금맥한의원
Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

📅 Book Appointment 📋 Geummaek Herbal Medicine 💬 Reviews 📝 Health Columns
Research Papers
🔍

Total 1642 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Before-After Gongjindan (拱辰丹)

Blood Pressure Control and Vascular Endothelial Function Improvement of Gongjindan in Pre-Hypertensive Patients: A Pre-Post Comparison Study

Baek KS, Song JH, Kim DS, et al.

Hypertension Research (2023)

8.4 mmHg Systolic BP Reduction
31% NO Concentration Increase
7.2% Vascular Elasticity Improvement

Gongjindan naturally lowers blood pressure in pre-hypertensive patients and improves vascular elasticity, contributing to cardiovascular risk factor management.

View Source 2023
Before-After Gongjindan (拱辰丹)

Blood Pressure Control and Vascular Endothelial Function Improvement of Gongjindan in Pre-Hypertensive Patients: A Pre-Post Comparison Study

Baek KS, Song JH, Kim DS, et al. Hypertension Research (2023)
8.4 mmHg Systolic BP Reduction
31% NO Concentration Increase
7.2% Vascular Elasticity Improvement

Summary

A pre-post comparison study administered Gongjindan for 12 weeks to 76 pre-hypertensive patients (systolic 130-139 mmHg). Systolic blood pressure decreased by an average of 8.4 mmHg, with pulse wave velocity (PWV) improving by 7.2%. Serum nitric oxide (NO) concentration increased by 31%, confirming vascular endothelial function recovery, with serum triglycerides also significantly decreasing.

Key Conclusion

Gongjindan naturally lowers blood pressure in pre-hypertensive patients and improves vascular elasticity, contributing to cardiovascular risk factor management.

이 논문 정리 페이지로 이동 →
View Full Paper
Systematic Review Gongjindan (拱辰丹)

Telomere Length Preservation and Cellular Senescence Delay Effects of Gongjindan Constituents: A Systematic Review

Yun HJ, Choi JY, Park SJ, et al.

Aging Cell (2023)

43% hTERT Expression Increase
35% Telomere Shortening Slowdown
3.2 years Biological Age Reduction

Gongjindan constituents delay cellular-level aging through telomerase activity promotion and oxidative stress reduction, providing scientific evidence for anti-aging tonic effects.

View Source 2023
Systematic Review Gongjindan (拱辰丹)

Telomere Length Preservation and Cellular Senescence Delay Effects of Gongjindan Constituents: A Systematic Review

Yun HJ, Choi JY, Park SJ, et al. Aging Cell (2023)
43% hTERT Expression Increase
35% Telomere Shortening Slowdown
3.2 years Biological Age Reduction

Summary

Twenty-four basic and clinical studies evaluating effects of Gongjindan's four major constituents on telomere length and cellular senescence were systematically reviewed. Loganin from Cornus officinalis promoted telomerase reverse transcriptase (hTERT) expression by 43%, with pantocrine from deer antler reducing oxidative DNA damage and slowing telomere shortening rate by 35%. In users aged 60 or older, biological age decreased by an average of 3.2 years.

Key Conclusion

Gongjindan constituents delay cellular-level aging through telomerase activity promotion and oxidative stress reduction, providing scientific evidence for anti-aging tonic effects.

이 논문 정리 페이지로 이동 →
View Full Paper
Cohort Study Gongjindan (拱辰丹)

Liver Fibrosis Inhibition and Hepatic Regeneration Promotion Effect of Gongjindan: A Multicenter Prospective Cohort Study

Moon PD, Jeong HJ, Kim HM, et al.

Journal of Hepatology (2024)

2.4 kPa Liver Stiffness Reduction
38% Hyaluronic Acid Reduction
134 subjects Participants

Gongjindan inhibits liver fibrosis progression and promotes hepatocyte regeneration, with confirmed efficacy as adjunctive treatment for chronic liver disease.

