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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 1642 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Before-After Skin Conditions

Skin Barrier Recovery Effect of Jaungo in Atopic Dermatitis Patients: A Pre-Post Comparison

Jung EK, Moon HJ, et al.

Skin Pharmacology and Physiology (2024)

50 patients Participants
42% TEWL reduction
6 weeks Treatment duration

Jaungo is an effective Korean medicine topical preparation for restoring the skin barrier in atopic dermatitis patients.

View Source 2024
Before-After Skin Conditions

Skin Barrier Recovery Effect of Jaungo in Atopic Dermatitis Patients: A Pre-Post Comparison

Jung EK, Moon HJ, et al. Skin Pharmacology and Physiology (2024)
50 patients Participants
42% TEWL reduction
6 weeks Treatment duration

Summary

Jaungo was applied for 6 weeks to 50 patients with atopic dermatitis, and TEWL, skin hydration, SCORAD, and ceramide levels were measured. All four indicators significantly improved.

Key Conclusion

Jaungo is an effective Korean medicine topical preparation for restoring the skin barrier in atopic dermatitis patients.

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RCT Skin Conditions

Immune Modulation Effect of Acupuncture in Psoriasis Patients: An RCT

Kim DS, Lee BJ, Nakamura K, et al.

Acupuncture in Medicine (2025)

80 patients Participants
38% PASI improvement
12 weeks Treatment duration

Acupuncture is effective for immune indicator modulation and symptom improvement in psoriasis patients.

View Source 2025
RCT Skin Conditions

Immune Modulation Effect of Acupuncture in Psoriasis Patients: An RCT

Kim DS, Lee BJ, Nakamura K, et al. Acupuncture in Medicine (2025)
80 patients Participants
38% PASI improvement
12 weeks Treatment duration

Summary

Eighty patients with moderate psoriasis were randomly assigned to acupuncture or sham acupuncture groups and compared over 12 weeks. The acupuncture group showed PASI score reduction along with significant decreases in blood IL-17 and TNF-α.

Key Conclusion

Acupuncture is effective for immune indicator modulation and symptom improvement in psoriasis patients.

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Narrative Review Skin Conditions

Role of Pharmacopuncture in Korean Medicine Skin Treatment: A Literature Review

Baek SH, Yoon KJ, et al.

Journal of Pharmacopuncture (2022)

28 studies Reviewed papers
4 types Disease groups
Hwangryeonhaedok-tang Most frequent prescription

Pharmacopuncture is promising as adjunctive treatment for various skin diseases, but standardized protocol development is needed.

View Source 2022
Narrative Review Skin Conditions

Role of Pharmacopuncture in Korean Medicine Skin Treatment: A Literature Review

Baek SH, Yoon KJ, et al. Journal of Pharmacopuncture (2022)
28 studies Reviewed papers
4 types Disease groups
Hwangryeonhaedok-tang Most frequent prescription

Summary

Twenty-eight studies on pharmacopuncture treatment for skin diseases (atopic dermatitis, psoriasis, acne, urticaria, etc.) were comprehensively reviewed. Hwangryeonhaedok-tang pharmacopuncture and anti-inflammatory pharmacopuncture were most frequently studied.

Key Conclusion

Pharmacopuncture is promising as adjunctive treatment for various skin diseases, but standardized protocol development is needed.

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Meta-Analysis Skin Conditions

Effect of Acupuncture for Chronic Urticaria: A Meta-Analysis

Son HJ, Kim YW, Chen X, et al.

Allergy (2023)

10 studies Included studies
820 patients Total participants
SMD -0.82 Effect size

Acupuncture shows significant efficacy for symptom management and reducing drug use in chronic urticaria.

View Source 2023
Meta-Analysis Skin Conditions

Effect of Acupuncture for Chronic Urticaria: A Meta-Analysis

Son HJ, Kim YW, Chen X, et al. Allergy (2023)
10 studies Included studies
820 patients Total participants
SMD -0.82 Effect size

Summary

Ten RCTs (total 820 patients) evaluating acupuncture for chronic spontaneous urticaria were meta-analyzed. The acupuncture group showed significant reductions in UAS7 scores and antihistamine use.

Key Conclusion

Acupuncture shows significant efficacy for symptom management and reducing drug use in chronic urticaria.

