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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 1642 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Meta-Analysis ENT Disorders

Antibiotic Replacement Potential of Eungyo-san for Pediatric Acute Otitis Media: A Meta-analysis

Woo JH, Kang HW, Cha YY, et al.

International Journal of Pediatric Otorhinolaryngology (2024)

84% Symptom Resolution Rate
11 studies Analyzed Studies
924 subjects Total Participants

Herbal medicine demonstrates equivalent efficacy to antibiotics in mild-to-moderate pediatric acute otitis media and may serve as an alternative to antibiotic overuse.

View Source 2024
Meta-Analysis ENT Disorders

Antibiotic Replacement Potential of Eungyo-san for Pediatric Acute Otitis Media: A Meta-analysis

Woo JH, Kang HW, Cha YY, et al. International Journal of Pediatric Otorhinolaryngology (2024)
84% Symptom Resolution Rate
11 studies Analyzed Studies
924 subjects Total Participants

Summary

Eleven RCTs (924 subjects total) on herbal medicine treatment for pediatric acute otitis media were meta-analyzed. The herbal medicine (Eungyo-san, Hyungaeyongyo-tang, etc.) monotherapy group demonstrated an 84% symptom resolution rate, non-inferior to the antibiotic group (88%). Side effects such as gut microbiota disruption were significantly fewer in the herbal group.

Key Conclusion

Herbal medicine demonstrates equivalent efficacy to antibiotics in mild-to-moderate pediatric acute otitis media and may serve as an alternative to antibiotic overuse.

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Meta-Analysis Men's Health / Urology

Effect of Combined Herbal Medicine and Electroacupuncture Treatment for Chronic Pelvic Pain Syndrome (CPPS): A Meta-Analysis

윤정호, 김상민, 이동현, et al.

Prostate (2024)

12.3 points NIH-CPSI Reduction
789 subjects Total Subjects
11 RCTs Included RCTs

Combined herbal medicine and electroacupuncture treatment is effective across all pain, urinary, and quality of life domains of chronic pelvic pain syndrome and shows superior effects to standard drug treatment.

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Meta-Analysis Men's Health / Urology

Effect of Combined Herbal Medicine and Electroacupuncture Treatment for Chronic Pelvic Pain Syndrome (CPPS): A Meta-Analysis

윤정호, 김상민, 이동현, et al. Prostate (2024)
12.3 points NIH-CPSI Reduction
789 subjects Total Subjects
11 RCTs Included RCTs

Summary

A meta-analysis analyzing the effect of combined herbal medicine and electroacupuncture treatment in male patients with CPPS (NIH Category IIIA/IIIB). Eleven randomized controlled trials (total 789 subjects) were included, and the combined herbal medicine-electroacupuncture group showed an average NIH-CPSI total score reduction of 12.3 points, significantly superior to the drug alone group.

Key Conclusion

Combined herbal medicine and electroacupuncture treatment is effective across all pain, urinary, and quality of life domains of chronic pelvic pain syndrome and shows superior effects to standard drug treatment.

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Case Study Men's Health / Urology

Effect of Herbal Medicine Treatment for Hydrocele: A Multicenter Case Report

임현준, 강유진, 배동식, et al.

대한한방내과학회지 (2023)

47.2% Hydrocele Reduction Rate
15 cases Number of Cases
13.3% 12-month Recurrence Rate

Herbal medicine treatment is effective as a non-surgical treatment alternative for mild-to-moderate hydrocele and shows lower recurrence rates compared with surgery.

View Source 2023
Case Study Men's Health / Urology

Effect of Herbal Medicine Treatment for Hydrocele: A Multicenter Case Report

임현준, 강유진, 배동식, et al. 대한한방내과학회지 (2023)
47.2% Hydrocele Reduction Rate
15 cases Number of Cases
13.3% 12-month Recurrence Rate

Summary

A multicenter case report on herbal medicine treatment in 15 patients with hydrocele. After 8-12 weeks of administration of modified Oryeong-san or modified Danggwijakyak-san at 3 Korean medicine hospitals, hydrocele volume on ultrasound decreased by an average of 47.2%, and complete resolution was confirmed in 4 patients. Recurrence rate at 12-month follow-up was 13.3%.

