금맥한의원
Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

Research Papers
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Total 1642 papers

Systematic Review Wellness / Restoration

Systematic Review of Immune-Enhancing Effects of Korean Medicine Tonifying Prescriptions

Kim TH, Hong JY, Leem JT, et al.

Evidence-Based Complementary and Alternative Medicine (2023)

35% NK cell activity increase
1,450 patients Total participants

Korean medicine tonifying prescriptions have significant effects on immune function enhancement and are useful for patients with chronic fatigue and immune decline.

Systematic Review Wellness / Restoration

Systematic Review of Immune-Enhancing Effects of Korean Medicine Tonifying Prescriptions

Kim TH, Hong JY, Leem JT, et al. Evidence-Based Complementary and Alternative Medicine (2023)
35% NK cell activity increase
1,450 patients Total participants

Summary

A systematic review evaluating immune-enhancing effects of Korean medicine tonifying prescriptions (Sipjeondaebo-tang, Bojungikgi-tang, etc.). A total of 20 studies were analyzed, with significant effects confirmed on NK cell activity and cytokine level improvement.

Key Conclusion

Korean medicine tonifying prescriptions have significant effects on immune function enhancement and are useful for patients with chronic fatigue and immune decline.

Cohort Study Wellness / Restoration

Postoperative Recovery Promotion Effect of Combined Herbal Medicine: A Prospective Cohort Study

Yoon SH, Kang BK, Han CH, et al.

Integrative Medicine Research (2023)

2.1 days Discharge duration reduction
45% Appetite recovery speed improvement
210 patients Study population

Combined herbal medicine treatment after surgery contributes to appetite recovery, normalization of bowel function, and shortened hospitalization, having value as an integrative medical recovery strategy.

Cohort Study Wellness / Restoration

Postoperative Recovery Promotion Effect of Combined Herbal Medicine: A Prospective Cohort Study

Yoon SH, Kang BK, Han CH, et al. Integrative Medicine Research (2023)
2.1 days Discharge duration reduction
45% Appetite recovery speed improvement
210 patients Study population

Summary

A cohort study comparing recovery speed between combined herbal medicine administration and general recovery groups in 210 patients after major surgery. In the herbal medicine combination group, mean time to appetite recovery was 3.2 days (general group 5.8 days), with average reduction of 2.1 days to discharge.

Key Conclusion

Combined herbal medicine treatment after surgery contributes to appetite recovery, normalization of bowel function, and shortened hospitalization, having value as an integrative medical recovery strategy.

Systematic Review Wellness / Restoration

Systematic Review of Anti-Fatigue and Immune-Enhancing Effects of Deer Antler Extract

Lee MK, Choi SJ, Kim HJ, et al.

Evidence-Based Complementary and Alternative Medicine (2022)

28% Endurance improvement
15 studies Analyzed studies
40s+ Maximum effect age

Deer antler extract shows significant effects on physical endurance improvement and immune function enhancement, and is scientifically valid as a tonifying treatment material for middle-aged and older adults.

Systematic Review Wellness / Restoration

Systematic Review of Anti-Fatigue and Immune-Enhancing Effects of Deer Antler Extract

Lee MK, Choi SJ, Kim HJ, et al. Evidence-Based Complementary and Alternative Medicine (2022)
28% Endurance improvement
15 studies Analyzed studies
40s+ Maximum effect age

Summary

Fifteen clinical studies examining anti-fatigue and immune-enhancing effects of deer antler extract were systematically analyzed. Meta-analysis showed an average 28% increase in physical endurance and significantly elevated IgG antibody levels in the deer antler group. Effects were particularly pronounced in the age group of 40s and older.

Key Conclusion

Deer antler extract shows significant effects on physical endurance improvement and immune function enhancement, and is scientifically valid as a tonifying treatment material for middle-aged and older adults.

RCT Wellness / Restoration

Therapeutic Effect of Bojungikgi-tang for Chronic Fatigue Syndrome: A Randomized Controlled Trial

Kim JH, Park SH, Lee JY, et al.

Journal of Korean Medicine (2023)

42% Fatigue reduction
35% NK cell activity increase
8 weeks Treatment duration

Bojungikgi-tang shows significant improvement effects on both subjective fatigue and objective immune indicators in chronic fatigue syndrome patients, providing scientific evidence for tonifying treatment.

RCT Wellness / Restoration

Therapeutic Effect of Bojungikgi-tang for Chronic Fatigue Syndrome: A Randomized Controlled Trial

Kim JH, Park SH, Lee JY, et al. Journal of Korean Medicine (2023)
42% Fatigue reduction
35% NK cell activity increase
8 weeks Treatment duration

Summary

A randomized controlled trial comparing 8 weeks of Bojungikgi-tang versus placebo in 96 patients with chronic fatigue syndrome. The Bojungikgi-tang group showed an average 42% reduction in Fatigue Severity Scale (FSS), significant improvement compared to placebo group (18% reduction). NK cell activity increased by 35%, also confirming immune function enhancement effects.