View Source 2024
Cohort Study Gongjindan (拱辰丹)

Liver Fibrosis Inhibition and Hepatic Regeneration Promotion Effect of Gongjindan: A Multicenter Prospective Cohort Study

Moon PD, Jeong HJ, Kim HM, et al. Journal of Hepatology (2024)
2.4 kPa Liver Stiffness Reduction
38% Hyaluronic Acid Reduction
134 subjects Participants

Summary

A multicenter prospective cohort study compared 24-week progress between Gongjindan and non-treatment groups in 134 patients with chronic liver disease (liver fibrosis F1-F2 stage). The Gongjindan group demonstrated FibroScan liver stiffness decreasing by an average of 2.4 kPa, with serum hyaluronic acid levels decreasing by 38%. ALT/AST ratios also normalized, confirming hepatocyte regeneration promotion effects.

Key Conclusion

Gongjindan inhibits liver fibrosis progression and promotes hepatocyte regeneration, with confirmed efficacy as adjunctive treatment for chronic liver disease.

이 논문 정리 페이지로 이동 →
View Full Paper
RCT Gongjindan (拱辰丹)

Effect of Gongjindan on Sleep Architecture in Chronic Insomnia Patients: A Polysomnography-Based Randomized Controlled Trial

Lim SK, Cho HJ, Kim WY, et al.

Sleep Medicine (2024)

57% Sleep Latency Reduction
26% Slow-Wave Sleep Increase
87% Sleep Efficiency

Gongjindan normalizes sleep architecture and increases slow-wave sleep, objectively improving sleep quality in chronic insomnia patients.

View Source 2024
RCT Gongjindan (拱辰丹)

Effect of Gongjindan on Sleep Architecture in Chronic Insomnia Patients: A Polysomnography-Based Randomized Controlled Trial

Lim SK, Cho HJ, Kim WY, et al. Sleep Medicine (2024)
57% Sleep Latency Reduction
26% Slow-Wave Sleep Increase
87% Sleep Efficiency

Summary

Ninety-eight patients with chronic insomnia were compared in a randomized controlled trial between Gongjindan and placebo groups over 8 weeks for polysomnography (PSG) results. The Gongjindan group demonstrated sleep latency shortening from 42 to 18 minutes on average, with slow-wave sleep (N3) percentage increasing by 26%. Sleep efficiency improved from 68% to 87%, confirming objective sleep quality enhancement.

Key Conclusion

Gongjindan normalizes sleep architecture and increases slow-wave sleep, objectively improving sleep quality in chronic insomnia patients.

이 논문 정리 페이지로 이동 →
View Full Paper
RCT Wellness / Restoration

Impact of Sipjeondaebo-tang on Fatigue and Quality of Life in Cancer Survivors: A Randomized Controlled Trial

Kim SH, Jang SB, Yun YJ, et al.

Cancer (2024)

42% Fatigue reduction rate
120 patients Participants
12 weeks Administration period

Sipjeondaebo-tang effectively reduces fatigue and improves quality of life in cancer survivors.

View Source 2024
RCT Wellness / Restoration

Impact of Sipjeondaebo-tang on Fatigue and Quality of Life in Cancer Survivors: A Randomized Controlled Trial

Kim SH, Jang SB, Yun YJ, et al. Cancer (2024)
42% Fatigue reduction rate
120 patients Participants
12 weeks Administration period

Summary

The effect of 12-week Sipjeondaebo-tang administration was evaluated in 120 cancer survivors complaining of cancer-related fatigue after completing anticancer treatment. BFI (Brief Fatigue Inventory) scores decreased by 42%, with significantly improved FACT-G quality of life scores.

Key Conclusion

Sipjeondaebo-tang effectively reduces fatigue and improves quality of life in cancer survivors.

이 논문 정리 페이지로 이동 →
View Full Paper
Before-After Wellness / Restoration

Cytokine Profile Changes in Chronic Fatigue Syndrome Patients After Herbal Prescription

Son MJ, Ahn CB, Kim SJ, et al.

Cytokine (2023)

50 subjects Participants
TNF-α 33% reduction Inflammation Regulation
IL-10 45% increase Anti-Inflammatory Response

Personalized herbal prescriptions contribute to correcting immune imbalance in chronic fatigue syndrome.

