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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Total 1642 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
RCT Mental Health

Effect of Mindfulness-Based Korean Medicine Treatment (MBKM) on Generalized Anxiety Disorder: An Exploratory RCT

Suh YJ, Kim EH, et al.

Journal of Anxiety Disorders (2024)

60 subjects Participants
49% GAD-7 Improvement Rate
10 weeks Program Period

Mindfulness-based Korean medicine treatment is a promising integrated treatment program for relieving generalized anxiety disorder symptoms.

View Source 2024
RCT Mental Health

Effect of Mindfulness-Based Korean Medicine Treatment (MBKM) on Generalized Anxiety Disorder: An Exploratory RCT

Suh YJ, Kim EH, et al. Journal of Anxiety Disorders (2024)
60 subjects Participants
49% GAD-7 Improvement Rate
10 weeks Program Period

Summary

Sixty patients with generalized anxiety disorder were randomly assigned to a mindfulness-based Korean medicine treatment group and a waiting list group and compared for 10 weeks. GAD-7 and PSWQ scores decreased significantly in the Korean medicine treatment group.

Key Conclusion

Mindfulness-based Korean medicine treatment is a promising integrated treatment program for relieving generalized anxiety disorder symptoms.

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Cross-Sectional Mental Health

Validation of Clinical Relevance of Korean Medicine Heart-Gallbladder Deficiency Pattern in Panic Disorder

Kang JW, Park SJ, et al.

Journal of Korean Medicine (2020)

180 subjects Analysis Subjects
r=0.74 Correlation Coefficient
p<0.001 Statistical Significance

Heart-gallbladder deficiency pattern is a pattern type with clinical validity for Korean medicine evaluation of panic disorder.

View Source 2020
Cross-Sectional Mental Health

Validation of Clinical Relevance of Korean Medicine Heart-Gallbladder Deficiency Pattern in Panic Disorder

Kang JW, Park SJ, et al. Journal of Korean Medicine (2020)
180 subjects Analysis Subjects
r=0.74 Correlation Coefficient
p<0.001 Statistical Significance

Summary

A cross-sectional study comparing heart-gallbladder deficiency pattern questionnaire scores in 120 panic disorder patients and 60 healthy controls and analyzing correlation with PDSS scores. Heart-gallbladder deficiency scores showed high correlation with panic symptom severity.

Key Conclusion

Heart-gallbladder deficiency pattern is a pattern type with clinical validity for Korean medicine evaluation of panic disorder.

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Cohort Study Mental Health

3-Year Follow-Up Study on Recurrence Rate of Depression Patients Receiving Korean Medicine Treatment

Chung HK, Lee WS, Pham TN, et al.

Journal of Affective Disorders (2023)

200 subjects Participants
28% 3-year Recurrence Rate
OR 0.42 Maintenance Treatment Protective Effect

Continued maintenance treatment after Korean medicine treatment can significantly lower depression recurrence risk.

View Source 2023
Cohort Study Mental Health

3-Year Follow-Up Study on Recurrence Rate of Depression Patients Receiving Korean Medicine Treatment

Chung HK, Lee WS, Pham TN, et al. Journal of Affective Disorders (2023)
200 subjects Participants
28% 3-year Recurrence Rate
OR 0.42 Maintenance Treatment Protective Effect

Summary

Two hundred depression patients in remission after Korean medicine treatment were followed for 3 years to analyze recurrence rates and related factors. The 3-year recurrence rate was 28%, and maintenance treatment continuation was a major predictive factor.

Key Conclusion

Continued maintenance treatment after Korean medicine treatment can significantly lower depression recurrence risk.

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RCT Women's Health / Infertility

Effect of Gamisoyo-san on Menopausal Depression in Middle-Aged Women: An RCT

Woo JK, Ahn MH, et al.

Menopause (2025)

100 subjects Participants
57% BDI Improvement Rate
12 weeks Treatment Period

Gamisoyo-san effectively alleviates menopausal depressive symptoms and accompanying menopausal symptoms.

View Source 2025
RCT Women's Health / Infertility

Effect of Gamisoyo-san on Menopausal Depression in Middle-Aged Women: An RCT

Woo JK, Ahn MH, et al. Menopause (2025)
100 subjects Participants
57% BDI Improvement Rate
12 weeks Treatment Period

Summary

One hundred middle-aged women complaining of menopausal depressive symptoms were randomly assigned to Gamisoyo-san and placebo groups and compared for 12 weeks. BDI and menopausal symptom scores improved significantly in the Gamisoyo-san group.

