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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 1642 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
RCT Men's Health / Urology

Effect of Jwagwiyin on Bone Mineral Density Improvement for Male Osteoporosis: A Randomized Controlled Trial

박성현, 노영진, 최준영, et al.

Osteoporosis International (2023)

3.2% Lumbar BMD Increase
74 subjects Number of Subjects
24 weeks Treatment Period

Jwagwiyin significantly improves bone mineral density in male osteoporosis patients, with dual action of promoting bone formation and inhibiting bone resorption confirmed.

View Source 2023
RCT Men's Health / Urology

Effect of Jwagwiyin on Bone Mineral Density Improvement for Male Osteoporosis: A Randomized Controlled Trial

박성현, 노영진, 최준영, et al. Osteoporosis International (2023)
3.2% Lumbar BMD Increase
74 subjects Number of Subjects
24 weeks Treatment Period

Summary

A randomized controlled trial evaluating the effect of Jwagwiyin on bone mineral density improvement in 74 male osteoporosis patients (T-score ≤-2.5). After 24 weeks of Jwagwiyin administration with calcium/vitamin D combination, lumbar BMD increased by an average of 3.2%, and bone metabolism markers (P1NP, CTx) also improved significantly.

Key Conclusion

Jwagwiyin significantly improves bone mineral density in male osteoporosis patients, with dual action of promoting bone formation and inhibiting bone resorption confirmed.

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Cohort Study Men's Health / Urology

Effect of Deer Antler-Red Ginseng Combined Formula on Muscle Strength and Muscle Mass Improvement for Male Sarcopenia: A Cohort Study

강태민, 서재환, 이상혁, et al.

Journal of Cachexia, Sarcopenia and Muscle (2024)

0.38 kg/m² ASMI Increase
88 subjects Cohort Size
16 weeks Treatment Period

Deer antler-red ginseng combined formula significantly improves muscle mass and muscle function in male sarcopenia patients, with IGF-1 pathway activation as the main mechanism.

View Source 2024
Cohort Study Men's Health / Urology

Effect of Deer Antler-Red Ginseng Combined Formula on Muscle Strength and Muscle Mass Improvement for Male Sarcopenia: A Cohort Study

강태민, 서재환, 이상혁, et al. Journal of Cachexia, Sarcopenia and Muscle (2024)
0.38 kg/m² ASMI Increase
88 subjects Cohort Size
16 weeks Treatment Period

Summary

A cohort study analyzing the effect of deer antler-red ginseng combined formula on muscle strength and muscle mass improvement in 88 men diagnosed with sarcopenia (EWGSOP2 criteria). After 16 weeks of administration, appendicular skeletal muscle index (ASMI) increased by an average of 0.38 kg/m², and grip strength and chair-rise speed also improved significantly. IGF-1 levels also increased.

Key Conclusion

Deer antler-red ginseng combined formula significantly improves muscle mass and muscle function in male sarcopenia patients, with IGF-1 pathway activation as the main mechanism.

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Cross-Sectional Men's Health / Urology

Antibacterial and Anti-Inflammatory Effect of Yongdamsagan-tang on Male Genital Infections: A Cross-Sectional Study

차현석, 김진우, 문승재, et al.

Journal of Microbiology and Biotechnology (2023)

3.8 days Treatment Period Shortened
48 subjects Number of Subjects
p=0.008 Statistical Significance

Yongdamsagan-tang enhances anti-inflammatory effects as an antibiotic adjunct treatment for male genital infections and shortens treatment duration.

View Source 2023
Cross-Sectional Men's Health / Urology

Antibacterial and Anti-Inflammatory Effect of Yongdamsagan-tang on Male Genital Infections: A Cross-Sectional Study

차현석, 김진우, 문승재, et al. Journal of Microbiology and Biotechnology (2023)
3.8 days Treatment Period Shortened
48 subjects Number of Subjects
p=0.008 Statistical Significance

Summary

A cross-sectional study analyzing the antibacterial and anti-inflammatory effect of Yongdamsagan-tang in 48 male patients with genital infections (epididymitis, seminal vesiculitis). With antibiotic combination, the Yongdamsagan-tang addition group showed faster decreases in CRP and semen leukocyte levels, and symptom resolution period was shortened by an average of 3.8 days.

