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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 1642 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
RCT Respiratory Conditions

Herbal Medicine Treatment for Immunity Enhancement After Pediatric Respiratory Infections: A Randomized Controlled Trial

김보경, 이상현, 조해인, et al.

Pediatric Allergy and Immunology (2024)

45% Reinfection rate reduction
84 patients Study population
IgA increase Immune indicator improvement

Samchulgeonbi-tang is an effective herbal medicine prescription that promotes immunity recovery after pediatric respiratory infections and prevents reinfection.

View Source 2024
RCT Respiratory Conditions

Herbal Medicine Treatment for Immunity Enhancement After Pediatric Respiratory Infections: A Randomized Controlled Trial

김보경, 이상현, 조해인, et al. Pediatric Allergy and Immunology (2024)
45% Reinfection rate reduction
84 patients Study population
IgA increase Immune indicator improvement

Summary

A comparison of 8-week administration of Samchulgeonbi-tang versus vitamin control in 84 children aged 4-10 years suspected of immune decline after respiratory infection. The herbal medicine group showed 45% reduction in subsequent infection occurrence, with significant increases in salivary IgA and blood lymphocyte counts.

Key Conclusion

Samchulgeonbi-tang is an effective herbal medicine prescription that promotes immunity recovery after pediatric respiratory infections and prevents reinfection.

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Meta-Analysis Respiratory Conditions

Systematic Review and Meta-Analysis of Herbal Medicine Maintenance Treatment for Stable-Phase COPD Patients

정민재, 김도현, 박소연, et al.

Chronic Respiratory Disease (2023)

0.8 episodes Annual exacerbation reduction
15 studies Analyzed studies
33% Hospitalization rate reduction

Herbal medicine maintenance treatment shows significant effects on acute exacerbation prevention and hospitalization rate reduction in stable-phase COPD patients and may be included in long-term management strategies.

View Source 2023
Meta-Analysis Respiratory Conditions

Systematic Review and Meta-Analysis of Herbal Medicine Maintenance Treatment for Stable-Phase COPD Patients

정민재, 김도현, 박소연, et al. Chronic Respiratory Disease (2023)
0.8 episodes Annual exacerbation reduction
15 studies Analyzed studies
33% Hospitalization rate reduction

Summary

A meta-analysis of 15 RCTs (total 1,378 patients) evaluating acute exacerbation prevention effects of herbal medicine maintenance treatment for stable-phase COPD patients. The herbal medicine maintenance treatment group showed 0.8-fewer annual acute exacerbations, with 33% lower hospitalization rate.

Key Conclusion

Herbal medicine maintenance treatment shows significant effects on acute exacerbation prevention and hospitalization rate reduction in stable-phase COPD patients and may be included in long-term management strategies.

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RCT Respiratory Conditions

Immune-Enhancing Effect of Herbal Medicine for Influenza Prevention: A Randomized Controlled Trial

이윤호, 김소라, 박종민, et al.

Influenza and Other Respiratory Viruses (2023)

38% ILI occurrence reduction
180 patients Study population
1.6 days Symptom duration reduction

Modified Ssanghwa-tang shows potential as a preventive immune-enhancing agent during influenza epidemic season, and additional research targeting high-risk groups is needed.

View Source 2023
RCT Respiratory Conditions

Immune-Enhancing Effect of Herbal Medicine for Influenza Prevention: A Randomized Controlled Trial

이윤호, 김소라, 박종민, et al. Influenza and Other Respiratory Viruses (2023)
38% ILI occurrence reduction
180 patients Study population
1.6 days Symptom duration reduction

Summary

A randomized controlled trial comparing 8-week administration of modified Ssanghwa-tang versus placebo in 180 healthy adults during influenza epidemic season. The herbal medicine group showed 38% lower influenza-like illness (ILI) occurrence rate, with average 1.6-day shorter symptom duration when illness occurred.

