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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Total 1642 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Meta-Analysis Mental Health

Cortisol Regulation Effect of Korean Medicine Interventions for Chronic Stress: A Meta-Analysis

Oh TY, Min SJ, Park BK, et al.

Psychoneuroendocrinology (2024)

10 studies Included Studies
780 subjects Total Participants
WMD -0.18 Cortisol Reduction

Korean medicine interventions significantly reduce cortisol levels in chronic stress patients.

View Source 2024
Meta-Analysis Mental Health

Cortisol Regulation Effect of Korean Medicine Interventions for Chronic Stress: A Meta-Analysis

Oh TY, Min SJ, Park BK, et al. Psychoneuroendocrinology (2024)
10 studies Included Studies
780 subjects Total Participants
WMD -0.18 Cortisol Reduction

Summary

A meta-analysis of 10 RCTs (total 780 subjects) evaluating the cortisol regulation effect of Korean medicine interventions (herbal medicine, acupuncture) for chronic stress. Both salivary cortisol and blood cortisol decreased significantly.

Key Conclusion

Korean medicine interventions significantly reduce cortisol levels in chronic stress patients.

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Before-After Mental Health

Brain Function Changes with Acupuncture Treatment in Depression Patients: An fMRI Study

Kim TY, Lee JH, Suzuki M, et al.

NeuroImage: Clinical (2025)

40 subjects Participants
Frontal-limbic Main Brain Region
p<0.05 Connectivity Change

Acupuncture treatment is presumed to exert antidepressant effects by changing brain functional connectivity in depression patients.

View Source 2025
Before-After Mental Health

Brain Function Changes with Acupuncture Treatment in Depression Patients: An fMRI Study

Kim TY, Lee JH, Suzuki M, et al. NeuroImage: Clinical (2025)
40 subjects Participants
Frontal-limbic Main Brain Region
p<0.05 Connectivity Change

Summary

Acupuncture treatment was administered for 8 weeks to 40 depression patients, and brain functional connectivity changes were analyzed by pre- and post-fMRI. Frontal-limbic connectivity significantly normalized.

Key Conclusion

Acupuncture treatment is presumed to exert antidepressant effects by changing brain functional connectivity in depression patients.

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Before-After Mental Health

Effect of Cheonwangbosim-dan in Patients with Comorbid Anxiety and Insomnia: A Pre-Post Comparison Study

Kwon SH, Lim GH, et al.

Sleep Medicine Reviews (2023)

60 subjects Participants
54% HAM-A Improvement Rate
8 weeks Treatment Period

Cheonwangbosim-dan can simultaneously and effectively improve both symptoms in patients with comorbid anxiety-insomnia.

View Source 2023
Before-After Mental Health

Effect of Cheonwangbosim-dan in Patients with Comorbid Anxiety and Insomnia: A Pre-Post Comparison Study

Kwon SH, Lim GH, et al. Sleep Medicine Reviews (2023)
60 subjects Participants
54% HAM-A Improvement Rate
8 weeks Treatment Period

Summary

Cheonwangbosim-dan was administered for 8 weeks to 60 patients with comorbid anxiety and insomnia, and HAM-A, PSQI, and polysomnography results were compared. All three indicators improved significantly.

Key Conclusion

Cheonwangbosim-dan can simultaneously and effectively improve both symptoms in patients with comorbid anxiety-insomnia.

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Systematic Review Mental Health

Systematic Review of Korean Medicine Treatment for Panic Disorder

Cho HJ, Yoo MJ, et al.

Psychiatry Research (2022)

18 studies Included Studies
14 studies Positive Results
Low-moderate Evidence Level

Korean medicine treatment is promising for panic disorder management, but high-quality large-scale RCTs are needed.

View Source 2022
Systematic Review Mental Health

Systematic Review of Korean Medicine Treatment for Panic Disorder

Cho HJ, Yoo MJ, et al. Psychiatry Research (2022)
18 studies Included Studies
14 studies Positive Results
Low-moderate Evidence Level

Summary

Eighteen studies on Korean medicine treatment for panic disorder were systematically reviewed. Both herbal medicine and acupuncture treatment showed positive results in PDSS and CGI scores, but methodological quality varied.

Key Conclusion

Korean medicine treatment is promising for panic disorder management, but high-quality large-scale RCTs are needed.

