금맥한의원
Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

Research Papers
🔍

Total 93 papers

Before-After Neurological Disorders

Peripheral Nerve Protective Effect of Herbal Medicine for Diabetic Foot Ulcer: A Pre-Post Comparison

Suh JW, Bae GE, Park YC, et al.

Diabetic Medicine (2024)

15% Conduction velocity↑
25 subjects Participants
Ulcer↓ Healing Promotion

Herbal medicine supports peripheral nerve protection and ulcer healing in diabetic feet.

Before-After Neurological Disorders

Peripheral Nerve Protective Effect of Herbal Medicine for Diabetic Foot Ulcer: A Pre-Post Comparison

Suh JW, Bae GE, Park YC, et al. Diabetic Medicine (2024)
15% Conduction velocity↑
25 subjects Participants
Ulcer↓ Healing Promotion

Summary

Herbal medicine (Samul-tang + Ucha-Sinki-hwan) was administered for 16 weeks to 25 patients with diabetic foot ulcer, and nerve conduction and ulcer healing were tracked. Sensory nerve conduction improved by 15%, and ulcer area decreased.

Key Conclusion

Herbal medicine supports peripheral nerve protection and ulcer healing in diabetic feet.

Narrative Review Neurological Disorders

Antiplatelet and Antioxidant Effects of Herbal Medicine for Stroke Prevention: A Narrative Review

Park BS, Kang JH, Lee EH, et al.

Cerebrovascular Diseases (2024)

22 sources Reviewed Literature
Antiplatelet Thrombosis Prevention
Antioxidant Brain Protection

Herbal medicine is promising as adjunctive antiplatelet and antioxidant treatment for secondary stroke prevention.

Narrative Review Neurological Disorders

Antiplatelet and Antioxidant Effects of Herbal Medicine for Stroke Prevention: A Narrative Review

Park BS, Kang JH, Lee EH, et al. Cerebrovascular Diseases (2024)
22 sources Reviewed Literature
Antiplatelet Thrombosis Prevention
Antioxidant Brain Protection

Summary

Twenty-two articles on the antiplatelet and antioxidant effects of herbal medicine for stroke prevention were reviewed. Danshen, Cnidium, and other herbs showed effects on platelet aggregation inhibition and oxidative stress reduction.

Key Conclusion

Herbal medicine is promising as adjunctive antiplatelet and antioxidant treatment for secondary stroke prevention.

Case Study Neurological Disorders

Case Report of Herbal Medicine (Cheonmaguodeung-eum) for Parkinson's Disease

Shin JH, Kang YH, Oh MS, et al.

Parkinson Disease (2024)

6 cases Number of Cases
Non-motor↓ Sleep, Constipation, Depression
24 weeks Administration Period

Cheonmaguodeung-eum may be useful as an adjunct for non-motor symptom management in Parkinson's disease.

Case Study Neurological Disorders

Case Report of Herbal Medicine (Cheonmaguodeung-eum) for Parkinson's Disease

Shin JH, Kang YH, Oh MS, et al. Parkinson Disease (2024)
6 cases Number of Cases
Non-motor↓ Sleep, Constipation, Depression
24 weeks Administration Period

Summary

A case report of Cheonmaguodeung-eum administration for 24 weeks in 6 patients with Parkinson's disease. While maintaining L-dopa dose, UPDRS non-motor symptoms (sleep, constipation, depression) improved.

Key Conclusion

Cheonmaguodeung-eum may be useful as an adjunct for non-motor symptom management in Parkinson's disease.

Cohort Study Neurological Disorders

Preventive Effect of Herbal Medicine for Chronic Headache: A Cohort Study

Noh HM, Ahn YJ, Cho HJ, et al.

Headache (2024)

55% Headache days↓
100 subjects Participants
Medication overuse↓ Dose Reduction Effect

Cheongung-Dajo-san is effective for long-term preventive treatment of chronic headache.

Cohort Study Neurological Disorders

Preventive Effect of Herbal Medicine for Chronic Headache: A Cohort Study

Noh HM, Ahn YJ, Cho HJ, et al. Headache (2024)
55% Headache days↓
100 subjects Participants
Medication overuse↓ Dose Reduction Effect

Summary

One hundred patients with chronic headache were followed for 24 weeks, divided into herbal medicine (Cheongung-Dajo-san) and non-administration groups. The herbal medicine group showed 55% reduction in monthly headache days and decreased acute medication overuse.