Key Conclusion

Modified Ssanghwa-tang shows potential as a preventive immune-enhancing agent during influenza epidemic season, and additional research targeting high-risk groups is needed.

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Case Study Respiratory Conditions

Effects of Herbal Medicine Adjuvant Treatment in Bronchiectasis Patients: A Case Series of 12 Cases

정가은, 김민수, 박윤아, et al.

한방재활의학과학회지 (2024)

54% Sputum volume reduction
12 patients Number of cases
12 weeks Treatment duration

Cheonggumganghwa-tang shows potential as adjunctive treatment for sputum reduction and acute exacerbation prevention in bronchiectasis patients.

View Source 2024
Case Study Respiratory Conditions

Effects of Herbal Medicine Adjuvant Treatment in Bronchiectasis Patients: A Case Series of 12 Cases

정가은, 김민수, 박윤아, et al. 한방재활의학과학회지 (2024)
54% Sputum volume reduction
12 patients Number of cases
12 weeks Treatment duration

Summary

A case series administering Cheonggumganghwa-tang for 12 weeks to 12 patients diagnosed with bronchiectasis. After treatment, daily sputum volume decreased by an average of 54%, with reduced acute exacerbation frequency and decreased hospitalizations. Bronchial wall thickening on chest CT also partially improved.

Key Conclusion

Cheonggumganghwa-tang shows potential as adjunctive treatment for sputum reduction and acute exacerbation prevention in bronchiectasis patients.

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Narrative Review Mental Health

Polysomnography-Based Effect of Herbal Medicine Prescriptions for Sleep Disorders: A Narrative Review

Choi AR, Lim JH, Han JM, et al.

Sleep Medicine Reviews (2024)

20 sources Reviewed Literature
Latency shortened Sleep Onset Improvement
Slow-wave sleep↑ Sleep Quality Improvement

Herbal medicine prescriptions improve PSG objective sleep indicators and show potential as alternatives to sleep medications.

View Source 2024
Narrative Review Mental Health

Polysomnography-Based Effect of Herbal Medicine Prescriptions for Sleep Disorders: A Narrative Review

Choi AR, Lim JH, Han JM, et al. Sleep Medicine Reviews (2024)
20 sources Reviewed Literature
Latency shortened Sleep Onset Improvement
Slow-wave sleep↑ Sleep Quality Improvement

Summary

Twenty articles on PSG-based effects of herbal medicine prescriptions for sleep disorders were reviewed. Sanjoin-tang and Ondam-tang showed effects on sleep latency shortening and slow-wave sleep increase.

Key Conclusion

Herbal medicine prescriptions improve PSG objective sleep indicators and show potential as alternatives to sleep medications.

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Systematic Review Neurological Disorders

Neuroprotective Effect of Herbal Medicine for Dementia Prevention: A Systematic Review

Han SJ, Cho KH, Yoon JH, et al.

Alzheimers Research & Therapy (2023)

25 studies Analyzed Studies
Aβ suppression Neuroprotective Mechanism
Hippocampal protection Structural Effect

The neuroprotective effects of herbal medicine can contribute to dementia prevention strategies.

View Source 2023
Systematic Review Neurological Disorders

Neuroprotective Effect of Herbal Medicine for Dementia Prevention: A Systematic Review

Han SJ, Cho KH, Yoon JH, et al. Alzheimers Research & Therapy (2023)
25 studies Analyzed Studies
Aβ suppression Neuroprotective Mechanism
Hippocampal protection Structural Effect

Summary

Twenty-five studies evaluating the neuroprotective effect of dementia prevention herbal medicines (Jogudeung-san, Danggwijakyak-san, etc.) were systematically reviewed. Herbal medicine showed significant effects on amyloid beta accumulation inhibition and hippocampal neuron protection.

Key Conclusion

The neuroprotective effects of herbal medicine can contribute to dementia prevention strategies.