Key Conclusion

Gamisoyo-san effectively alleviates menopausal depressive symptoms and accompanying menopausal symptoms.

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Systematic Review Mental Health

Effect of Pharmacopuncture Treatment for Autonomic Dysfunction: A Systematic Review

Noh JH, Kim WS, Chen Z, et al.

Journal of Pharmacopuncture (2022)

14 studies Included Studies
11 studies Positive Results
Moderate Evidence Level

Pharmacopuncture treatment is a promising Korean medicine intervention for autonomic dysfunction management.

View Source 2022
Systematic Review Mental Health

Effect of Pharmacopuncture Treatment for Autonomic Dysfunction: A Systematic Review

Noh JH, Kim WS, Chen Z, et al. Journal of Pharmacopuncture (2022)
14 studies Included Studies
11 studies Positive Results
Moderate Evidence Level

Summary

Fourteen studies evaluating the effect of pharmacopuncture treatment for autonomic dysfunction were systematically reviewed. Pharmacopuncture treatment showed positive results in HRV and autonomic symptom score improvement.

Key Conclusion

Pharmacopuncture treatment is a promising Korean medicine intervention for autonomic dysfunction management.

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Before-After Mental Health

Impact of Combined Meditation and Acupuncture Treatment on EEG in Chronic Anxiety Patients

Lee BH, Song MR, et al.

Mindfulness (2023)

50 subjects Participants
Alpha wave 28% increase Brain Wave Change
8 weeks Program Period

Combined meditation-acupuncture treatment is effective for stabilizing brain waves in anxiety patients.

View Source 2023
Before-After Mental Health

Impact of Combined Meditation and Acupuncture Treatment on EEG in Chronic Anxiety Patients

Lee BH, Song MR, et al. Mindfulness (2023)
50 subjects Participants
Alpha wave 28% increase Brain Wave Change
8 weeks Program Period

Summary

A meditation-acupuncture combined program was administered for 8 weeks to 50 chronic anxiety patients, and electroencephalogram (EEG) changes were analyzed. Alpha wave increase and beta wave decrease were significantly observed.

Key Conclusion

Combined meditation-acupuncture treatment is effective for stabilizing brain waves in anxiety patients.

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RCT Digestive Disorders

Effect of Herbal Medicine for Stress-Related Functional Dyspepsia: An RCT

Jin WY, Han SH, et al.

Digestive Diseases and Sciences (2024)

90 subjects Participants
63% Dyspepsia Improvement Rate
8 weeks Treatment Period

Sihosogan-san is an effective treatment for breaking the vicious cycle of stress and dyspepsia.

View Source 2024
RCT Digestive Disorders

Effect of Herbal Medicine for Stress-Related Functional Dyspepsia: An RCT

Jin WY, Han SH, et al. Digestive Diseases and Sciences (2024)
90 subjects Participants
63% Dyspepsia Improvement Rate
8 weeks Treatment Period

Summary

Ninety patients with stress-related functional dyspepsia were randomly assigned to Sihosogan-san and placebo groups and compared for 8 weeks. Dyspepsia symptoms and PSS scores simultaneously improved in the herbal medicine group.

Key Conclusion

Sihosogan-san is an effective treatment for breaking the vicious cycle of stress and dyspepsia.

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Case Study Mental Health

Korean Medicine Approach to Psychosomatic Disorders: A Case Series and Literature Review

Moon TK, Choi EY, et al.

Integrative Medicine Research (2021)

10 cases Number of Cases
80% Improvement Rate
5 types Psychosomatic Disorder Types

Korean medicine mind-body integrated treatment can simultaneously improve physical and psychological symptoms in psychosomatic disorder patients.

View Source 2021
Case Study Mental Health

Korean Medicine Approach to Psychosomatic Disorders: A Case Series and Literature Review

Moon TK, Choi EY, et al. Integrative Medicine Research (2021)
10 cases Number of Cases
80% Improvement Rate
5 types Psychosomatic Disorder Types

Summary

Cases of pattern-specific Korean medicine treatment in 10 patients with various psychosomatic disorders (irritable bowel syndrome, tension headache, chronic fatigue) were reported, and related literature was reviewed.

Key Conclusion

Korean medicine mind-body integrated treatment can simultaneously improve physical and psychological symptoms in psychosomatic disorder patients.

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Cohort Study Mental Health

Effect of Korean Medicine Combined Treatment in Anxiety-Depression Patients After COVID-19: A Cohort Study

Yoo HK, Park GN, et al.

