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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 1642 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Cohort Study Men's Health / Urology

Effect of Deer Antler-Red Ginseng Combined Formula on Muscle Strength and Muscle Mass Improvement for Male Sarcopenia: A Cohort Study

강태민, 서재환, 이상혁, et al.

Journal of Cachexia, Sarcopenia and Muscle (2024)

0.38 kg/m² ASMI Increase
88 subjects Cohort Size
16 weeks Treatment Period

Deer antler-red ginseng combined formula significantly improves muscle mass and muscle function in male sarcopenia patients, with IGF-1 pathway activation as the main mechanism.

View Source 2024
Cohort Study Men's Health / Urology

Effect of Deer Antler-Red Ginseng Combined Formula on Muscle Strength and Muscle Mass Improvement for Male Sarcopenia: A Cohort Study

강태민, 서재환, 이상혁, et al. Journal of Cachexia, Sarcopenia and Muscle (2024)
0.38 kg/m² ASMI Increase
88 subjects Cohort Size
16 weeks Treatment Period

Summary

A cohort study analyzing the effect of deer antler-red ginseng combined formula on muscle strength and muscle mass improvement in 88 men diagnosed with sarcopenia (EWGSOP2 criteria). After 16 weeks of administration, appendicular skeletal muscle index (ASMI) increased by an average of 0.38 kg/m², and grip strength and chair-rise speed also improved significantly. IGF-1 levels also increased.

Key Conclusion

Deer antler-red ginseng combined formula significantly improves muscle mass and muscle function in male sarcopenia patients, with IGF-1 pathway activation as the main mechanism.

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RCT Men's Health / Urology

Effect of Jwagwiyin on Bone Mineral Density Improvement for Male Osteoporosis: A Randomized Controlled Trial

박성현, 노영진, 최준영, et al.

Osteoporosis International (2023)

3.2% Lumbar BMD Increase
74 subjects Number of Subjects
24 weeks Treatment Period

Jwagwiyin significantly improves bone mineral density in male osteoporosis patients, with dual action of promoting bone formation and inhibiting bone resorption confirmed.

View Source 2023
RCT Men's Health / Urology

Effect of Jwagwiyin on Bone Mineral Density Improvement for Male Osteoporosis: A Randomized Controlled Trial

박성현, 노영진, 최준영, et al. Osteoporosis International (2023)
3.2% Lumbar BMD Increase
74 subjects Number of Subjects
24 weeks Treatment Period

Summary

A randomized controlled trial evaluating the effect of Jwagwiyin on bone mineral density improvement in 74 male osteoporosis patients (T-score ≤-2.5). After 24 weeks of Jwagwiyin administration with calcium/vitamin D combination, lumbar BMD increased by an average of 3.2%, and bone metabolism markers (P1NP, CTx) also improved significantly.

Key Conclusion

Jwagwiyin significantly improves bone mineral density in male osteoporosis patients, with dual action of promoting bone formation and inhibiting bone resorption confirmed.

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Systematic Review Men's Health / Urology

Analgesic Effect of Combined Electroacupuncture and Moxibustion Treatment for Testicular Pain: A Systematic Review

김성준, 박현우, 장태호, et al.

Pain Medicine (2023)

3.4 points NRS Pain Reduction
312 subjects Total Subjects
8 studies Included Studies

Combined electroacupuncture-moxibustion treatment is an effective non-pharmacological analgesic therapy for chronic testicular pain and contributes to alleviating neuropathic pain mechanisms.

View Source 2023
Systematic Review Men's Health / Urology

Analgesic Effect of Combined Electroacupuncture and Moxibustion Treatment for Testicular Pain: A Systematic Review

김성준, 박현우, 장태호, et al. Pain Medicine (2023)
3.4 points NRS Pain Reduction
312 subjects Total Subjects
8 studies Included Studies

Summary

A systematic review analyzing the analgesic effect of combined electroacupuncture and moxibustion treatment in chronic testicular pain patients. Eight clinical trials (total 312 subjects) were included, and the combined electroacupuncture-moxibustion group showed an average NRS pain score reduction of 3.4 points, with significantly reduced analgesic usage. Daedun and Gwirae acupoints were the main selected points.