Key Conclusion

Bojungikgi-tang shows significant improvement effects on both subjective fatigue and objective immune indicators in chronic fatigue syndrome patients, providing scientific evidence for tonifying treatment.

Cross-Sectional Wellness / Restoration

Correlation Between Korean Medicine Yangsaeng Practice and Healthy Lifespan in Longevity Region Elderly: A Multi-Region Cross-Sectional Study

Kang SH, Lee JM, Park DH, et al.

Archives of Gerontology and Geriatrics (2023)

420 patients Participants
4.7 years Healthy lifespan difference
3 regions Multi-region study

Korean medicine yangsaeng practice shows significant correlation with healthy lifespan extension in the elderly.

Cross-Sectional Wellness / Restoration

Correlation Between Korean Medicine Yangsaeng Practice and Healthy Lifespan in Longevity Region Elderly: A Multi-Region Cross-Sectional Study

Kang SH, Lee JM, Park DH, et al. Archives of Gerontology and Geriatrics (2023)
420 patients Participants
4.7 years Healthy lifespan difference
3 regions Multi-region study

Summary

Levels of Korean medicine yangsaeng practice (diet, exercise, sleep, emotion management) and healthy lifespan indicators were analyzed in 420 elderly from 3 Korean longevity belt regions. The top 25% yangsaeng practice score group had an average 4.7 years longer ADL independence period than the bottom 25%.

Key Conclusion

Korean medicine yangsaeng practice shows significant correlation with healthy lifespan extension in the elderly.

RCT Respiratory Conditions

Effect of Korean Medicine Smoking Cessation Program: A Randomized Controlled Trial of Combined Auricular Acupuncture and Herbal Medicine

Shin SM, Park HJ, Lim BV, et al.

Nicotine & Tobacco Research (2024)

48% Smoking cessation success rate
100 patients Participants
12 weeks Program duration

Combined auricular acupuncture and herbal medicine smoking cessation program shows higher smoking cessation success rates than existing nicotine replacement therapy.

RCT Respiratory Conditions

Effect of Korean Medicine Smoking Cessation Program: A Randomized Controlled Trial of Combined Auricular Acupuncture and Herbal Medicine

Shin SM, Park HJ, Lim BV, et al. Nicotine & Tobacco Research (2024)
48% Smoking cessation success rate
100 patients Participants
12 weeks Program duration

Summary

One hundred smokers with intention to quit were divided into auricular acupuncture plus herbal medicine smoking cessation program and nicotine patch groups and compared over 12 weeks. The 12-week smoking cessation success rate of the Korean medicine program group was 48%, significantly higher than the nicotine patch group at 35%.

Key Conclusion

Combined auricular acupuncture and herbal medicine smoking cessation program shows higher smoking cessation success rates than existing nicotine replacement therapy.

Meta-Analysis Women's Health / Infertility

Impact of Combined Tonifying Prescription and Exercise on Bone Density in Women with Pre-Osteoporosis: A Meta-Analysis

Yoon HJ, Choi SY, Kim EH, et al.

Osteoporosis International (2023)

14 RCTs Analyzed RCTs
Lumbar BMD +0.034 Bone density improvement
Osteopenic women Target

Combined tonifying herbal medicine and exercise effectively improves bone density in osteopenic women and contributes to osteoporosis prevention.

Meta-Analysis Women's Health / Infertility

Impact of Combined Tonifying Prescription and Exercise on Bone Density in Women with Pre-Osteoporosis: A Meta-Analysis

Yoon HJ, Choi SY, Kim EH, et al. Osteoporosis International (2023)
14 RCTs Analyzed RCTs
Lumbar BMD +0.034 Bone density improvement
Osteopenic women Target

Summary

Fourteen RCTs evaluating the combined effect of tonifying herbal medicine and exercise in osteopenic women were meta-analyzed. The combination group showed significant additional improvements compared to exercise alone in lumbar bone density (MD: 0.034 g/cm²) and femoral bone density (MD: 0.021 g/cm²).

Key Conclusion

Combined tonifying herbal medicine and exercise effectively improves bone density in osteopenic women and contributes to osteoporosis prevention.

Before-After Skin Conditions

Effect of Herbal Bath Therapy on Autonomic Nervous System and Skin Health in Chronic Stress Patients: A Pre-Post Comparison Study

Roh JD, Kang YH, Lee EJ, et al.

Complementary Therapies in Clinical Practice (2024)

31% Parasympathetic activity increase
45 patients Participants
8 weeks Application period

Herbal bath therapy is an effective wellness treatment for autonomic balance recovery and skin health improvement.

Before-After Skin Conditions

Effect of Herbal Bath Therapy on Autonomic Nervous System and Skin Health in Chronic Stress Patients: A Pre-Post Comparison Study

Roh JD, Kang YH, Lee EJ, et al. Complementary Therapies in Clinical Practice (2024)
31% Parasympathetic activity increase
45 patients Participants
8 weeks Application period

Summary

Herbal bath (based on Artemisia, Angelica, Cnidium) was applied twice weekly for 8 weeks to 45 adults complaining of chronic stress. HRV analysis showed 31% increase in parasympathetic activity, with significantly improved skin hydration and elasticity.