Key Conclusion

Yongdamsagan-tang enhances anti-inflammatory effects as an antibiotic adjunct treatment for male genital infections and shortens treatment duration.

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Before-After Men's Health / Urology

Effect of Modified Dojeok-san on Residual Symptoms After Urethritis: A Pre-Post Comparison Study

안성호, 배진혁, 홍유진, et al.

대한한방내과학회지 (2024)

73.1% VAS Reduction Rate
36 subjects Number of Subjects
6 weeks Treatment Period

Modified Dojeok-san is effective for alleviating residual urethral symptoms after antibiotic treatment, with a mechanism through local inflammatory response suppression confirmed.

View Source 2024
Before-After Men's Health / Urology

Effect of Modified Dojeok-san on Residual Symptoms After Urethritis: A Pre-Post Comparison Study

안성호, 배진혁, 홍유진, et al. 대한한방내과학회지 (2024)
73.1% VAS Reduction Rate
36 subjects Number of Subjects
6 weeks Treatment Period

Summary

A pre-post comparison study analyzing the effect of modified Dojeok-san in 36 men with persistent urethral discomfort after antibiotic treatment. After 6 weeks of administration, urethral burning VAS decreased from an average of 6.7 to 1.8, and urinary frequency and residual urine sensation also improved significantly. Urinary cytokine (IL-8, IL-1β) levels also decreased.

Key Conclusion

Modified Dojeok-san is effective for alleviating residual urethral symptoms after antibiotic treatment, with a mechanism through local inflammatory response suppression confirmed.

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Case Study Men's Health / Urology

Effect of Taeumjowi-tang on Metabolic Indicator Improvement for Visceral Fat-Type Male Obesity: A Case Study

김하준, 이채원, 정태욱, et al.

Metabolism (2023)

31.4 cm² Visceral Fat Reduction
10 cases Number of Cases
12 weeks Treatment Period

Taeumjowi-tang is an effective and safe treatment for visceral fat reduction and metabolic indicator improvement in visceral fat-type male obesity.

View Source 2023
Case Study Men's Health / Urology

Effect of Taeumjowi-tang on Metabolic Indicator Improvement for Visceral Fat-Type Male Obesity: A Case Study

김하준, 이채원, 정태욱, et al. Metabolism (2023)
31.4 cm² Visceral Fat Reduction
10 cases Number of Cases
12 weeks Treatment Period

Summary

A case study on Taeumjowi-tang treatment in 10 male patients with visceral fat-type obesity (CT visceral fat area ≥100 cm²). After 12 weeks of administration, visceral fat area decreased by an average of 31.4 cm², and metabolic indicators including fasting blood glucose, HbA1c, triglycerides, and LDL-C also improved significantly. Liver function indicators (AST/ALT) remained within normal ranges.

Key Conclusion

Taeumjowi-tang is an effective and safe treatment for visceral fat reduction and metabolic indicator improvement in visceral fat-type male obesity.

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RCT ENT Disorders

Effect of Combined Nasal Pharmacopuncture and Acupuncture for Nasal Obstruction in Chronic Rhinitis: A Randomized Controlled Trial

김태은, 이준석, 박가현, et al.

Rhinology (2024)

52% NOSE score improvement
88 patients Study population
8 weeks Treatment duration

Combined nasal pharmacopuncture and acupuncture shows effects equivalent to nasal steroids for chronic rhinitis nasal obstruction and is an alternative that can reduce steroid use.

View Source 2024
RCT ENT Disorders

Effect of Combined Nasal Pharmacopuncture and Acupuncture for Nasal Obstruction in Chronic Rhinitis: A Randomized Controlled Trial

김태은, 이준석, 박가현, et al. Rhinology (2024)
52% NOSE score improvement
88 patients Study population
8 weeks Treatment duration

Summary

A randomized controlled trial comparing nasal pharmacopuncture (Magnolia-Xanthium extract) plus acupuncture combination group versus nasal steroid alone group in 88 patients with nasal obstruction due to chronic rhinitis. After 8 weeks, NOSE (Nasal Obstruction Assessment) scores significantly improved in the combination group, with equivalent rhinomanometry results.

