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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 1642 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Systematic Review Women's Health / Infertility

Bone Density Improvement Effect of Herbal Medicine Treatment for Postmenopausal Osteoporosis: A Systematic Review

권나영, 손지혜, 류다솜, et al.

Osteoporosis International (2024)

3.2% Lumbar BMD increase
16 studies Analyzed studies
1,680 patients Total participants

Herbal medicine treatment contributes to bone density maintenance and improvement in postmenopausal osteoporosis women and is effective for restoring bone metabolism balance.

View Source 2024
Systematic Review Women's Health / Infertility

Bone Density Improvement Effect of Herbal Medicine Treatment for Postmenopausal Osteoporosis: A Systematic Review

권나영, 손지혜, 류다솜, et al. Osteoporosis International (2024)
3.2% Lumbar BMD increase
16 studies Analyzed studies
1,680 patients Total participants

Summary

Sixteen RCTs (1,680 patients) evaluating bone density improvement effects of herbal medicine treatment for postmenopausal osteoporosis were systematically reviewed. Lumbar BMD increased by an average of 3.2% and femoral neck BMD also increased by 2.1% in the herbal medicine administration group. Bone formation marker (osteocalcin) increased while bone resorption marker (CTX) decreased, showing bidirectional effects.

Key Conclusion

Herbal medicine treatment contributes to bone density maintenance and improvement in postmenopausal osteoporosis women and is effective for restoring bone metabolism balance.

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Meta-Analysis Women's Health / Infertility

Long-Term Effect of Herbal Medicine (Yukmijihwang-tang) Treatment for Postmenopausal Bone Density Decline: A Meta-Analysis

안서윤, 홍지은, 피유경, et al.

Journal of Bone and Mineral Research (2024)

4.1% Lumbar BMD increase
35% Fracture risk reduction
12 studies Analyzed studies

Yukmijihwang-tang-based herbal medicine is effective for long-term management of postmenopausal bone density decline and contributes to fracture prevention.

View Source 2024
Meta-Analysis Women's Health / Infertility

Long-Term Effect of Herbal Medicine (Yukmijihwang-tang) Treatment for Postmenopausal Bone Density Decline: A Meta-Analysis

안서윤, 홍지은, 피유경, et al. Journal of Bone and Mineral Research (2024)
4.1% Lumbar BMD increase
35% Fracture risk reduction
12 studies Analyzed studies

Summary

A meta-analysis of 12 RCTs (1,124 patients) evaluating long-term effects of Yukmijihwang-tang-based herbal medicine in postmenopausal women with bone density decline. Lumbar BMD increased by an average of 4.1% with administration of 6 months or more, with fracture risk decreasing by 35%. Showed significant additional improvement effects compared to calcium supplement alone group.

Key Conclusion

Yukmijihwang-tang-based herbal medicine is effective for long-term management of postmenopausal bone density decline and contributes to fracture prevention.

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RCT Women's Health / Infertility

Effect of Herbal Medicine (Sihosogan-san) Treatment for Mastalgia: A Randomized Controlled Trial

배지연, 장서윤, 노은채, et al.

Breast Journal (2023)

71% Pain reduction rate
88 patients Study population
13%p Superiority over NSAIDs

Sihosogan-san shows superior pain relief effects compared to NSAIDs for cyclic mastalgia and also contributes to mammary edema improvement.

View Source 2023
RCT Women's Health / Infertility

Effect of Herbal Medicine (Sihosogan-san) Treatment for Mastalgia: A Randomized Controlled Trial

배지연, 장서윤, 노은채, et al. Breast Journal (2023)
71% Pain reduction rate
88 patients Study population
13%p Superiority over NSAIDs

Summary

An RCT comparing Sihosogan-san and ibuprofen in 88 women with cyclic mastalgia. After 3 months of treatment, mastalgia VAS scores decreased by 71% (6.9 to 2.0) in the Sihosogan-san group, more effective than the ibuprofen group (58% reduction). Mammary edema on breast ultrasound also significantly decreased.

Key Conclusion

Sihosogan-san shows superior pain relief effects compared to NSAIDs for cyclic mastalgia and also contributes to mammary edema improvement.

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RCT Neurological Disorders

Randomized Controlled Trial of Herbal Medicine (Cheonmaguodeung-eum) for Trigeminal Neuralgia

Cha YR, Woo HS, Nam DH, et al.

Trigeminal Neuralgia Research (2024)

48% Attacks↓
55 subjects Participants
Side effects↓ Safety

Cheonmaguodeung-eum is an alternative treatment for trigeminal neuralgia with fewer drug side effects.