Key Conclusion

Herbal bath therapy is an effective wellness treatment for autonomic balance recovery and skin health improvement.

Cross-Sectional Wellness / Restoration

Disease Prediction Accuracy of Korean Medicine Constitution-Tailored Health Examination: A Cross-Sectional Analysis

Go JH, Lee SY, Bae HS, et al.

BMJ Open (2023)

500 patients Participants
AUC +0.12 Predictive accuracy improvement
5 years Follow-up period

Sasang constitution-based health examination has higher disease prediction accuracy compared to standard examination and can be utilized as a tool for personalized preventive medicine.

Cross-Sectional Wellness / Restoration

Disease Prediction Accuracy of Korean Medicine Constitution-Tailored Health Examination: A Cross-Sectional Analysis

Go JH, Lee SY, Bae HS, et al. BMJ Open (2023)
500 patients Participants
AUC +0.12 Predictive accuracy improvement
5 years Follow-up period

Summary

Five-year disease occurrence prediction accuracy of Sasang constitution diagnosis-based health examination and standard health examination was compared in 500 health check-up subjects. AUC of constitution-tailored examination was 0.12 higher than standard examination, with particularly large differences in metabolic disease prediction.

Key Conclusion

Sasang constitution-based health examination has higher disease prediction accuracy compared to standard examination and can be utilized as a tool for personalized preventive medicine.

RCT Men's Health / Urology

Effect of Tonifying Herbal Medicine on Male Menopausal Symptoms: A Randomized Double-Blind Placebo-Controlled Trial

Yoo JH, Shin WC, Kim TH, et al.

Andrology (2024)

35% AMS symptom improvement
80 patients Participants
Double-blind Study design

Tonifying herbal medicine effectively improves male menopausal symptoms and is a complementary alternative to testosterone replacement therapy.

RCT Men's Health / Urology

Effect of Tonifying Herbal Medicine on Male Menopausal Symptoms: A Randomized Double-Blind Placebo-Controlled Trial

Yoo JH, Shin WC, Kim TH, et al. Andrology (2024)
35% AMS symptom improvement
80 patients Participants
Double-blind Study design

Summary

Deer antler and musk-based tonifying herbal medicine was administered in a double-blind manner for 16 weeks to 80 men aged 50-70 with male menopausal symptoms (AMS score ≥37). The herbal medicine group showed 35% improvement in AMS scores, with significantly increased free testosterone.

Key Conclusion

Tonifying herbal medicine effectively improves male menopausal symptoms and is a complementary alternative to testosterone replacement therapy.

Narrative Review Wellness / Restoration

Effect of Qigong Practice on Stress Hormones and Telomere Length: A Narrative Review

Shin JH, Oh MS, Park JK, et al.

Journal of Integrative Medicine (2023)

28 studies Reviewed papers
Telomere Anti-aging biomarker
Cortisol reduction Stress regulation

Qigong practice can delay cellular aging through stress hormone regulation and telomere maintenance.

Narrative Review Wellness / Restoration

Effect of Qigong Practice on Stress Hormones and Telomere Length: A Narrative Review

Shin JH, Oh MS, Park JK, et al. Journal of Integrative Medicine (2023)
28 studies Reviewed papers
Telomere Anti-aging biomarker
Cortisol reduction Stress regulation

Summary

Twenty-eight papers on anti-aging effects of qigong practice were narratively reviewed. Regular qigong practice was associated with cortisol reduction, DHEA-S increase, and telomere length maintenance, suggesting potential for cellular aging delay.

Key Conclusion

Qigong practice can delay cellular aging through stress hormone regulation and telomere maintenance.

Before-After Wellness / Restoration

Effect of Korean Medicine Detoxification Program on Heavy Metal Excretion: A Pre-Post Comparison Study

Chung SH, Lee HJ, Yoo SR, et al.

Environmental Health and Preventive Medicine (2023)

32% Mercury reduction
18% Lead reduction
60 patients Participants

Korean medicine detoxification program promotes heavy metal excretion from the body and is useful for health management of modern people with high environmental pollution exposure.

Before-After Wellness / Restoration

Effect of Korean Medicine Detoxification Program on Heavy Metal Excretion: A Pre-Post Comparison Study

Chung SH, Lee HJ, Yoo SR, et al. Environmental Health and Preventive Medicine (2023)
32% Mercury reduction
18% Lead reduction
60 patients Participants

Summary

Korean medicine detoxification program (mung bean drink, acupuncture, sweat therapy) was applied for 6 weeks to 60 adults with high body heavy metal (mercury, lead, cadmium) levels. Blood mercury (-32%), lead (-18%), and urine cadmium (-25%) significantly decreased.

Key Conclusion

Korean medicine detoxification program promotes heavy metal excretion from the body and is useful for health management of modern people with high environmental pollution exposure.