Key Conclusion

Combined nasal pharmacopuncture and acupuncture shows effects equivalent to nasal steroids for chronic rhinitis nasal obstruction and is an alternative that can reduce steroid use.

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Systematic Review Respiratory Conditions

Systematic Review on Effects of Moxibustion Treatment for Asthmatic Children

한도윤, 정수빈, 김영민, et al.

Journal of Traditional Chinese Medicine (2024)

7 studies Analyzed studies
486 patients Total study population
PEFR increase Pulmonary function improvement trend

Moxibustion treatment is promising as an adjunctive treatment for pediatric asthma, but standardized treatment protocols and high-quality clinical trials are needed.

View Source 2024
Systematic Review Respiratory Conditions

Systematic Review on Effects of Moxibustion Treatment for Asthmatic Children

한도윤, 정수빈, 김영민, et al. Journal of Traditional Chinese Medicine (2024)
7 studies Analyzed studies
486 patients Total study population
PEFR increase Pulmonary function improvement trend

Summary

Seven clinical studies (total 486 patients) evaluating moxibustion treatment for pediatric asthma were systematically reviewed. The moxibustion group performed at GV14, BL13, CV22 showed decreasing trends in asthma attack frequency and improving PEFR, but heterogeneity between studies was high.

Key Conclusion

Moxibustion treatment is promising as an adjunctive treatment for pediatric asthma, but standardized treatment protocols and high-quality clinical trials are needed.

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Before-After ENT Disorders

Korean Medicine Combination Treatment for Residual Symptoms After Chronic Sinusitis Surgery: A Pre-Post Comparison Study

이건호, 김미소, 조원빈, et al.

한방안이비인후피부과학회지 (2023)

44% SNOT-22 improvement rate
36 patients Study population
8 weeks Treatment duration

Korean medicine combination treatment is effective for managing residual symptoms after sinus surgery and may contribute to reducing reoperation rates.

View Source 2023
Before-After ENT Disorders

Korean Medicine Combination Treatment for Residual Symptoms After Chronic Sinusitis Surgery: A Pre-Post Comparison Study

이건호, 김미소, 조원빈, et al. 한방안이비인후피부과학회지 (2023)
44% SNOT-22 improvement rate
36 patients Study population
8 weeks Treatment duration

Summary

A pre-post comparison study performing 8 weeks of herbal medicine (modified Hyeonggaeyeongyo-tang), acupuncture, and nasal fumigation in 36 patients with residual symptoms persisting more than 6 months after endoscopic sinus surgery (ESS). SNOT-22 scores improved by an average of 44%, with reduced mucosal edema and discharge on nasal endoscopy.

Key Conclusion

Korean medicine combination treatment is effective for managing residual symptoms after sinus surgery and may contribute to reducing reoperation rates.

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RCT Respiratory Conditions

Antioxidant Effect of Jaeumganghwa-tang in Pulmonary Fibrosis Progression Suppression: A Randomized Controlled Trial

이민경, 김도영, 조서연, et al.

Oxidative Medicine and Cellular Longevity (2024)

34% MDA level reduction
66 patients Study population
24 weeks Treatment duration

Jaeumganghwa-tang shows adjunctive therapeutic effects suppressing pulmonary fibrosis progression through antioxidant mechanisms.

View Source 2024
RCT Respiratory Conditions

Antioxidant Effect of Jaeumganghwa-tang in Pulmonary Fibrosis Progression Suppression: A Randomized Controlled Trial

이민경, 김도영, 조서연, et al. Oxidative Medicine and Cellular Longevity (2024)
34% MDA level reduction
66 patients Study population
24 weeks Treatment duration

Summary

A 24-week randomized controlled trial comparing pirfenidone plus Jaeumganghwa-tang versus pirfenidone alone in 66 patients with mild-to-moderate pulmonary fibrosis. The herbal medicine combination group showed significant reductions in blood oxidative stress markers (MDA, 8-OHdG), with attenuated DLCO (diffusion capacity) decline rate.

Key Conclusion

Jaeumganghwa-tang shows adjunctive therapeutic effects suppressing pulmonary fibrosis progression through antioxidant mechanisms.

