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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 1642 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Meta-Analysis Neurological Disorders

Systematic Review and Meta-Analysis of Korean Medicine Treatment for Post-Herpetic Neuralgia

Kwon DY, Song MK, Zhang W, et al.

Pain Medicine (2019)

15 studies Included Studies
WMD -2.1 VAS Reduction
p<0.01 Statistical Significance

Korean medicine treatment is effective for pain relief and quality of life improvement in post-herpetic neuralgia.

View Source 2019
Meta-Analysis Neurological Disorders

Systematic Review and Meta-Analysis of Korean Medicine Treatment for Post-Herpetic Neuralgia

Kwon DY, Song MK, Zhang W, et al. Pain Medicine (2019)
15 studies Included Studies
WMD -2.1 VAS Reduction
p<0.01 Statistical Significance

Summary

Fifteen studies on Korean medicine treatment (acupuncture, herbal medicine, pharmacopuncture) for post-herpetic neuralgia were systematically reviewed and meta-analyzed. The Korean medicine treatment group showed significant improvements in VAS and SF-36 scores.

Key Conclusion

Korean medicine treatment is effective for pain relief and quality of life improvement in post-herpetic neuralgia.

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RCT Mental Health

Antidepressant Effect of Guibi-tang in Mild-to-Moderate Depression Patients: A Double-Blind Randomized Controlled Trial

Kim MJ, Lee SH, Park YC, et al.

Journal of Affective Disorders (2024)

120 subjects Participants
52% HAM-D Response Rate
12 weeks Treatment Period

Guibi-tang is effective for improving depressive symptoms in mild-to-moderate depression patients with few side effects.

View Source 2024
RCT Mental Health

Antidepressant Effect of Guibi-tang in Mild-to-Moderate Depression Patients: A Double-Blind Randomized Controlled Trial

Kim MJ, Lee SH, Park YC, et al. Journal of Affective Disorders (2024)
120 subjects Participants
52% HAM-D Response Rate
12 weeks Treatment Period

Summary

One hundred twenty patients with mild-to-moderate major depressive disorder were double-blind randomly assigned to Guibi-tang and placebo groups and compared for 12 weeks. HAM-D scores decreased significantly in the Guibi-tang group.

Key Conclusion

Guibi-tang is effective for improving depressive symptoms in mild-to-moderate depression patients with few side effects.

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Meta-Analysis Mental Health

Effect of Acupuncture Treatment for Anxiety Disorder: A Systematic Review and Meta-Analysis

Choi SY, Jung WS, Kim YI, et al.

Journal of Clinical Medicine (2023)

20 studies Included Studies
1,680 subjects Total Participants
SMD -0.68 Effect Size

Acupuncture treatment shows significant effects on anxiety symptom relief in generalized anxiety disorder patients.

View Source 2023
Meta-Analysis Mental Health

Effect of Acupuncture Treatment for Anxiety Disorder: A Systematic Review and Meta-Analysis

Choi SY, Jung WS, Kim YI, et al. Journal of Clinical Medicine (2023)
20 studies Included Studies
1,680 subjects Total Participants
SMD -0.68 Effect Size

Summary

A meta-analysis of 20 RCTs (total 1,680 subjects) evaluating the effect of acupuncture treatment in generalized anxiety disorder patients. HAM-A scores decreased significantly in the acupuncture treatment group compared with the control group.

Key Conclusion

Acupuncture treatment shows significant effects on anxiety symptom relief in generalized anxiety disorder patients.

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Cohort Study Mental Health

Effect of Combined Herbal Medicine-Acupuncture Treatment in Panic Disorder Patients: A Prospective Cohort Study

Park JY, Lee DH, Wang XF, et al.

Neuropsychiatric Disease and Treatment (2024)

90 subjects Participants
68% Attack Frequency Reduction
24 weeks Follow-up Period

Combined herbal medicine-acupuncture treatment shows effects similar to SSRIs in symptom management of panic disorder patients and can be considered as an alternative treatment.

View Source 2024
Cohort Study Mental Health

Effect of Combined Herbal Medicine-Acupuncture Treatment in Panic Disorder Patients: A Prospective Cohort Study

Park JY, Lee DH, Wang XF, et al. Neuropsychiatric Disease and Treatment (2024)
90 subjects Participants
68% Attack Frequency Reduction
24 weeks Follow-up Period

Summary

A prospective cohort study following 90 panic disorder patients for 24 weeks, divided into combined herbal medicine-acupuncture treatment and SSRI alone groups. Panic attack frequency and PDSS scores decreased significantly in the combined treatment group.

