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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 1642 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
RCT Pediatric / Adolescent Care

Effects of Herbal Medicine-Behavioral Therapy Combination Intervention for Pediatric Tic Disorders: A Multicenter RCT

Kwon HJ, Choi YH, Lee KM, et al.

European Child & Adolescent Psychiatry (2025)

120 patients Participants
65% YGTSS improvement rate
3 centers Multicenter participation

Combination of herbal medicine and behavioral therapy showed superior efficacy compared to monotherapy in pediatric tic disorder.

View Source 2025
RCT Pediatric / Adolescent Care

Effects of Herbal Medicine-Behavioral Therapy Combination Intervention for Pediatric Tic Disorders: A Multicenter RCT

Kwon HJ, Choi YH, Lee KM, et al. European Child & Adolescent Psychiatry (2025)
120 patients Participants
65% YGTSS improvement rate
3 centers Multicenter participation

Summary

One hundred twenty children with chronic tic disorder were randomly assigned to herbal medicine plus behavioral therapy, herbal medicine alone, or behavioral therapy alone groups and compared over 16 weeks. The combination group showed the greatest YGTSS score reduction.

Key Conclusion

Combination of herbal medicine and behavioral therapy showed superior efficacy compared to monotherapy in pediatric tic disorder.

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Cohort Study Pediatric / Adolescent Care

Final Adult Height in Children with Short Stature Receiving Korean Medicine Growth-Promoting Therapy: A Retrospective Cohort

Bae JH, Kim MN, et al.

Annals of Pediatric Endocrinology & Metabolism (2024)

200 patients Analysis subjects
2.8 cm Additional growth
10 years Follow-up period

Korean medicine growth therapy has a positive impact on achieving final adult height in children with short stature.

View Source 2024
Cohort Study Pediatric / Adolescent Care

Final Adult Height in Children with Short Stature Receiving Korean Medicine Growth-Promoting Therapy: A Retrospective Cohort

Bae JH, Kim MN, et al. Annals of Pediatric Endocrinology & Metabolism (2024)
200 patients Analysis subjects
2.8 cm Additional growth
10 years Follow-up period

Summary

Final adult height was retrospectively analyzed in 200 children with short stature who received Korean medicine growth-promoting therapy. An average additional growth of 2.8 cm over predicted adult height was confirmed.

Key Conclusion

Korean medicine growth therapy has a positive impact on achieving final adult height in children with short stature.

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Before-After Pediatric / Adolescent Care

NK Cell Activity Enhancement Effect of Herbal Medicine for Pediatric Immunity: A Pre-Post Comparison

Han DY, Seo GR, et al.

Immunological Investigations (2023)

50 patients Participants
34% NK activity increase
12 weeks Treatment duration

Modified Bojungikgi-tang enhances innate immune function in children and contributes to infection prevention.

View Source 2023
Before-After Pediatric / Adolescent Care

NK Cell Activity Enhancement Effect of Herbal Medicine for Pediatric Immunity: A Pre-Post Comparison

Han DY, Seo GR, et al. Immunological Investigations (2023)
50 patients Participants
34% NK activity increase
12 weeks Treatment duration

Summary

Modified Bojungikgi-tang was administered for 12 weeks to 50 children with frequent colds, and NK cell activity, IgA levels, and cold frequency were measured. NK cell activity and IgA significantly increased and cold frequency decreased.

Key Conclusion

Modified Bojungikgi-tang enhances innate immune function in children and contributes to infection prevention.

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Narrative Review Pediatric / Adolescent Care

Effect of Korean Medicine Topical Preparations on Pediatric Atopic Dermatitis: A Literature Review

Cho SH, Im KJ, Liu F, et al.

Dermatologic Therapy (2022)

30 studies Reviewed papers
85% Positive outcomes
Jaungo Most frequent prescription

Korean medicine topical preparations are safe and effective adjunctive treatments for pediatric atopic dermatitis.

View Source 2022
Narrative Review Pediatric / Adolescent Care

Effect of Korean Medicine Topical Preparations on Pediatric Atopic Dermatitis: A Literature Review

Cho SH, Im KJ, Liu F, et al. Dermatologic Therapy (2022)
30 studies Reviewed papers
85% Positive outcomes
Jaungo Most frequent prescription

Summary

Thirty studies on Korean medicine topical preparations (Jaungo, Hwangryeonhaedok-tang lotion, etc.) for pediatric atopic dermatitis were comprehensively reviewed. Most topical preparations improved transepidermal water loss (TEWL) and pruritus.