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Before-After Mental Health

Pre-Post Comparison Study of Combined Auricular Acupuncture and Herbal Medicine for Binge Eating Disorder

Kim GH, Park HJ, Lee SH, et al.

Eating Behaviors (2024)

52% Binge score↓
3.2 kg Weight Reduction
55 subjects Participants

The combination of auricular acupuncture and herbal medicine is effective for binge impulse suppression and weight management.

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Before-After Mental Health

Pre-Post Comparison Study of Combined Auricular Acupuncture and Herbal Medicine for Binge Eating Disorder

Kim GH, Park HJ, Lee SH, et al. Eating Behaviors (2024)
52% Binge score↓
3.2 kg Weight Reduction
55 subjects Participants

Summary

Auricular acupuncture (Shenmen, Stomach point) + herbal medicine (Banhasasim-tang) were applied for 10 weeks to 55 binge eating disorder patients. BES binge eating scores decreased by 52%, and weight decreased by an average of 3.2 kg.

Key Conclusion

The combination of auricular acupuncture and herbal medicine is effective for binge impulse suppression and weight management.

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RCT ENT Disorders

Therapeutic Effect of Gamchosashim-tang for Recurrent Aphthous Stomatitis: A Randomized Controlled Trial

Yang SB, Kim KS, Park MC, et al.

Oral Diseases (2024)

3.2 days Healing Time Reduction
3.8→1.4 Recurrence Frequency
96 subjects Participants

Gamchosashim-tang demonstrates significant efficacy compared with placebo in healing promotion and recurrence prevention of recurrent aphthous stomatitis.

View Source 2024
RCT ENT Disorders

Therapeutic Effect of Gamchosashim-tang for Recurrent Aphthous Stomatitis: A Randomized Controlled Trial

Yang SB, Kim KS, Park MC, et al. Oral Diseases (2024)
3.2 days Healing Time Reduction
3.8→1.4 Recurrence Frequency
96 subjects Participants

Summary

Ninety-six patients with aphthous stomatitis recurring at least once monthly were assigned to Gamchosashim-tang or placebo groups and treated for 12 weeks. The herbal group demonstrated ulcer healing time shortened by an average of 3.2 days, with recurrence frequency over 12 weeks decreasing from 3.8 to 1.4 episodes.

Key Conclusion

Gamchosashim-tang demonstrates significant efficacy compared with placebo in healing promotion and recurrence prevention of recurrent aphthous stomatitis.

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Case Study ENT Disorders

Therapeutic Effect of Combined Acupuncture and Herbal Medicine for Taste Disorders: A Case Series of 12

Hwang EH, Song HS, Choi JB, et al.

대한침구의학회지 (2023)

2.3 grades Taste Threshold Improvement
4.1→7.3 Taste VAS
12 cases Case Number

Combined acupuncture and herbal medicine significantly improves taste thresholds and subjective taste function in taste disorder patients.

View Source 2023
Case Study ENT Disorders

Therapeutic Effect of Combined Acupuncture and Herbal Medicine for Taste Disorders: A Case Series of 12

Hwang EH, Song HS, Choi JB, et al. 대한침구의학회지 (2023)
2.3 grades Taste Threshold Improvement
4.1→7.3 Taste VAS
12 cases Case Number

Summary

Twelve patients with taste disorders persisting more than 3 months received combined acupuncture at Lianquan (CV23) and Jinjin Yuye (EX-HN12) plus Jaeumganghwa-tang for 8 weeks. Taste threshold tests showed an average 2.3-grade improvement in whole-taste recognition thresholds, with self-reported taste function VAS improving from 4.1 to 7.3.

Key Conclusion

Combined acupuncture and herbal medicine significantly improves taste thresholds and subjective taste function in taste disorder patients.

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Cohort Study ENT Disorders

Effect of Modified Soshiho-tang for Recurrent Tonsillitis: A Cohort Study

Ryu BH, Lee SG, Jang IS, et al.