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RCT Skin Conditions

Effect of Combined Herbal Medicine-LED Light Therapy Intervention for Acne Patients: An RCT

Lim SY, Park GH, et al.

Dermatologic Therapy (2024)

90 patients Participants
3-arm comparison Study design
74% Lesion reduction rate

Combined herbal medicine and LED light therapy shows synergistic effects in acne treatment.

View Source 2024
RCT Skin Conditions

Effect of Combined Herbal Medicine-LED Light Therapy Intervention for Acne Patients: An RCT

Lim SY, Park GH, et al. Dermatologic Therapy (2024)
90 patients Participants
3-arm comparison Study design
74% Lesion reduction rate

Summary

Ninety patients with moderate acne were randomly assigned to herbal medicine plus LED, herbal medicine alone, or LED alone groups and compared over 8 weeks. The combination group showed the greatest reductions in inflammatory lesion counts and GAGS scores.

Key Conclusion

Combined herbal medicine and LED light therapy shows synergistic effects in acne treatment.

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Cross-Sectional Skin Conditions

Correlation Between Korean Medicine Pattern Differentiation and Skin Microbiota in Eczema Patients: A Cross-Sectional Study

Cho KM, Lee SH, et al.

Journal of Investigative Dermatology (2023)

120 patients Analysis population
4 types Pattern types
p<0.01 Microbiota differences

Korean medicine pattern differentiation in eczema is associated with skin microbiota composition and can be utilized for pattern-tailored treatment.

View Source 2023
Cross-Sectional Skin Conditions

Correlation Between Korean Medicine Pattern Differentiation and Skin Microbiota in Eczema Patients: A Cross-Sectional Study

Cho KM, Lee SH, et al. Journal of Investigative Dermatology (2023)
120 patients Analysis population
4 types Pattern types
p<0.01 Microbiota differences

Summary

A cross-sectional study performing Korean medicine pattern differentiation and skin microbiota analysis in 120 patients with eczema. The damp-heat pattern showed significantly higher Staphylococcus aureus ratios.

Key Conclusion

Korean medicine pattern differentiation in eczema is associated with skin microbiota composition and can be utilized for pattern-tailored treatment.

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Cohort Study Skin Conditions

Steroid-Sparing Effect of Herbal Medicine Treatment in Atopic Dermatitis Patients: A Cohort Study

Kwon DH, Shin MK, Sato Y, et al.

British Journal of Dermatology (2024)

160 patients Participants
45% Steroid reduction
24 weeks Follow-up period

Herbal medicine combination is effective in reducing topical steroid dependence in atopic dermatitis patients.

View Source 2024
Cohort Study Skin Conditions

Steroid-Sparing Effect of Herbal Medicine Treatment in Atopic Dermatitis Patients: A Cohort Study

Kwon DH, Shin MK, Sato Y, et al. British Journal of Dermatology (2024)
160 patients Participants
45% Steroid reduction
24 weeks Follow-up period

Summary

One hundred sixty atopic dermatitis patients using topical steroids were followed for 24 weeks for steroid use, divided into an herbal medicine combination group and a non-combination group. Steroid use significantly decreased in the herbal medicine combination group.

Key Conclusion

Herbal medicine combination is effective in reducing topical steroid dependence in atopic dermatitis patients.

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Before-After Skin Conditions

Effect of Herbal Bath Therapy in Psoriasis Patients: A Pre-Post Comparison Study

Yoon HK, Oh DS, et al.

Complementary Therapies in Clinical Practice (2022)

40 patients Participants
35% PASI improvement
6 weeks Treatment duration

Herbal bath therapy is an adjunctive treatment that improves skin symptoms and quality of life in psoriasis patients.

View Source 2022
Before-After Skin Conditions

Effect of Herbal Bath Therapy in Psoriasis Patients: A Pre-Post Comparison Study

Yoon HK, Oh DS, et al. Complementary Therapies in Clinical Practice (2022)
40 patients Participants
35% PASI improvement
6 weeks Treatment duration

Summary

Herbal bathing based on Sophora flavescens, Dictamnus, and Cnidium was performed for 6 weeks on 40 patients with moderate psoriasis, and PASI, BSA, and DLQI were evaluated. All three indicators significantly improved.

Key Conclusion

Herbal bath therapy is an adjunctive treatment that improves skin symptoms and quality of life in psoriasis patients.