Key Conclusion

Korean medicine topical preparations are safe and effective adjunctive treatments for pediatric atopic dermatitis.

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RCT Pediatric / Adolescent Care

Gastrointestinal Motility-Promoting Effect of Sogeonjung-tang on Pediatric Anorexia: An RCT

Jung SK, Woo HJ, et al.

World Journal of Gastroenterology (2024)

60 patients Participants
40% Gastric emptying improvement
6 weeks Treatment duration

Sogeonjung-tang promotes gastrointestinal motility and restores appetite in pediatric anorexia patients.

View Source 2024
RCT Pediatric / Adolescent Care

Gastrointestinal Motility-Promoting Effect of Sogeonjung-tang on Pediatric Anorexia: An RCT

Jung SK, Woo HJ, et al. World Journal of Gastroenterology (2024)
60 patients Participants
40% Gastric emptying improvement
6 weeks Treatment duration

Summary

Sixty children with functional anorexia were randomized to Sogeonjung-tang or placebo and compared over 6 weeks. The Sogeonjung-tang group showed significant improvements in gastric emptying time and food intake.

Key Conclusion

Sogeonjung-tang promotes gastrointestinal motility and restores appetite in pediatric anorexia patients.

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Cross-Sectional Pediatric / Adolescent Care

Predictive Factors for Treatment Response to Korean Medicine in Children with Enuresis: A Multivariate Regression Analysis

Lee HW, Song YS, et al.

Journal of Pediatric Urology (2022)

150 patients Analysis subjects
3 factors Independent predictors
AUC 0.79 Predictive model accuracy

Tailored treatment strategies according to patient characteristics are needed in Korean medicine treatment for enuresis.

View Source 2022
Cross-Sectional Pediatric / Adolescent Care

Predictive Factors for Treatment Response to Korean Medicine in Children with Enuresis: A Multivariate Regression Analysis

Lee HW, Song YS, et al. Journal of Pediatric Urology (2022)
150 patients Analysis subjects
3 factors Independent predictors
AUC 0.79 Predictive model accuracy

Summary

Medical records of 150 children with enuresis who received Korean medicine were retrospectively analyzed to identify predictive factors for treatment response. Age, comorbid daytime frequency, and family history were identified as independent predictors.

Key Conclusion

Tailored treatment strategies according to patient characteristics are needed in Korean medicine treatment for enuresis.

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Meta-Analysis Pediatric / Adolescent Care

Effect of Korean Medicine on Pediatric Tic Disorder: A Systematic Review and Meta-Analysis

Ryu SH, Kim TS, Huang X, et al.

Complementary Therapies in Medicine (2023)

16 studies Included studies
1,320 patients Total participants
SMD -0.84 Effect size

Korean medicine is effective in improving symptoms of pediatric tic disorder with few adverse effects.

View Source 2023
Meta-Analysis Pediatric / Adolescent Care

Effect of Korean Medicine on Pediatric Tic Disorder: A Systematic Review and Meta-Analysis

Ryu SH, Kim TS, Huang X, et al. Complementary Therapies in Medicine (2023)
16 studies Included studies
1,320 patients Total participants
SMD -0.84 Effect size

Summary

Sixteen studies (total 1,320 patients) on Korean medicine for pediatric tic disorder were systematically reviewed and meta-analyzed. Both herbal medicine and acupuncture showed significant effects in reducing total YGTSS scores.

Key Conclusion

Korean medicine is effective in improving symptoms of pediatric tic disorder with few adverse effects.

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Cohort Study Pediatric / Adolescent Care

Effect of Herbal Medicine on Pubertal Progression Rate in Girls with Precocious Puberty: A Cohort Study

Ahn SJ, Park KR, et al.

Journal of Pediatric Endocrinology and Metabolism (2024)

80 patients Participants
12 months Follow-up period
BA/CA reduction Bone age suppression

Herbal medicine can serve as an alternative treatment for regulating pubertal progression in mild precocious puberty.

View Source 2024
Cohort Study Pediatric / Adolescent Care

Effect of Herbal Medicine on Pubertal Progression Rate in Girls with Precocious Puberty: A Cohort Study

Ahn SJ, Park KR, et al. Journal of Pediatric Endocrinology and Metabolism (2024)
80 patients Participants
12 months Follow-up period
BA/CA reduction Bone age suppression

Summary

Eighty girls with precocious puberty were compared over 12 months between an herbal medicine (modified Jibaekjihwang-hwan) treatment group and a GnRH agonist treatment group regarding pubertal progression rate. Both groups showed pubertal suppression effects.

