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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 1642 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
RCT Skin Conditions

Randomized Controlled Trial of Herbal Medicine for Dyshidrotic Eczema: Focus on Damp-Resolving Prescriptions

노영수, 김하영, 이승민, et al.

대한한방내과학회지 (2023)

72 patients Participants
-74.1% Blister reduction rate
15.3% Recurrence rate (herbal)

Damp-resolving herbal medicine treatment is effective for both acute symptom relief and recurrence prevention in dyshidrotic eczema.

View Source 2023
RCT Skin Conditions

Randomized Controlled Trial of Herbal Medicine for Dyshidrotic Eczema: Focus on Damp-Resolving Prescriptions

노영수, 김하영, 이승민, et al. 대한한방내과학회지 (2023)
72 patients Participants
-74.1% Blister reduction rate
15.3% Recurrence rate (herbal)

Summary

Seventy-two patients with dyshidrotic eczema of hands and feet were randomly assigned to compare damp-resolving herbal medicine (modified Pyeongwi-san) versus topical steroids for 8 weeks. The herbal medicine group showed significantly reduced blister occurrence frequency and pruritus, with significantly lower recurrence rates at 8 weeks after treatment completion than the steroid group.

Key Conclusion

Damp-resolving herbal medicine treatment is effective for both acute symptom relief and recurrence prevention in dyshidrotic eczema.

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Cohort Study Skin Conditions

Cohort Study of Combined Oral Herbal Medicine and Korean Medicine Topical Preparation for Melasma

서민정, 류태규, 김은혜, et al.

Journal of Cosmetic Dermatology (2024)

75 patients Cohort size
-45.3% MASI reduction rate
12.8% Recurrence rate

Combined oral herbal medicine and Korean medicine topical preparation therapy is effective for melasma treatment, with lower recurrence rates than conventional treatment in long-term pigment management.

View Source 2024
Cohort Study Skin Conditions

Cohort Study of Combined Oral Herbal Medicine and Korean Medicine Topical Preparation for Melasma

서민정, 류태규, 김은혜, et al. Journal of Cosmetic Dermatology (2024)
75 patients Cohort size
-45.3% MASI reduction rate
12.8% Recurrence rate

Summary

Seventy-five patients with facial melasma underwent combined therapy with oral Gamisoyo-san and Bombyx mori-containing topical preparation, followed up for 20 weeks. MASI scores significantly decreased in the combination group, with also improved melanin index and skin brightness indicators. Recurrence rate was lower compared to hydroquinone alone group.

Key Conclusion

Combined oral herbal medicine and Korean medicine topical preparation therapy is effective for melasma treatment, with lower recurrence rates than conventional treatment in long-term pigment management.

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RCT Skin Conditions

Randomized Controlled Trial of Combined Herbal Medicine and Minoxidil for Male Pattern Baldness

강동민, 서유라, 박성진, et al.

대한한방내과학회지 (2023)

96 patients Participants
+34.2% Hair density increase
p<0.01 Hair thickness improvement

Combined He Shou Wu-based herbal medicine and minoxidil therapy significantly improves hair growth indicators in male pattern baldness compared to monotherapy.

View Source 2023
RCT Skin Conditions

Randomized Controlled Trial of Combined Herbal Medicine and Minoxidil for Male Pattern Baldness

강동민, 서유라, 박성진, et al. 대한한방내과학회지 (2023)
96 patients Participants
+34.2% Hair density increase
p<0.01 Hair thickness improvement

Summary

Ninety-six patients with androgenetic alopecia (AGA) were evaluated for the effect of He Shou Wu-based herbal medicine combined with 5% minoxidil compared to minoxidil alone. After 24 weeks, the combination group showed significantly higher hair density increase rate and hair thickness improvement rate, with also decreased scalp sebum secretion.

Key Conclusion

Combined He Shou Wu-based herbal medicine and minoxidil therapy significantly improves hair growth indicators in male pattern baldness compared to monotherapy.

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Cohort Study Men's Health / Urology

Concurrent Treatment Effect of Herbal Medicine for Sleep Disorders and Nocturia in Middle-Aged Men: A Cohort Study

정호진, 윤서현, 강병준, et al.

Sleep Medicine (2024)

45.1% PSQI Improvement Rate
54.8% Nocturia Reduction Rate
110 subjects Cohort Size

Sanjoin-tang combined with Chukcheon-hwan is effective for concurrent treatment of sleep disorders and nocturia and is an integrated approach blocking the vicious cycle between the two symptoms.

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Cohort Study Men's Health / Urology

Concurrent Treatment Effect of Herbal Medicine for Sleep Disorders and Nocturia in Middle-Aged Men: A Cohort Study

정호진, 윤서현, 강병준, et al. Sleep Medicine (2024)
45.1% PSQI Improvement Rate
54.8% Nocturia Reduction Rate
110 subjects Cohort Size

Summary

A cohort study analyzing the effect of Sanjoin-tang combined with Chukcheon-hwan in 110 men aged 45-65 simultaneously complaining of sleep disorders and nocturia. After 12 weeks of administration, PSQI improved from an average of 14.2 to 7.8, and nocturnal urination frequency decreased from an average of 3.1 to 1.4 times. Simultaneous improvement of both symptoms was confirmed.