Phytomedicine (2024)

4.8→1.6 Annual Recurrence
67 subjects Participants
1 year Follow-up Period

Modified Soshiho-tang significantly reduces recurrence frequency and decreases tonsil size in recurrent tonsillitis.

View Source 2024
Cohort Study ENT Disorders

Effect of Modified Soshiho-tang for Recurrent Tonsillitis: A Cohort Study

Ryu BH, Lee SG, Jang IS, et al. Phytomedicine (2024)
4.8→1.6 Annual Recurrence
67 subjects Participants
1 year Follow-up Period

Summary

Sixty-seven patients with tonsillitis recurring 4 or more times annually received modified Soshiho-tang for 12 weeks and were followed for 1 year. Average annual recurrence frequency decreased from 4.8 to 1.6 episodes after treatment, with tonsillar hypertrophy grade improving by an average of 0.8 stages.

Key Conclusion

Modified Soshiho-tang significantly reduces recurrence frequency and decreases tonsil size in recurrent tonsillitis.

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RCT Men's Health / Urology

Long-Term Effect of Herbal Medicine Treatment for Kidney Stone Recurrence Prevention: A Randomized Controlled Trial

김영호, 손재현, 박지민, et al.

Journal of Ethnopharmacology (2024)

63.7% Recurrence Rate Reduction
128 subjects Number of Subjects
24 months Follow-up Period

Geumjeoncho combined formula is effective for preventing kidney stone recurrence, and a mechanism regulating excretion of stone-forming substances in urine was confirmed.

View Source 2024
RCT Men's Health / Urology

Long-Term Effect of Herbal Medicine Treatment for Kidney Stone Recurrence Prevention: A Randomized Controlled Trial

김영호, 손재현, 박지민, et al. Journal of Ethnopharmacology (2024)
63.7% Recurrence Rate Reduction
128 subjects Number of Subjects
24 months Follow-up Period

Summary

A randomized controlled trial evaluating the long-term effect of herbal medicine (Geumjeoncho combined formula) for recurrence prevention after kidney stone removal. After 24 months of follow-up of 128 subjects, the herbal medicine group's stone recurrence rate was 12.5%, significantly lower than the control group (34.4%), and urinary calcium and oxalate excretion also decreased.

Key Conclusion

Geumjeoncho combined formula is effective for preventing kidney stone recurrence, and a mechanism regulating excretion of stone-forming substances in urine was confirmed.

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Meta-Analysis Men's Health / Urology

Effect of Combined Herbal Medicine and Acupuncture Treatment on Stone Expulsion Promotion in Urolithiasis Patients: A Meta-Analysis

서민호, 곽영진, 이태규, et al.

Urological Research (2023)

78.3% Stone Expulsion Rate
5.2 days Expulsion Time Shortened
634 subjects Total Subjects

Combined herbal medicine and acupuncture treatment significantly promotes spontaneous expulsion of urolithiasis 10 mm or less and is effective as adjunctive treatment for watchful waiting.

View Source 2023
Meta-Analysis Men's Health / Urology

Effect of Combined Herbal Medicine and Acupuncture Treatment on Stone Expulsion Promotion in Urolithiasis Patients: A Meta-Analysis

서민호, 곽영진, 이태규, et al. Urological Research (2023)
78.3% Stone Expulsion Rate
5.2 days Expulsion Time Shortened
634 subjects Total Subjects

Summary

A meta-analysis of 9 randomized controlled trials including 634 urolithiasis patients. The combined herbal medicine (modified Seokwi-san) and acupuncture treatment group showed a stone spontaneous expulsion rate of 78.3%, significantly higher than the control group (54.2%), with average expulsion time also shortened by 5.2 days.

Key Conclusion

Combined herbal medicine and acupuncture treatment significantly promotes spontaneous expulsion of urolithiasis 10 mm or less and is effective as adjunctive treatment for watchful waiting.

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