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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Total 1642 papers

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RCT Respiratory Conditions

Effect of Combination Herbal Medicine on FVC and FEV1 Improvement in Patients with Reduced Pulmonary Function: An RCT

Cho SJ, Park BH, Li M, et al.

Phytomedicine (2025)

80 patients Participants
8.5% FVC improvement
16 weeks Treatment duration

Combination herbal medicine is effective for improving respiratory function in patients with reduced pulmonary function.

View Source 2025
RCT Respiratory Conditions

Effect of Combination Herbal Medicine on FVC and FEV1 Improvement in Patients with Reduced Pulmonary Function: An RCT

Cho SJ, Park BH, Li M, et al. Phytomedicine (2025)
80 patients Participants
8.5% FVC improvement
16 weeks Treatment duration

Summary

Eighty patients with restrictive lung disease were randomized to a combination herbal medicine or placebo group and compared over 16 weeks. The herbal medicine group showed significant improvements in FVC and FEV1.

Key Conclusion

Combination herbal medicine is effective for improving respiratory function in patients with reduced pulmonary function.

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Cohort Study Respiratory Conditions

Exercise Tolerance Improvement Effect of Bopye-tang in Stable COPD Patients: A Prospective Cohort

Kim DH, Song MJ, et al.

International Journal of Chronic Obstructive Pulmonary Disease (2024)

100 patients Participants
42 m 6-min walk improvement
6 months Follow-up period

Bopye-tang combination improves exercise tolerance and quality of life in stable COPD patients.

View Source 2024
Cohort Study Respiratory Conditions

Exercise Tolerance Improvement Effect of Bopye-tang in Stable COPD Patients: A Prospective Cohort

Kim DH, Song MJ, et al. International Journal of Chronic Obstructive Pulmonary Disease (2024)
100 patients Participants
42 m 6-min walk improvement
6 months Follow-up period

Summary

One hundred patients with GOLD 2-3 stage COPD were followed for 6 months, divided into a Bopye-tang combination group and a standard treatment group. The Bopye-tang group showed significant improvements in 6-minute walk distance and SGRQ scores.

Key Conclusion

Bopye-tang combination improves exercise tolerance and quality of life in stable COPD patients.

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Meta-Analysis Respiratory Conditions

Effect of Korean Medicine Treatment for Chronic Cough: A Systematic Review and Meta-Analysis

Lee SY, Choi HK, Watanabe K, et al.

Pulmonary Pharmacology & Therapeutics (2023)

14 studies Included studies
1,180 patients Total participants
WMD 3.2 LCQ improvement

Herbal medicine shows significant efficacy in reducing chronic cough frequency and improving quality of life.

View Source 2023
Meta-Analysis Respiratory Conditions

Effect of Korean Medicine Treatment for Chronic Cough: A Systematic Review and Meta-Analysis

Lee SY, Choi HK, Watanabe K, et al. Pulmonary Pharmacology & Therapeutics (2023)
14 studies Included studies
1,180 patients Total participants
WMD 3.2 LCQ improvement

Summary

Fourteen RCTs (total 1,180 patients) evaluating herbal medicine treatment for chronic cough lasting more than 8 weeks were meta-analyzed. The herbal medicine group showed significant improvements in cough frequency and LCQ scores.

Key Conclusion

Herbal medicine shows significant efficacy in reducing chronic cough frequency and improving quality of life.

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RCT Respiratory Conditions

Airway Hyperresponsiveness Improvement Effect of Socheongryong-tang for Bronchial Asthma: A Double-Blind RCT

Park HS, Kim JM, Lee WK, et al.

Respiratory Medicine (2024)

120 patients Participants
23% FEV1 improvement
12 weeks Treatment duration

Socheongryong-tang is effective for improving airway hyperresponsiveness and pulmonary function in asthma patients.

View Source 2024
RCT Respiratory Conditions

Airway Hyperresponsiveness Improvement Effect of Socheongryong-tang for Bronchial Asthma: A Double-Blind RCT

Park HS, Kim JM, Lee WK, et al. Respiratory Medicine (2024)
120 patients Participants
23% FEV1 improvement
12 weeks Treatment duration

Summary

A double-blind randomized trial comparing Socheongryong-tang versus placebo over 12 weeks in 120 patients with mild-to-moderate asthma. The Socheongryong-tang group showed significant improvements in PC20 methacholine, FEV1, and ACT scores.

Key Conclusion

Socheongryong-tang is effective for improving airway hyperresponsiveness and pulmonary function in asthma patients.

