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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 1642 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Cross-Sectional Pediatric / Adolescent Care

Correlation Between Gut Microbiota and Korean Medicine Pattern Differentiation in Pediatric Atopic Dermatitis

Cho MR, Lee KJ, Nakamura S, et al.

Beneficial Microbes (2024)

100 patients Analysis subjects
4 types Pattern types
p<0.01 Microbiota differences

Pattern differentiation in pediatric atopic dermatitis is associated with gut microbiota composition and may be useful for personalized treatment.

View Source 2024
Cross-Sectional Pediatric / Adolescent Care

Correlation Between Gut Microbiota and Korean Medicine Pattern Differentiation in Pediatric Atopic Dermatitis

Cho MR, Lee KJ, Nakamura S, et al. Beneficial Microbes (2024)
100 patients Analysis subjects
4 types Pattern types
p<0.01 Microbiota differences

Summary

A cross-sectional study performing gut microbiota analysis and Korean medicine pattern differentiation in 100 children with atopic dermatitis. The damp-heat pattern showed significantly higher Firmicutes/Bacteroidetes ratios.

Key Conclusion

Pattern differentiation in pediatric atopic dermatitis is associated with gut microbiota composition and may be useful for personalized treatment.

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Before-After Pediatric / Adolescent Care

Effect of Modified Socheongryong-tang in Children with Enuresis: A Pre-Post Comparison Study

Yang MJ, Kwon BH, et al.

Journal of Korean Medicine Rehabilitation (2022)

40 patients Participants
70% Enuresis reduction rate
8 weeks Treatment duration

Modified Socheongryong-tang is effective in reducing enuresis frequency in children with enuresis.

View Source 2022
Before-After Pediatric / Adolescent Care

Effect of Modified Socheongryong-tang in Children with Enuresis: A Pre-Post Comparison Study

Yang MJ, Kwon BH, et al. Journal of Korean Medicine Rehabilitation (2022)
40 patients Participants
70% Enuresis reduction rate
8 weeks Treatment duration

Summary

Modified Socheongryong-tang was administered for 8 weeks to 40 children with enuresis, and weekly enuresis frequency and functional bladder capacity were evaluated. Enuresis frequency decreased by an average of 70%.

Key Conclusion

Modified Socheongryong-tang is effective in reducing enuresis frequency in children with enuresis.

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Cohort Study Pediatric / Adolescent Care

Long-Term Outcomes Following Korean Medicine Treatment for Pediatric Tic Disorder: A 5-Year Follow-Up Study

Go HJ, Lee SE, et al.

Child Psychiatry & Human Development (2025)

80 patients Participants
62% 5-year remission rate
5 years Follow-up period

Korean medicine treatment for pediatric tic disorder shows favorable long-term outcomes, and early treatment response is important for prognostic prediction.

View Source 2025
Cohort Study Pediatric / Adolescent Care

Long-Term Outcomes Following Korean Medicine Treatment for Pediatric Tic Disorder: A 5-Year Follow-Up Study

Go HJ, Lee SE, et al. Child Psychiatry & Human Development (2025)
80 patients Participants
62% 5-year remission rate
5 years Follow-up period

Summary

Eighty children with tic disorder who received Korean medicine treatment were followed for 5 years to analyze long-term outcomes and remission rates. The 5-year complete remission rate was 62%, and groups with good initial treatment response had favorable prognosis.

Key Conclusion

Korean medicine treatment for pediatric tic disorder shows favorable long-term outcomes, and early treatment response is important for prognostic prediction.

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Cross-Sectional Pediatric / Adolescent Care

Correlation Between Pediatric Growth Retardation and Sleep Quality and Effect of Korean Medicine Treatment: A Cross-Sectional Analysis

Seo JK, Park YJ, et al.

Sleep Medicine (2023)

120 patients Analysis subjects
r=0.62 Sleep-growth correlation
p<0.001 Statistical significance

In pediatric growth retardation, improving sleep quality plays an important role in growth promotion, and Korean medicine treatment improves both factors simultaneously.

View Source 2023
Cross-Sectional Pediatric / Adolescent Care

Correlation Between Pediatric Growth Retardation and Sleep Quality and Effect of Korean Medicine Treatment: A Cross-Sectional Analysis

Seo JK, Park YJ, et al. Sleep Medicine (2023)
120 patients Analysis subjects
r=0.62 Sleep-growth correlation
p<0.001 Statistical significance

Summary

The correlation between sleep quality (CSHQ), growth hormone secretion, and growth velocity was analyzed in 120 children with growth retardation, and changes after Korean medicine treatment were evaluated. A significant positive correlation between sleep quality and growth velocity was confirmed.