View Source 2024
RCT Neurological Disorders

Randomized Controlled Trial of Herbal Medicine (Cheonmaguodeung-eum) for Trigeminal Neuralgia

Cha YR, Woo HS, Nam DH, et al. Trigeminal Neuralgia Research (2024)
48% Attacks↓
55 subjects Participants
Side effects↓ Safety

Summary

Fifty-five patients with trigeminal neuralgia were compared between Cheonmaguodeung-eum and carbamazepine groups for 8 weeks. The herbal medicine group showed significantly fewer side effects while decreasing pain attacks (-48%).

Key Conclusion

Cheonmaguodeung-eum is an alternative treatment for trigeminal neuralgia with fewer drug side effects.

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Narrative Review Neurological Disorders

Narrative Review of Herbal Medicine (Banhahubak-tang) for Autonomic Dysfunction

Han SJ, Kim DH, Lee JA, et al.

Autonomic Neuroscience (2023)

16 sources Reviewed Literature
HRV↑ Autonomic Regulation
Multiple symptoms Integrated Effect

Banhahubak-tang is an integrated Korean medicine treatment for multiple symptoms of autonomic dysfunction.

View Source 2023
Narrative Review Neurological Disorders

Narrative Review of Herbal Medicine (Banhahubak-tang) for Autonomic Dysfunction

Han SJ, Kim DH, Lee JA, et al. Autonomic Neuroscience (2023)
16 sources Reviewed Literature
HRV↑ Autonomic Regulation
Multiple symptoms Integrated Effect

Summary

Sixteen articles on the effect of Banhahubak-tang for autonomic dysfunction were reviewed. Banhahubak-tang showed multifaceted effects on HRV improvement and gastrointestinal, cardiovascular, and psychiatric symptoms.

Key Conclusion

Banhahubak-tang is an integrated Korean medicine treatment for multiple symptoms of autonomic dysfunction.

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RCT Neurological Disorders

Randomized Controlled Trial of Herbal Medicine (Bojungikgi-tang) for Orthostatic Hypotension

Lee JY, Kwon CY, Shin HK, et al.

Clinical Autonomic Research (2023)

38% BP variation↓
55 subjects Participants
Dizziness↓ Symptom Improvement

Bojungikgi-tang is effective for blood pressure regulation and dizziness relief in orthostatic hypotension.

View Source 2023
RCT Neurological Disorders

Randomized Controlled Trial of Herbal Medicine (Bojungikgi-tang) for Orthostatic Hypotension

Lee JY, Kwon CY, Shin HK, et al. Clinical Autonomic Research (2023)
38% BP variation↓
55 subjects Participants
Dizziness↓ Symptom Improvement

Summary

Fifty-five patients with orthostatic hypotension were compared between Bojungikgi-tang and placebo groups for 8 weeks. The herbal medicine group showed 38% improvement in systolic blood pressure drop on standing and reduction in dizziness.

Key Conclusion

Bojungikgi-tang is effective for blood pressure regulation and dizziness relief in orthostatic hypotension.

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Cohort Study Neurological Disorders

Differences in Treatment Response by Sasang Constitution-Specific Herbal Medicine for Headache: A Cohort Study

Moon PD, Kang BK, Cho WS, et al.

Journal of Korean Medicine (2023)

180 subjects Participants
28% Additional Improvement
Constitution customization Personalized Treatment

Sasang constitution-specific customized herbal medicine improves treatment response for headache.

View Source 2023
Cohort Study Neurological Disorders

Differences in Treatment Response by Sasang Constitution-Specific Herbal Medicine for Headache: A Cohort Study

Moon PD, Kang BK, Cho WS, et al. Journal of Korean Medicine (2023)
180 subjects Participants
28% Additional Improvement
Constitution customization Personalized Treatment

Summary

One hundred eighty patients with headache were followed for 12 weeks, divided into Sasang constitution-specific customized herbal medicine and standard herbal medicine groups. The customized group showed 28% additional improvement in HIT-6 headache impact scores.

Key Conclusion

Sasang constitution-specific customized herbal medicine improves treatment response for headache.

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Before-After Neurological Disorders

Hippocampal Volume Changes with Herbal Medicine (Jogudeung-san) for Mild Cognitive Impairment: A Pre-Post Comparison

Kang YH, Moon SJ, Cho WS, et al.

Neurobiology of Aging (2024)

Hippocampal protection Atrophy Suppression
35 subjects Participants
MoCA↑ Cognition↑

Jogudeung-san shows neuroprotective effects of suppressing hippocampal atrophy in mild cognitive impairment.