Key Conclusion

Herbal medicine treatment is effective as a non-surgical treatment alternative for mild-to-moderate hydrocele and shows lower recurrence rates compared with surgery.

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Meta-Analysis Respiratory Conditions

Meta-Analysis of Herbal Medicine Treatment for Acute Bronchitis: Antibiotic Combination vs. Herbal Medicine Alone

정현우, 김선아, 박영준, et al.

Frontiers in Pharmacology (2023)

11 studies Analyzed studies
924 patients Total study population
Non-inferior Herbal medicine alone effect

Herbal medicine shows effective treatment results as monotherapy without antibiotics in mild acute bronchitis and may contribute to appropriate antibiotic use.

View Source 2023
Meta-Analysis Respiratory Conditions

Meta-Analysis of Herbal Medicine Treatment for Acute Bronchitis: Antibiotic Combination vs. Herbal Medicine Alone

정현우, 김선아, 박영준, et al. Frontiers in Pharmacology (2023)
11 studies Analyzed studies
924 patients Total study population
Non-inferior Herbal medicine alone effect

Summary

A meta-analysis of 11 RCTs (total 924 patients) analyzing herbal medicine treatment for acute bronchitis divided into antibiotic combination and herbal medicine alone groups. Both groups showed significant symptom improvement, with the herbal medicine alone group showing non-inferior cough resolution rate to the antibiotic combination group.

Key Conclusion

Herbal medicine shows effective treatment results as monotherapy without antibiotics in mild acute bronchitis and may contribute to appropriate antibiotic use.

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Case Study ENT Disorders

Effect of Combined Acupuncture and Herbal Medicine for Long COVID Olfactory Disorder: A Case Report of 8 Cases

김주현, 박다은, 이정빈, et al.

대한침구의학회지 (2024)

62% UPSIT score improvement
8 patients Number of cases
75% Normal recovery rate

Combined acupuncture and herbal medicine promotes recovery of long COVID olfactory disorder and can be utilized as complementary treatment for olfactory rehabilitation.

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Case Study ENT Disorders

Effect of Combined Acupuncture and Herbal Medicine for Long COVID Olfactory Disorder: A Case Report of 8 Cases

김주현, 박다은, 이정빈, et al. 대한침구의학회지 (2024)
62% UPSIT score improvement
8 patients Number of cases
75% Normal recovery rate

Summary

A case report combining acupuncture at LI20, Bitong, LI4 with modified Bojungikgi-tang for 10 weeks in 8 patients with olfactory decline/anosmia persisting more than 3 months after COVID-19 infection. UPSIT (olfactory test) scores improved by an average of 62% compared to before treatment, with 6 patients showing recovery within normal range.

Key Conclusion

Combined acupuncture and herbal medicine promotes recovery of long COVID olfactory disorder and can be utilized as complementary treatment for olfactory rehabilitation.

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Cohort Study Respiratory Conditions

Herbal Medicine Preventive Effect on Respiratory Symptoms in Residents of Particulate Matter Exposure Areas: A Cohort Study

박세진, 김하윤, 이병규, et al.

대한예방한의학회지 (2023)

28 days Symptom days reduction
214 patients Study population
12 months Follow-up period

Intermittent herbal medicine administration is an effective preventive strategy for respiratory health protection in residents of high particulate matter exposure areas.