Key Conclusion

In pediatric growth retardation, improving sleep quality plays an important role in growth promotion, and Korean medicine treatment improves both factors simultaneously.

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RCT Pediatric / Adolescent Care

Synergistic Effects of Combined Herbal Medicine and Probiotics for Pediatric Immunity: An RCT

Kim TH, Ahn BG, et al.

Nutrients (2024)

120 patients Participants
4-arm comparison Study design
61% Cold reduction rate

Combined administration of herbal medicine and probiotics shows synergistic effects in enhancing pediatric immunity.

View Source 2024
RCT Pediatric / Adolescent Care

Synergistic Effects of Combined Herbal Medicine and Probiotics for Pediatric Immunity: An RCT

Kim TH, Ahn BG, et al. Nutrients (2024)
120 patients Participants
4-arm comparison Study design
61% Cold reduction rate

Summary

One hundred twenty children with frequent colds were randomly assigned to herbal medicine plus probiotics, herbal medicine alone, probiotics alone, or placebo groups and compared over 12 weeks. The herbal medicine plus probiotics group showed the most pronounced sIgA increase and cold frequency reduction.

Key Conclusion

Combined administration of herbal medicine and probiotics shows synergistic effects in enhancing pediatric immunity.

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Cohort Study Pediatric / Adolescent Care

Safety Profile of Pediatric Korean Medicine Treatment: 3-Year Adverse Event Monitoring Results

Hwang KS, Lee DH, et al.

BMC Pediatrics (2023)

2,500 patients Monitoring subjects
4.2% Adverse event incidence
3 years Monitoring period

The overall safety of pediatric Korean medicine treatment is favorable, and serious adverse events are very rare.

View Source 2023
Cohort Study Pediatric / Adolescent Care

Safety Profile of Pediatric Korean Medicine Treatment: 3-Year Adverse Event Monitoring Results

Hwang KS, Lee DH, et al. BMC Pediatrics (2023)
2,500 patients Monitoring subjects
4.2% Adverse event incidence
3 years Monitoring period

Summary

Adverse events were prospectively monitored over 3 years in 2,500 pediatric patients who received Korean medicine treatment. The adverse event incidence rate was 4.2%, with most being mild gastrointestinal symptoms.

Key Conclusion

The overall safety of pediatric Korean medicine treatment is favorable, and serious adverse events are very rare.

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Before-After Pediatric / Adolescent Care

Effect of Jaungo on Skin Barrier Recovery in Pediatric Atopic Dermatitis: A Pre-Post Comparison

Noh EH, Song BK, et al.

Skin Pharmacology and Physiology (2022)

35 patients Participants
38% TEWL reduction
4 weeks Treatment duration

Jaungo is an effective topical preparation for restoring skin barrier function in pediatric atopic dermatitis.

View Source 2022
Before-After Pediatric / Adolescent Care

Effect of Jaungo on Skin Barrier Recovery in Pediatric Atopic Dermatitis: A Pre-Post Comparison

Noh EH, Song BK, et al. Skin Pharmacology and Physiology (2022)
35 patients Participants
38% TEWL reduction
4 weeks Treatment duration

Summary

Jaungo was applied for 4 weeks to 35 children with atopic dermatitis, and TEWL, skin hydration, and SCORAD were measured. All three indicators significantly improved.

Key Conclusion

Jaungo is an effective topical preparation for restoring skin barrier function in pediatric atopic dermatitis.

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Meta-Analysis Pediatric / Adolescent Care

Bone Mineral Density and Bone Metabolism Marker Changes with Herbal Medicine in Pediatric Growth Treatment: A Meta-Analysis

Min JK, Lee YR, Wang C, et al.

Calcified Tissue International (2024)

10 studies Included studies
680 patients Total participants
p<0.01 BMD increase

Herbal medicine activates bone metabolism in children and contributes to growth promotion.

View Source 2024
Meta-Analysis Pediatric / Adolescent Care

Bone Mineral Density and Bone Metabolism Marker Changes with Herbal Medicine in Pediatric Growth Treatment: A Meta-Analysis

Min JK, Lee YR, Wang C, et al. Calcified Tissue International (2024)
10 studies Included studies
680 patients Total participants
p<0.01 BMD increase

Summary

Ten studies evaluating bone mineral density and bone metabolism marker changes with herbal medicine treatment for pediatric growth promotion were meta-analyzed. The herbal medicine group showed significant increases in bone mineral density and serum osteocalcin.

Key Conclusion

Herbal medicine activates bone metabolism in children and contributes to growth promotion.