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RCT Mental Health

Impact of Korean Medicine Stress Management Program on College Student Burnout: An RCT

Jeon KS, Park HM, et al.

BMC Complementary Medicine and Therapies (2024)

100 subjects Participants
45% MBI Improvement Rate
8 weeks Program Period

The Korean medicine stress management program is effective for alleviating burnout symptoms in college students.

View Source 2024
RCT Mental Health

Impact of Korean Medicine Stress Management Program on College Student Burnout: An RCT

Jeon KS, Park HM, et al. BMC Complementary Medicine and Therapies (2024)
100 subjects Participants
45% MBI Improvement Rate
8 weeks Program Period

Summary

One hundred college students complaining of burnout symptoms were randomly assigned to a Korean medicine stress management program group and a waiting list group and compared for 8 weeks. MBI scores and PSS scores improved significantly.

Key Conclusion

The Korean medicine stress management program is effective for alleviating burnout symptoms in college students.

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Cohort Study Women's Health / Infertility

Effect of Korean Medicine Treatment for Postpartum Depression: A Prospective Cohort Study

Yun SH, Kim EJ, Li Y, et al.

Journal of Affective Disorders (2023)

80 subjects Participants
61% EPDS Improvement Rate
12 weeks Follow-up Period

Korean medicine treatment is effective for postpartum depression management and is a safe treatment option compatible with breastfeeding.

View Source 2023
Cohort Study Women's Health / Infertility

Effect of Korean Medicine Treatment for Postpartum Depression: A Prospective Cohort Study

Yun SH, Kim EJ, Li Y, et al. Journal of Affective Disorders (2023)
80 subjects Participants
61% EPDS Improvement Rate
12 weeks Follow-up Period

Summary

A cohort study following 80 women with postpartum depression for 12 weeks, divided into combined herbal medicine-acupuncture and general management groups. EPDS scores decreased significantly in the Korean medicine treatment group, with higher breastfeeding continuation rates.

Key Conclusion

Korean medicine treatment is effective for postpartum depression management and is a safe treatment option compatible with breastfeeding.

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Meta-Analysis Mental Health

HRV Improvement Effect of Acupuncture Treatment for Autonomic Dysfunction: A Meta-Analysis

Shin JE, Lee AR, Kim DH, et al.

Complementary Therapies in Medicine (2024)

12 studies Included Studies
920 subjects Total Participants
p<0.001 HRV Improvement

Acupuncture treatment shows significant effects on autonomic balance recovery in autonomic dysfunction patients.

View Source 2024
Meta-Analysis Mental Health

HRV Improvement Effect of Acupuncture Treatment for Autonomic Dysfunction: A Meta-Analysis

Shin JE, Lee AR, Kim DH, et al. Complementary Therapies in Medicine (2024)
12 studies Included Studies
920 subjects Total Participants
p<0.001 HRV Improvement

Summary

A meta-analysis of 12 RCTs (total 920 subjects) evaluating the HRV improvement effect of acupuncture treatment in autonomic dysfunction patients. SDNN and RMSSD significantly increased and LF/HF ratio decreased in the acupuncture treatment group.

Key Conclusion

Acupuncture treatment shows significant effects on autonomic balance recovery in autonomic dysfunction patients.

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Cross-Sectional Mental Health

Correlation Between Workplace Stress and Korean Medicine Pattern Types: A Cross-Sectional Study

Baek SY, Moon JH, et al.

Journal of Occupational Health (2022)

400 subjects Analysis Subjects
4 types Pattern Types
p<0.01 Qi Stagnation Correlation

Workplace stress shows significant correlation with Korean medicine pattern types, and pattern-specific customized management is needed.

View Source 2022
Cross-Sectional Mental Health

Correlation Between Workplace Stress and Korean Medicine Pattern Types: A Cross-Sectional Study

Baek SY, Moon JH, et al. Journal of Occupational Health (2022)
400 subjects Analysis Subjects
4 types Pattern Types
p<0.01 Qi Stagnation Correlation

Summary

Korean medicine pattern types, Korean Occupational Stress Scale (KOSS), and cortisol levels were cross-sectionally analyzed in 400 workers complaining of workplace stress. Stress scores were highest in the qi stagnation constitution.