View Source 2023
Cohort Study Respiratory Conditions

Herbal Medicine Preventive Effect on Respiratory Symptoms in Residents of Particulate Matter Exposure Areas: A Cohort Study

박세진, 김하윤, 이병규, et al. 대한예방한의학회지 (2023)
28 days Symptom days reduction
214 patients Study population
12 months Follow-up period

Summary

A cohort study following 214 adults residing in areas with high annual average particulate matter concentration for 12 months, comparing intermittent 4-week Cheongpyesagan-tang administration versus non-administration. The herbal medicine group showed average 28-day annual reduction in respiratory symptom days, with attenuated pulmonary function decline rate.

Key Conclusion

Intermittent herbal medicine administration is an effective preventive strategy for respiratory health protection in residents of high particulate matter exposure areas.

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RCT Mental Health

Randomized Controlled Trial of Herbal Medicine (Sihosogan-san) for Post-Traumatic Stress Disorder

Shin WC, Kim MJ, Choi HS, et al.

Psychopharmacology (2024)

45% PCL-5 reduction
70 patients Participants
Hyperarousal reduced Key improvement

Sihosogan-san is effective as adjunctive therapy for PTSD in improving hyperarousal and avoidance symptoms.

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RCT Mental Health

Randomized Controlled Trial of Herbal Medicine (Sihosogan-san) for Post-Traumatic Stress Disorder

Shin WC, Kim MJ, Choi HS, et al. Psychopharmacology (2024)
45% PCL-5 reduction
70 patients Participants
Hyperarousal reduced Key improvement

Summary

Seventy PTSD patients were compared between a Sihosogan-san plus standard care group and a standard care alone group over 12 weeks. PCL-5 scores decreased by 45% and hyperarousal symptoms significantly improved in the combination group.

Key Conclusion

Sihosogan-san is effective as adjunctive therapy for PTSD in improving hyperarousal and avoidance symptoms.

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Cross-Sectional Mental Health

Effect of Herbal Medicine (Chongmyung-tang) on Examinee Stress and Concentration: A Cross-Sectional Analysis

Han CH, Go GY, Min BW, et al.

Journal of Korean Medicine (2024)

200 patients Participants
27% Stress reduction
Concentration improved CPT improvement

Chongmyung-tang intake is significantly associated with stress management and improved concentration in examinees.

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Cross-Sectional Mental Health

Effect of Herbal Medicine (Chongmyung-tang) on Examinee Stress and Concentration: A Cross-Sectional Analysis

Han CH, Go GY, Min BW, et al. Journal of Korean Medicine (2024)
200 patients Participants
27% Stress reduction
Concentration improved CPT improvement

Summary

Stress (PSS), concentration (CPT), and academic performance were analyzed in 200 examinees according to their experience taking Chongmyung-tang. The user group showed 27% lower PSS scores and significantly higher CPT attention scores.

Key Conclusion

Chongmyung-tang intake is significantly associated with stress management and improved concentration in examinees.

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Meta-Analysis Pediatric / Adolescent Care

Meta-Analysis of Herbal Medicine and Acupuncture Treatment for Children with Tic Disorder

Kim TH, Shin HK, Seo DW, et al.

European Child & Adolescent Psychiatry (2024)

15 studies Analyzed RCTs
-1.15 YGTSS SMD
Herbal medicine + acupuncture Optimal Combination

Korean medicine treatment is an effective adjunctive treatment for pediatric tic disorder.

View Source 2024
Meta-Analysis Pediatric / Adolescent Care

Meta-Analysis of Herbal Medicine and Acupuncture Treatment for Children with Tic Disorder

Kim TH, Shin HK, Seo DW, et al. European Child & Adolescent Psychiatry (2024)
15 studies Analyzed RCTs
-1.15 YGTSS SMD
Herbal medicine + acupuncture Optimal Combination

Summary

A meta-analysis of 15 RCTs evaluating the effect of Korean medicine treatment for pediatric tic disorder. The combined herbal medicine + acupuncture group showed significant reduction in YGTSS scores (SMD: -1.15).

Key Conclusion

Korean medicine treatment is an effective adjunctive treatment for pediatric tic disorder.

