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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 1642 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Before-After Women's Health / Infertility

Effect of Combined Herbal Medicine and Moxibustion Treatment on Progesterone Levels in Women with Luteal Phase Defect (LPD)

정아름, 김서현, 이은비, et al.

대한한의학회지 (2024)

8.7 ng/mL Post-treatment progesterone
2.3 days Luteal phase extension
64 patients Study population

Combined herbal medicine and moxibustion treatment is effective for promoting progesterone secretion and normalizing luteal phase duration in women with luteal phase defect.

View Source 2024
Before-After Women's Health / Infertility

Effect of Combined Herbal Medicine and Moxibustion Treatment on Progesterone Levels in Women with Luteal Phase Defect (LPD)

정아름, 김서현, 이은비, et al. 대한한의학회지 (2024)
8.7 ng/mL Post-treatment progesterone
2.3 days Luteal phase extension
64 patients Study population

Summary

A pre-post comparison study combining herbal medicine (modified Gwibi-tang) and moxibustion treatment at CV4 in 64 women diagnosed with luteal phase defect. After 3 months of treatment, luteal phase progesterone levels significantly increased from an average of 4.2 ng/mL to 8.7 ng/mL, with luteal phase duration also extended by an average of 2.3 days.

Key Conclusion

Combined herbal medicine and moxibustion treatment is effective for promoting progesterone secretion and normalizing luteal phase duration in women with luteal phase defect.

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Meta-Analysis Women's Health / Infertility

Systematic Review and Meta-Analysis on Effect of Herbal Medicine Treatment for Women with Ovulation Disorder

김영은, 최지혜, 송유진, et al.

European Journal of Integrative Medicine (2023)

74.3% Herbal medicine group ovulation rate
22 studies Analyzed studies
12.2%p Ovulation rate improvement

Herbal medicine treatment is effective for ovulation rate improvement in women with ovulation disorder and is a safe alternative with fewer side effects compared to existing ovulation induction agents.

View Source 2023
Meta-Analysis Women's Health / Infertility

Systematic Review and Meta-Analysis on Effect of Herbal Medicine Treatment for Women with Ovulation Disorder

김영은, 최지혜, 송유진, et al. European Journal of Integrative Medicine (2023)
74.3% Herbal medicine group ovulation rate
22 studies Analyzed studies
12.2%p Ovulation rate improvement

Summary

A meta-analysis of 22 RCTs (1,856 patients) evaluating effects of herbal medicine treatment in women with ovulation disorder. Ovulation rate of the herbal medicine administration group was 74.3%, significantly higher than the clomiphene alone group (62.1%), with also improved follicle maturation and endometrial thickness. Adverse event incidence was markedly lower in the herbal medicine group.

Key Conclusion

Herbal medicine treatment is effective for ovulation rate improvement in women with ovulation disorder and is a safe alternative with fewer side effects compared to existing ovulation induction agents.

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Systematic Review Women's Health / Infertility

Impact of Herbal Medicine Treatment on Ovarian Reserve and Pregnancy Success Rate in Infertile Women: A Systematic Review

김수진, 박은혜, 이정민, et al.

Journal of Korean Medicine (2024)

0.8 ng/mL AMH mean increase
18 studies Analyzed studies
1,420 patients Total participants

Herbal medicine treatment has significant effects on AMH and AFC improvement in infertile women with diminished ovarian reserve, and can be utilized as an ovarian function improvement strategy before assisted reproductive technology.

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Systematic Review Women's Health / Infertility

Impact of Herbal Medicine Treatment on Ovarian Reserve and Pregnancy Success Rate in Infertile Women: A Systematic Review

김수진, 박은혜, 이정민, et al. Journal of Korean Medicine (2024)
0.8 ng/mL AMH mean increase
18 studies Analyzed studies
1,420 patients Total participants

Summary

A systematic review analyzing ovarian reserve (AMH, AFC) improvement effects of herbal medicine treatment in infertile women. Analysis of 18 studies (1,420 patients) showed AMH levels increased by an average of 0.8 ng/mL in the herbal medicine administration group, with significantly increased antral follicle count (AFC). Effects were particularly pronounced in advanced infertility patients aged 35 or older.

Key Conclusion

Herbal medicine treatment has significant effects on AMH and AFC improvement in infertile women with diminished ovarian reserve, and can be utilized as an ovarian function improvement strategy before assisted reproductive technology.

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Cohort Study Digestive Disorders

Cohort Study of Combined Herbal Medicine and Lifestyle Modification for GERD

Han CH, Seo JY, Moon KW, et al.

Journal of Gastroenterology and Hepatology (2024)

25% Relapse Rate
130 subjects Participants
After PPI discontinuation Long-term Effect

The combination of herbal medicine and lifestyle modification is more effective than PPI in long-term relapse prevention of GERD.