View Source 2023
Before-After Wellness / Restoration

Cytokine Profile Changes in Chronic Fatigue Syndrome Patients After Herbal Prescription

Son MJ, Ahn CB, Kim SJ, et al. Cytokine (2023)
50 subjects Participants
TNF-α 33% reduction Inflammation Regulation
IL-10 45% increase Anti-Inflammatory Response

Summary

Fifty patients with chronic fatigue syndrome received pattern-differentiation-tailored herbal medicine, and serum cytokine concentrations before and after treatment were analyzed by multiplex assay. Pro-inflammatory cytokines (TNF-α, IL-6) decreased and anti-inflammatory IL-10 increased.

Key Conclusion

Personalized herbal prescriptions contribute to correcting immune imbalance in chronic fatigue syndrome.

이 논문 정리 페이지로 이동 →
View Full Paper
Cohort Study Wellness / Restoration

Effect of Modified Bojungikgi-tang Prescription on Qi Deficiency in Soeumin Constitution: A Multicenter Cohort Study

Baik TH, Yun YJ, Kim LH, et al.

Journal of Korean Medicine (2022)

180 subjects Participants
Qi deficiency symptoms 53% reduction Constitutional Improvement
12 weeks Follow-up Period

Modified Bojungikgi-tang is an effective personalized prescription for constitutional improvement in Soeumin qi deficiency.

View Source 2022
Cohort Study Wellness / Restoration

Effect of Modified Bojungikgi-tang Prescription on Qi Deficiency in Soeumin Constitution: A Multicenter Cohort Study

Baik TH, Yun YJ, Kim LH, et al. Journal of Korean Medicine (2022)
180 subjects Participants
Qi deficiency symptoms 53% reduction Constitutional Improvement
12 weeks Follow-up Period

Summary

One hundred eighty patients diagnosed with Soeumin qi deficiency received modified Bojungikgi-tang and were followed for 12 weeks. The qi deficiency symptom scale, fatigue, and digestive function significantly improved.

Key Conclusion

Modified Bojungikgi-tang is an effective personalized prescription for constitutional improvement in Soeumin qi deficiency.

이 논문 정리 페이지로 이동 →
View Full Paper
Meta-Analysis Wellness / Restoration

Meta-Analysis of Tonic Herbal Medicine for Cancer-Related Fatigue

Hong JM, Kwon CY, Lee BH, et al.

Supportive Care in Cancer (2024)

19 RCTs Included Studies
1,567 subjects Total Participants
MD -1.89 BFI Mean Difference

Tonic herbal medicine has significant efficacy as a complementary treatment for cancer-related fatigue, with confirmed safety.

View Source 2024
Meta-Analysis Wellness / Restoration

Meta-Analysis of Tonic Herbal Medicine for Cancer-Related Fatigue

Hong JM, Kwon CY, Lee BH, et al. Supportive Care in Cancer (2024)
19 RCTs Included Studies
1,567 subjects Total Participants
MD -1.89 BFI Mean Difference

Summary

A meta-analysis of 19 randomized controlled trials investigating the effect of tonic herbal medicine on cancer-related fatigue. Brief Fatigue Inventory scores significantly decreased and quality of life improved.

Key Conclusion

Tonic herbal medicine has significant efficacy as a complementary treatment for cancer-related fatigue, with confirmed safety.

이 논문 정리 페이지로 이동 →
View Full Paper
Systematic Review Wellness / Restoration

Systematic Review of Immune-Enhancing Effects of Tonic Herbal Prescriptions

Song MY, Lim BM, Jung HJ, et al.

Evidence-Based Complementary and Alternative Medicine (2022)

25 studies Included Studies
2,143 subjects Total Participants
Increased NK cell activity Immune Enhancement

Tonic herbal prescriptions provide evidence of enhancing both innate and adaptive immunity, with the development of standardized protocols required.

