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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Total 1642 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Narrative Review Neurological Disorders

Neuroprotective Effect of Bee Venom Pharmacopuncture for Peripheral Neuropathy: A Literature Review

Lee SJ, Kim TH, et al.

Toxins (2024)

38 sources Reviewed Literature
4 mechanisms Main Mechanisms
High Clinical Applicability

Bee venom pharmacopuncture has multi-mechanistic neuroprotective effects in peripheral neuropathy, with accumulating clinical application evidence.

View Source 2024
Narrative Review Neurological Disorders

Neuroprotective Effect of Bee Venom Pharmacopuncture for Peripheral Neuropathy: A Literature Review

Lee SJ, Kim TH, et al. Toxins (2024)
38 sources Reviewed Literature
4 mechanisms Main Mechanisms
High Clinical Applicability

Summary

Basic and clinical studies on the effect of bee venom pharmacopuncture (bee venom acupuncture) for peripheral neuropathy were comprehensively reviewed. Various mechanisms of bee venom including anti-inflammation and neurotrophic factor promotion were reported.

Key Conclusion

Bee venom pharmacopuncture has multi-mechanistic neuroprotective effects in peripheral neuropathy, with accumulating clinical application evidence.

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Cohort Study Neurological Disorders

Development of a Machine Learning Model for Predicting Herbal Medicine Treatment Response in Chronic Dizziness Patients

Kim GH, Cho SY, Park JK, et al.

Frontiers in Neurology (2025)

420 subjects Analysis Subjects
AUC 0.84 Prediction Accuracy
12 variables Predictive Variables

Machine learning-based predictive models can be utilized for prior evaluation of herbal medicine treatment responsiveness in chronic dizziness.

View Source 2025
Cohort Study Neurological Disorders

Development of a Machine Learning Model for Predicting Herbal Medicine Treatment Response in Chronic Dizziness Patients

Kim GH, Cho SY, Park JK, et al. Frontiers in Neurology (2025)
420 subjects Analysis Subjects
AUC 0.84 Prediction Accuracy
12 variables Predictive Variables

Summary

A machine learning model for predicting treatment response was developed using data from 420 chronic dizziness patients receiving herbal medicine treatment. The Random Forest model showed the highest predictive power with AUC 0.84.

Key Conclusion

Machine learning-based predictive models can be utilized for prior evaluation of herbal medicine treatment responsiveness in chronic dizziness.

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Meta-Analysis Neurological Disorders

Prognostic Difference by Acupuncture Treatment Timing in Acute Facial Palsy: A Meta-Analysis

Kwak HY, Jang SY, Tanaka H, et al.

Acupuncture in Medicine (2023)

11 studies Included Studies
RR 1.45 Early Treatment Effect
3 days Optimal Start Time

Early initiation of acupuncture treatment is critically important for prognosis improvement in facial palsy.

View Source 2023
Meta-Analysis Neurological Disorders

Prognostic Difference by Acupuncture Treatment Timing in Acute Facial Palsy: A Meta-Analysis

Kwak HY, Jang SY, Tanaka H, et al. Acupuncture in Medicine (2023)
11 studies Included Studies
RR 1.45 Early Treatment Effect
3 days Optimal Start Time

Summary

Eleven studies comparing prognosis by acupuncture treatment initiation timing in acute facial palsy were meta-analyzed. The group starting acupuncture treatment within 3 days of onset showed significantly higher complete recovery rates compared with the group starting after 7 days.

Key Conclusion

Early initiation of acupuncture treatment is critically important for prognosis improvement in facial palsy.

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Cross-Sectional Neurological Disorders

Evaluation of Utility of Infrared Thermography Diagnosis in Korean Medicine Treatment of Cold Hypersensitivity

Woo CH, Lee JM, et al.

Infrared Physics & Technology (2022)

225 subjects Analysis Subjects
r=0.78 Correlation Coefficient
p<0.001 Statistical Significance

Infrared thermography is a useful tool for objective diagnosis and treatment effect evaluation of cold hypersensitivity.

View Source 2022
Cross-Sectional Neurological Disorders

Evaluation of Utility of Infrared Thermography Diagnosis in Korean Medicine Treatment of Cold Hypersensitivity

Woo CH, Lee JM, et al. Infrared Physics & Technology (2022)
225 subjects Analysis Subjects
r=0.78 Correlation Coefficient
p<0.001 Statistical Significance

Summary

The correlation between infrared thermography measurements and subjective cold sensation VAS was analyzed in 150 cold hypersensitivity patients and 75 healthy controls. Thermography indicators showed high correlation with subjective symptoms.

