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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 1642 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Cross-Sectional Men's Health / Urology

Changes in AMS Scores with Combined Herbal Medicine and Moxibustion Treatment for Male Climacteric Syndrome (LOH): A Cross-Sectional Analysis

정현석, 김영태, 이상우, et al.

대한한의학회지 (2023)

38.9% AMS Score Reduction Rate
120 subjects Analysis Subjects
p<0.001 Statistical Significance

Combined herbal medicine and moxibustion treatment effectively alleviates the multidimensional symptoms of male climacteric syndrome and enables clinically meaningful improvement without hormone replacement therapy.

View Source 2023
Cross-Sectional Men's Health / Urology

Changes in AMS Scores with Combined Herbal Medicine and Moxibustion Treatment for Male Climacteric Syndrome (LOH): A Cross-Sectional Analysis

정현석, 김영태, 이상우, et al. 대한한의학회지 (2023)
38.9% AMS Score Reduction Rate
120 subjects Analysis Subjects
p<0.001 Statistical Significance

Summary

A cross-sectional analysis of medical records of 120 patients receiving Korean medicine treatment for male climacteric syndrome. AMS (Aging Males Symptoms) scores of the herbal medicine and moxibustion combined treatment group decreased from an average of 36.7 to 22.4, and significant improvements were confirmed in cardiovascular, somatic, and psychological subdomains.

Key Conclusion

Combined herbal medicine and moxibustion treatment effectively alleviates the multidimensional symptoms of male climacteric syndrome and enables clinically meaningful improvement without hormone replacement therapy.

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Cohort Study Men's Health / Urology

Effect of Deer Antler Combined Herbal Medicine on Testosterone and Libido Improvement in Libido Reduction: A Cohort Study

윤재석, 배한솔, 임성진, et al.

Evidence-Based Complementary and Alternative Medicine (2024)

2.8 ng/dL Free Testosterone Increase
96 subjects Cohort Size
73.9% SDI Improvement Rate

Deer antler combined herbal medicine significantly improves testosterone levels and libido-related indicators in libido reduction patients and is particularly effective for middle-aged and older men.

View Source 2024
Cohort Study Men's Health / Urology

Effect of Deer Antler Combined Herbal Medicine on Testosterone and Libido Improvement in Libido Reduction: A Cohort Study

윤재석, 배한솔, 임성진, et al. Evidence-Based Complementary and Alternative Medicine (2024)
2.8 ng/dL Free Testosterone Increase
96 subjects Cohort Size
73.9% SDI Improvement Rate

Summary

A prospective cohort study analyzing the effect of deer antler combined herbal medicine in 96 men complaining of libido reduction. After 16 weeks of administration, serum free testosterone increased by an average of 2.8 ng/dL, and SDI (Sexual Desire Inventory) scores improved significantly. Response rates were highest in the 40-55 age group.

Key Conclusion

Deer antler combined herbal medicine significantly improves testosterone levels and libido-related indicators in libido reduction patients and is particularly effective for middle-aged and older men.

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Meta-Analysis Respiratory Conditions

Meta-Analysis of Herbal Medicine Treatment Efficacy for Pulmonary Fibrosis Patients

김현우, 이나영, 정태섭, et al.

Journal of Integrative Medicine (2023)

2.8% FVC decline attenuation
8 studies Analyzed studies
612 patients Total study population

Herbal medicine treatment can play an adjunctive role in slowing pulmonary fibrosis progression and improving quality of life, with notable potential for combination with antifibrotic agents.

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Meta-Analysis Respiratory Conditions

Meta-Analysis of Herbal Medicine Treatment Efficacy for Pulmonary Fibrosis Patients

김현우, 이나영, 정태섭, et al. Journal of Integrative Medicine (2023)
2.8% FVC decline attenuation
8 studies Analyzed studies
612 patients Total study population

Summary

Eight RCTs (total 612 patients) evaluating herbal medicine treatment for idiopathic pulmonary fibrosis (IPF) were meta-analyzed. The herbal medicine combination group showed 2.8% annual FVC decline rate attenuation, with significantly improved SGRQ (respiratory quality of life) scores.