Key Conclusion

Sanjoin-tang combined with Chukcheon-hwan is effective for concurrent treatment of sleep disorders and nocturia and is an integrated approach blocking the vicious cycle between the two symptoms.

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Meta-Analysis Men's Health / Urology

Comparative Effect of Combined Herbal Medicine and Tadalafil Treatment for Benign Prostatic Hyperplasia: A Meta-Analysis

최재원, 박영훈, 이동수, et al.

World Journal of Urology (2024)

3.8 points Additional IPSS Reduction
2.1 mL/s Additional Qmax Increase
612 subjects Total Subjects

Combined herbal medicine-tadalafil treatment significantly additionally improves lower urinary tract symptoms and urodynamic indicators in BPH patients compared with single treatment.

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Meta-Analysis Men's Health / Urology

Comparative Effect of Combined Herbal Medicine and Tadalafil Treatment for Benign Prostatic Hyperplasia: A Meta-Analysis

최재원, 박영훈, 이동수, et al. World Journal of Urology (2024)
3.8 points Additional IPSS Reduction
2.1 mL/s Additional Qmax Increase
612 subjects Total Subjects

Summary

A meta-analysis comparing the effects of herbal medicine + tadalafil combination and tadalafil alone in benign prostatic hyperplasia (BPH) patients. Nine randomized controlled trials (total 612 subjects) were included, and the combined group showed an average 3.8 additional points reduction in IPSS and an average 2.1 mL/s additional increase in Qmax, confirming the additive effect of combined treatment.

Key Conclusion

Combined herbal medicine-tadalafil treatment significantly additionally improves lower urinary tract symptoms and urodynamic indicators in BPH patients compared with single treatment.

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Systematic Review Men's Health / Urology

Protective Effect of Antioxidant Combined Herbal Medicine on Sperm DNA Damage: A Systematic Review

송영석, 안태진, 김재홍, et al.

Antioxidants (2023)

18.7% DFI Reduction
14 studies Included Studies
p<0.001 Statistical Significance

Antioxidant combined herbal medicine significantly reduces sperm DNA damage and is effective for protecting male fertility through oxidative stress regulation.

View Source 2023
Systematic Review Men's Health / Urology

Protective Effect of Antioxidant Combined Herbal Medicine on Sperm DNA Damage: A Systematic Review

송영석, 안태진, 김재홍, et al. Antioxidants (2023)
18.7% DFI Reduction
14 studies Included Studies
p<0.001 Statistical Significance

Summary

A systematic review analyzing the protective effect of antioxidant combined herbal medicine on sperm DNA damage in male infertility patients with sperm DNA damage (DFI ≥30%). Fourteen studies were included, and in Cornus officinalis-Schisandra-Lycium chinense-based prescriptions, DFI decreased by an average of 18.7%, and sperm intracellular ROS levels and MDA concentration also decreased significantly.

Key Conclusion

Antioxidant combined herbal medicine significantly reduces sperm DNA damage and is effective for protecting male fertility through oxidative stress regulation.

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Before-After Pediatric / Adolescent Care

Pre-Post Comparison Study of Pediatric Acupuncture and Herbal Medicine for Children with Separation Anxiety Disorder

Suh JW, Shin MK, Kang JH, et al.

Child Psychiatry & Human Development (2023)

46% Separation anxiety reduction
30 patients Participants
8 weeks Treatment duration

Combination of pediatric acupuncture and herbal medicine is effective in alleviating symptoms in children with separation anxiety disorder.

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Before-After Pediatric / Adolescent Care

Pre-Post Comparison Study of Pediatric Acupuncture and Herbal Medicine for Children with Separation Anxiety Disorder

Suh JW, Shin MK, Kang JH, et al. Child Psychiatry & Human Development (2023)
46% Separation anxiety reduction
30 patients Participants
8 weeks Treatment duration

Summary

Pediatric acupuncture plus herbal medicine (Gammaekdaejo-tang) was applied to 30 children with separation anxiety disorder for 8 weeks. SASC separation anxiety scores decreased by 46% and parent-reported behavioral problems improved.

Key Conclusion

Combination of pediatric acupuncture and herbal medicine is effective in alleviating symptoms in children with separation anxiety disorder.

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Cross-Sectional Digestive Disorders

Effect of Herbal Medicine (Banhahubak-tang) on Functional Dyspepsia with Anxiety: A Cross-Sectional Analysis

Woo HS, Cho HJ, Nam DH, et al.

Functional Dyspepsia Research (2023)

160 patients Participants
38% Dyspepsia reduction
32% Anxiety reduction

Banhahubak-tang is effective for the simultaneous management of anxiety and functional dyspepsia.

View Source 2023
Cross-Sectional Digestive Disorders

Effect of Herbal Medicine (Banhahubak-tang) on Functional Dyspepsia with Anxiety: A Cross-Sectional Analysis

Woo HS, Cho HJ, Nam DH, et al. Functional Dyspepsia Research (2023)
160 patients Participants
38% Dyspepsia reduction
32% Anxiety reduction

Summary

Symptom differences were analyzed in 160 patients with functional dyspepsia comorbid with anxiety according to Banhahubak-tang use. Both FD symptoms (-38%) and anxiety (-32%) were significantly lower in the user group.

