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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 1642 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Before-After Mental Health

Effect of Korean Medicine Combined Treatment on Cortisol and HRV in Chronic Stress Workers

Seo MH, Kim JK, et al.

Stress and Health (2023)

100 subjects Participants
31% Cortisol Reduction
8 weeks Treatment Period

Korean medicine combined treatment effectively regulates physiological and psychological changes due to chronic stress.

View Source 2023
Before-After Mental Health

Effect of Korean Medicine Combined Treatment on Cortisol and HRV in Chronic Stress Workers

Seo MH, Kim JK, et al. Stress and Health (2023)
100 subjects Participants
31% Cortisol Reduction
8 weeks Treatment Period

Summary

Herbal medicine and acupuncture treatment were administered for 8 weeks to 100 workers complaining of chronic stress, and salivary cortisol, HRV, and PSS scores were evaluated. All three indicators improved significantly.

Key Conclusion

Korean medicine combined treatment effectively regulates physiological and psychological changes due to chronic stress.

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Cohort Study Mental Health

Effect of Combined Herbal Medicine-Acupuncture Treatment in Panic Disorder Patients: A Prospective Cohort Study

Park JY, Lee DH, Wang XF, et al.

Neuropsychiatric Disease and Treatment (2024)

90 subjects Participants
68% Attack Frequency Reduction
24 weeks Follow-up Period

Combined herbal medicine-acupuncture treatment shows effects similar to SSRIs in symptom management of panic disorder patients and can be considered as an alternative treatment.

View Source 2024
Cohort Study Mental Health

Effect of Combined Herbal Medicine-Acupuncture Treatment in Panic Disorder Patients: A Prospective Cohort Study

Park JY, Lee DH, Wang XF, et al. Neuropsychiatric Disease and Treatment (2024)
90 subjects Participants
68% Attack Frequency Reduction
24 weeks Follow-up Period

Summary

A prospective cohort study following 90 panic disorder patients for 24 weeks, divided into combined herbal medicine-acupuncture treatment and SSRI alone groups. Panic attack frequency and PDSS scores decreased significantly in the combined treatment group.

Key Conclusion

Combined herbal medicine-acupuncture treatment shows effects similar to SSRIs in symptom management of panic disorder patients and can be considered as an alternative treatment.

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Meta-Analysis Mental Health

Effect of Acupuncture Treatment for Anxiety Disorder: A Systematic Review and Meta-Analysis

Choi SY, Jung WS, Kim YI, et al.

Journal of Clinical Medicine (2023)

20 studies Included Studies
1,680 subjects Total Participants
SMD -0.68 Effect Size

Acupuncture treatment shows significant effects on anxiety symptom relief in generalized anxiety disorder patients.

View Source 2023
Meta-Analysis Mental Health

Effect of Acupuncture Treatment for Anxiety Disorder: A Systematic Review and Meta-Analysis

Choi SY, Jung WS, Kim YI, et al. Journal of Clinical Medicine (2023)
20 studies Included Studies
1,680 subjects Total Participants
SMD -0.68 Effect Size

Summary

A meta-analysis of 20 RCTs (total 1,680 subjects) evaluating the effect of acupuncture treatment in generalized anxiety disorder patients. HAM-A scores decreased significantly in the acupuncture treatment group compared with the control group.

Key Conclusion

Acupuncture treatment shows significant effects on anxiety symptom relief in generalized anxiety disorder patients.

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RCT Mental Health

Antidepressant Effect of Guibi-tang in Mild-to-Moderate Depression Patients: A Double-Blind Randomized Controlled Trial

Kim MJ, Lee SH, Park YC, et al.

Journal of Affective Disorders (2024)

120 subjects Participants
52% HAM-D Response Rate
12 weeks Treatment Period

Guibi-tang is effective for improving depressive symptoms in mild-to-moderate depression patients with few side effects.

View Source 2024
RCT Mental Health

Antidepressant Effect of Guibi-tang in Mild-to-Moderate Depression Patients: A Double-Blind Randomized Controlled Trial

Kim MJ, Lee SH, Park YC, et al. Journal of Affective Disorders (2024)
120 subjects Participants
52% HAM-D Response Rate
12 weeks Treatment Period

Summary

One hundred twenty patients with mild-to-moderate major depressive disorder were double-blind randomly assigned to Guibi-tang and placebo groups and compared for 12 weeks. HAM-D scores decreased significantly in the Guibi-tang group.

Key Conclusion

Guibi-tang is effective for improving depressive symptoms in mild-to-moderate depression patients with few side effects.