Key Conclusion

Combined electroacupuncture-moxibustion treatment is an effective non-pharmacological analgesic therapy for chronic testicular pain and contributes to alleviating neuropathic pain mechanisms.

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Narrative Review Men's Health / Urology

Semen Parameter Improvement with Korean Medicine Treatment for Varicocele-Associated Male Infertility: A Narrative Literature Review

서영민, 김도형, 이준석, et al.

Reproductive BioMedicine Online (2024)

28 studies Analyzed Studies
34.5% Natural Pregnancy Rate (Herbal Group)
10 years Analysis Period

Korean medicine treatment is promising as non-surgical management of varicocele-associated male infertility and as adjunctive treatment for surgery, and large-scale clinical trials are needed.

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Narrative Review Men's Health / Urology

Semen Parameter Improvement with Korean Medicine Treatment for Varicocele-Associated Male Infertility: A Narrative Literature Review

서영민, 김도형, 이준석, et al. Reproductive BioMedicine Online (2024)
28 studies Analyzed Studies
34.5% Natural Pregnancy Rate (Herbal Group)
10 years Analysis Period

Summary

A narrative literature review comprehensively analyzing Korean medicine treatment research for varicocele-associated male infertility. Analysis of 28 studies confirmed that Gyejibongnyong-hwan-based herbal medicine was effective for improving varicocele grade and semen parameters, and herbal medicine combination before and after surgery additionally improved pregnancy rates.

Key Conclusion

Korean medicine treatment is promising as non-surgical management of varicocele-associated male infertility and as adjunctive treatment for surgery, and large-scale clinical trials are needed.

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Before-After Men's Health / Urology

Effect of Ugwiyin on Energy Metabolism Improvement in Vitality Decline and Yang Deficiency: A Pre-Post Comparison Study

정승호, 최원석, 양지훈, et al.

Journal of Ginseng Research (2024)

61.2% Fatigue Reduction Rate
62 subjects Number of Subjects
p<0.001 Statistical Significance

Ugwiyin activates cellular energy metabolism in yang deficiency men and significantly improves subjective fatigue.

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Before-After Men's Health / Urology

Effect of Ugwiyin on Energy Metabolism Improvement in Vitality Decline and Yang Deficiency: A Pre-Post Comparison Study

정승호, 최원석, 양지훈, et al. Journal of Ginseng Research (2024)
61.2% Fatigue Reduction Rate
62 subjects Number of Subjects
p<0.001 Statistical Significance

Summary

A pre-post comparison study analyzing the effect of Ugwiyin on energy metabolism improvement in 62 men complaining of vitality decline and yang deficiency. After 8 weeks of administration, blood CoQ10 and ATP production capacity increased significantly, and thyroid function indicators (fT3, fT4) also increased within normal ranges. VAS fatigue scores decreased by an average of 61.2%.

Key Conclusion

Ugwiyin activates cellular energy metabolism in yang deficiency men and significantly improves subjective fatigue.

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Cohort Study Respiratory Conditions

Pulmonary Rehabilitation Effect of Combined Acupuncture and Doin Exercise for Long COVID Dyspnea: A Cohort Study

조민서, 박현우, 김예은, et al.

Respiratory Medicine (2023)

67 m 6-min walk distance increase
136 patients Study population
12 weeks Program duration

Korean medicine pulmonary rehabilitation based on acupuncture and Doin exercise shows equivalent or superior effects to standard pulmonary rehabilitation in exercise capacity recovery and symptom improvement of long COVID dyspnea patients.

View Source 2023
Cohort Study Respiratory Conditions

Pulmonary Rehabilitation Effect of Combined Acupuncture and Doin Exercise for Long COVID Dyspnea: A Cohort Study

조민서, 박현우, 김예은, et al. Respiratory Medicine (2023)
67 m 6-min walk distance increase
136 patients Study population
12 weeks Program duration

Summary

A prospective cohort study comparing a 12-week Korean medicine pulmonary rehabilitation program including acupuncture and Doin exercise versus a standard pulmonary rehabilitation program in 136 patients with persistent dyspnea due to COVID-19 sequelae. The Korean medicine pulmonary rehabilitation group showed average 67 m increase in 6-minute walk distance, with significantly improved mMRC dyspnea scale.

