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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 1642 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Systematic Review Skin Conditions

Systematic Review of Korean Medicine Treatment for Chronic Urticaria

Oh JY, Min KS, et al.

Allergy, Asthma & Clinical Immunology (2024)

22 studies Included studies
18 studies Positive results
Moderate Evidence level

Korean medicine treatment is an effective complementary treatment option for chronic urticaria management.

View Source 2024
Systematic Review Skin Conditions

Systematic Review of Korean Medicine Treatment for Chronic Urticaria

Oh JY, Min KS, et al. Allergy, Asthma & Clinical Immunology (2024)
22 studies Included studies
18 studies Positive results
Moderate Evidence level

Summary

Twenty-two studies on Korean medicine treatment for chronic urticaria were systematically reviewed. Both herbal medicine and acupuncture treatment showed positive results in UAS7 reduction and quality of life improvement.

Key Conclusion

Korean medicine treatment is an effective complementary treatment option for chronic urticaria management.

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Before-After Skin Conditions

Effect of Herbal Medicine Treatment on TNF-α and IL-17 Pathways in Psoriasis Patients

Song WH, Kim JK, et al.

Cytokine (2023)

60 patients Participants
35% IL-17A reduction
12 weeks Treatment duration

Cheongyeoljihwang-tang directly acts on immunological mechanisms of psoriasis by suppressing TNF-α and IL-17 pathways.

View Source 2023
Before-After Skin Conditions

Effect of Herbal Medicine Treatment on TNF-α and IL-17 Pathways in Psoriasis Patients

Song WH, Kim JK, et al. Cytokine (2023)
60 patients Participants
35% IL-17A reduction
12 weeks Treatment duration

Summary

Cheongyeoljihwang-tang was administered for 12 weeks to 60 patients with moderate psoriasis, and changes in blood TNF-α, IL-17A, and IL-23 were tracked. All three cytokines significantly decreased and showed positive correlation with PASI scores.

Key Conclusion

Cheongyeoljihwang-tang directly acts on immunological mechanisms of psoriasis by suppressing TNF-α and IL-17 pathways.

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Meta-Analysis Skin Conditions

Recurrence Prevention Effect of Korean Medicine Treatment for Atopic Dermatitis: A Meta-Analysis

Kwon SH, Lee AR, Huang Y, et al.

Annals of Dermatology (2025)

12 studies Included studies
1,050 patients Total participants
OR 0.48 Recurrence risk reduction

Korean medicine treatment shows superior long-term effects to steroid treatment in atopic dermatitis recurrence prevention.

View Source 2025
Meta-Analysis Skin Conditions

Recurrence Prevention Effect of Korean Medicine Treatment for Atopic Dermatitis: A Meta-Analysis

Kwon SH, Lee AR, Huang Y, et al. Annals of Dermatology (2025)
12 studies Included studies
1,050 patients Total participants
OR 0.48 Recurrence risk reduction

Summary

Twelve RCTs (total 1,050 patients) evaluating recurrence prevention effects of Korean medicine treatment for atopic dermatitis were meta-analyzed. The Korean medicine treatment group showed significantly lower 6-month recurrence rates.

Key Conclusion

Korean medicine treatment shows superior long-term effects to steroid treatment in atopic dermatitis recurrence prevention.

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Cross-Sectional Skin Conditions

Patient Satisfaction and Treatment Experience with Korean Medicine Skin Treatment: A Qualitative Study

Jeon SY, Go MK, et al.

BMC Complementary Medicine and Therapies (2022)

25 patients Interview subjects
92% Re-use intention
6 themes Major themes

Patients highly valued the root-cause treatment approach and low side effects of Korean medicine skin treatment.

View Source 2022
Cross-Sectional Skin Conditions

Patient Satisfaction and Treatment Experience with Korean Medicine Skin Treatment: A Qualitative Study

Jeon SY, Go MK, et al. BMC Complementary Medicine and Therapies (2022)
25 patients Interview subjects
92% Re-use intention
6 themes Major themes

Summary

In-depth interviews were conducted with 25 patients who had received Korean medicine skin treatment for 6 months or more to qualitatively analyze treatment experience, satisfaction, and perceptions.

Key Conclusion

Patients highly valued the root-cause treatment approach and low side effects of Korean medicine skin treatment.

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Before-After Skin Conditions

Anti-Inflammatory Effect of Hwangryeonhaedok-tang Topical Preparation for Eczema: In Vitro and Clinical Studies

Ryu SJ, Kim BH, et al.