Key Conclusion

Infrared thermography is a useful tool for objective diagnosis and treatment effect evaluation of cold hypersensitivity.

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RCT Neurological Disorders

Effect of Electroacupuncture Treatment for Noise-Induced Tinnitus: A Double-Blind RCT

Son ML, Park DY, Kim SJ, et al.

Complementary Therapies in Medicine (2024)

90 subjects Participants
34% THI Reduction Rate
10 weeks Treatment Period

Electroacupuncture treatment showed significant effects on symptom improvement in noise-induced tinnitus compared with sham acupuncture.

View Source 2024
RCT Neurological Disorders

Effect of Electroacupuncture Treatment for Noise-Induced Tinnitus: A Double-Blind RCT

Son ML, Park DY, Kim SJ, et al. Complementary Therapies in Medicine (2024)
90 subjects Participants
34% THI Reduction Rate
10 weeks Treatment Period

Summary

Ninety patients with noise-induced tinnitus were double-blind randomly assigned to electroacupuncture and sham electroacupuncture groups and compared for 10 weeks. The electroacupuncture group showed significant decreases in THI and TFI scores.

Key Conclusion

Electroacupuncture treatment showed significant effects on symptom improvement in noise-induced tinnitus compared with sham acupuncture.

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Case Study Neurological Disorders

Korean Medicine Treatment Case Report and Literature Review for Cluster Headache

Baek JH, Cho MS, et al.

Journal of Korean Medicine (2021)

6 cases Number of Cases
67% Response Rate
50% Attack Reduction Standard

Korean medicine combined treatment shows potential for complementary management of cluster headache, but additional research is needed.

View Source 2021
Case Study Neurological Disorders

Korean Medicine Treatment Case Report and Literature Review for Cluster Headache

Baek JH, Cho MS, et al. Journal of Korean Medicine (2021)
6 cases Number of Cases
67% Response Rate
50% Attack Reduction Standard

Summary

Treatment cases were reported for 6 cluster headache patients who received combined acupuncture and herbal medicine treatment, and related literature was reviewed. Attack frequency decreased by more than 50% in 4 patients.

Key Conclusion

Korean medicine combined treatment shows potential for complementary management of cluster headache, but additional research is needed.

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RCT Neurological Disorders

NCV Improvement Effect of Astragalus-Based Herbal Medicine for Diabetic Peripheral Neuropathy: An RCT

Jung HJ, Kim YW, Li Z, et al.

Phytomedicine (2025)

100 subjects Participants
4.2 m/s NCV Improvement
16 weeks Treatment Period

Astragalus-based herbal medicine showed superior effects to mecobalamin in nerve conduction function improvement in diabetic peripheral neuropathy.

View Source 2025
RCT Neurological Disorders

NCV Improvement Effect of Astragalus-Based Herbal Medicine for Diabetic Peripheral Neuropathy: An RCT

Jung HJ, Kim YW, Li Z, et al. Phytomedicine (2025)
100 subjects Participants
4.2 m/s NCV Improvement
16 weeks Treatment Period

Summary

One hundred patients with diabetic peripheral neuropathy were randomly assigned to Astragalus-based herbal medicine and mecobalamin groups and compared for 16 weeks. The herbal medicine group showed significant improvements in NCV and vibration perception threshold (VPT).

Key Conclusion

Astragalus-based herbal medicine showed superior effects to mecobalamin in nerve conduction function improvement in diabetic peripheral neuropathy.

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Cross-Sectional Neurological Disorders

Korean Medicine Treatment Satisfaction and Quality of Life in Facial Palsy Patients: A Multicenter Survey Study

Go MH, Shin YJ, et al.

Patient Preference and Adherence (2023)

280 subjects Number of Respondents
88.5% Satisfaction
r=0.72 QoL Correlation

Patient satisfaction with Korean medicine treatment for facial palsy is high, and positive correlation with quality of life improvement was shown.

View Source 2023
Cross-Sectional Neurological Disorders

Korean Medicine Treatment Satisfaction and Quality of Life in Facial Palsy Patients: A Multicenter Survey Study

Go MH, Shin YJ, et al. Patient Preference and Adherence (2023)
280 subjects Number of Respondents
88.5% Satisfaction
r=0.72 QoL Correlation

Summary

Treatment satisfaction, quality of life (FDI), and treatment adherence were evaluated by multicenter survey in 280 patients who received Korean medicine treatment for facial palsy. Overall satisfaction was 88.5%.

Key Conclusion

Patient satisfaction with Korean medicine treatment for facial palsy is high, and positive correlation with quality of life improvement was shown.