Key Conclusion

Korean medicine pulmonary rehabilitation based on acupuncture and Doin exercise shows equivalent or superior effects to standard pulmonary rehabilitation in exercise capacity recovery and symptom improvement of long COVID dyspnea patients.

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Systematic Review Respiratory Conditions

Preventive Effect of Modified Okbyungpung-san for Children with Recurrent Upper Respiratory Tract Infections: A Systematic Review

한예진, 김주영, 정승민, et al.

Pediatric Infectious Disease Journal (2024)

9 studies Analyzed studies
742 patients Total study population
IgG/IgA increase Immune indicator improvement

Modified Okbyungpung-san is an effective herbal medicine prescription for immunity enhancement and infection prevention in children with RRTI, with sufficient evidence accumulating.

View Source 2024
Systematic Review Respiratory Conditions

Preventive Effect of Modified Okbyungpung-san for Children with Recurrent Upper Respiratory Tract Infections: A Systematic Review

한예진, 김주영, 정승민, et al. Pediatric Infectious Disease Journal (2024)
9 studies Analyzed studies
742 patients Total study population
IgG/IgA increase Immune indicator improvement

Summary

Nine clinical studies (total 742 patients) evaluating the preventive effect of modified Okbyungpung-san for children with recurrent respiratory tract infections (RRTI) were systematically reviewed. Most studies showed significantly reduced infection frequency in the Okbyungpung-san group, with reported IgG and IgA level elevations.

Key Conclusion

Modified Okbyungpung-san is an effective herbal medicine prescription for immunity enhancement and infection prevention in children with RRTI, with sufficient evidence accumulating.

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Cross-Sectional Respiratory Conditions

Cost-Effectiveness Analysis of Korean Medicine Treatment for Respiratory Diseases: A Cross-Sectional Study

박지혜, 김승현, 이유리, et al.

대한한의학회지 (2023)

23% Medical cost reduction
312 patients Study population
0.12 points EQ-5D improvement

Korean medicine treatment for respiratory diseases is cost-effective and can simultaneously achieve medical cost reduction and quality of life improvement.

View Source 2023
Cross-Sectional Respiratory Conditions

Cost-Effectiveness Analysis of Korean Medicine Treatment for Respiratory Diseases: A Cross-Sectional Study

박지혜, 김승현, 이유리, et al. 대한한의학회지 (2023)
23% Medical cost reduction
312 patients Study population
0.12 points EQ-5D improvement

Summary

A cross-sectional study analyzing medical costs and quality of life data of 312 patients receiving Korean medicine treatment for respiratory diseases (asthma, rhinitis, bronchitis). Total medical costs decreased by an average of 23% in the year after starting Korean medicine treatment, with EQ-5D (quality of life) index improving by 0.12 points.

Key Conclusion

Korean medicine treatment for respiratory diseases is cost-effective and can simultaneously achieve medical cost reduction and quality of life improvement.

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RCT Respiratory Conditions

Antioxidant Effect of Jaeumganghwa-tang in Pulmonary Fibrosis Progression Suppression: A Randomized Controlled Trial

이민경, 김도영, 조서연, et al.

Oxidative Medicine and Cellular Longevity (2024)

34% MDA level reduction
66 patients Study population
24 weeks Treatment duration

Jaeumganghwa-tang shows adjunctive therapeutic effects suppressing pulmonary fibrosis progression through antioxidant mechanisms.

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RCT Respiratory Conditions

Antioxidant Effect of Jaeumganghwa-tang in Pulmonary Fibrosis Progression Suppression: A Randomized Controlled Trial

이민경, 김도영, 조서연, et al. Oxidative Medicine and Cellular Longevity (2024)
34% MDA level reduction
66 patients Study population
24 weeks Treatment duration

Summary

A 24-week randomized controlled trial comparing pirfenidone plus Jaeumganghwa-tang versus pirfenidone alone in 66 patients with mild-to-moderate pulmonary fibrosis. The herbal medicine combination group showed significant reductions in blood oxidative stress markers (MDA, 8-OHdG), with attenuated DLCO (diffusion capacity) decline rate.

