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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 1642 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Cross-Sectional Men's Health / Urology

Effect of Herbal Medicine Treatment on Sperm DNA Fragmentation Reduction in Male Infertility: A Cross-Sectional Analysis

Cho HY, Lee SM, Nguyen VT, et al.

Reproductive BioMedicine Online (2023)

200 subjects Analysis Subjects
31% DFI Reduction Rate
p<0.01 Statistical Significance

Longer herbal medicine treatment duration showed significant correlation with reduction in sperm DNA fragmentation index.

View Source 2023
Cross-Sectional Men's Health / Urology

Effect of Herbal Medicine Treatment on Sperm DNA Fragmentation Reduction in Male Infertility: A Cross-Sectional Analysis

Cho HY, Lee SM, Nguyen VT, et al. Reproductive BioMedicine Online (2023)
200 subjects Analysis Subjects
31% DFI Reduction Rate
p<0.01 Statistical Significance

Summary

Medical records of 200 male infertility patients who received herbal medicine treatment were cross-sectionally analyzed to evaluate changes in sperm DNA fragmentation index (DFI). DFI was significantly lower in the group treated for more than 3 months.

Key Conclusion

Longer herbal medicine treatment duration showed significant correlation with reduction in sperm DNA fragmentation index.

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Meta-Analysis Men's Health / Urology

Efficacy and Safety of Korean Medicine Treatment for Male Climacteric Syndrome: A Meta-Analysis

Yang SJ, Hwang EH, Kim JS, et al.

Maturitas (2024)

14 RCTs Number of RCTs
1,180 subjects Total Participants
OR 2.34 Effect Size

Korean medicine treatment showed significant effects on symptom improvement and hormone level normalization in male climacteric syndrome.

View Source 2024
Meta-Analysis Men's Health / Urology

Efficacy and Safety of Korean Medicine Treatment for Male Climacteric Syndrome: A Meta-Analysis

Yang SJ, Hwang EH, Kim JS, et al. Maturitas (2024)
14 RCTs Number of RCTs
1,180 subjects Total Participants
OR 2.34 Effect Size

Summary

A meta-analysis of 14 RCTs evaluating the effect of Korean medicine treatment (herbal medicine, acupuncture, pharmacopuncture) for male climacteric syndrome was conducted. Data from a total of 1,180 subjects were included.

Key Conclusion

Korean medicine treatment showed significant effects on symptom improvement and hormone level normalization in male climacteric syndrome.

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Case Study Men's Health / Urology

Effect of Korean Medicine Heat Therapy on Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Case Report

Im DS, Kang YG, et al.

Journal of Korean Medicine Rehabilitation (2022)

5 cases Number of Cases
52% Pain Reduction Rate
4 weeks Treatment Period

Korean medicine heat therapy can be utilized as adjunctive treatment for pain and urinary symptom relief in chronic prostatitis patients.

View Source 2022
Case Study Men's Health / Urology

Effect of Korean Medicine Heat Therapy on Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Case Report

Im DS, Kang YG, et al. Journal of Korean Medicine Rehabilitation (2022)
5 cases Number of Cases
52% Pain Reduction Rate
4 weeks Treatment Period

Summary

A case report on 5 patients with chronic prostatitis/chronic pelvic pain syndrome who received Korean medicine sitz bath and moxibustion treatment in combination. After 4 weeks of treatment, pain VAS and NIH-CPSI scores improved.

Key Conclusion

Korean medicine heat therapy can be utilized as adjunctive treatment for pain and urinary symptom relief in chronic prostatitis patients.

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Narrative Review Men's Health / Urology

Experimental Review on the Effect of Palmijihwang-hwan on Male Sexual Function Improvement

Son JE, Min BW, Park KJ, et al.

Journal of Ethnopharmacology (2020)

28 sources Reviewed Literature
3 mechanisms Main Mechanisms
87% Positive Results

Palmijihwang-hwan improves male sexual function through multiple mechanisms, and future large-scale clinical trials are needed.

View Source 2020
Narrative Review Men's Health / Urology

Experimental Review on the Effect of Palmijihwang-hwan on Male Sexual Function Improvement

Son JE, Min BW, Park KJ, et al. Journal of Ethnopharmacology (2020)
28 sources Reviewed Literature
3 mechanisms Main Mechanisms
87% Positive Results

Summary

Twenty-eight animal experiments and clinical studies were comprehensively reviewed to investigate the male sexual function improvement mechanism of Palmijihwang-hwan. Various mechanisms including NO production promotion and testosterone synthesis increase were confirmed.

Key Conclusion

Palmijihwang-hwan improves male sexual function through multiple mechanisms, and future large-scale clinical trials are needed.

