금맥한의원
Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

Research Papers
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Total 1642 papers

RCT Mental Health

Anti-Stress Effect of Herbal Medicine (Soyo-san) in Adjustment Disorder Patients: A Randomized Controlled Trial

Baek IH, Lee JH, Park CW, et al.

Stress and Health (2023)

39% Stress Reduction
90 subjects Participants
Cortisol normalization Physiological Indicator

Soyo-san has effects on regulating the stress response of adjustment disorder at the physiological level.

RCT Mental Health

Anti-Stress Effect of Herbal Medicine (Soyo-san) in Adjustment Disorder Patients: A Randomized Controlled Trial

Baek IH, Lee JH, Park CW, et al. Stress and Health (2023)
39% Stress Reduction
90 subjects Participants
Cortisol normalization Physiological Indicator

Summary

Ninety adjustment disorder patients were divided into Soyo-san administration and placebo groups and compared for 6 weeks. PSS stress scores decreased by 39% and cortisol awakening response normalized in the Soyo-san group.

Key Conclusion

Soyo-san has effects on regulating the stress response of adjustment disorder at the physiological level.

Cross-Sectional ENT Disorders

Anti-Inflammatory and Analgesic Effects of Lonicera-Glycyrrhiza Combination Herbal Medicine for Sore Throat: A Cross-Sectional Study

박태영, 김민지, 이찬호, et al.

대한본초학회지 (2024)

5.2 points Sore throat VAS reduction
134 patients Study population
24 hours Effect onset time

Lonicera-Glycyrrhiza combination herbal medicine shows rapid anti-inflammatory and analgesic effects on acute sore throat and can be utilized as complementary treatment at the primary care level.

Cross-Sectional ENT Disorders

Anti-Inflammatory and Analgesic Effects of Lonicera-Glycyrrhiza Combination Herbal Medicine for Sore Throat: A Cross-Sectional Study

박태영, 김민지, 이찬호, et al. 대한본초학회지 (2024)
5.2 points Sore throat VAS reduction
134 patients Study population
24 hours Effect onset time

Summary

A cross-sectional study analyzing symptom changes after administration of Lonicera-Glycyrrhiza combination herbal medicine in 134 patients with acute sore throat. Sore throat VAS decreased by an average of 5.2 points within 24 hours after administration, with significant improvements in odynophagia and erythema findings.

Key Conclusion

Lonicera-Glycyrrhiza combination herbal medicine shows rapid anti-inflammatory and analgesic effects on acute sore throat and can be utilized as complementary treatment at the primary care level.

Cohort Study Respiratory Conditions

Combined Herbal Medicine and Pediatric Chuna Treatment for Recurrent Upper Respiratory Infections in Children: A Cohort Study

조미영, 박건우, 김서연, et al.

대한한방소아과학회지 (2024)

58% Infection frequency reduction
72 patients Study population
41% Antibiotic use reduction

Combined herbal medicine and pediatric Chuna treatment is an effective Korean medicine management method that reduces both illness frequency and antibiotic use in children with recurrent upper respiratory infections.

Cohort Study Respiratory Conditions

Combined Herbal Medicine and Pediatric Chuna Treatment for Recurrent Upper Respiratory Infections in Children: A Cohort Study

조미영, 박건우, 김서연, et al. 대한한방소아과학회지 (2024)
58% Infection frequency reduction
72 patients Study population
41% Antibiotic use reduction

Summary

A prospective cohort study performing 6 months of combined herbal medicine (modified Samso-eum) and pediatric Chuna in 72 children aged 3-8 years with recurrent upper respiratory infections (6 or more annually). Upper respiratory infections decreased by an average of 58% during treatment period, with significantly reduced antibiotic use days.

Key Conclusion

Combined herbal medicine and pediatric Chuna treatment is an effective Korean medicine management method that reduces both illness frequency and antibiotic use in children with recurrent upper respiratory infections.

