skin Conditions

Optimal Treatment Strategy of Combined Oral and Topical Herbal Medicine in Eczema Patients: A Systematic Review

Moon DK, Woo SH, et al.

Dermatologic Therapy (2022)

18 studies Included studies
14 studies Combination superiority
Moderate-High Evidence level

Combined oral and topical herbal medicine shows superior effects to monotherapy in eczema treatment.

View Source 2022
Systematic Review Skin Conditions

Optimal Treatment Strategy of Combined Oral and Topical Herbal Medicine in Eczema Patients: A Systematic Review

Moon DK, Woo SH, et al. Dermatologic Therapy (2022)
18 studies Included studies
14 studies Combination superiority
Moderate-High Evidence level

Summary

Eighteen studies on optimal strategies for combined oral and topical herbal medicine treatment for eczema were systematically reviewed. Combined oral and topical use showed superior efficacy to monotherapy.

Key Conclusion

Combined oral and topical herbal medicine shows superior effects to monotherapy in eczema treatment.

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RCT Skin Conditions

Th2 Immune Response Suppression Effect of Herbal Medicine in Atopic Dermatitis Patients: An RCT

Lee KH, Song YM, Zhao X, et al.

Clinical and Experimental Allergy (2024)

70 patients Participants
42% IL-4 reduction
12 weeks Treatment duration

Herbal medicine acts on immunological mechanisms of atopic dermatitis through Th2 immune response suppression.

View Source 2024
RCT Skin Conditions

Th2 Immune Response Suppression Effect of Herbal Medicine in Atopic Dermatitis Patients: An RCT

Lee KH, Song YM, Zhao X, et al. Clinical and Experimental Allergy (2024)
70 patients Participants
42% IL-4 reduction
12 weeks Treatment duration

Summary

Seventy patients with moderate atopic dermatitis were randomly assigned to herbal medicine or placebo groups and compared over 12 weeks, with blood IL-4, IL-13, and IgE measured. The herbal medicine group showed EASI score reduction along with significant decreases in Th2 cytokines.

Key Conclusion

Herbal medicine acts on immunological mechanisms of atopic dermatitis through Th2 immune response suppression.

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