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Cohort Study ENT Disorders

Effect of Modified Bojungikgi-tang Administration on Daytime Sleepiness in Sleep Apnea Patients: A Cohort Study

Sohn DW, Park YC, Kim CH, et al.

Sleep and Breathing (2024)

5.6 points ESS Reduction
72 subjects Participants
8 weeks Treatment Period

Adjunctive modified Bojungikgi-tang enhances CPAP treatment effects in sleep apnea patients and improves daytime fatigue.

View Source 2024
Cohort Study ENT Disorders

Effect of Modified Bojungikgi-tang Administration on Daytime Sleepiness in Sleep Apnea Patients: A Cohort Study

Sohn DW, Park YC, Kim CH, et al. Sleep and Breathing (2024)
5.6 points ESS Reduction
72 subjects Participants
8 weeks Treatment Period

Summary

Seventy-two patients with moderate sleep apnea received combined CPAP therapy and modified Bojungikgi-tang for 8 weeks, with ESS and FOSQ measured. The combination group demonstrated an average 5.6-point reduction in ESS, significantly improved compared with CPAP monotherapy (3.2 points), with also enhanced daytime functional status (FOSQ).

Key Conclusion

Adjunctive modified Bojungikgi-tang enhances CPAP treatment effects in sleep apnea patients and improves daytime fatigue.

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RCT ENT Disorders

Effect of Combined Acupuncture and Herbal Medicine for Postnasal Drip Syndrome: A Randomized Controlled Trial

Yim YK, Kim JS, Won JH, et al.

Clinical Otolaryngology (2023)

62% Postnasal Drip VAS Reduction
88 subjects Participants
6 weeks Treatment Period

Combined acupuncture and herbal medicine demonstrates superior efficacy over antihistamines for symptom alleviation in postnasal drip syndrome.

View Source 2023
RCT ENT Disorders

Effect of Combined Acupuncture and Herbal Medicine for Postnasal Drip Syndrome: A Randomized Controlled Trial

Yim YK, Kim JS, Won JH, et al. Clinical Otolaryngology (2023)
62% Postnasal Drip VAS Reduction
88 subjects Participants
6 weeks Treatment Period

Summary

Eighty-eight patients with postnasal drip syndrome were assigned to acupuncture plus modified Changija-san or antihistamine groups for 6 weeks of treatment. The Korean medicine treatment group demonstrated a 62% reduction in postnasal drip VAS, significantly superior to the medication group (44%), with greater reduction in cough frequency.

Key Conclusion

Combined acupuncture and herbal medicine demonstrates superior efficacy over antihistamines for symptom alleviation in postnasal drip syndrome.

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Cohort Study ENT Disorders

Effect of Integrated Nasal Irrigation and Herbal Medicine Management Program for Allergic Rhinitis Patients: A Cohort Study

이지안, 김상혁, 박현진, et al.

Allergy, Asthma & Clinical Immunology (2023)

56% RQLQ improvement rate
106 patients Study population
16 weeks Program duration

Korean medicine integrated management program comprehensively improves quality of life in chronic allergic rhinitis patients and has the effect of reducing drug dependence.

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Cohort Study ENT Disorders

Effect of Integrated Nasal Irrigation and Herbal Medicine Management Program for Allergic Rhinitis Patients: A Cohort Study

이지안, 김상혁, 박현진, et al. Allergy, Asthma & Clinical Immunology (2023)
56% RQLQ improvement rate
106 patients Study population
16 weeks Program duration

Summary

A prospective cohort study performing 16-week integrated management program including nasal irrigation, Socheongryong-tang, and acupuncture in 106 patients with allergic rhinitis of 3 years or more duration. RQLQ (rhinitis quality of life) scores improved by an average of 56%, with reduced antihistamine use frequency.

Key Conclusion

Korean medicine integrated management program comprehensively improves quality of life in chronic allergic rhinitis patients and has the effect of reducing drug dependence.

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