Meta-Analysis Respiratory Conditions

Meta-Analysis of Herbal Medicine Treatment Efficacy for Pulmonary Fibrosis Patients

김현우, 이나영, 정태섭, et al.

Journal of Integrative Medicine (2023)

2.8% FVC decline attenuation
8 studies Analyzed studies
612 patients Total study population

Herbal medicine treatment can play an adjunctive role in slowing pulmonary fibrosis progression and improving quality of life, with notable potential for combination with antifibrotic agents.

Meta-Analysis Respiratory Conditions

Meta-Analysis of Herbal Medicine Treatment Efficacy for Pulmonary Fibrosis Patients

김현우, 이나영, 정태섭, et al. Journal of Integrative Medicine (2023)
2.8% FVC decline attenuation
8 studies Analyzed studies
612 patients Total study population

Summary

Eight RCTs (total 612 patients) evaluating herbal medicine treatment for idiopathic pulmonary fibrosis (IPF) were meta-analyzed. The herbal medicine combination group showed 2.8% annual FVC decline rate attenuation, with significantly improved SGRQ (respiratory quality of life) scores.

Key Conclusion

Herbal medicine treatment can play an adjunctive role in slowing pulmonary fibrosis progression and improving quality of life, with notable potential for combination with antifibrotic agents.

Cohort Study Men's Health / Urology

Effect of Deer Antler Combined Herbal Medicine on Testosterone and Libido Improvement in Libido Reduction: A Cohort Study

윤재석, 배한솔, 임성진, et al.

Evidence-Based Complementary and Alternative Medicine (2024)

2.8 ng/dL Free Testosterone Increase
96 subjects Cohort Size
73.9% SDI Improvement Rate

Deer antler combined herbal medicine significantly improves testosterone levels and libido-related indicators in libido reduction patients and is particularly effective for middle-aged and older men.

Cohort Study Men's Health / Urology

Effect of Deer Antler Combined Herbal Medicine on Testosterone and Libido Improvement in Libido Reduction: A Cohort Study

윤재석, 배한솔, 임성진, et al. Evidence-Based Complementary and Alternative Medicine (2024)
2.8 ng/dL Free Testosterone Increase
96 subjects Cohort Size
73.9% SDI Improvement Rate

Summary

A prospective cohort study analyzing the effect of deer antler combined herbal medicine in 96 men complaining of libido reduction. After 16 weeks of administration, serum free testosterone increased by an average of 2.8 ng/dL, and SDI (Sexual Desire Inventory) scores improved significantly. Response rates were highest in the 40-55 age group.

Key Conclusion

Deer antler combined herbal medicine significantly improves testosterone levels and libido-related indicators in libido reduction patients and is particularly effective for middle-aged and older men.

Cross-Sectional Men's Health / Urology

Changes in AMS Scores with Combined Herbal Medicine and Moxibustion Treatment for Male Climacteric Syndrome (LOH): A Cross-Sectional Analysis

정현석, 김영태, 이상우, et al.

대한한의학회지 (2023)

38.9% AMS Score Reduction Rate
120 subjects Analysis Subjects
p<0.001 Statistical Significance

Combined herbal medicine and moxibustion treatment effectively alleviates the multidimensional symptoms of male climacteric syndrome and enables clinically meaningful improvement without hormone replacement therapy.

Cross-Sectional Men's Health / Urology

Changes in AMS Scores with Combined Herbal Medicine and Moxibustion Treatment for Male Climacteric Syndrome (LOH): A Cross-Sectional Analysis

정현석, 김영태, 이상우, et al. 대한한의학회지 (2023)
38.9% AMS Score Reduction Rate
120 subjects Analysis Subjects
p<0.001 Statistical Significance

Summary

A cross-sectional analysis of medical records of 120 patients receiving Korean medicine treatment for male climacteric syndrome. AMS (Aging Males Symptoms) scores of the herbal medicine and moxibustion combined treatment group decreased from an average of 36.7 to 22.4, and significant improvements were confirmed in cardiovascular, somatic, and psychological subdomains.