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Narrative Review Pediatric / Adolescent Care

Effects of Korean Medicine Combination Therapy on Nutritional Status in Pediatric Anorexia: A Literature Review

Jang HK, Kim WJ, et al.

Clinical Nutrition Research (2019)

22 studies Reviewed papers
3 types Treatment types
High Clinical applicability

Korean medicine combination therapy contributes in multiple ways to improving nutritional status and growth indicators in pediatric anorexia patients.

View Source 2019
Narrative Review Pediatric / Adolescent Care

Effects of Korean Medicine Combination Therapy on Nutritional Status in Pediatric Anorexia: A Literature Review

Jang HK, Kim WJ, et al. Clinical Nutrition Research (2019)
22 studies Reviewed papers
3 types Treatment types
High Clinical applicability

Summary

Twenty-two studies on the nutritional status improvement effects of Korean medicine combination therapy (herbal medicine, acupuncture, Chuna) for pediatric anorexia were comprehensively reviewed.

Key Conclusion

Korean medicine combination therapy contributes in multiple ways to improving nutritional status and growth indicators in pediatric anorexia patients.

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Before-After Pediatric / Adolescent Care

Effect of Korean Medicine Treatment for Pediatric Obesity with Comorbid Precocious Puberty: A Pre-Post Comparison Study

Im BK, Cho SH, et al.

Journal of Pediatric Endocrinology and Metabolism (2023)

35 patients Participants
BMI reduction Weight management
16 weeks Treatment duration

Korean medicine treatment helps with weight management and pubertal suppression in pediatric obesity-precocious puberty comorbid patients.

View Source 2023
Before-After Pediatric / Adolescent Care

Effect of Korean Medicine Treatment for Pediatric Obesity with Comorbid Precocious Puberty: A Pre-Post Comparison Study

Im BK, Cho SH, et al. Journal of Pediatric Endocrinology and Metabolism (2023)
35 patients Participants
BMI reduction Weight management
16 weeks Treatment duration

Summary

Herbal medicine and lifestyle guidance were performed for 16 weeks on 35 children with comorbid obesity and precocious puberty, and BMI, bone age, and LH levels were evaluated. BMI and bone age progression rate significantly decreased.

Key Conclusion

Korean medicine treatment helps with weight management and pubertal suppression in pediatric obesity-precocious puberty comorbid patients.

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Systematic Review Pediatric / Adolescent Care

Effectiveness and Safety of Korean Medicine Treatment for Pediatric Enuresis: A Systematic Review

Woo SH, Lee HK, Zhang Q, et al.

Journal of Pediatric Urology (2024)

18 studies Included studies
1,480 patients Total participants
OR 2.18 Effect size

Korean medicine is an effective and safe treatment option for pediatric enuresis.

View Source 2024
Systematic Review Pediatric / Adolescent Care

Effectiveness and Safety of Korean Medicine Treatment for Pediatric Enuresis: A Systematic Review

Woo SH, Lee HK, Zhang Q, et al. Journal of Pediatric Urology (2024)
18 studies Included studies
1,480 patients Total participants
OR 2.18 Effect size

Summary

Eighteen studies on Korean medicine treatment (herbal medicine, acupuncture, moxibustion) for pediatric enuresis were systematically reviewed. The Korean medicine treatment group showed significantly higher reductions in enuresis frequency and complete remission rates compared to controls.

Key Conclusion

Korean medicine is an effective and safe treatment option for pediatric enuresis.

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Cross-Sectional Pediatric / Adolescent Care

Relationship Between Pediatric Immunity and Korean Medicine Constitution: Comparison of Immune Indicators by Sasang Constitution

Kang SY, Park JM, et al.

Journal of Sasang Constitutional Medicine (2023)

300 patients Analysis subjects
4 types Constitution types
p<0.05 NK cell differences

Sasang constitution is significantly associated with pediatric immune characteristics, and constitution-tailored immune management is needed.

View Source 2023
Cross-Sectional Pediatric / Adolescent Care

Relationship Between Pediatric Immunity and Korean Medicine Constitution: Comparison of Immune Indicators by Sasang Constitution

Kang SY, Park JM, et al. Journal of Sasang Constitutional Medicine (2023)
300 patients Analysis subjects
4 types Constitution types
p<0.05 NK cell differences

Summary

A cross-sectional study comparing Sasang constitution and immune indicators (NK cells, IgG, IgA, complement) in 300 children. The Soeumin constitution showed the lowest NK cell activity and the highest cold frequency.