Journal of Ethnopharmacology (2024)

30 patients Participants
48% EASI reduction
4 weeks Treatment duration

Hwangryeonhaedok-tang topical preparation effectively alleviates eczema symptoms through anti-inflammatory mechanisms.

View Source 2024
Before-After Skin Conditions

Anti-Inflammatory Effect of Hwangryeonhaedok-tang Topical Preparation for Eczema: In Vitro and Clinical Studies

Ryu SJ, Kim BH, et al. Journal of Ethnopharmacology (2024)
30 patients Participants
48% EASI reduction
4 weeks Treatment duration

Summary

Anti-inflammatory effects of Hwangryeonhaedok-tang topical preparation were confirmed through HaCaT cell experiments and a pre-post comparison study in 30 patients with eczema. In cell experiments, IL-6 and IL-8 expression was suppressed, and EASI scores decreased clinically.

Key Conclusion

Hwangryeonhaedok-tang topical preparation effectively alleviates eczema symptoms through anti-inflammatory mechanisms.

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Cohort Study Skin Conditions

Simultaneous Skin-Joint Improvement Effect of Korean Medicine Combination Therapy in Patients with Comorbid Psoriatic Arthritis

Park KH, Lee YM, et al.

Rheumatology International (2023)

50 patients Participants
42% PASI improvement
38% DAS28 improvement

Korean medicine combination therapy is effective in simultaneously managing skin and joint symptoms in patients with psoriatic arthritis.

View Source 2023
Cohort Study Skin Conditions

Simultaneous Skin-Joint Improvement Effect of Korean Medicine Combination Therapy in Patients with Comorbid Psoriatic Arthritis

Park KH, Lee YM, et al. Rheumatology International (2023)
50 patients Participants
42% PASI improvement
38% DAS28 improvement

Summary

Korean medicine combination therapy with herbal medicine and acupuncture was performed for 16 weeks on 50 patients with comorbid psoriatic arthritis, and PASI, DAS28, and HAQ were evaluated. Both skin and joint symptoms simultaneously and significantly improved.

Key Conclusion

Korean medicine combination therapy is effective in simultaneously managing skin and joint symptoms in patients with psoriatic arthritis.

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Before-After Skin Conditions

Gut Microbiota Changes with Korean Medicine Treatment for Atopic Dermatitis: An Exploratory Study

Min SH, Cho YR, Wang L, et al.

Gut Microbes (2024)

40 patients Participants
Microbiota changes Major finding
r=-0.62 SCORAD correlation

Herbal medicine has a mechanism of improving atopic dermatitis through gut microbiota modulation.

View Source 2024
Before-After Skin Conditions

Gut Microbiota Changes with Korean Medicine Treatment for Atopic Dermatitis: An Exploratory Study

Min SH, Cho YR, Wang L, et al. Gut Microbes (2024)
40 patients Participants
Microbiota changes Major finding
r=-0.62 SCORAD correlation

Summary

Herbal medicine was administered for 12 weeks to 40 atopic dermatitis patients, with gut microbiota analysis performed before and after. After herbal medicine administration, Lactobacillus and Bifidobacterium increased and SCORAD decreased.

Key Conclusion

Herbal medicine has a mechanism of improving atopic dermatitis through gut microbiota modulation.

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RCT Skin Conditions

Effect of Korean Medicine Treatment for Adult Acne: A Randomized Controlled Trial

Lee GH, Song KS, et al.

Journal of Cosmetic Dermatology (2023)

80 patients Participants
Non-inferiority confirmed Primary outcome
8 weeks Treatment duration

Korean medicine treatment shows similar effects to oral antibiotics in adult acne with superior safety.

View Source 2023
RCT Skin Conditions

Effect of Korean Medicine Treatment for Adult Acne: A Randomized Controlled Trial

Lee GH, Song KS, et al. Journal of Cosmetic Dermatology (2023)
80 patients Participants
Non-inferiority confirmed Primary outcome
8 weeks Treatment duration

Summary

Eighty adult acne (25 years or older) patients were randomly assigned to herbal medicine plus acupuncture or oral antibiotic groups and compared over 8 weeks. Both groups showed similar effects, but adverse effects were significantly fewer in the Korean medicine treatment group.

Key Conclusion

Korean medicine treatment shows similar effects to oral antibiotics in adult acne with superior safety.