Journal of Korean Medicine (2023)

60 subjects Participants
55% PHQ-9 Improvement Rate
12 weeks Follow-up Period

Korean medicine combined treatment is effective for managing anxiety-depressive symptoms occurring as COVID-19 sequelae.

View Source 2023
Cohort Study Mental Health

Effect of Korean Medicine Combined Treatment in Anxiety-Depression Patients After COVID-19: A Cohort Study

Yoo HK, Park GN, et al. Journal of Korean Medicine (2023)
60 subjects Participants
55% PHQ-9 Improvement Rate
12 weeks Follow-up Period

Summary

A cohort study following 60 patients with anxiety and depressive symptoms after COVID-19 infection for 12 weeks, divided into Korean medicine treatment and general management groups. PHQ-9 and GAD-7 scores improved significantly in the Korean medicine treatment group.

Key Conclusion

Korean medicine combined treatment is effective for managing anxiety-depressive symptoms occurring as COVID-19 sequelae.

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Narrative Review Mental Health

Role of Gut-Brain Axis in Korean Medicine Mental Health Treatment: An Integrated Review

Ahn GJ, Kim HY, Patel R, et al.

Frontiers in Psychiatry (2025)

48 sources Reviewed Literature
3 pathways Main Pathways
Gut microbiota Key Mechanism

Korean medicine treatment can improve mental health symptoms such as depression and anxiety through gut-brain axis regulation.

View Source 2025
Narrative Review Mental Health

Role of Gut-Brain Axis in Korean Medicine Mental Health Treatment: An Integrated Review

Ahn GJ, Kim HY, Patel R, et al. Frontiers in Psychiatry (2025)
48 sources Reviewed Literature
3 pathways Main Pathways
Gut microbiota Key Mechanism

Summary

Basic and clinical studies on the impact of Korean medicine treatment (herbal medicine, acupuncture) on mental health via the gut-brain axis were integratively reviewed. Various pathways including gut microbiota regulation and vagal nerve activation were confirmed.

Key Conclusion

Korean medicine treatment can improve mental health symptoms such as depression and anxiety through gut-brain axis regulation.

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RCT Mental Health

Effect of Herbal Medicine Combination on Withdrawal Symptom Prevention During Antidepressant Tapering: An RCT

Song BK, Lee YH, et al.

Journal of Clinical Psychopharmacology (2024)

70 subjects Participants
28% vs 58% Withdrawal Symptom Incidence
16 weeks Tapering Period

Herbal medicine combination is effective for preventing withdrawal symptoms during antidepressant tapering.

View Source 2024
RCT Mental Health

Effect of Herbal Medicine Combination on Withdrawal Symptom Prevention During Antidepressant Tapering: An RCT

Song BK, Lee YH, et al. Journal of Clinical Psychopharmacology (2024)
70 subjects Participants
28% vs 58% Withdrawal Symptom Incidence
16 weeks Tapering Period

Summary

Seventy depression patients planning antidepressant tapering were randomly assigned to herbal medicine combined and non-combined groups, and withdrawal symptom incidence during the tapering process was compared. Withdrawal symptoms were significantly fewer in the herbal medicine combined group.

Key Conclusion

Herbal medicine combination is effective for preventing withdrawal symptoms during antidepressant tapering.

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Cross-Sectional Mental Health

Symptom Cluster Analysis of Autonomic Dysfunction Patients: A Multicenter Cross-Sectional Study

Ryu HJ, Jung YM, et al.

Journal of Psychosomatic Research (2022)

350 subjects Analysis Subjects
4 types Subtypes
6 institutions Participating Institutions

Autonomic dysfunction is classified into 4 symptom clusters, and type-specific customized Korean medicine treatment strategies are needed.

View Source 2022
Cross-Sectional Mental Health

Symptom Cluster Analysis of Autonomic Dysfunction Patients: A Multicenter Cross-Sectional Study

Ryu HJ, Jung YM, et al. Journal of Psychosomatic Research (2022)
350 subjects Analysis Subjects
4 types Subtypes
6 institutions Participating Institutions

Summary

Symptoms of 350 autonomic dysfunction patients were cluster-analyzed to derive 4 subtypes. Korean medicine pattern distribution and HRV characteristics differed by each type.

Key Conclusion

Autonomic dysfunction is classified into 4 symptom clusters, and type-specific customized Korean medicine treatment strategies are needed.

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