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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Total 1642 papers

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RCT Pediatric / Adolescent Care

Synergistic Effects of Combined Herbal Medicine and Probiotics for Pediatric Immunity: An RCT

Kim TH, Ahn BG, et al.

Nutrients (2024)

120 patients Participants
4-arm comparison Study design
61% Cold reduction rate

Combined administration of herbal medicine and probiotics shows synergistic effects in enhancing pediatric immunity.

View Source 2024
RCT Pediatric / Adolescent Care

Synergistic Effects of Combined Herbal Medicine and Probiotics for Pediatric Immunity: An RCT

Kim TH, Ahn BG, et al. Nutrients (2024)
120 patients Participants
4-arm comparison Study design
61% Cold reduction rate

Summary

One hundred twenty children with frequent colds were randomly assigned to herbal medicine plus probiotics, herbal medicine alone, probiotics alone, or placebo groups and compared over 12 weeks. The herbal medicine plus probiotics group showed the most pronounced sIgA increase and cold frequency reduction.

Key Conclusion

Combined administration of herbal medicine and probiotics shows synergistic effects in enhancing pediatric immunity.

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Cross-Sectional Pediatric / Adolescent Care

Correlation Between Pediatric Growth Retardation and Sleep Quality and Effect of Korean Medicine Treatment: A Cross-Sectional Analysis

Seo JK, Park YJ, et al.

Sleep Medicine (2023)

120 patients Analysis subjects
r=0.62 Sleep-growth correlation
p<0.001 Statistical significance

In pediatric growth retardation, improving sleep quality plays an important role in growth promotion, and Korean medicine treatment improves both factors simultaneously.

View Source 2023
Cross-Sectional Pediatric / Adolescent Care

Correlation Between Pediatric Growth Retardation and Sleep Quality and Effect of Korean Medicine Treatment: A Cross-Sectional Analysis

Seo JK, Park YJ, et al. Sleep Medicine (2023)
120 patients Analysis subjects
r=0.62 Sleep-growth correlation
p<0.001 Statistical significance

Summary

The correlation between sleep quality (CSHQ), growth hormone secretion, and growth velocity was analyzed in 120 children with growth retardation, and changes after Korean medicine treatment were evaluated. A significant positive correlation between sleep quality and growth velocity was confirmed.

Key Conclusion

In pediatric growth retardation, improving sleep quality plays an important role in growth promotion, and Korean medicine treatment improves both factors simultaneously.

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Cohort Study Pediatric / Adolescent Care

Long-Term Outcomes Following Korean Medicine Treatment for Pediatric Tic Disorder: A 5-Year Follow-Up Study

Go HJ, Lee SE, et al.

Child Psychiatry & Human Development (2025)

80 patients Participants
62% 5-year remission rate
5 years Follow-up period

Korean medicine treatment for pediatric tic disorder shows favorable long-term outcomes, and early treatment response is important for prognostic prediction.

View Source 2025
Cohort Study Pediatric / Adolescent Care

Long-Term Outcomes Following Korean Medicine Treatment for Pediatric Tic Disorder: A 5-Year Follow-Up Study

Go HJ, Lee SE, et al. Child Psychiatry & Human Development (2025)
80 patients Participants
62% 5-year remission rate
5 years Follow-up period

Summary

Eighty children with tic disorder who received Korean medicine treatment were followed for 5 years to analyze long-term outcomes and remission rates. The 5-year complete remission rate was 62%, and groups with good initial treatment response had favorable prognosis.

Key Conclusion

Korean medicine treatment for pediatric tic disorder shows favorable long-term outcomes, and early treatment response is important for prognostic prediction.

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Before-After Pediatric / Adolescent Care

Effect of Modified Socheongryong-tang in Children with Enuresis: A Pre-Post Comparison Study

Yang MJ, Kwon BH, et al.

Journal of Korean Medicine Rehabilitation (2022)

40 patients Participants
70% Enuresis reduction rate
8 weeks Treatment duration

Modified Socheongryong-tang is effective in reducing enuresis frequency in children with enuresis.

View Source 2022
Before-After Pediatric / Adolescent Care

Effect of Modified Socheongryong-tang in Children with Enuresis: A Pre-Post Comparison Study

Yang MJ, Kwon BH, et al. Journal of Korean Medicine Rehabilitation (2022)
40 patients Participants
70% Enuresis reduction rate
8 weeks Treatment duration

Summary

Modified Socheongryong-tang was administered for 8 weeks to 40 children with enuresis, and weekly enuresis frequency and functional bladder capacity were evaluated. Enuresis frequency decreased by an average of 70%.