Key Conclusion

Workplace stress shows significant correlation with Korean medicine pattern types, and pattern-specific customized management is needed.

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Case Study Mental Health

Korean Medicine Treatment Case Report of Panic Disorder Patients: 5 Cases

Im HJ, Choi WJ, et al.

Journal of Korean Medicine (2021)

5 cases Number of Cases
100% Response Rate
40% Complete Remission Rate

Korean medicine pattern-based treatment can be utilized as a complementary treatment for symptom management in panic disorder patients.

View Source 2021
Case Study Mental Health

Korean Medicine Treatment Case Report of Panic Disorder Patients: 5 Cases

Im HJ, Choi WJ, et al. Journal of Korean Medicine (2021)
5 cases Number of Cases
100% Response Rate
40% Complete Remission Rate

Summary

Case reports of pattern-based herbal medicine and acupuncture treatment in 5 patients diagnosed with panic disorder. PDSS scores decreased by more than 50% in all patients, and 2 reached complete remission.

Key Conclusion

Korean medicine pattern-based treatment can be utilized as a complementary treatment for symptom management in panic disorder patients.

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Narrative Review Mental Health

GABA Receptor-Related Mechanism Study and Clinical Review of Gamisoyo-san in Anxiety Disorder Patients

Yang HJ, Kim BC, et al.

Phytomedicine (2023)

35 sources Reviewed Literature
GABA-A Main Mechanism
High Evidence Accumulation

Gamisoyo-san exerts anxiolytic effects through GABA receptor modulation, and clinical evidence is accumulating.

View Source 2023
Narrative Review Mental Health

GABA Receptor-Related Mechanism Study and Clinical Review of Gamisoyo-san in Anxiety Disorder Patients

Yang HJ, Kim BC, et al. Phytomedicine (2023)
35 sources Reviewed Literature
GABA-A Main Mechanism
High Evidence Accumulation

Summary

The anxiolytic mechanism of Gamisoyo-san was reviewed from the GABA receptor aspect, and 35 related basic and clinical studies were comprehensively examined. GABA-A receptor modulation was confirmed in animal experiments.

Key Conclusion

Gamisoyo-san exerts anxiolytic effects through GABA receptor modulation, and clinical evidence is accumulating.

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RCT Mental Health

Effect of Acupuncture Treatment on Sleep Quality in Depression Patients: An RCT

Hwang MK, Son JW, et al.

Sleep Medicine (2025)

80 subjects Participants
58% PSQI Improvement Rate
8 weeks Treatment Period

Acupuncture treatment provides additional effects on sleep quality improvement in depression patients.

View Source 2025
RCT Mental Health

Effect of Acupuncture Treatment on Sleep Quality in Depression Patients: An RCT

Hwang MK, Son JW, et al. Sleep Medicine (2025)
80 subjects Participants
58% PSQI Improvement Rate
8 weeks Treatment Period

Summary

Eighty patients with comorbid depression and insomnia were randomly assigned to acupuncture treatment + sleep hygiene and sleep hygiene alone groups and compared for 8 weeks. The acupuncture treatment group showed significant improvements in PSQI and ISI scores.

Key Conclusion

Acupuncture treatment provides additional effects on sleep quality improvement in depression patients.

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Systematic Review Mental Health

Systematic Review of Korean Medicine Treatment for Autonomic Dysfunction

Lee GE, Cho AR, Nakagawa Y, et al.

Autonomic Neuroscience (2022)

22 studies Included Studies
16 studies Positive Results
Moderate Evidence Level

Korean medicine treatment is an effective intervention for autonomic balance recovery and symptom relief in autonomic dysfunction.

View Source 2022
Systematic Review Mental Health

Systematic Review of Korean Medicine Treatment for Autonomic Dysfunction

Lee GE, Cho AR, Nakagawa Y, et al. Autonomic Neuroscience (2022)
22 studies Included Studies
16 studies Positive Results
Moderate Evidence Level

Summary

Twenty-two studies on Korean medicine treatment for autonomic dysfunction were systematically reviewed. Both herbal medicine and acupuncture treatment showed significant effects on HRV indicator improvement and symptom relief.

Key Conclusion

Korean medicine treatment is an effective intervention for autonomic balance recovery and symptom relief in autonomic dysfunction.

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