Key Conclusion

Banhahubak-tang is effective for the simultaneous management of anxiety and functional dyspepsia.

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RCT Mental Health

Randomized Controlled Trial of Moxibustion Combined with Herbal Medicine for Sleep Disorders in the Elderly

Seo DW, Park BS, Lee SY, et al.

Geriatrics & Gerontology International (2024)

6.2 points PSQI reduction
80 patients Participants
Moxibustion + herbs Optimal combination

Combination of moxibustion and herbal medicine is more effective than monotherapy for sleep disorders in the elderly.

View Source 2024
RCT Mental Health

Randomized Controlled Trial of Moxibustion Combined with Herbal Medicine for Sleep Disorders in the Elderly

Seo DW, Park BS, Lee SY, et al. Geriatrics & Gerontology International (2024)
6.2 points PSQI reduction
80 patients Participants
Moxibustion + herbs Optimal combination

Summary

Eighty elderly patients aged 65 or older with sleep disorders were compared between a moxibustion plus herbal medicine group and herbal medicine alone group for 8 weeks. The combination group showed a 6.2-point reduction in PSQI, significantly superior to the monotherapy group (3.8 points).

Key Conclusion

Combination of moxibustion and herbal medicine is more effective than monotherapy for sleep disorders in the elderly.

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Meta-Analysis Mental Health

Effect of Meditation Combined with Herbal Medicine on Chronic Anxiety: A Meta-Analysis

Kim CH, Baek YH, Jeon SW, et al.

Journal of Psychosomatic Research (2023)

14 RCTs Analyzed RCTs
-4.21 BAI MD
Synergistic effect Combination benefit

The combination of meditation and herbal medicine provides synergistic effects for chronic anxiety.

View Source 2023
Meta-Analysis Mental Health

Effect of Meditation Combined with Herbal Medicine on Chronic Anxiety: A Meta-Analysis

Kim CH, Baek YH, Jeon SW, et al. Journal of Psychosomatic Research (2023)
14 RCTs Analyzed RCTs
-4.21 BAI MD
Synergistic effect Combination benefit

Summary

Fourteen RCTs evaluating the combined effects of meditation and herbal medicine on chronic anxiety were meta-analyzed. The combination group showed additional BAI score reduction (MD: -4.21) compared to monotherapy.

Key Conclusion

The combination of meditation and herbal medicine provides synergistic effects for chronic anxiety.

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RCT Neurological Disorders

Effect of Combined Jinmu-tang and Vestibular Rehabilitation for Geriatric Vertigo: A Randomized Controlled Trial

Sung WS, Hong JW, Park SH, et al.

Geriatrics & Gerontology International (2024)

56% DHI Reduction Rate
108 subjects Participants
8 weeks Treatment Period

Adjunctive Jinmu-tang enhances vestibular rehabilitation effects in geriatric vertigo and reduces fall risk.

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RCT Neurological Disorders

Effect of Combined Jinmu-tang and Vestibular Rehabilitation for Geriatric Vertigo: A Randomized Controlled Trial

Sung WS, Hong JW, Park SH, et al. Geriatrics & Gerontology International (2024)
56% DHI Reduction Rate
108 subjects Participants
8 weeks Treatment Period

Summary

One hundred eight patients aged 65 or older with chronic vertigo were assigned to vestibular rehabilitation monotherapy or rehabilitation plus Jinmu-tang combination groups for 8 weeks of treatment. The combination group demonstrated a 56% reduction in DHI, significantly superior to monotherapy (38%), with greater improvement also in fall fear (FES-I).

Key Conclusion

Adjunctive Jinmu-tang enhances vestibular rehabilitation effects in geriatric vertigo and reduces fall risk.

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Before-After Neurological Disorders

Effect of Banhabaekchulcheonma-tang for Residual Dizziness in BPPV: A Pre-Post Comparison Study

Gu BM, Seol IC, Kim YS, et al.

Journal of Vestibular Research (2023)

52% DHI Reduction Rate
74% Dizziness Resolution
54 subjects Participants

Banhabaekchulcheonma-tang is effective for rapid resolution of residual dizziness after BPPV canalith repositioning.

View Source 2023
Before-After Neurological Disorders

Effect of Banhabaekchulcheonma-tang for Residual Dizziness in BPPV: A Pre-Post Comparison Study

Gu BM, Seol IC, Kim YS, et al. Journal of Vestibular Research (2023)
52% DHI Reduction Rate
74% Dizziness Resolution
54 subjects Participants

Summary

Fifty-four BPPV patients with residual dizziness persisting more than 2 weeks after canalith repositioning received Banhabaekchulcheonma-tang for 4 weeks. DHI scores decreased by an average of 52%, with complete residual dizziness resolution rate reaching 74%. Gait stability (TUG) also improved significantly.

Key Conclusion

Banhabaekchulcheonma-tang is effective for rapid resolution of residual dizziness after BPPV canalith repositioning.

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