Key Conclusion

Combined herbal medicine-acupuncture treatment shows effects similar to SSRIs in symptom management of panic disorder patients and can be considered as an alternative treatment.

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Before-After Mental Health

Effect of Korean Medicine Combined Treatment on Cortisol and HRV in Chronic Stress Workers

Seo MH, Kim JK, et al.

Stress and Health (2023)

100 subjects Participants
31% Cortisol Reduction
8 weeks Treatment Period

Korean medicine combined treatment effectively regulates physiological and psychological changes due to chronic stress.

View Source 2023
Before-After Mental Health

Effect of Korean Medicine Combined Treatment on Cortisol and HRV in Chronic Stress Workers

Seo MH, Kim JK, et al. Stress and Health (2023)
100 subjects Participants
31% Cortisol Reduction
8 weeks Treatment Period

Summary

Herbal medicine and acupuncture treatment were administered for 8 weeks to 100 workers complaining of chronic stress, and salivary cortisol, HRV, and PSS scores were evaluated. All three indicators improved significantly.

Key Conclusion

Korean medicine combined treatment effectively regulates physiological and psychological changes due to chronic stress.

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Systematic Review Mental Health

Systematic Review of Korean Medicine Treatment for Autonomic Dysfunction

Lee GE, Cho AR, Nakagawa Y, et al.

Autonomic Neuroscience (2022)

22 studies Included Studies
16 studies Positive Results
Moderate Evidence Level

Korean medicine treatment is an effective intervention for autonomic balance recovery and symptom relief in autonomic dysfunction.

View Source 2022
Systematic Review Mental Health

Systematic Review of Korean Medicine Treatment for Autonomic Dysfunction

Lee GE, Cho AR, Nakagawa Y, et al. Autonomic Neuroscience (2022)
22 studies Included Studies
16 studies Positive Results
Moderate Evidence Level

Summary

Twenty-two studies on Korean medicine treatment for autonomic dysfunction were systematically reviewed. Both herbal medicine and acupuncture treatment showed significant effects on HRV indicator improvement and symptom relief.

Key Conclusion

Korean medicine treatment is an effective intervention for autonomic balance recovery and symptom relief in autonomic dysfunction.

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RCT Mental Health

Effect of Acupuncture Treatment on Sleep Quality in Depression Patients: An RCT

Hwang MK, Son JW, et al.

Sleep Medicine (2025)

80 subjects Participants
58% PSQI Improvement Rate
8 weeks Treatment Period

Acupuncture treatment provides additional effects on sleep quality improvement in depression patients.

View Source 2025
RCT Mental Health

Effect of Acupuncture Treatment on Sleep Quality in Depression Patients: An RCT

Hwang MK, Son JW, et al. Sleep Medicine (2025)
80 subjects Participants
58% PSQI Improvement Rate
8 weeks Treatment Period

Summary

Eighty patients with comorbid depression and insomnia were randomly assigned to acupuncture treatment + sleep hygiene and sleep hygiene alone groups and compared for 8 weeks. The acupuncture treatment group showed significant improvements in PSQI and ISI scores.

Key Conclusion

Acupuncture treatment provides additional effects on sleep quality improvement in depression patients.

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Narrative Review Mental Health

GABA Receptor-Related Mechanism Study and Clinical Review of Gamisoyo-san in Anxiety Disorder Patients

Yang HJ, Kim BC, et al.

Phytomedicine (2023)

35 sources Reviewed Literature
GABA-A Main Mechanism
High Evidence Accumulation

Gamisoyo-san exerts anxiolytic effects through GABA receptor modulation, and clinical evidence is accumulating.

View Source 2023
Narrative Review Mental Health

GABA Receptor-Related Mechanism Study and Clinical Review of Gamisoyo-san in Anxiety Disorder Patients

Yang HJ, Kim BC, et al. Phytomedicine (2023)
35 sources Reviewed Literature
GABA-A Main Mechanism
High Evidence Accumulation

Summary

The anxiolytic mechanism of Gamisoyo-san was reviewed from the GABA receptor aspect, and 35 related basic and clinical studies were comprehensively examined. GABA-A receptor modulation was confirmed in animal experiments.

Key Conclusion

Gamisoyo-san exerts anxiolytic effects through GABA receptor modulation, and clinical evidence is accumulating.