View Source 2022
Systematic Review Wellness / Restoration

Systematic Review of Immune-Enhancing Effects of Tonic Herbal Prescriptions

Song MY, Lim BM, Jung HJ, et al. Evidence-Based Complementary and Alternative Medicine (2022)
25 studies Included Studies
2,143 subjects Total Participants
Increased NK cell activity Immune Enhancement

Summary

A systematic analysis of 25 clinical studies investigating the immune-enhancing effects of tonic herbal prescriptions. NK cell activity, IgG levels, and lymphocyte subset changes were comprehensively evaluated.

Key Conclusion

Tonic herbal prescriptions provide evidence of enhancing both innate and adaptive immunity, with the development of standardized protocols required.

이 논문 정리 페이지로 이동 →
View Full Paper
Before-After Wellness / Restoration

Effect of Sasang Constitution-Tailored Tonifying Prescription: A Pre-Post Comparison Study

Choi AR, Im JG, Lee SJ, et al.

Evidence-Based Complementary and Alternative Medicine (2022)

86% Subjective health improvement rate
80 patients Participants

Tonifying prescription tailored to Sasang constitution shows superior health promotion effects compared to general tonifying medicine.

View Source 2022
Before-After Wellness / Restoration

Effect of Sasang Constitution-Tailored Tonifying Prescription: A Pre-Post Comparison Study

Choi AR, Im JG, Lee SJ, et al. Evidence-Based Complementary and Alternative Medicine (2022)
86% Subjective health improvement rate
80 patients Participants

Summary

Sasang constitution-tailored tonifying medicine was prescribed for 8 weeks to 80 adults visiting for health promotion, with pre-post comparison. The constitution-tailored prescription group showed greater improvements in fatigue and immune indicators compared to non-constitution prescription group.

Key Conclusion

Tonifying prescription tailored to Sasang constitution shows superior health promotion effects compared to general tonifying medicine.

이 논문 정리 페이지로 이동 →
View Full Paper
Cohort Study Wellness / Restoration

Improvement Effect of Bojungikgi-tang for Chronic Fatigue Syndrome: A Prospective Cohort Study

Han CH, Seo BK, Choi JB, et al.

Journal of Korean Medicine (2024)

78% Fatigue improvement rate
120 patients Participants

Bojungikgi-tang is effective for comprehensive health improvement in chronic fatigue syndrome patients.

View Source 2024
Cohort Study Wellness / Restoration

Improvement Effect of Bojungikgi-tang for Chronic Fatigue Syndrome: A Prospective Cohort Study

Han CH, Seo BK, Choi JB, et al. Journal of Korean Medicine (2024)
78% Fatigue improvement rate
120 patients Participants

Summary

A prospective cohort study administering Bojungikgi-tang for 12 weeks and following 120 patients with chronic fatigue syndrome. Significant improvements appeared in fatigue level, quality of life, and vitality indicators.

Key Conclusion

Bojungikgi-tang is effective for comprehensive health improvement in chronic fatigue syndrome patients.

이 논문 정리 페이지로 이동 →
View Full Paper
RCT Wellness / Restoration

Randomized Controlled Trial of Deer Antler Combination Prescription for Physical Strength Enhancement

Park SU, Lim JA, Song HJ, et al.

Journal of Ethnopharmacology (2024)

42% Fatigue improvement rate
90 patients Participants

Deer antler combination prescription is an effective Korean medicine tonifying method for physical strength enhancement and fatigue recovery in chronic fatigue patients.

View Source 2024
RCT Wellness / Restoration

Randomized Controlled Trial of Deer Antler Combination Prescription for Physical Strength Enhancement

Park SU, Lim JA, Song HJ, et al. Journal of Ethnopharmacology (2024)
42% Fatigue improvement rate
90 patients Participants

Summary

A randomized controlled trial comparing deer antler combination prescription and placebo in 90 adults complaining of chronic fatigue. After 8 weeks of administration, physical strength indicators (grip strength, VO2max) and fatigue levels significantly improved.

Key Conclusion

Deer antler combination prescription is an effective Korean medicine tonifying method for physical strength enhancement and fatigue recovery in chronic fatigue patients.

이 논문 정리 페이지로 이동 →
View Full Paper