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Case Study Pediatric / Adolescent Care

Case Report of Korean Medicine Combination Therapy for Children with Comorbid Tic Disorder and ADHD

Son MH, Choi JK, et al.

Journal of Attention Disorders (2021)

6 patients Cases
83% Tic improvement rate
67% ADHD improvement rate

Korean medicine combination therapy may be effective in simultaneously managing both symptoms in children with comorbid tic disorder-ADHD.

View Source 2021
Case Study Pediatric / Adolescent Care

Case Report of Korean Medicine Combination Therapy for Children with Comorbid Tic Disorder and ADHD

Son MH, Choi JK, et al. Journal of Attention Disorders (2021)
6 patients Cases
83% Tic improvement rate
67% ADHD improvement rate

Summary

A case series of 6 pediatric patients with comorbid tic disorder and ADHD treated with pattern-differentiated herbal medicine and acupuncture for 16 weeks was reported. Both YGTSS and ADHD-RS scores improved.

Key Conclusion

Korean medicine combination therapy may be effective in simultaneously managing both symptoms in children with comorbid tic disorder-ADHD.

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Cross-Sectional Pediatric / Adolescent Care

Relationship Between Pediatric Immunity and Korean Medicine Constitution: Comparison of Immune Indicators by Sasang Constitution

Kang SY, Park JM, et al.

Journal of Sasang Constitutional Medicine (2023)

300 patients Analysis subjects
4 types Constitution types
p<0.05 NK cell differences

Sasang constitution is significantly associated with pediatric immune characteristics, and constitution-tailored immune management is needed.

View Source 2023
Cross-Sectional Pediatric / Adolescent Care

Relationship Between Pediatric Immunity and Korean Medicine Constitution: Comparison of Immune Indicators by Sasang Constitution

Kang SY, Park JM, et al. Journal of Sasang Constitutional Medicine (2023)
300 patients Analysis subjects
4 types Constitution types
p<0.05 NK cell differences

Summary

A cross-sectional study comparing Sasang constitution and immune indicators (NK cells, IgG, IgA, complement) in 300 children. The Soeumin constitution showed the lowest NK cell activity and the highest cold frequency.

Key Conclusion

Sasang constitution is significantly associated with pediatric immune characteristics, and constitution-tailored immune management is needed.

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Systematic Review Pediatric / Adolescent Care

Effectiveness and Safety of Korean Medicine Treatment for Pediatric Enuresis: A Systematic Review

Woo SH, Lee HK, Zhang Q, et al.

Journal of Pediatric Urology (2024)

18 studies Included studies
1,480 patients Total participants
OR 2.18 Effect size

Korean medicine is an effective and safe treatment option for pediatric enuresis.

View Source 2024
Systematic Review Pediatric / Adolescent Care

Effectiveness and Safety of Korean Medicine Treatment for Pediatric Enuresis: A Systematic Review

Woo SH, Lee HK, Zhang Q, et al. Journal of Pediatric Urology (2024)
18 studies Included studies
1,480 patients Total participants
OR 2.18 Effect size

Summary

Eighteen studies on Korean medicine treatment (herbal medicine, acupuncture, moxibustion) for pediatric enuresis were systematically reviewed. The Korean medicine treatment group showed significantly higher reductions in enuresis frequency and complete remission rates compared to controls.

Key Conclusion

Korean medicine is an effective and safe treatment option for pediatric enuresis.

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Before-After Pediatric / Adolescent Care

Effect of Korean Medicine Treatment for Pediatric Obesity with Comorbid Precocious Puberty: A Pre-Post Comparison Study

Im BK, Cho SH, et al.

Journal of Pediatric Endocrinology and Metabolism (2023)

35 patients Participants
BMI reduction Weight management
16 weeks Treatment duration

Korean medicine treatment helps with weight management and pubertal suppression in pediatric obesity-precocious puberty comorbid patients.

View Source 2023
Before-After Pediatric / Adolescent Care

Effect of Korean Medicine Treatment for Pediatric Obesity with Comorbid Precocious Puberty: A Pre-Post Comparison Study

Im BK, Cho SH, et al. Journal of Pediatric Endocrinology and Metabolism (2023)
35 patients Participants
BMI reduction Weight management
16 weeks Treatment duration

Summary

Herbal medicine and lifestyle guidance were performed for 16 weeks on 35 children with comorbid obesity and precocious puberty, and BMI, bone age, and LH levels were evaluated. BMI and bone age progression rate significantly decreased.

Key Conclusion

Korean medicine treatment helps with weight management and pubertal suppression in pediatric obesity-precocious puberty comorbid patients.

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