Key Conclusion

Sasang constitution is significantly associated with pediatric immune characteristics, and constitution-tailored immune management is needed.

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Case Study Pediatric / Adolescent Care

Case Report of Korean Medicine Combination Therapy for Children with Comorbid Tic Disorder and ADHD

Son MH, Choi JK, et al.

Journal of Attention Disorders (2021)

6 patients Cases
83% Tic improvement rate
67% ADHD improvement rate

Korean medicine combination therapy may be effective in simultaneously managing both symptoms in children with comorbid tic disorder-ADHD.

View Source 2021
Case Study Pediatric / Adolescent Care

Case Report of Korean Medicine Combination Therapy for Children with Comorbid Tic Disorder and ADHD

Son MH, Choi JK, et al. Journal of Attention Disorders (2021)
6 patients Cases
83% Tic improvement rate
67% ADHD improvement rate

Summary

A case series of 6 pediatric patients with comorbid tic disorder and ADHD treated with pattern-differentiated herbal medicine and acupuncture for 16 weeks was reported. Both YGTSS and ADHD-RS scores improved.

Key Conclusion

Korean medicine combination therapy may be effective in simultaneously managing both symptoms in children with comorbid tic disorder-ADHD.

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Meta-Analysis Pediatric / Adolescent Care

Bone Mineral Density and Bone Metabolism Marker Changes with Herbal Medicine in Pediatric Growth Treatment: A Meta-Analysis

Min JK, Lee YR, Wang C, et al.

Calcified Tissue International (2024)

10 studies Included studies
680 patients Total participants
p<0.01 BMD increase

Herbal medicine activates bone metabolism in children and contributes to growth promotion.

View Source 2024
Meta-Analysis Pediatric / Adolescent Care

Bone Mineral Density and Bone Metabolism Marker Changes with Herbal Medicine in Pediatric Growth Treatment: A Meta-Analysis

Min JK, Lee YR, Wang C, et al. Calcified Tissue International (2024)
10 studies Included studies
680 patients Total participants
p<0.01 BMD increase

Summary

Ten studies evaluating bone mineral density and bone metabolism marker changes with herbal medicine treatment for pediatric growth promotion were meta-analyzed. The herbal medicine group showed significant increases in bone mineral density and serum osteocalcin.

Key Conclusion

Herbal medicine activates bone metabolism in children and contributes to growth promotion.

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Before-After Pediatric / Adolescent Care

Effect of Jaungo on Skin Barrier Recovery in Pediatric Atopic Dermatitis: A Pre-Post Comparison

Noh EH, Song BK, et al.

Skin Pharmacology and Physiology (2022)

35 patients Participants
38% TEWL reduction
4 weeks Treatment duration

Jaungo is an effective topical preparation for restoring skin barrier function in pediatric atopic dermatitis.

View Source 2022
Before-After Pediatric / Adolescent Care

Effect of Jaungo on Skin Barrier Recovery in Pediatric Atopic Dermatitis: A Pre-Post Comparison

Noh EH, Song BK, et al. Skin Pharmacology and Physiology (2022)
35 patients Participants
38% TEWL reduction
4 weeks Treatment duration

Summary

Jaungo was applied for 4 weeks to 35 children with atopic dermatitis, and TEWL, skin hydration, and SCORAD were measured. All three indicators significantly improved.

Key Conclusion

Jaungo is an effective topical preparation for restoring skin barrier function in pediatric atopic dermatitis.

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Cohort Study Pediatric / Adolescent Care

Safety Profile of Pediatric Korean Medicine Treatment: 3-Year Adverse Event Monitoring Results

Hwang KS, Lee DH, et al.

BMC Pediatrics (2023)

2,500 patients Monitoring subjects
4.2% Adverse event incidence
3 years Monitoring period

The overall safety of pediatric Korean medicine treatment is favorable, and serious adverse events are very rare.

View Source 2023
Cohort Study Pediatric / Adolescent Care

Safety Profile of Pediatric Korean Medicine Treatment: 3-Year Adverse Event Monitoring Results

Hwang KS, Lee DH, et al. BMC Pediatrics (2023)
2,500 patients Monitoring subjects
4.2% Adverse event incidence
3 years Monitoring period

Summary

Adverse events were prospectively monitored over 3 years in 2,500 pediatric patients who received Korean medicine treatment. The adverse event incidence rate was 4.2%, with most being mild gastrointestinal symptoms.

Key Conclusion

The overall safety of pediatric Korean medicine treatment is favorable, and serious adverse events are very rare.

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