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Cohort Study Men's Health / Urology

Effect of Pharmacopuncture Treatment on Prostate Symptom Improvement in Urological Disorder Patients: A Cohort Study

Lim JH, Song KJ, Watanabe T, et al.

Urologia Internationalis (2023)

180 subjects Participants
12 months Follow-up Period
p<0.05 Statistical Significance

Combined pharmacopuncture treatment provides additional benefits for long-term management of prostate-related lower urinary tract symptoms.

View Source 2023
Cohort Study Men's Health / Urology

Effect of Pharmacopuncture Treatment on Prostate Symptom Improvement in Urological Disorder Patients: A Cohort Study

Lim JH, Song KJ, Watanabe T, et al. Urologia Internationalis (2023)
180 subjects Participants
12 months Follow-up Period
p<0.05 Statistical Significance

Summary

A cohort study tracking 180 men complaining of prostate symptoms for 12 months, divided into a pharmacopuncture combined treatment group and a herbal medicine alone group. IPSS and maximum flow rate improved significantly in the pharmacopuncture combined group.

Key Conclusion

Combined pharmacopuncture treatment provides additional benefits for long-term management of prostate-related lower urinary tract symptoms.

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RCT Men's Health / Urology

Effect of Deer Antler-Red Ginseng Combined Extract on Oligospermia Men: A Randomized Controlled Trial

Ahn TY, Chung MK, Lee SG, et al.

Journal of Ginseng Research (2024)

70 subjects Participants
28% Sperm Concentration Increase
p<0.01 Statistical Significance

The deer antler-red ginseng combined extract is effective for improving semen parameters in oligospermia men.

View Source 2024
RCT Men's Health / Urology

Effect of Deer Antler-Red Ginseng Combined Extract on Oligospermia Men: A Randomized Controlled Trial

Ahn TY, Chung MK, Lee SG, et al. Journal of Ginseng Research (2024)
70 subjects Participants
28% Sperm Concentration Increase
p<0.01 Statistical Significance

Summary

A double-blind randomized controlled trial in which a deer antler-red ginseng combined extract was administered for 12 weeks to 70 men with oligospermia. The treatment group showed significant increases in sperm concentration and total motile sperm count.

Key Conclusion

The deer antler-red ginseng combined extract is effective for improving semen parameters in oligospermia men.

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Before-After Men's Health / Urology

Effect of Korean Medicine Rehabilitation on Urinary Incontinence Recovery After Prostate Cancer Surgery

Go YJ, Kim HN, et al.

Supportive Care in Cancer (2022)

40 subjects Participants
62% Urinary Incontinence Improvement Rate
6 months Treatment Period

Korean medicine rehabilitation treatment can promote urinary incontinence recovery after prostate cancer surgery.

View Source 2022
Before-After Men's Health / Urology

Effect of Korean Medicine Rehabilitation on Urinary Incontinence Recovery After Prostate Cancer Surgery

Go YJ, Kim HN, et al. Supportive Care in Cancer (2022)
40 subjects Participants
62% Urinary Incontinence Improvement Rate
6 months Treatment Period

Summary

A rehabilitation program combining acupuncture treatment and pelvic floor muscle exercises was administered for 6 months to 40 patients with urinary incontinence after radical prostatectomy for prostate cancer. Urinary incontinence pad usage and I-QOL scores improved significantly.

Key Conclusion

Korean medicine rehabilitation treatment can promote urinary incontinence recovery after prostate cancer surgery.

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Cross-Sectional Men's Health / Urology

Analysis of Korean Medicine Treatment Patterns for Male Urological Symptoms: A Multicenter Cross-Sectional Study

Seo JH, Baek SH, Wu Y, et al.

BMC Urology (2021)

850 subjects Analysis Subjects
12 institutions Participating Institutions
78% Acupuncture Combination Rate

In Korean medicine, kidney deficiency pattern is most frequent in male urological disorders, and development of standardized treatment guidelines is needed.

View Source 2021
Cross-Sectional Men's Health / Urology

Analysis of Korean Medicine Treatment Patterns for Male Urological Symptoms: A Multicenter Cross-Sectional Study

Seo JH, Baek SH, Wu Y, et al. BMC Urology (2021)
850 subjects Analysis Subjects
12 institutions Participating Institutions
78% Acupuncture Combination Rate

Summary

Medical records of 850 patients who visited 12 Korean medicine hospitals nationwide for male urological symptoms were cross-sectionally analyzed. The most frequent prescription was Palmijihwang-hwan, and the acupuncture treatment combination rate was 78%.