Key Conclusion

Combined herbal medicine and moxibustion treatment effectively alleviates the multidimensional symptoms of male climacteric syndrome and enables clinically meaningful improvement without hormone replacement therapy.

Meta-Analysis Men's Health / Urology

Effect of Combined Herbal Medicine and Acupuncture Treatment on Stone Expulsion Promotion in Urolithiasis Patients: A Meta-Analysis

서민호, 곽영진, 이태규, et al.

Urological Research (2023)

78.3% Stone Expulsion Rate
5.2 days Expulsion Time Shortened
634 subjects Total Subjects

Combined herbal medicine and acupuncture treatment significantly promotes spontaneous expulsion of urolithiasis 10 mm or less and is effective as adjunctive treatment for watchful waiting.

Meta-Analysis Men's Health / Urology

Effect of Combined Herbal Medicine and Acupuncture Treatment on Stone Expulsion Promotion in Urolithiasis Patients: A Meta-Analysis

서민호, 곽영진, 이태규, et al. Urological Research (2023)
78.3% Stone Expulsion Rate
5.2 days Expulsion Time Shortened
634 subjects Total Subjects

Summary

A meta-analysis of 9 randomized controlled trials including 634 urolithiasis patients. The combined herbal medicine (modified Seokwi-san) and acupuncture treatment group showed a stone spontaneous expulsion rate of 78.3%, significantly higher than the control group (54.2%), with average expulsion time also shortened by 5.2 days.

Key Conclusion

Combined herbal medicine and acupuncture treatment significantly promotes spontaneous expulsion of urolithiasis 10 mm or less and is effective as adjunctive treatment for watchful waiting.

RCT Men's Health / Urology

Long-Term Effect of Herbal Medicine Treatment for Kidney Stone Recurrence Prevention: A Randomized Controlled Trial

김영호, 손재현, 박지민, et al.

Journal of Ethnopharmacology (2024)

63.7% Recurrence Rate Reduction
128 subjects Number of Subjects
24 months Follow-up Period

Geumjeoncho combined formula is effective for preventing kidney stone recurrence, and a mechanism regulating excretion of stone-forming substances in urine was confirmed.

RCT Men's Health / Urology

Long-Term Effect of Herbal Medicine Treatment for Kidney Stone Recurrence Prevention: A Randomized Controlled Trial

김영호, 손재현, 박지민, et al. Journal of Ethnopharmacology (2024)
63.7% Recurrence Rate Reduction
128 subjects Number of Subjects
24 months Follow-up Period

Summary

A randomized controlled trial evaluating the long-term effect of herbal medicine (Geumjeoncho combined formula) for recurrence prevention after kidney stone removal. After 24 months of follow-up of 128 subjects, the herbal medicine group's stone recurrence rate was 12.5%, significantly lower than the control group (34.4%), and urinary calcium and oxalate excretion also decreased.

Key Conclusion

Geumjeoncho combined formula is effective for preventing kidney stone recurrence, and a mechanism regulating excretion of stone-forming substances in urine was confirmed.

Cohort Study ENT Disorders

Effect of Modified Soshiho-tang for Recurrent Tonsillitis: A Cohort Study

Ryu BH, Lee SG, Jang IS, et al.

Phytomedicine (2024)

4.8→1.6 Annual Recurrence
67 subjects Participants
1 year Follow-up Period

Modified Soshiho-tang significantly reduces recurrence frequency and decreases tonsil size in recurrent tonsillitis.

Cohort Study ENT Disorders

Effect of Modified Soshiho-tang for Recurrent Tonsillitis: A Cohort Study

Ryu BH, Lee SG, Jang IS, et al. Phytomedicine (2024)
4.8→1.6 Annual Recurrence
67 subjects Participants
1 year Follow-up Period

Summary

Sixty-seven patients with tonsillitis recurring 4 or more times annually received modified Soshiho-tang for 12 weeks and were followed for 1 year. Average annual recurrence frequency decreased from 4.8 to 1.6 episodes after treatment, with tonsillar hypertrophy grade improving by an average of 0.8 stages.