Key Conclusion

Modified Socheongryong-tang is effective in reducing enuresis frequency in children with enuresis.

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Cross-Sectional Pediatric / Adolescent Care

Correlation Between Gut Microbiota and Korean Medicine Pattern Differentiation in Pediatric Atopic Dermatitis

Cho MR, Lee KJ, Nakamura S, et al.

Beneficial Microbes (2024)

100 patients Analysis subjects
4 types Pattern types
p<0.01 Microbiota differences

Pattern differentiation in pediatric atopic dermatitis is associated with gut microbiota composition and may be useful for personalized treatment.

View Source 2024
Cross-Sectional Pediatric / Adolescent Care

Correlation Between Gut Microbiota and Korean Medicine Pattern Differentiation in Pediatric Atopic Dermatitis

Cho MR, Lee KJ, Nakamura S, et al. Beneficial Microbes (2024)
100 patients Analysis subjects
4 types Pattern types
p<0.01 Microbiota differences

Summary

A cross-sectional study performing gut microbiota analysis and Korean medicine pattern differentiation in 100 children with atopic dermatitis. The damp-heat pattern showed significantly higher Firmicutes/Bacteroidetes ratios.

Key Conclusion

Pattern differentiation in pediatric atopic dermatitis is associated with gut microbiota composition and may be useful for personalized treatment.

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RCT Pediatric / Adolescent Care

Immunomodulatory Effects of Okbyungpung-san on Pediatric Frequent Colds: A Double-Blind RCT

Song JH, Park MK, Kim DW, et al.

Phytomedicine (2023)

90 patients Participants
52% Cold frequency reduction
6 months Observation period

Okbyungpung-san is effective for the prevention of recurrent colds and immune modulation in children.

View Source 2023
RCT Pediatric / Adolescent Care

Immunomodulatory Effects of Okbyungpung-san on Pediatric Frequent Colds: A Double-Blind RCT

Song JH, Park MK, Kim DW, et al. Phytomedicine (2023)
90 patients Participants
52% Cold frequency reduction
6 months Observation period

Summary

Ninety children with 6 or more colds per year were randomly assigned in a double-blind manner to Okbyungpung-san or placebo groups and compared over 6 months. The Okbyungpung-san group showed significant improvements in cold frequency, sick days, and IgA.

Key Conclusion

Okbyungpung-san is effective for the prevention of recurrent colds and immune modulation in children.

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RCT Pediatric / Adolescent Care

Effect of Chuna Therapy for Pediatric Growth Plate Stimulation: An RCT

Lim JY, Baek GH, et al.

Journal of Manipulative and Physiological Therapeutics (2024)

80 patients Participants
1.2 cm Additional 12-month growth
p<0.05 Statistical significance

Combined Chuna therapy provides additional benefits to herbal medicine monotherapy for pediatric growth promotion.

View Source 2024
RCT Pediatric / Adolescent Care

Effect of Chuna Therapy for Pediatric Growth Plate Stimulation: An RCT

Lim JY, Baek GH, et al. Journal of Manipulative and Physiological Therapeutics (2024)
80 patients Participants
1.2 cm Additional 12-month growth
p<0.05 Statistical significance

Summary

Eighty children with short stature were randomized to a Chuna plus herbal medicine group or herbal medicine alone group and compared over 12 months. The Chuna combination group showed significantly higher growth velocities at 6 and 12 months.

Key Conclusion

Combined Chuna therapy provides additional benefits to herbal medicine monotherapy for pediatric growth promotion.

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Case Study Pediatric / Adolescent Care

Effect of Herbal Medicine on Pediatric Chronic Constipation with Comorbid Anorexia: A Case Series

Kim GH, Jeon JH, et al.

Journal of Korean Medicine (2020)

8 patients Cases
100% Improvement rate
6 weeks Treatment duration

Herbal medicine can be effectively utilized for managing pediatric constipation-anorexia comorbid symptoms.

View Source 2020
Case Study Pediatric / Adolescent Care

Effect of Herbal Medicine on Pediatric Chronic Constipation with Comorbid Anorexia: A Case Series

Kim GH, Jeon JH, et al. Journal of Korean Medicine (2020)
8 patients Cases
100% Improvement rate
6 weeks Treatment duration

Summary

A case series of 8 pediatric patients with chronic constipation comorbid with anorexia treated with pattern-differentiated herbal medicine for 6 weeks was reported. All patients showed improvements in bowel frequency and food intake.

Key Conclusion

Herbal medicine can be effectively utilized for managing pediatric constipation-anorexia comorbid symptoms.