Key Conclusion

Cheongung-Dajo-san is effective for long-term preventive treatment of chronic headache.

RCT Neurological Disorders

Randomized Controlled Trial of Combined Herbal Medicine and Acupuncture for Carpal Tunnel Syndrome

Kim TH, Song MY, Park CW, et al.

Muscle & Nerve (2023)

48% BQ↓
65 subjects Participants
Conduction↑ Nerve Improvement

Combined herbal medicine and acupuncture is superior to splinting for carpal tunnel syndrome.

RCT Neurological Disorders

Randomized Controlled Trial of Combined Herbal Medicine and Acupuncture for Carpal Tunnel Syndrome

Kim TH, Song MY, Park CW, et al. Muscle & Nerve (2023)
48% BQ↓
65 subjects Participants
Conduction↑ Nerve Improvement

Summary

Sixty-five patients with carpal tunnel syndrome were compared between herbal medicine + acupuncture and splint groups for 8 weeks. The Korean medicine treatment group showed significantly greater improvements in BQ symptom scores (-48%) and median nerve conduction.

Key Conclusion

Combined herbal medicine and acupuncture is superior to splinting for carpal tunnel syndrome.

Before-After Neurological Disorders

Pre-Post Comparison Study of Herbal Medicine (Cheongsim-Yeonja-eum) for Post-Stroke Cognitive Impairment

Kwon CY, Song JH, Lee DH, et al.

Stroke (2024)

MoCA +4.2 Cognition↑
40 subjects Participants
TMT↑ Executive Function

Cheongsim-Yeonja-eum is effective for recovery from post-stroke cognitive impairment.

Before-After Neurological Disorders

Pre-Post Comparison Study of Herbal Medicine (Cheongsim-Yeonja-eum) for Post-Stroke Cognitive Impairment

Kwon CY, Song JH, Lee DH, et al. Stroke (2024)
MoCA +4.2 Cognition↑
40 subjects Participants
TMT↑ Executive Function

Summary

Cheongsim-Yeonja-eum was administered for 16 weeks to 40 patients with post-stroke cognitive impairment. MoCA (+4.2 points) and Trail Making Test significantly improved.

Key Conclusion

Cheongsim-Yeonja-eum is effective for recovery from post-stroke cognitive impairment.

Case Study Neurological Disorders

Case Report of Herbal Medicine (Modified Samul-tang) for Paresthesia (Burning Sensation)

Kim GH, Cho WS, Park HJ, et al.

Pain Medicine (2023)

8 cases Number of Cases
70%↓ Burning Sensation Reduction
Sleep↑ Additional Effect

Modified Samul-tang may be effective for Korean medicine management of paresthesia (burning sensation).

Case Study Neurological Disorders

Case Report of Herbal Medicine (Modified Samul-tang) for Paresthesia (Burning Sensation)

Kim GH, Cho WS, Park HJ, et al. Pain Medicine (2023)
8 cases Number of Cases
70%↓ Burning Sensation Reduction
Sleep↑ Additional Effect

Summary

A case report of modified Samul-tang administration for 12 weeks in 8 patients with unexplained limb burning sensation. Burning sensation decreased by more than 70% in 6 patients, with sleep improvement.

Key Conclusion

Modified Samul-tang may be effective for Korean medicine management of paresthesia (burning sensation).

Before-After Neurological Disorders

Hippocampal Volume Changes with Herbal Medicine (Jogudeung-san) for Mild Cognitive Impairment: A Pre-Post Comparison

Kang YH, Moon SJ, Cho WS, et al.

Neurobiology of Aging (2024)

Hippocampal protection Atrophy Suppression
35 subjects Participants
MoCA↑ Cognition↑

Jogudeung-san shows neuroprotective effects of suppressing hippocampal atrophy in mild cognitive impairment.

Before-After Neurological Disorders

Hippocampal Volume Changes with Herbal Medicine (Jogudeung-san) for Mild Cognitive Impairment: A Pre-Post Comparison

Kang YH, Moon SJ, Cho WS, et al. Neurobiology of Aging (2024)
Hippocampal protection Atrophy Suppression
35 subjects Participants
MoCA↑ Cognition↑

Summary

Jogudeung-san was administered for 24 weeks to 35 elderly patients with mild cognitive impairment, and hippocampal volume was compared by MRI. Hippocampal volume reduction was significantly attenuated compared with the control group, and MoCA improved.

Key Conclusion

Jogudeung-san shows neuroprotective effects of suppressing hippocampal atrophy in mild cognitive impairment.