Key Conclusion

Herbal medicine treatment can play an adjunctive role in slowing pulmonary fibrosis progression and improving quality of life, with notable potential for combination with antifibrotic agents.

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Cohort Study Respiratory Conditions

Combined Herbal Medicine and Pediatric Chuna Treatment for Recurrent Upper Respiratory Infections in Children: A Cohort Study

조미영, 박건우, 김서연, et al.

대한한방소아과학회지 (2024)

58% Infection frequency reduction
72 patients Study population
41% Antibiotic use reduction

Combined herbal medicine and pediatric Chuna treatment is an effective Korean medicine management method that reduces both illness frequency and antibiotic use in children with recurrent upper respiratory infections.

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Cohort Study Respiratory Conditions

Combined Herbal Medicine and Pediatric Chuna Treatment for Recurrent Upper Respiratory Infections in Children: A Cohort Study

조미영, 박건우, 김서연, et al. 대한한방소아과학회지 (2024)
58% Infection frequency reduction
72 patients Study population
41% Antibiotic use reduction

Summary

A prospective cohort study performing 6 months of combined herbal medicine (modified Samso-eum) and pediatric Chuna in 72 children aged 3-8 years with recurrent upper respiratory infections (6 or more annually). Upper respiratory infections decreased by an average of 58% during treatment period, with significantly reduced antibiotic use days.

Key Conclusion

Combined herbal medicine and pediatric Chuna treatment is an effective Korean medicine management method that reduces both illness frequency and antibiotic use in children with recurrent upper respiratory infections.

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Cross-Sectional ENT Disorders

Anti-Inflammatory and Analgesic Effects of Lonicera-Glycyrrhiza Combination Herbal Medicine for Sore Throat: A Cross-Sectional Study

박태영, 김민지, 이찬호, et al.

대한본초학회지 (2024)

5.2 points Sore throat VAS reduction
134 patients Study population
24 hours Effect onset time

Lonicera-Glycyrrhiza combination herbal medicine shows rapid anti-inflammatory and analgesic effects on acute sore throat and can be utilized as complementary treatment at the primary care level.

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Cross-Sectional ENT Disorders

Anti-Inflammatory and Analgesic Effects of Lonicera-Glycyrrhiza Combination Herbal Medicine for Sore Throat: A Cross-Sectional Study

박태영, 김민지, 이찬호, et al. 대한본초학회지 (2024)
5.2 points Sore throat VAS reduction
134 patients Study population
24 hours Effect onset time

Summary

A cross-sectional study analyzing symptom changes after administration of Lonicera-Glycyrrhiza combination herbal medicine in 134 patients with acute sore throat. Sore throat VAS decreased by an average of 5.2 points within 24 hours after administration, with significant improvements in odynophagia and erythema findings.

Key Conclusion

Lonicera-Glycyrrhiza combination herbal medicine shows rapid anti-inflammatory and analgesic effects on acute sore throat and can be utilized as complementary treatment at the primary care level.

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RCT Mental Health

Anti-Stress Effect of Herbal Medicine (Soyo-san) in Adjustment Disorder Patients: A Randomized Controlled Trial

Baek IH, Lee JH, Park CW, et al.

Stress and Health (2023)

39% Stress Reduction
90 subjects Participants
Cortisol normalization Physiological Indicator

Soyo-san has effects on regulating the stress response of adjustment disorder at the physiological level.

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RCT Mental Health

Anti-Stress Effect of Herbal Medicine (Soyo-san) in Adjustment Disorder Patients: A Randomized Controlled Trial

Baek IH, Lee JH, Park CW, et al. Stress and Health (2023)
39% Stress Reduction
90 subjects Participants
Cortisol normalization Physiological Indicator

Summary

Ninety adjustment disorder patients were divided into Soyo-san administration and placebo groups and compared for 6 weeks. PSS stress scores decreased by 39% and cortisol awakening response normalized in the Soyo-san group.

Key Conclusion

Soyo-san has effects on regulating the stress response of adjustment disorder at the physiological level.