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Before-After Skin Conditions

Histamine-Independent Mechanism Study of Gamisoyo-san in Urticaria Patients

Han MJ, Kim TY, et al.

Frontiers in Pharmacology (2025)

45 patients Participants
58% UAS7 improvement
12 weeks Treatment duration

Gamisoyo-san can manage chronic urticaria through histamine-independent pathways.

View Source 2025
Before-After Skin Conditions

Histamine-Independent Mechanism Study of Gamisoyo-san in Urticaria Patients

Han MJ, Kim TY, et al. Frontiers in Pharmacology (2025)
45 patients Participants
58% UAS7 improvement
12 weeks Treatment duration

Summary

Gamisoyo-san was administered for 12 weeks to 45 patients with chronic urticaria unresponsive to antihistamines, and UAS7, mast cell degranulation markers, and autonomic function were evaluated. Symptoms and biomarkers improved after herbal medicine administration.

Key Conclusion

Gamisoyo-san can manage chronic urticaria through histamine-independent pathways.

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RCT Skin Conditions

Effect of Korean Medicine Treatment for Adult Acne: A Randomized Controlled Trial

Lee GH, Song KS, et al.

Journal of Cosmetic Dermatology (2023)

80 patients Participants
Non-inferiority confirmed Primary outcome
8 weeks Treatment duration

Korean medicine treatment shows similar effects to oral antibiotics in adult acne with superior safety.

View Source 2023
RCT Skin Conditions

Effect of Korean Medicine Treatment for Adult Acne: A Randomized Controlled Trial

Lee GH, Song KS, et al. Journal of Cosmetic Dermatology (2023)
80 patients Participants
Non-inferiority confirmed Primary outcome
8 weeks Treatment duration

Summary

Eighty adult acne (25 years or older) patients were randomly assigned to herbal medicine plus acupuncture or oral antibiotic groups and compared over 8 weeks. Both groups showed similar effects, but adverse effects were significantly fewer in the Korean medicine treatment group.

Key Conclusion

Korean medicine treatment shows similar effects to oral antibiotics in adult acne with superior safety.

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Before-After Skin Conditions

Gut Microbiota Changes with Korean Medicine Treatment for Atopic Dermatitis: An Exploratory Study

Min SH, Cho YR, Wang L, et al.

Gut Microbes (2024)

40 patients Participants
Microbiota changes Major finding
r=-0.62 SCORAD correlation

Herbal medicine has a mechanism of improving atopic dermatitis through gut microbiota modulation.

View Source 2024
Before-After Skin Conditions

Gut Microbiota Changes with Korean Medicine Treatment for Atopic Dermatitis: An Exploratory Study

Min SH, Cho YR, Wang L, et al. Gut Microbes (2024)
40 patients Participants
Microbiota changes Major finding
r=-0.62 SCORAD correlation

Summary

Herbal medicine was administered for 12 weeks to 40 atopic dermatitis patients, with gut microbiota analysis performed before and after. After herbal medicine administration, Lactobacillus and Bifidobacterium increased and SCORAD decreased.

Key Conclusion

Herbal medicine has a mechanism of improving atopic dermatitis through gut microbiota modulation.

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Cohort Study Skin Conditions

Simultaneous Skin-Joint Improvement Effect of Korean Medicine Combination Therapy in Patients with Comorbid Psoriatic Arthritis

Park KH, Lee YM, et al.

Rheumatology International (2023)

50 patients Participants
42% PASI improvement
38% DAS28 improvement

Korean medicine combination therapy is effective in simultaneously managing skin and joint symptoms in patients with psoriatic arthritis.

View Source 2023
Cohort Study Skin Conditions

Simultaneous Skin-Joint Improvement Effect of Korean Medicine Combination Therapy in Patients with Comorbid Psoriatic Arthritis

Park KH, Lee YM, et al. Rheumatology International (2023)
50 patients Participants
42% PASI improvement
38% DAS28 improvement

Summary

Korean medicine combination therapy with herbal medicine and acupuncture was performed for 16 weeks on 50 patients with comorbid psoriatic arthritis, and PASI, DAS28, and HAQ were evaluated. Both skin and joint symptoms simultaneously and significantly improved.

Key Conclusion

Korean medicine combination therapy is effective in simultaneously managing skin and joint symptoms in patients with psoriatic arthritis.

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