Cohort Study Neurological Disorders

Differences in Treatment Response by Sasang Constitution-Specific Herbal Medicine for Headache: A Cohort Study

Moon PD, Kang BK, Cho WS, et al.

Journal of Korean Medicine (2023)

180 subjects Participants
28% Additional Improvement
Constitution customization Personalized Treatment

Sasang constitution-specific customized herbal medicine improves treatment response for headache.

Cohort Study Neurological Disorders

Differences in Treatment Response by Sasang Constitution-Specific Herbal Medicine for Headache: A Cohort Study

Moon PD, Kang BK, Cho WS, et al. Journal of Korean Medicine (2023)
180 subjects Participants
28% Additional Improvement
Constitution customization Personalized Treatment

Summary

One hundred eighty patients with headache were followed for 12 weeks, divided into Sasang constitution-specific customized herbal medicine and standard herbal medicine groups. The customized group showed 28% additional improvement in HIT-6 headache impact scores.

Key Conclusion

Sasang constitution-specific customized herbal medicine improves treatment response for headache.

RCT Neurological Disorders

Randomized Controlled Trial of Herbal Medicine (Bojungikgi-tang) for Orthostatic Hypotension

Lee JY, Kwon CY, Shin HK, et al.

Clinical Autonomic Research (2023)

38% BP variation↓
55 subjects Participants
Dizziness↓ Symptom Improvement

Bojungikgi-tang is effective for blood pressure regulation and dizziness relief in orthostatic hypotension.

RCT Neurological Disorders

Randomized Controlled Trial of Herbal Medicine (Bojungikgi-tang) for Orthostatic Hypotension

Lee JY, Kwon CY, Shin HK, et al. Clinical Autonomic Research (2023)
38% BP variation↓
55 subjects Participants
Dizziness↓ Symptom Improvement

Summary

Fifty-five patients with orthostatic hypotension were compared between Bojungikgi-tang and placebo groups for 8 weeks. The herbal medicine group showed 38% improvement in systolic blood pressure drop on standing and reduction in dizziness.

Key Conclusion

Bojungikgi-tang is effective for blood pressure regulation and dizziness relief in orthostatic hypotension.

Narrative Review Neurological Disorders

Narrative Review of Herbal Medicine (Banhahubak-tang) for Autonomic Dysfunction

Han SJ, Kim DH, Lee JA, et al.

Autonomic Neuroscience (2023)

16 sources Reviewed Literature
HRV↑ Autonomic Regulation
Multiple symptoms Integrated Effect

Banhahubak-tang is an integrated Korean medicine treatment for multiple symptoms of autonomic dysfunction.

Narrative Review Neurological Disorders

Narrative Review of Herbal Medicine (Banhahubak-tang) for Autonomic Dysfunction

Han SJ, Kim DH, Lee JA, et al. Autonomic Neuroscience (2023)
16 sources Reviewed Literature
HRV↑ Autonomic Regulation
Multiple symptoms Integrated Effect

Summary

Sixteen articles on the effect of Banhahubak-tang for autonomic dysfunction were reviewed. Banhahubak-tang showed multifaceted effects on HRV improvement and gastrointestinal, cardiovascular, and psychiatric symptoms.

Key Conclusion

Banhahubak-tang is an integrated Korean medicine treatment for multiple symptoms of autonomic dysfunction.

RCT Neurological Disorders

Randomized Controlled Trial of Herbal Medicine (Cheonmaguodeung-eum) for Trigeminal Neuralgia

Cha YR, Woo HS, Nam DH, et al.

Trigeminal Neuralgia Research (2024)

48% Attacks↓
55 subjects Participants
Side effects↓ Safety

Cheonmaguodeung-eum is an alternative treatment for trigeminal neuralgia with fewer drug side effects.

RCT Neurological Disorders

Randomized Controlled Trial of Herbal Medicine (Cheonmaguodeung-eum) for Trigeminal Neuralgia

Cha YR, Woo HS, Nam DH, et al. Trigeminal Neuralgia Research (2024)
48% Attacks↓
55 subjects Participants
Side effects↓ Safety

Summary

Fifty-five patients with trigeminal neuralgia were compared between Cheonmaguodeung-eum and carbamazepine groups for 8 weeks. The herbal medicine group showed significantly fewer side effects while decreasing pain attacks (-48%).

Key Conclusion

Cheonmaguodeung-eum is an alternative treatment for trigeminal neuralgia with fewer drug side effects.