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Cross-Sectional Respiratory Conditions

Cost-Effectiveness Analysis of Korean Medicine Treatment for Respiratory Diseases: A Cross-Sectional Study

박지혜, 김승현, 이유리, et al.

대한한의학회지 (2023)

23% Medical cost reduction
312 patients Study population
0.12 points EQ-5D improvement

Korean medicine treatment for respiratory diseases is cost-effective and can simultaneously achieve medical cost reduction and quality of life improvement.

View Source 2023
Cross-Sectional Respiratory Conditions

Cost-Effectiveness Analysis of Korean Medicine Treatment for Respiratory Diseases: A Cross-Sectional Study

박지혜, 김승현, 이유리, et al. 대한한의학회지 (2023)
23% Medical cost reduction
312 patients Study population
0.12 points EQ-5D improvement

Summary

A cross-sectional study analyzing medical costs and quality of life data of 312 patients receiving Korean medicine treatment for respiratory diseases (asthma, rhinitis, bronchitis). Total medical costs decreased by an average of 23% in the year after starting Korean medicine treatment, with EQ-5D (quality of life) index improving by 0.12 points.

Key Conclusion

Korean medicine treatment for respiratory diseases is cost-effective and can simultaneously achieve medical cost reduction and quality of life improvement.

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Systematic Review Respiratory Conditions

Preventive Effect of Modified Okbyungpung-san for Children with Recurrent Upper Respiratory Tract Infections: A Systematic Review

한예진, 김주영, 정승민, et al.

Pediatric Infectious Disease Journal (2024)

9 studies Analyzed studies
742 patients Total study population
IgG/IgA increase Immune indicator improvement

Modified Okbyungpung-san is an effective herbal medicine prescription for immunity enhancement and infection prevention in children with RRTI, with sufficient evidence accumulating.

View Source 2024
Systematic Review Respiratory Conditions

Preventive Effect of Modified Okbyungpung-san for Children with Recurrent Upper Respiratory Tract Infections: A Systematic Review

한예진, 김주영, 정승민, et al. Pediatric Infectious Disease Journal (2024)
9 studies Analyzed studies
742 patients Total study population
IgG/IgA increase Immune indicator improvement

Summary

Nine clinical studies (total 742 patients) evaluating the preventive effect of modified Okbyungpung-san for children with recurrent respiratory tract infections (RRTI) were systematically reviewed. Most studies showed significantly reduced infection frequency in the Okbyungpung-san group, with reported IgG and IgA level elevations.

Key Conclusion

Modified Okbyungpung-san is an effective herbal medicine prescription for immunity enhancement and infection prevention in children with RRTI, with sufficient evidence accumulating.

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Cohort Study Respiratory Conditions

Pulmonary Rehabilitation Effect of Combined Acupuncture and Doin Exercise for Long COVID Dyspnea: A Cohort Study

조민서, 박현우, 김예은, et al.

Respiratory Medicine (2023)

67 m 6-min walk distance increase
136 patients Study population
12 weeks Program duration

Korean medicine pulmonary rehabilitation based on acupuncture and Doin exercise shows equivalent or superior effects to standard pulmonary rehabilitation in exercise capacity recovery and symptom improvement of long COVID dyspnea patients.

View Source 2023
Cohort Study Respiratory Conditions

Pulmonary Rehabilitation Effect of Combined Acupuncture and Doin Exercise for Long COVID Dyspnea: A Cohort Study

조민서, 박현우, 김예은, et al. Respiratory Medicine (2023)
67 m 6-min walk distance increase
136 patients Study population
12 weeks Program duration

Summary

A prospective cohort study comparing a 12-week Korean medicine pulmonary rehabilitation program including acupuncture and Doin exercise versus a standard pulmonary rehabilitation program in 136 patients with persistent dyspnea due to COVID-19 sequelae. The Korean medicine pulmonary rehabilitation group showed average 67 m increase in 6-minute walk distance, with significantly improved mMRC dyspnea scale.

Key Conclusion

Korean medicine pulmonary rehabilitation based on acupuncture and Doin exercise shows equivalent or superior effects to standard pulmonary rehabilitation in exercise capacity recovery and symptom improvement of long COVID dyspnea patients.

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