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Before-After Skin Conditions

Histamine-Independent Mechanism Study of Gamisoyo-san in Urticaria Patients

Han MJ, Kim TY, et al.

Frontiers in Pharmacology (2025)

45 patients Participants
58% UAS7 improvement
12 weeks Treatment duration

Gamisoyo-san can manage chronic urticaria through histamine-independent pathways.

View Source 2025
Before-After Skin Conditions

Histamine-Independent Mechanism Study of Gamisoyo-san in Urticaria Patients

Han MJ, Kim TY, et al. Frontiers in Pharmacology (2025)
45 patients Participants
58% UAS7 improvement
12 weeks Treatment duration

Summary

Gamisoyo-san was administered for 12 weeks to 45 patients with chronic urticaria unresponsive to antihistamines, and UAS7, mast cell degranulation markers, and autonomic function were evaluated. Symptoms and biomarkers improved after herbal medicine administration.

Key Conclusion

Gamisoyo-san can manage chronic urticaria through histamine-independent pathways.

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Before-After Skin Conditions

Effect of Herbal Bath Therapy in Psoriasis Patients: A Pre-Post Comparison Study

Yoon HK, Oh DS, et al.

Complementary Therapies in Clinical Practice (2022)

40 patients Participants
35% PASI improvement
6 weeks Treatment duration

Herbal bath therapy is an adjunctive treatment that improves skin symptoms and quality of life in psoriasis patients.

View Source 2022
Before-After Skin Conditions

Effect of Herbal Bath Therapy in Psoriasis Patients: A Pre-Post Comparison Study

Yoon HK, Oh DS, et al. Complementary Therapies in Clinical Practice (2022)
40 patients Participants
35% PASI improvement
6 weeks Treatment duration

Summary

Herbal bathing based on Sophora flavescens, Dictamnus, and Cnidium was performed for 6 weeks on 40 patients with moderate psoriasis, and PASI, BSA, and DLQI were evaluated. All three indicators significantly improved.

Key Conclusion

Herbal bath therapy is an adjunctive treatment that improves skin symptoms and quality of life in psoriasis patients.

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Cohort Study Skin Conditions

Steroid-Sparing Effect of Herbal Medicine Treatment in Atopic Dermatitis Patients: A Cohort Study

Kwon DH, Shin MK, Sato Y, et al.

British Journal of Dermatology (2024)

160 patients Participants
45% Steroid reduction
24 weeks Follow-up period

Herbal medicine combination is effective in reducing topical steroid dependence in atopic dermatitis patients.

View Source 2024
Cohort Study Skin Conditions

Steroid-Sparing Effect of Herbal Medicine Treatment in Atopic Dermatitis Patients: A Cohort Study

Kwon DH, Shin MK, Sato Y, et al. British Journal of Dermatology (2024)
160 patients Participants
45% Steroid reduction
24 weeks Follow-up period

Summary

One hundred sixty atopic dermatitis patients using topical steroids were followed for 24 weeks for steroid use, divided into an herbal medicine combination group and a non-combination group. Steroid use significantly decreased in the herbal medicine combination group.

Key Conclusion

Herbal medicine combination is effective in reducing topical steroid dependence in atopic dermatitis patients.

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Cross-Sectional Skin Conditions

Correlation Between Korean Medicine Pattern Differentiation and Skin Microbiota in Eczema Patients: A Cross-Sectional Study

Cho KM, Lee SH, et al.

Journal of Investigative Dermatology (2023)

120 patients Analysis population
4 types Pattern types
p<0.01 Microbiota differences

Korean medicine pattern differentiation in eczema is associated with skin microbiota composition and can be utilized for pattern-tailored treatment.

View Source 2023
Cross-Sectional Skin Conditions

Correlation Between Korean Medicine Pattern Differentiation and Skin Microbiota in Eczema Patients: A Cross-Sectional Study

Cho KM, Lee SH, et al. Journal of Investigative Dermatology (2023)
120 patients Analysis population
4 types Pattern types
p<0.01 Microbiota differences

Summary

A cross-sectional study performing Korean medicine pattern differentiation and skin microbiota analysis in 120 patients with eczema. The damp-heat pattern showed significantly higher Staphylococcus aureus ratios.

Key Conclusion

Korean medicine pattern differentiation in eczema is associated with skin microbiota composition and can be utilized for pattern-tailored treatment.

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