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Cohort Study Digestive Disorders

Cohort Study of Combined Herbal Medicine and Lifestyle Modification for GERD

Han CH, Seo JY, Moon KW, et al. Journal of Gastroenterology and Hepatology (2024)
25% Relapse Rate
130 subjects Participants
After PPI discontinuation Long-term Effect

Summary

One hundred thirty GERD patients were followed for 24 weeks, divided into herbal medicine plus lifestyle modification and PPI-alone groups. The Korean medicine approach group showed a relapse rate of 25% after PPI discontinuation, significantly lower than 55% in the PPI group.

Key Conclusion

The combination of herbal medicine and lifestyle modification is more effective than PPI in long-term relapse prevention of GERD.

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Before-After Digestive Disorders

fMRI Study of Herbal Medicine for the Brain-Gut Axis in IBS Patients: A Pre-Post Comparison

Kwon CY, Song JH, Lee DH, et al.

Brain Imaging and Behavior (2024)

ACC activity↓ Central Modulation
30 subjects Participants
fMRI Neuroimaging Confirmation

Herbal medicine modulates IBS at the central level of the brain-gut axis.

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Before-After Digestive Disorders

fMRI Study of Herbal Medicine for the Brain-Gut Axis in IBS Patients: A Pre-Post Comparison

Kwon CY, Song JH, Lee DH, et al. Brain Imaging and Behavior (2024)
ACC activity↓ Central Modulation
30 subjects Participants
fMRI Neuroimaging Confirmation

Summary

Thirty IBS patients received Tongxieyao-fang for 8 weeks, with fMRI comparison of brain activity. Hyperactivity in the anterior cingulate cortex (ACC) and insula decreased, and IBS-SSS showed concurrent improvement.

Key Conclusion

Herbal medicine modulates IBS at the central level of the brain-gut axis.

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RCT Digestive Disorders

Randomized Controlled Trial of Herbal Medicine for Post-Chemotherapy Digestive Side Effects

Han SJ, Kim DH, Lee JA, et al.

Supportive Care in Cancer (2024)

55% Nausea↓
42% Appetite↑
60 subjects Participants

Yukgunja-tang is useful for the effective management of chemotherapy-related digestive side effects.

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RCT Digestive Disorders

Randomized Controlled Trial of Herbal Medicine for Post-Chemotherapy Digestive Side Effects

Han SJ, Kim DH, Lee JA, et al. Supportive Care in Cancer (2024)
55% Nausea↓
42% Appetite↑
60 subjects Participants

Summary

Sixty patients with chemotherapy-related digestive side effects (nausea, anorexia, diarrhea) were compared over 6 weeks between Yukgunja-tang and placebo groups. The herbal group showed significant improvement in nausea (-55%) and appetite (+42%).

Key Conclusion

Yukgunja-tang is useful for the effective management of chemotherapy-related digestive side effects.

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Systematic Review Digestive Disorders

Systematic Review of Topical Herbal Application (Gastric Patch) for Gastritis

Yoon HJ, Park BS, Kim SH, et al.

Evidence-Based Complementary and Alternative Medicine (2023)

10 studies Analyzed Papers
Upper abdominal pain↓ Main Effect
External therapy Treatment Modality

Topical herbal gastric patches are useful as adjunctive external treatment for gastritis.

View Source 2023
Systematic Review Digestive Disorders

Systematic Review of Topical Herbal Application (Gastric Patch) for Gastritis

Yoon HJ, Park BS, Kim SH, et al. Evidence-Based Complementary and Alternative Medicine (2023)
10 studies Analyzed Papers
Upper abdominal pain↓ Main Effect
External therapy Treatment Modality

Summary

Ten studies evaluating the effect of topical herbal gastric patches on gastritis were systematically reviewed. Patch therapy demonstrated adjunctive improvement effects on upper abdominal pain and dyspeptic symptoms.

Key Conclusion

Topical herbal gastric patches are useful as adjunctive external treatment for gastritis.

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Narrative Review Digestive Disorders

Herbal Prescription Patterns by Sasang Constitution for Digestive Disorders: A Narrative Review

Chae HB, Lim BV, Kim KW, et al.

Journal of Sasang Constitutional Medicine (2024)

24 papers Reviewed Papers
4 constitutions Classification System
Tailored prescription Core Strategy

Sasang constitution-tailored prescription is essential for therapeutic efficacy and side-effect reduction in digestive disorders.

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Narrative Review Digestive Disorders

Herbal Prescription Patterns by Sasang Constitution for Digestive Disorders: A Narrative Review

Chae HB, Lim BV, Kim KW, et al. Journal of Sasang Constitutional Medicine (2024)
24 papers Reviewed Papers
4 constitutions Classification System
Tailored prescription Core Strategy

Summary

Twenty-four articles on herbal prescription patterns by Sasang constitution for digestive disorders were reviewed. Soeumin received Ijung-tang formulas, Taeumin received Taeumjowi-tang formulas, and Soyangin received Yangkyeoksanhwa-tang formulas predominantly.