Key Conclusion

In Korean medicine, kidney deficiency pattern is most frequent in male urological disorders, and development of standardized treatment guidelines is needed.

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RCT Men's Health / Urology

RCT on Whether Herbal Medicine Combination Enhances PDE5 Inhibitor Effects in Erectile Dysfunction Patients

Min KJ, Yoo DH, Suzuki A, et al.

International Journal of Impotence Research (2025)

100 subjects Participants
4.7 points Additional IIEF-EF Improvement
16 weeks Treatment Period

Combined herbal medicine administration can additionally improve erectile function in PDE5 inhibitor partial responders.

View Source 2025
RCT Men's Health / Urology

RCT on Whether Herbal Medicine Combination Enhances PDE5 Inhibitor Effects in Erectile Dysfunction Patients

Min KJ, Yoo DH, Suzuki A, et al. International Journal of Impotence Research (2025)
100 subjects Participants
4.7 points Additional IIEF-EF Improvement
16 weeks Treatment Period

Summary

One hundred patients with erectile dysfunction showing partial response to PDE5 inhibitors were randomly assigned to herbal medicine combined and PDE5 alone groups and compared for 16 weeks. IIEF-EF domain scores were significantly higher in the herbal medicine combined group.

Key Conclusion

Combined herbal medicine administration can additionally improve erectile function in PDE5 inhibitor partial responders.

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Cohort Study Men's Health / Urology

Long-Term Prognosis Tracking of Male Climacteric Patients Receiving Korean Medicine Treatment: A 5-Year Cohort

Noh SY, Jeon HK, Park MR, et al.

Aging Male (2023)

250 subjects Participants
5 years Follow-up Period
82% Long-term Improvement Maintenance Rate

Korean medicine treatment showed significant effects on improving long-term prognosis of male climacteric patients.

View Source 2023
Cohort Study Men's Health / Urology

Long-Term Prognosis Tracking of Male Climacteric Patients Receiving Korean Medicine Treatment: A 5-Year Cohort

Noh SY, Jeon HK, Park MR, et al. Aging Male (2023)
250 subjects Participants
5 years Follow-up Period
82% Long-term Improvement Maintenance Rate

Summary

A prospective cohort study following 250 male climacteric patients receiving Korean medicine treatment for 5 years. AMS scores and quality of life continuously improved, and cardiovascular event incidence was also lower than the control group.

Key Conclusion

Korean medicine treatment showed significant effects on improving long-term prognosis of male climacteric patients.

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Before-After Men's Health / Urology

Effect of Gongjindan in Middle-Aged Men Complaining of Vitality Decline: A Pre-Post Comparison Study

Hwang CJ, Lee AR, et al.

Journal of Korean Medicine (2020)

50 subjects Participants
71% Sexual Function Improvement Rate
8 weeks Treatment Period

Gongjindan is effective for improving vitality decline and overall vitality reduction in middle-aged men.

View Source 2020
Before-After Men's Health / Urology

Effect of Gongjindan in Middle-Aged Men Complaining of Vitality Decline: A Pre-Post Comparison Study

Hwang CJ, Lee AR, et al. Journal of Korean Medicine (2020)
50 subjects Participants
71% Sexual Function Improvement Rate
8 weeks Treatment Period

Summary

Gongjindan was administered for 8 weeks to 50 men aged 45-60 complaining of vitality decline, and sexual function, vitality, and sleep quality were evaluated. All three indicators improved significantly.

Key Conclusion

Gongjindan is effective for improving vitality decline and overall vitality reduction in middle-aged men.

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Systematic Review Men's Health / Urology

Additional Effect of Moxibustion Combination in Benign Prostatic Hyperplasia Korean Medicine Treatment: A Systematic Review

Jung YK, Oh MH, Zhao J, et al.

Moxibustion Medicine Research (2024)

10 studies Included Studies
67% Nocturia Improvement
Moderate Evidence Level

Moxibustion treatment has utility value as an adjunctive intervention in benign prostatic hyperplasia Korean medicine treatment.

View Source 2024
Systematic Review Men's Health / Urology

Additional Effect of Moxibustion Combination in Benign Prostatic Hyperplasia Korean Medicine Treatment: A Systematic Review

Jung YK, Oh MH, Zhao J, et al. Moxibustion Medicine Research (2024)
10 studies Included Studies
67% Nocturia Improvement
Moderate Evidence Level

Summary

Ten studies combining moxibustion treatment in benign prostatic hyperplasia treatment were systematically reviewed. The moxibustion combined group showed superior improvements in nocturia and residual urine sensation.

Key Conclusion

Moxibustion treatment has utility value as an adjunctive intervention in benign prostatic hyperplasia Korean medicine treatment.

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