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Cohort Study Mental Health

Cohort Study of Herbal Medicine (Guibi-tang) for Geriatric Depression

Moon KW, Go JH, Shin BC, et al.

Aging & Mental Health (2024)

41% GDS Reduction
180 subjects Participants
24 weeks Follow-up Period

Guibi-tang is effective for improving geriatric depression and preventing accompanying cognitive decline.

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Cohort Study Mental Health

Cohort Study of Herbal Medicine (Guibi-tang) for Geriatric Depression

Moon KW, Go JH, Shin BC, et al. Aging & Mental Health (2024)
41% GDS Reduction
180 subjects Participants
24 weeks Follow-up Period

Summary

One hundred eighty elderly depression patients aged 65 and older were followed for 24 weeks, divided into Guibi-tang administration and non-administration groups. GDS scores decreased by 41% and cognitive function (MMSE) was significantly maintained in the Guibi-tang group.

Key Conclusion

Guibi-tang is effective for improving geriatric depression and preventing accompanying cognitive decline.

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Cohort Study ENT Disorders

Long-Term Effects of Korean Medicine Combination Therapy (Herbal Medicine, Acupuncture, Fumigation) for Chronic Sinusitis: A Cohort Study

박소영, 김재원, 정은지, et al.

대한한방내과학회지 (2023)

48% SNOT-22 improvement rate
98 patients Study population
72% Effect maintenance at 6 months

Korean medicine combination therapy is effective for long-term symptom management of chronic sinusitis and may contribute to recurrence reduction.

View Source 2023
Cohort Study ENT Disorders

Long-Term Effects of Korean Medicine Combination Therapy (Herbal Medicine, Acupuncture, Fumigation) for Chronic Sinusitis: A Cohort Study

박소영, 김재원, 정은지, et al. 대한한방내과학회지 (2023)
48% SNOT-22 improvement rate
98 patients Study population
72% Effect maintenance at 6 months

Summary

A cohort study performing 12 weeks of herbal medicine (modified Changi-san), acupuncture, and Korean medicine fumigation in 98 patients with chronic sinusitis of 1 year or more duration, with 6-month follow-up. SNOT-22 scores improved by average 48% at treatment end, and 72% of improvement was maintained at 6 months.

Key Conclusion

Korean medicine combination therapy is effective for long-term symptom management of chronic sinusitis and may contribute to recurrence reduction.

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Meta-Analysis Men's Health / Urology

Effect of Combined Herbal Medicine and Acupuncture Treatment for Sexual Dysfunction: A Meta-Analysis of Randomized Controlled Trials

이정환, 김도윤, 최병훈, et al.

The Journal of Sexual Medicine (2024)

7.2 points IIEF Total Score Difference
892 subjects Total Subjects
14 RCTs Included RCTs

Combined herbal medicine and acupuncture treatment is effective for multidimensional improvement of male sexual dysfunction, with synergistic effects confirmed compared with single treatments.

View Source 2024
Meta-Analysis Men's Health / Urology

Effect of Combined Herbal Medicine and Acupuncture Treatment for Sexual Dysfunction: A Meta-Analysis of Randomized Controlled Trials

이정환, 김도윤, 최병훈, et al. The Journal of Sexual Medicine (2024)
7.2 points IIEF Total Score Difference
892 subjects Total Subjects
14 RCTs Included RCTs

Summary

A meta-analysis of 14 randomized controlled trials including 892 male sexual dysfunction patients. The combined herbal medicine and acupuncture treatment group showed an average IIEF total score improvement 7.2 points higher than the control group, with significant differences confirmed in all subdomains of libido, erectile function, orgasm, and sexual satisfaction.

Key Conclusion

Combined herbal medicine and acupuncture treatment is effective for multidimensional improvement of male sexual dysfunction, with synergistic effects confirmed compared with single treatments.

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Systematic Review Men's Health / Urology

Effect of Epimedium-Based Herbal Medicine on Erectile Dysfunction (ED): A Systematic Review

신동혁, 문성환, 박준혁, et al.