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Meta-Analysis Neurological Disorders

Systematic Review and Meta-Analysis of Korean Medicine Treatment for Post-Herpetic Neuralgia

Kwon DY, Song MK, Zhang W, et al.

Pain Medicine (2019)

15 studies Included Studies
WMD -2.1 VAS Reduction
p<0.01 Statistical Significance

Korean medicine treatment is effective for pain relief and quality of life improvement in post-herpetic neuralgia.

View Source 2019
Meta-Analysis Neurological Disorders

Systematic Review and Meta-Analysis of Korean Medicine Treatment for Post-Herpetic Neuralgia

Kwon DY, Song MK, Zhang W, et al. Pain Medicine (2019)
15 studies Included Studies
WMD -2.1 VAS Reduction
p<0.01 Statistical Significance

Summary

Fifteen studies on Korean medicine treatment (acupuncture, herbal medicine, pharmacopuncture) for post-herpetic neuralgia were systematically reviewed and meta-analyzed. The Korean medicine treatment group showed significant improvements in VAS and SF-36 scores.

Key Conclusion

Korean medicine treatment is effective for pain relief and quality of life improvement in post-herpetic neuralgia.

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Cohort Study Neurological Disorders

Differences in Treatment Response by Korean Medicine Constitution in Tinnitus Patients: A Multicenter Cohort Study

Cho MH, Lee SK, Park YS, et al.

Audiology and Neurotology (2023)

260 subjects Participants
4 types Constitution Types
p<0.01 Constitution Differences

Sasang constitution is a significant factor for predicting treatment response in tinnitus Korean medicine treatment, and constitution-based personalized treatment is needed.

View Source 2023
Cohort Study Neurological Disorders

Differences in Treatment Response by Korean Medicine Constitution in Tinnitus Patients: A Multicenter Cohort Study

Cho MH, Lee SK, Park YS, et al. Audiology and Neurotology (2023)
260 subjects Participants
4 types Constitution Types
p<0.01 Constitution Differences

Summary

A multicenter cohort study classifying 260 patients receiving Korean medicine treatment for tinnitus by Sasang constitution and analyzing differences in treatment response. Acupuncture treatment response was best in the Soyangin constitution.

Key Conclusion

Sasang constitution is a significant factor for predicting treatment response in tinnitus Korean medicine treatment, and constitution-based personalized treatment is needed.

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Before-After Neurological Disorders

Changes in Microvascular Reactivity Before and After Herbal Medicine Treatment in Cold Hypersensitivity Patients: A Laser Doppler Imaging Study

Yoon MK, Han SB, et al.

Microvascular Research (2023)

45 subjects Participants
35% Vascular Reactivity Increase
12 weeks Treatment Period

Herbal medicine treatment is effective for restoring microvascular reactivity in cold hypersensitivity patients.

View Source 2023
Before-After Neurological Disorders

Changes in Microvascular Reactivity Before and After Herbal Medicine Treatment in Cold Hypersensitivity Patients: A Laser Doppler Imaging Study

Yoon MK, Han SB, et al. Microvascular Research (2023)
45 subjects Participants
35% Vascular Reactivity Increase
12 weeks Treatment Period

Summary

Danggwisayeokgaosuyusaenggang-tang was administered for 12 weeks to 45 cold hypersensitivity patients, and microvascular reactivity was evaluated by laser Doppler imaging. Vascular dilation response to thermal stimulation increased significantly after herbal medicine administration.

Key Conclusion

Herbal medicine treatment is effective for restoring microvascular reactivity in cold hypersensitivity patients.

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Narrative Review Neurological Disorders

Pattern Identification System and Modern Interpretation of Neurological Disorders in Korean Medicine: An Integrated Literature Review

Kim BS, Oh JY, Nakamura T, et al.

Neurological Research (2024)

65 sources Reviewed Literature
5 disease groups Disease Categories
12 types Main Pattern Types

The Korean medicine pattern identification system provides a useful framework for personalized treatment of neurological disorders.

View Source 2024
Narrative Review Neurological Disorders

Pattern Identification System and Modern Interpretation of Neurological Disorders in Korean Medicine: An Integrated Literature Review

Kim BS, Oh JY, Nakamura T, et al. Neurological Research (2024)
65 sources Reviewed Literature
5 disease groups Disease Categories
12 types Main Pattern Types

Summary

An integrated literature review interpreting the Korean medicine pattern identification system for neurological disorders (headache, dizziness, facial palsy, tinnitus, peripheral neuropathy) from a modern neuroscience perspective.