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Case Study Mental Health

Korean Medicine Treatment Case Report of Panic Disorder Patients: 5 Cases

Im HJ, Choi WJ, et al.

Journal of Korean Medicine (2021)

5 cases Number of Cases
100% Response Rate
40% Complete Remission Rate

Korean medicine pattern-based treatment can be utilized as a complementary treatment for symptom management in panic disorder patients.

View Source 2021
Case Study Mental Health

Korean Medicine Treatment Case Report of Panic Disorder Patients: 5 Cases

Im HJ, Choi WJ, et al. Journal of Korean Medicine (2021)
5 cases Number of Cases
100% Response Rate
40% Complete Remission Rate

Summary

Case reports of pattern-based herbal medicine and acupuncture treatment in 5 patients diagnosed with panic disorder. PDSS scores decreased by more than 50% in all patients, and 2 reached complete remission.

Key Conclusion

Korean medicine pattern-based treatment can be utilized as a complementary treatment for symptom management in panic disorder patients.

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Cross-Sectional Mental Health

Correlation Between Workplace Stress and Korean Medicine Pattern Types: A Cross-Sectional Study

Baek SY, Moon JH, et al.

Journal of Occupational Health (2022)

400 subjects Analysis Subjects
4 types Pattern Types
p<0.01 Qi Stagnation Correlation

Workplace stress shows significant correlation with Korean medicine pattern types, and pattern-specific customized management is needed.

View Source 2022
Cross-Sectional Mental Health

Correlation Between Workplace Stress and Korean Medicine Pattern Types: A Cross-Sectional Study

Baek SY, Moon JH, et al. Journal of Occupational Health (2022)
400 subjects Analysis Subjects
4 types Pattern Types
p<0.01 Qi Stagnation Correlation

Summary

Korean medicine pattern types, Korean Occupational Stress Scale (KOSS), and cortisol levels were cross-sectionally analyzed in 400 workers complaining of workplace stress. Stress scores were highest in the qi stagnation constitution.

Key Conclusion

Workplace stress shows significant correlation with Korean medicine pattern types, and pattern-specific customized management is needed.

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Meta-Analysis Mental Health

HRV Improvement Effect of Acupuncture Treatment for Autonomic Dysfunction: A Meta-Analysis

Shin JE, Lee AR, Kim DH, et al.

Complementary Therapies in Medicine (2024)

12 studies Included Studies
920 subjects Total Participants
p<0.001 HRV Improvement

Acupuncture treatment shows significant effects on autonomic balance recovery in autonomic dysfunction patients.

View Source 2024
Meta-Analysis Mental Health

HRV Improvement Effect of Acupuncture Treatment for Autonomic Dysfunction: A Meta-Analysis

Shin JE, Lee AR, Kim DH, et al. Complementary Therapies in Medicine (2024)
12 studies Included Studies
920 subjects Total Participants
p<0.001 HRV Improvement

Summary

A meta-analysis of 12 RCTs (total 920 subjects) evaluating the HRV improvement effect of acupuncture treatment in autonomic dysfunction patients. SDNN and RMSSD significantly increased and LF/HF ratio decreased in the acupuncture treatment group.

Key Conclusion

Acupuncture treatment shows significant effects on autonomic balance recovery in autonomic dysfunction patients.

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Cohort Study Women's Health / Infertility

Effect of Korean Medicine Treatment for Postpartum Depression: A Prospective Cohort Study

Yun SH, Kim EJ, Li Y, et al.

Journal of Affective Disorders (2023)

80 subjects Participants
61% EPDS Improvement Rate
12 weeks Follow-up Period

Korean medicine treatment is effective for postpartum depression management and is a safe treatment option compatible with breastfeeding.

View Source 2023
Cohort Study Women's Health / Infertility

Effect of Korean Medicine Treatment for Postpartum Depression: A Prospective Cohort Study

Yun SH, Kim EJ, Li Y, et al. Journal of Affective Disorders (2023)
80 subjects Participants
61% EPDS Improvement Rate
12 weeks Follow-up Period

Summary

A cohort study following 80 women with postpartum depression for 12 weeks, divided into combined herbal medicine-acupuncture and general management groups. EPDS scores decreased significantly in the Korean medicine treatment group, with higher breastfeeding continuation rates.

Key Conclusion

Korean medicine treatment is effective for postpartum depression management and is a safe treatment option compatible with breastfeeding.

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