Phytomedicine (2023)

5.8 points IIEF-5 Improvement
18 studies Included Studies
p=0.002 Statistical Significance

Epimedium-based herbal medicine is effective for mild-to-moderate erectile dysfunction and promotes corpus cavernosum relaxation through mechanisms similar to PDE5 inhibitors.

View Source 2023
Systematic Review Men's Health / Urology

Effect of Epimedium-Based Herbal Medicine on Erectile Dysfunction (ED): A Systematic Review

신동혁, 문성환, 박준혁, et al. Phytomedicine (2023)
5.8 points IIEF-5 Improvement
18 studies Included Studies
p=0.002 Statistical Significance

Summary

A systematic review analyzing the effect of Epimedium (icariin-containing)-based herbal medicine in erectile dysfunction patients. Eighteen clinical trials were included, and the Epimedium extract administration group showed an average IIEF-5 score improvement of 5.8 points. PDE5 inhibitory activity and NO/cGMP pathway activation were confirmed as main mechanisms.

Key Conclusion

Epimedium-based herbal medicine is effective for mild-to-moderate erectile dysfunction and promotes corpus cavernosum relaxation through mechanisms similar to PDE5 inhibitors.

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Systematic Review Men's Health / Urology

Effect of Herbal Medicine Treatment on Semen Parameter Improvement in Male Infertility Patients: A Systematic Review and Meta-Analysis

김동현, 이재훈, 박성민, et al.

Journal of Ethnopharmacology (2024)

67.3% Sperm Motility Improvement Rate
1.8 fold Sperm Concentration Increase
p<0.001 Statistical Significance

Herbal medicine treatment significantly improves semen parameters in male infertility patients and can contribute to pregnancy rate improvement when combined with assisted reproductive technology.

View Source 2024
Systematic Review Men's Health / Urology

Effect of Herbal Medicine Treatment on Semen Parameter Improvement in Male Infertility Patients: A Systematic Review and Meta-Analysis

김동현, 이재훈, 박성민, et al. Journal of Ethnopharmacology (2024)
67.3% Sperm Motility Improvement Rate
1.8 fold Sperm Concentration Increase
p<0.001 Statistical Significance

Summary

A systematic review and meta-analysis analyzing the effect of herbal medicine treatment on semen parameter improvement in 1,247 male infertility patients. Twenty-three randomized controlled trials were included, and the herbal medicine administration group showed significant improvements in sperm concentration, motility, and normal morphology rate. The highest effect size was observed in Ojayeonjong-hwan-based prescriptions.

Key Conclusion

Herbal medicine treatment significantly improves semen parameters in male infertility patients and can contribute to pregnancy rate improvement when combined with assisted reproductive technology.

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Before-After ENT Disorders

Effect of Imyeongumheo-tang Administration for Noise-Induced Hearing Loss Prevention: A Pre-Post Comparison Study

Kim TH, Jung SY, Bae HS, et al.

대한한방이비인후피부과학회지 (2024)

7.2 dB Hearing Threshold Improvement
34%→19% Tinnitus Comorbidity Reduction
58 subjects Participants

Imyeongumheo-tang may contribute to delaying the progression of noise-induced hearing loss and reducing accompanying tinnitus occurrence.

View Source 2024
Before-After ENT Disorders

Effect of Imyeongumheo-tang Administration for Noise-Induced Hearing Loss Prevention: A Pre-Post Comparison Study

Kim TH, Jung SY, Bae HS, et al. 대한한방이비인후피부과학회지 (2024)
7.2 dB Hearing Threshold Improvement
34%→19% Tinnitus Comorbidity Reduction
58 subjects Participants

Summary

Fifty-eight workers in noise-exposed environments received Imyeongumheo-tang for 12 weeks, with pre- and post-treatment pure tone audiometry compared. Hearing thresholds improved by an average of 7.2 dB in high-frequency ranges (4 kHz, 8 kHz), and the rate of accompanying tinnitus decreased from 34% to 19%.

Key Conclusion

Imyeongumheo-tang may contribute to delaying the progression of noise-induced hearing loss and reducing accompanying tinnitus occurrence.

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