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Before-After Neurological Disorders

Effect of Auricular Acupuncture in Dizziness Patients: A Single-Arm Pre-Post Comparison

Lee WK, Ahn SH, et al.

Journal of Alternative and Complementary Medicine (2020)

60 subjects Participants
42% DHI Improvement Rate
4 weeks Treatment Period

Auricular acupuncture treatment is effective for symptom relief and balance function improvement in chronic dizziness patients.

View Source 2020
Before-After Neurological Disorders

Effect of Auricular Acupuncture in Dizziness Patients: A Single-Arm Pre-Post Comparison

Lee WK, Ahn SH, et al. Journal of Alternative and Complementary Medicine (2020)
60 subjects Participants
42% DHI Improvement Rate
4 weeks Treatment Period

Summary

Auricular acupuncture treatment was administered for 4 weeks to 60 chronic dizziness patients of various causes, and DHI scores and balance ability were evaluated. DHI scores and static balance indicators improved significantly.

Key Conclusion

Auricular acupuncture treatment is effective for symptom relief and balance function improvement in chronic dizziness patients.

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Narrative Review Neurological Disorders

Pattern Identification System and Modern Interpretation of Neurological Disorders in Korean Medicine: An Integrated Literature Review

Kim BS, Oh JY, Nakamura T, et al.

Neurological Research (2024)

65 sources Reviewed Literature
5 disease groups Disease Categories
12 types Main Pattern Types

The Korean medicine pattern identification system provides a useful framework for personalized treatment of neurological disorders.

View Source 2024
Narrative Review Neurological Disorders

Pattern Identification System and Modern Interpretation of Neurological Disorders in Korean Medicine: An Integrated Literature Review

Kim BS, Oh JY, Nakamura T, et al. Neurological Research (2024)
65 sources Reviewed Literature
5 disease groups Disease Categories
12 types Main Pattern Types

Summary

An integrated literature review interpreting the Korean medicine pattern identification system for neurological disorders (headache, dizziness, facial palsy, tinnitus, peripheral neuropathy) from a modern neuroscience perspective.

Key Conclusion

The Korean medicine pattern identification system provides a useful framework for personalized treatment of neurological disorders.

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Before-After Neurological Disorders

Changes in Microvascular Reactivity Before and After Herbal Medicine Treatment in Cold Hypersensitivity Patients: A Laser Doppler Imaging Study

Yoon MK, Han SB, et al.

Microvascular Research (2023)

45 subjects Participants
35% Vascular Reactivity Increase
12 weeks Treatment Period

Herbal medicine treatment is effective for restoring microvascular reactivity in cold hypersensitivity patients.

View Source 2023
Before-After Neurological Disorders

Changes in Microvascular Reactivity Before and After Herbal Medicine Treatment in Cold Hypersensitivity Patients: A Laser Doppler Imaging Study

Yoon MK, Han SB, et al. Microvascular Research (2023)
45 subjects Participants
35% Vascular Reactivity Increase
12 weeks Treatment Period

Summary

Danggwisayeokgaosuyusaenggang-tang was administered for 12 weeks to 45 cold hypersensitivity patients, and microvascular reactivity was evaluated by laser Doppler imaging. Vascular dilation response to thermal stimulation increased significantly after herbal medicine administration.

Key Conclusion

Herbal medicine treatment is effective for restoring microvascular reactivity in cold hypersensitivity patients.

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Cohort Study Neurological Disorders

Differences in Treatment Response by Korean Medicine Constitution in Tinnitus Patients: A Multicenter Cohort Study

Cho MH, Lee SK, Park YS, et al.

Audiology and Neurotology (2023)

260 subjects Participants
4 types Constitution Types
p<0.01 Constitution Differences

Sasang constitution is a significant factor for predicting treatment response in tinnitus Korean medicine treatment, and constitution-based personalized treatment is needed.

View Source 2023
Cohort Study Neurological Disorders

Differences in Treatment Response by Korean Medicine Constitution in Tinnitus Patients: A Multicenter Cohort Study

Cho MH, Lee SK, Park YS, et al. Audiology and Neurotology (2023)
260 subjects Participants
4 types Constitution Types
p<0.01 Constitution Differences

Summary

A multicenter cohort study classifying 260 patients receiving Korean medicine treatment for tinnitus by Sasang constitution and analyzing differences in treatment response. Acupuncture treatment response was best in the Soyangin constitution.

Key Conclusion

Sasang constitution is a significant factor for predicting treatment response in tinnitus Korean medicine treatment, and constitution-based personalized treatment is needed.

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