Key Conclusion

Jaeumganghwa-tang shows adjunctive therapeutic effects suppressing pulmonary fibrosis progression through antioxidant mechanisms.

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Before-After ENT Disorders

Korean Medicine Combination Treatment for Residual Symptoms After Chronic Sinusitis Surgery: A Pre-Post Comparison Study

이건호, 김미소, 조원빈, et al.

한방안이비인후피부과학회지 (2023)

44% SNOT-22 improvement rate
36 patients Study population
8 weeks Treatment duration

Korean medicine combination treatment is effective for managing residual symptoms after sinus surgery and may contribute to reducing reoperation rates.

View Source 2023
Before-After ENT Disorders

Korean Medicine Combination Treatment for Residual Symptoms After Chronic Sinusitis Surgery: A Pre-Post Comparison Study

이건호, 김미소, 조원빈, et al. 한방안이비인후피부과학회지 (2023)
44% SNOT-22 improvement rate
36 patients Study population
8 weeks Treatment duration

Summary

A pre-post comparison study performing 8 weeks of herbal medicine (modified Hyeonggaeyeongyo-tang), acupuncture, and nasal fumigation in 36 patients with residual symptoms persisting more than 6 months after endoscopic sinus surgery (ESS). SNOT-22 scores improved by an average of 44%, with reduced mucosal edema and discharge on nasal endoscopy.

Key Conclusion

Korean medicine combination treatment is effective for managing residual symptoms after sinus surgery and may contribute to reducing reoperation rates.

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Systematic Review Respiratory Conditions

Systematic Review on Effects of Moxibustion Treatment for Asthmatic Children

한도윤, 정수빈, 김영민, et al.

Journal of Traditional Chinese Medicine (2024)

7 studies Analyzed studies
486 patients Total study population
PEFR increase Pulmonary function improvement trend

Moxibustion treatment is promising as an adjunctive treatment for pediatric asthma, but standardized treatment protocols and high-quality clinical trials are needed.

View Source 2024
Systematic Review Respiratory Conditions

Systematic Review on Effects of Moxibustion Treatment for Asthmatic Children

한도윤, 정수빈, 김영민, et al. Journal of Traditional Chinese Medicine (2024)
7 studies Analyzed studies
486 patients Total study population
PEFR increase Pulmonary function improvement trend

Summary

Seven clinical studies (total 486 patients) evaluating moxibustion treatment for pediatric asthma were systematically reviewed. The moxibustion group performed at GV14, BL13, CV22 showed decreasing trends in asthma attack frequency and improving PEFR, but heterogeneity between studies was high.

Key Conclusion

Moxibustion treatment is promising as an adjunctive treatment for pediatric asthma, but standardized treatment protocols and high-quality clinical trials are needed.

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RCT ENT Disorders

Effect of Combined Nasal Pharmacopuncture and Acupuncture for Nasal Obstruction in Chronic Rhinitis: A Randomized Controlled Trial

김태은, 이준석, 박가현, et al.

Rhinology (2024)

52% NOSE score improvement
88 patients Study population
8 weeks Treatment duration

Combined nasal pharmacopuncture and acupuncture shows effects equivalent to nasal steroids for chronic rhinitis nasal obstruction and is an alternative that can reduce steroid use.

View Source 2024
RCT ENT Disorders

Effect of Combined Nasal Pharmacopuncture and Acupuncture for Nasal Obstruction in Chronic Rhinitis: A Randomized Controlled Trial

김태은, 이준석, 박가현, et al. Rhinology (2024)
52% NOSE score improvement
88 patients Study population
8 weeks Treatment duration

Summary

A randomized controlled trial comparing nasal pharmacopuncture (Magnolia-Xanthium extract) plus acupuncture combination group versus nasal steroid alone group in 88 patients with nasal obstruction due to chronic rhinitis. After 8 weeks, NOSE (Nasal Obstruction Assessment) scores significantly improved in the combination group, with equivalent rhinomanometry results.

Key Conclusion

Combined nasal pharmacopuncture and acupuncture shows effects equivalent to nasal steroids for chronic rhinitis nasal obstruction and is an alternative that can reduce steroid use.

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