Key Conclusion

Sasang constitution-tailored prescription is essential for therapeutic efficacy and side-effect reduction in digestive disorders.

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Cross-Sectional Digestive Disorders

Dual Effect of Herbal Medicine on Acid Reflux with Comorbid Sleep Disturbance: A Cross-Sectional Analysis

Moon PD, Kang BK, Cho WS, et al.

Sleep and Digestive Disorders (2023)

140 subjects Participants
38% GERD↓
35% Sleep↑

Banhahubak-tang demonstrates a dual effect by simultaneously improving GERD and comorbid sleep disturbance.

View Source 2023
Cross-Sectional Digestive Disorders

Dual Effect of Herbal Medicine on Acid Reflux with Comorbid Sleep Disturbance: A Cross-Sectional Analysis

Moon PD, Kang BK, Cho WS, et al. Sleep and Digestive Disorders (2023)
140 subjects Participants
38% GERD↓
35% Sleep↑

Summary

Symptom differences according to herbal medicine (Banhahubak-tang) use were analyzed in 140 patients with GERD and comorbid sleep disturbance. The herbal use group showed significantly lower GERD-Q (-38%) and PSQI (-35%) scores.

Key Conclusion

Banhahubak-tang demonstrates a dual effect by simultaneously improving GERD and comorbid sleep disturbance.

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Case Study Digestive Disorders

Case Report of Modified Daesiho-tang for Cholecystitis

Yun YG, Seo DW, Han JM, et al.

Journal of Clinical Medicine (2023)

6 cases Case Number
5 improved Symptom Resolution
12 weeks Treatment Period

Modified Daesiho-tang may demonstrate efficacy in non-surgical management of acute cholecystitis.

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Case Study Digestive Disorders

Case Report of Modified Daesiho-tang for Cholecystitis

Yun YG, Seo DW, Han JM, et al. Journal of Clinical Medicine (2023)
6 cases Case Number
5 improved Symptom Resolution
12 weeks Treatment Period

Summary

Six patients with acute cholecystitis who refused surgery received modified Daesiho-tang plus Lonicera japonica for 12 weeks in a reported case series. Five patients showed complete resolution of symptoms, and gallbladder wall edema decreased on ultrasound.

Key Conclusion

Modified Daesiho-tang may demonstrate efficacy in non-surgical management of acute cholecystitis.

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Meta-Analysis Digestive Disorders

Meta-analysis of Immunomodulatory Effects of Herbal Medicine for Inflammatory Bowel Disease

Kim TH, Song MY, Park CW, et al.

Journal of Crohns and Colitis (2024)

16 RCTs Analyzed RCTs
38% CRP↓
42% Calprotectin↓

Herbal medicine is an effective adjunctive treatment that suppresses intestinal inflammation in IBD.

View Source 2024
Meta-Analysis Digestive Disorders

Meta-analysis of Immunomodulatory Effects of Herbal Medicine for Inflammatory Bowel Disease

Kim TH, Song MY, Park CW, et al. Journal of Crohns and Colitis (2024)
16 RCTs Analyzed RCTs
38% CRP↓
42% Calprotectin↓

Summary

Sixteen RCTs evaluating the immunomodulatory effects of herbal medicine for IBD were meta-analyzed. The herbal adjunctive group showed significant reductions in CRP (-38%) and calprotectin (-42%).

Key Conclusion

Herbal medicine is an effective adjunctive treatment that suppresses intestinal inflammation in IBD.

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Before-After Digestive Disorders

Mucosal Protection Effect of Banhasasim-tang for Duodenal Ulcer: A Pre-Post Comparison

Jung WS, Lee AR, Park SJ, et al.

Ulcer Research (2024)

90% Healing Rate
40 subjects Participants
EGF↑ Mucosal Regeneration

Banhasasim-tang promotes mucosal protection and healing in duodenal ulcer.

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Before-After Digestive Disorders

Mucosal Protection Effect of Banhasasim-tang for Duodenal Ulcer: A Pre-Post Comparison

Jung WS, Lee AR, Park SJ, et al. Ulcer Research (2024)
90% Healing Rate
40 subjects Participants
EGF↑ Mucosal Regeneration

Summary

Forty patients with duodenal ulcer received Banhasasim-tang plus PPI for 8 weeks, with endoscopic evaluation. The ulcer healing rate was 90%, and mucosal regeneration markers (EGF) increased significantly.

Key Conclusion

Banhasasim-tang promotes mucosal protection and healing in duodenal ulcer.

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