Key Conclusion

Herbal medicine can serve as an alternative treatment for regulating pubertal progression in mild precocious puberty.

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Before-After Pediatric / Adolescent Care

Safety and Efficacy of Herbal Bath Therapy for Atopic Dermatitis in Infants: A Pre-Post Comparison

Moon SJ, Cho YK, et al.

Journal of Dermatological Treatment (2021)

30 patients Participants
45% SCORAD improvement
4 weeks Treatment duration

Herbal bath therapy is a safe and effective adjunctive treatment for infantile atopic dermatitis.

View Source 2021
Before-After Pediatric / Adolescent Care

Safety and Efficacy of Herbal Bath Therapy for Atopic Dermatitis in Infants: A Pre-Post Comparison

Moon SJ, Cho YK, et al. Journal of Dermatological Treatment (2021)
30 patients Participants
45% SCORAD improvement
4 weeks Treatment duration

Summary

Herbal medicine-based bathing was performed for 4 weeks on 30 infants under 2 years with atopic dermatitis, and SCORAD, TEWL, and sleep quality were evaluated. All three indicators significantly improved.

Key Conclusion

Herbal bath therapy is a safe and effective adjunctive treatment for infantile atopic dermatitis.

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Case Study Pediatric / Adolescent Care

Effect of Herbal Medicine on Pediatric Chronic Constipation with Comorbid Anorexia: A Case Series

Kim GH, Jeon JH, et al.

Journal of Korean Medicine (2020)

8 patients Cases
100% Improvement rate
6 weeks Treatment duration

Herbal medicine can be effectively utilized for managing pediatric constipation-anorexia comorbid symptoms.

View Source 2020
Case Study Pediatric / Adolescent Care

Effect of Herbal Medicine on Pediatric Chronic Constipation with Comorbid Anorexia: A Case Series

Kim GH, Jeon JH, et al. Journal of Korean Medicine (2020)
8 patients Cases
100% Improvement rate
6 weeks Treatment duration

Summary

A case series of 8 pediatric patients with chronic constipation comorbid with anorexia treated with pattern-differentiated herbal medicine for 6 weeks was reported. All patients showed improvements in bowel frequency and food intake.

Key Conclusion

Herbal medicine can be effectively utilized for managing pediatric constipation-anorexia comorbid symptoms.

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RCT Pediatric / Adolescent Care

Effect of Chuna Therapy for Pediatric Growth Plate Stimulation: An RCT

Lim JY, Baek GH, et al.

Journal of Manipulative and Physiological Therapeutics (2024)

80 patients Participants
1.2 cm Additional 12-month growth
p<0.05 Statistical significance

Combined Chuna therapy provides additional benefits to herbal medicine monotherapy for pediatric growth promotion.

View Source 2024
RCT Pediatric / Adolescent Care

Effect of Chuna Therapy for Pediatric Growth Plate Stimulation: An RCT

Lim JY, Baek GH, et al. Journal of Manipulative and Physiological Therapeutics (2024)
80 patients Participants
1.2 cm Additional 12-month growth
p<0.05 Statistical significance

Summary

Eighty children with short stature were randomized to a Chuna plus herbal medicine group or herbal medicine alone group and compared over 12 months. The Chuna combination group showed significantly higher growth velocities at 6 and 12 months.

Key Conclusion

Combined Chuna therapy provides additional benefits to herbal medicine monotherapy for pediatric growth promotion.

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RCT Pediatric / Adolescent Care

Immunomodulatory Effects of Okbyungpung-san on Pediatric Frequent Colds: A Double-Blind RCT

Song JH, Park MK, Kim DW, et al.

Phytomedicine (2023)

90 patients Participants
52% Cold frequency reduction
6 months Observation period

Okbyungpung-san is effective for the prevention of recurrent colds and immune modulation in children.

View Source 2023
RCT Pediatric / Adolescent Care

Immunomodulatory Effects of Okbyungpung-san on Pediatric Frequent Colds: A Double-Blind RCT

Song JH, Park MK, Kim DW, et al. Phytomedicine (2023)
90 patients Participants
52% Cold frequency reduction
6 months Observation period

Summary

Ninety children with 6 or more colds per year were randomly assigned in a double-blind manner to Okbyungpung-san or placebo groups and compared over 6 months. The Okbyungpung-san group showed significant improvements in cold frequency, sick days, and IgA.

Key Conclusion

Okbyungpung-san is effective for the prevention of recurrent colds and immune modulation in children.

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