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Before-After Pediatric / Adolescent Care

Safety and Efficacy of Herbal Bath Therapy for Atopic Dermatitis in Infants: A Pre-Post Comparison

Moon SJ, Cho YK, et al.

Journal of Dermatological Treatment (2021)

30 patients Participants
45% SCORAD improvement
4 weeks Treatment duration

Herbal bath therapy is a safe and effective adjunctive treatment for infantile atopic dermatitis.

View Source 2021
Before-After Pediatric / Adolescent Care

Safety and Efficacy of Herbal Bath Therapy for Atopic Dermatitis in Infants: A Pre-Post Comparison

Moon SJ, Cho YK, et al. Journal of Dermatological Treatment (2021)
30 patients Participants
45% SCORAD improvement
4 weeks Treatment duration

Summary

Herbal medicine-based bathing was performed for 4 weeks on 30 infants under 2 years with atopic dermatitis, and SCORAD, TEWL, and sleep quality were evaluated. All three indicators significantly improved.

Key Conclusion

Herbal bath therapy is a safe and effective adjunctive treatment for infantile atopic dermatitis.

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Cohort Study Pediatric / Adolescent Care

Effect of Herbal Medicine on Pubertal Progression Rate in Girls with Precocious Puberty: A Cohort Study

Ahn SJ, Park KR, et al.

Journal of Pediatric Endocrinology and Metabolism (2024)

80 patients Participants
12 months Follow-up period
BA/CA reduction Bone age suppression

Herbal medicine can serve as an alternative treatment for regulating pubertal progression in mild precocious puberty.

View Source 2024
Cohort Study Pediatric / Adolescent Care

Effect of Herbal Medicine on Pubertal Progression Rate in Girls with Precocious Puberty: A Cohort Study

Ahn SJ, Park KR, et al. Journal of Pediatric Endocrinology and Metabolism (2024)
80 patients Participants
12 months Follow-up period
BA/CA reduction Bone age suppression

Summary

Eighty girls with precocious puberty were compared over 12 months between an herbal medicine (modified Jibaekjihwang-hwan) treatment group and a GnRH agonist treatment group regarding pubertal progression rate. Both groups showed pubertal suppression effects.

Key Conclusion

Herbal medicine can serve as an alternative treatment for regulating pubertal progression in mild precocious puberty.

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Meta-Analysis Pediatric / Adolescent Care

Effect of Korean Medicine on Pediatric Tic Disorder: A Systematic Review and Meta-Analysis

Ryu SH, Kim TS, Huang X, et al.

Complementary Therapies in Medicine (2023)

16 studies Included studies
1,320 patients Total participants
SMD -0.84 Effect size

Korean medicine is effective in improving symptoms of pediatric tic disorder with few adverse effects.

View Source 2023
Meta-Analysis Pediatric / Adolescent Care

Effect of Korean Medicine on Pediatric Tic Disorder: A Systematic Review and Meta-Analysis

Ryu SH, Kim TS, Huang X, et al. Complementary Therapies in Medicine (2023)
16 studies Included studies
1,320 patients Total participants
SMD -0.84 Effect size

Summary

Sixteen studies (total 1,320 patients) on Korean medicine for pediatric tic disorder were systematically reviewed and meta-analyzed. Both herbal medicine and acupuncture showed significant effects in reducing total YGTSS scores.

Key Conclusion

Korean medicine is effective in improving symptoms of pediatric tic disorder with few adverse effects.

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Cross-Sectional Pediatric / Adolescent Care

Predictive Factors for Treatment Response to Korean Medicine in Children with Enuresis: A Multivariate Regression Analysis

Lee HW, Song YS, et al.

Journal of Pediatric Urology (2022)

150 patients Analysis subjects
3 factors Independent predictors
AUC 0.79 Predictive model accuracy

Tailored treatment strategies according to patient characteristics are needed in Korean medicine treatment for enuresis.

View Source 2022
Cross-Sectional Pediatric / Adolescent Care

Predictive Factors for Treatment Response to Korean Medicine in Children with Enuresis: A Multivariate Regression Analysis

Lee HW, Song YS, et al. Journal of Pediatric Urology (2022)
150 patients Analysis subjects
3 factors Independent predictors
AUC 0.79 Predictive model accuracy

Summary

Medical records of 150 children with enuresis who received Korean medicine were retrospectively analyzed to identify predictive factors for treatment response. Age, comorbid daytime frequency, and family history were identified as independent predictors.

Key Conclusion

Tailored treatment strategies according to patient characteristics are needed in Korean medicine treatment for enuresis.

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