Key Conclusion

Modified Soshiho-tang significantly reduces recurrence frequency and decreases tonsil size in recurrent tonsillitis.

Case Study ENT Disorders

Therapeutic Effect of Combined Acupuncture and Herbal Medicine for Taste Disorders: A Case Series of 12

Hwang EH, Song HS, Choi JB, et al.

대한침구의학회지 (2023)

2.3 grades Taste Threshold Improvement
4.1→7.3 Taste VAS
12 cases Case Number

Combined acupuncture and herbal medicine significantly improves taste thresholds and subjective taste function in taste disorder patients.

Case Study ENT Disorders

Therapeutic Effect of Combined Acupuncture and Herbal Medicine for Taste Disorders: A Case Series of 12

Hwang EH, Song HS, Choi JB, et al. 대한침구의학회지 (2023)
2.3 grades Taste Threshold Improvement
4.1→7.3 Taste VAS
12 cases Case Number

Summary

Twelve patients with taste disorders persisting more than 3 months received combined acupuncture at Lianquan (CV23) and Jinjin Yuye (EX-HN12) plus Jaeumganghwa-tang for 8 weeks. Taste threshold tests showed an average 2.3-grade improvement in whole-taste recognition thresholds, with self-reported taste function VAS improving from 4.1 to 7.3.

Key Conclusion

Combined acupuncture and herbal medicine significantly improves taste thresholds and subjective taste function in taste disorder patients.

RCT ENT Disorders

Therapeutic Effect of Gamchosashim-tang for Recurrent Aphthous Stomatitis: A Randomized Controlled Trial

Yang SB, Kim KS, Park MC, et al.

Oral Diseases (2024)

3.2 days Healing Time Reduction
3.8→1.4 Recurrence Frequency
96 subjects Participants

Gamchosashim-tang demonstrates significant efficacy compared with placebo in healing promotion and recurrence prevention of recurrent aphthous stomatitis.

RCT ENT Disorders

Therapeutic Effect of Gamchosashim-tang for Recurrent Aphthous Stomatitis: A Randomized Controlled Trial

Yang SB, Kim KS, Park MC, et al. Oral Diseases (2024)
3.2 days Healing Time Reduction
3.8→1.4 Recurrence Frequency
96 subjects Participants

Summary

Ninety-six patients with aphthous stomatitis recurring at least once monthly were assigned to Gamchosashim-tang or placebo groups and treated for 12 weeks. The herbal group demonstrated ulcer healing time shortened by an average of 3.2 days, with recurrence frequency over 12 weeks decreasing from 3.8 to 1.4 episodes.

Key Conclusion

Gamchosashim-tang demonstrates significant efficacy compared with placebo in healing promotion and recurrence prevention of recurrent aphthous stomatitis.

Before-After Mental Health

Pre-Post Comparison Study of Combined Auricular Acupuncture and Herbal Medicine for Binge Eating Disorder

Kim GH, Park HJ, Lee SH, et al.

Eating Behaviors (2024)

52% Binge score↓
3.2 kg Weight Reduction
55 subjects Participants

The combination of auricular acupuncture and herbal medicine is effective for binge impulse suppression and weight management.

Before-After Mental Health

Pre-Post Comparison Study of Combined Auricular Acupuncture and Herbal Medicine for Binge Eating Disorder

Kim GH, Park HJ, Lee SH, et al. Eating Behaviors (2024)
52% Binge score↓
3.2 kg Weight Reduction
55 subjects Participants

Summary

Auricular acupuncture (Shenmen, Stomach point) + herbal medicine (Banhasasim-tang) were applied for 10 weeks to 55 binge eating disorder patients. BES binge eating scores decreased by 52%, and weight decreased by an average of 3.2 kg.

Key Conclusion

The combination of auricular acupuncture and herbal medicine is effective for binge impulse suppression and weight management.