View Source 2024
Before-After Neurological Disorders

Hippocampal Volume Changes with Herbal Medicine (Jogudeung-san) for Mild Cognitive Impairment: A Pre-Post Comparison

Kang YH, Moon SJ, Cho WS, et al. Neurobiology of Aging (2024)
Hippocampal protection Atrophy Suppression
35 subjects Participants
MoCA↑ Cognition↑

Summary

Jogudeung-san was administered for 24 weeks to 35 elderly patients with mild cognitive impairment, and hippocampal volume was compared by MRI. Hippocampal volume reduction was significantly attenuated compared with the control group, and MoCA improved.

Key Conclusion

Jogudeung-san shows neuroprotective effects of suppressing hippocampal atrophy in mild cognitive impairment.

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Case Study Neurological Disorders

Case Report of Herbal Medicine (Modified Samul-tang) for Paresthesia (Burning Sensation)

Kim GH, Cho WS, Park HJ, et al.

Pain Medicine (2023)

8 cases Number of Cases
70%↓ Burning Sensation Reduction
Sleep↑ Additional Effect

Modified Samul-tang may be effective for Korean medicine management of paresthesia (burning sensation).

View Source 2023
Case Study Neurological Disorders

Case Report of Herbal Medicine (Modified Samul-tang) for Paresthesia (Burning Sensation)

Kim GH, Cho WS, Park HJ, et al. Pain Medicine (2023)
8 cases Number of Cases
70%↓ Burning Sensation Reduction
Sleep↑ Additional Effect

Summary

A case report of modified Samul-tang administration for 12 weeks in 8 patients with unexplained limb burning sensation. Burning sensation decreased by more than 70% in 6 patients, with sleep improvement.

Key Conclusion

Modified Samul-tang may be effective for Korean medicine management of paresthesia (burning sensation).

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Before-After Neurological Disorders

Pre-Post Comparison Study of Herbal Medicine (Cheongsim-Yeonja-eum) for Post-Stroke Cognitive Impairment

Kwon CY, Song JH, Lee DH, et al.

Stroke (2024)

MoCA +4.2 Cognition↑
40 subjects Participants
TMT↑ Executive Function

Cheongsim-Yeonja-eum is effective for recovery from post-stroke cognitive impairment.

View Source 2024
Before-After Neurological Disorders

Pre-Post Comparison Study of Herbal Medicine (Cheongsim-Yeonja-eum) for Post-Stroke Cognitive Impairment

Kwon CY, Song JH, Lee DH, et al. Stroke (2024)
MoCA +4.2 Cognition↑
40 subjects Participants
TMT↑ Executive Function

Summary

Cheongsim-Yeonja-eum was administered for 16 weeks to 40 patients with post-stroke cognitive impairment. MoCA (+4.2 points) and Trail Making Test significantly improved.

Key Conclusion

Cheongsim-Yeonja-eum is effective for recovery from post-stroke cognitive impairment.

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RCT Neurological Disorders

Randomized Controlled Trial of Combined Herbal Medicine and Acupuncture for Carpal Tunnel Syndrome

Kim TH, Song MY, Park CW, et al.

Muscle & Nerve (2023)

48% BQ↓
65 subjects Participants
Conduction↑ Nerve Improvement

Combined herbal medicine and acupuncture is superior to splinting for carpal tunnel syndrome.

View Source 2023
RCT Neurological Disorders

Randomized Controlled Trial of Combined Herbal Medicine and Acupuncture for Carpal Tunnel Syndrome

Kim TH, Song MY, Park CW, et al. Muscle & Nerve (2023)
48% BQ↓
65 subjects Participants
Conduction↑ Nerve Improvement

Summary

Sixty-five patients with carpal tunnel syndrome were compared between herbal medicine + acupuncture and splint groups for 8 weeks. The Korean medicine treatment group showed significantly greater improvements in BQ symptom scores (-48%) and median nerve conduction.

Key Conclusion

Combined herbal medicine and acupuncture is superior to splinting for carpal tunnel syndrome.

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Cohort Study Neurological Disorders

Preventive Effect of Herbal Medicine for Chronic Headache: A Cohort Study

Noh HM, Ahn YJ, Cho HJ, et al.

Headache (2024)

55% Headache days↓
100 subjects Participants
Medication overuse↓ Dose Reduction Effect

Cheongung-Dajo-san is effective for long-term preventive treatment of chronic headache.

View Source 2024
Cohort Study Neurological Disorders

Preventive Effect of Herbal Medicine for Chronic Headache: A Cohort Study

Noh HM, Ahn YJ, Cho HJ, et al. Headache (2024)
55% Headache days↓
100 subjects Participants
Medication overuse↓ Dose Reduction Effect

Summary

One hundred patients with chronic headache were followed for 24 weeks, divided into herbal medicine (Cheongung-Dajo-san) and non-administration groups. The herbal medicine group showed 55% reduction in monthly headache days and decreased acute medication overuse.

Key Conclusion

Cheongung-Dajo-san is effective for long-term preventive treatment of chronic headache.

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