Key Conclusion

The Korean medicine pattern identification system provides a useful framework for personalized treatment of neurological disorders.

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Before-After Neurological Disorders

Effect of Auricular Acupuncture in Dizziness Patients: A Single-Arm Pre-Post Comparison

Lee WK, Ahn SH, et al.

Journal of Alternative and Complementary Medicine (2020)

60 subjects Participants
42% DHI Improvement Rate
4 weeks Treatment Period

Auricular acupuncture treatment is effective for symptom relief and balance function improvement in chronic dizziness patients.

View Source 2020
Before-After Neurological Disorders

Effect of Auricular Acupuncture in Dizziness Patients: A Single-Arm Pre-Post Comparison

Lee WK, Ahn SH, et al. Journal of Alternative and Complementary Medicine (2020)
60 subjects Participants
42% DHI Improvement Rate
4 weeks Treatment Period

Summary

Auricular acupuncture treatment was administered for 4 weeks to 60 chronic dizziness patients of various causes, and DHI scores and balance ability were evaluated. DHI scores and static balance indicators improved significantly.

Key Conclusion

Auricular acupuncture treatment is effective for symptom relief and balance function improvement in chronic dizziness patients.

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Cross-Sectional Neurological Disorders

Korean Medicine Treatment Satisfaction and Quality of Life in Facial Palsy Patients: A Multicenter Survey Study

Go MH, Shin YJ, et al.

Patient Preference and Adherence (2023)

280 subjects Number of Respondents
88.5% Satisfaction
r=0.72 QoL Correlation

Patient satisfaction with Korean medicine treatment for facial palsy is high, and positive correlation with quality of life improvement was shown.

View Source 2023
Cross-Sectional Neurological Disorders

Korean Medicine Treatment Satisfaction and Quality of Life in Facial Palsy Patients: A Multicenter Survey Study

Go MH, Shin YJ, et al. Patient Preference and Adherence (2023)
280 subjects Number of Respondents
88.5% Satisfaction
r=0.72 QoL Correlation

Summary

Treatment satisfaction, quality of life (FDI), and treatment adherence were evaluated by multicenter survey in 280 patients who received Korean medicine treatment for facial palsy. Overall satisfaction was 88.5%.

Key Conclusion

Patient satisfaction with Korean medicine treatment for facial palsy is high, and positive correlation with quality of life improvement was shown.

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RCT Neurological Disorders

NCV Improvement Effect of Astragalus-Based Herbal Medicine for Diabetic Peripheral Neuropathy: An RCT

Jung HJ, Kim YW, Li Z, et al.

Phytomedicine (2025)

100 subjects Participants
4.2 m/s NCV Improvement
16 weeks Treatment Period

Astragalus-based herbal medicine showed superior effects to mecobalamin in nerve conduction function improvement in diabetic peripheral neuropathy.

View Source 2025
RCT Neurological Disorders

NCV Improvement Effect of Astragalus-Based Herbal Medicine for Diabetic Peripheral Neuropathy: An RCT

Jung HJ, Kim YW, Li Z, et al. Phytomedicine (2025)
100 subjects Participants
4.2 m/s NCV Improvement
16 weeks Treatment Period

Summary

One hundred patients with diabetic peripheral neuropathy were randomly assigned to Astragalus-based herbal medicine and mecobalamin groups and compared for 16 weeks. The herbal medicine group showed significant improvements in NCV and vibration perception threshold (VPT).

Key Conclusion

Astragalus-based herbal medicine showed superior effects to mecobalamin in nerve conduction function improvement in diabetic peripheral neuropathy.

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Case Study Neurological Disorders

Korean Medicine Treatment Case Report and Literature Review for Cluster Headache

Baek JH, Cho MS, et al.

Journal of Korean Medicine (2021)

6 cases Number of Cases
67% Response Rate
50% Attack Reduction Standard

Korean medicine combined treatment shows potential for complementary management of cluster headache, but additional research is needed.

View Source 2021
Case Study Neurological Disorders

Korean Medicine Treatment Case Report and Literature Review for Cluster Headache

Baek JH, Cho MS, et al. Journal of Korean Medicine (2021)
6 cases Number of Cases
67% Response Rate
50% Attack Reduction Standard

Summary

Treatment cases were reported for 6 cluster headache patients who received combined acupuncture and herbal medicine treatment, and related literature was reviewed. Attack frequency decreased by more than 50% in 4 patients.

Key Conclusion

Korean medicine combined treatment shows potential for complementary management of cluster headache, but additional research is needed.

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