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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 1642 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Meta-Analysis TMJ Disorder

Effect of acupuncture on temporomandibular disorder pain: a systematic review and meta-analysis

La Touche R, Goddard G, De-la-Hoz JL, et al.

Journal of Alternative and Complementary Medicine (2010)

72% Pain Improvement
4.3mm Mouth Opening Increase
7 Studies Studies Included

Acupuncture-moxibustion shows significant effects on pain relief and functional recovery in TMD patients, and may be considered as a first-line treatment option particularly in the masticatory myofascial pain subtype.

View Source 2010
Meta-Analysis TMJ Disorder

Effect of acupuncture on temporomandibular disorder pain: a systematic review and meta-analysis

La Touche R, Goddard G, De-la-Hoz JL, et al. Journal of Alternative and Complementary Medicine (2010)
72% Pain Improvement
4.3mm Mouth Opening Increase
7 Studies Studies Included

Summary

A meta-analysis of 7 RCTs on acupuncture for TMD patients showed the acupuncture group reduced VAS pain scores by an average 2.2 points (out of 10) more than controls. The largest effect size appeared in the myofascial pain subtype.

Key Conclusion

Acupuncture-moxibustion shows significant effects on pain relief and functional recovery in TMD patients, and may be considered as a first-line treatment option particularly in the masticatory myofascial pain subtype.

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RCT TMJ Disorder

Comparison of pharmacopuncture vs. physical therapy for temporomandibular disorder: a randomized controlled trial

Kim TH, Kang JW, Kim KH, et al.

Journal of Korean Medicine (2021)

41% Pressure Threshold Increase
89% Patient Satisfaction
6 Weeks Treatment Duration

Pharmacopuncture therapy demonstrates superior effects compared to physical therapy in reducing masticatory muscle tenderness and recovering function in chronic TMD patients, and can be utilized as a core component of non-surgical integrated treatment.

View Source 2021
RCT TMJ Disorder

Comparison of pharmacopuncture vs. physical therapy for temporomandibular disorder: a randomized controlled trial

Kim TH, Kang JW, Kim KH, et al. Journal of Korean Medicine (2021)
41% Pressure Threshold Increase
89% Patient Satisfaction
6 Weeks Treatment Duration

Summary

A 6-week RCT in 86 patients with chronic TMD comparing pharmacopuncture vs. physical therapy (TENS + ultrasound). The pharmacopuncture group raised masticatory muscle pain pressure threshold by an average 41% from baseline — significantly more than physical therapy (23%).

Key Conclusion

Pharmacopuncture therapy demonstrates superior effects compared to physical therapy in reducing masticatory muscle tenderness and recovering function in chronic TMD patients, and can be utilized as a core component of non-surgical integrated treatment.

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Narrative Review TMJ Disorder

Effect of combined herbal prescriptions on TMD-related tinnitus and headache: a prospective observational study

Cho SH, Kim JH, Lee YJ, et al.

Journal of Korean Medicine (2023)

46% Mouth Opening Increase
72% Accompanying Symptom Improvement
48 Patients Participants

Integrated Korean medicine treatment significantly improved not only joint function in temporomandibular disorder but also accompanying symptoms such as tinnitus and headache, confirming the validity of an integrated treatment approach.

View Source 2023
Narrative Review TMJ Disorder

Effect of combined herbal prescriptions on TMD-related tinnitus and headache: a prospective observational study

Cho SH, Kim JH, Lee YJ, et al. Journal of Korean Medicine (2023)
46% Mouth Opening Increase
72% Accompanying Symptom Improvement
48 Patients Participants

Summary

An 8-week observational study of 48 patients with TMD accompanied by tinnitus/headache receiving herbal medicine (modified So-shi-ho-tang) with acupuncture and chuna therapy. Mouth opening increased from 28mm to 41mm on average, and accompanying symptoms (tinnitus/headache) improved in 72%.

Key Conclusion

Integrated Korean medicine treatment significantly improved not only joint function in temporomandibular disorder but also accompanying symptoms such as tinnitus and headache, confirming the validity of an integrated treatment approach.

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RCT ENT Disorders

Randomized Controlled Trial of Combined Intranasal Pharmacopuncture and Herbal Medicine for Chronic Sinusitis

Yang JC, Lee SH, Moon JY, et al.

BMC Complementary Medicine and Therapies (2023)

84.3% Combination Group Improvement Rate
102 subjects Participants
p=0.003 Inter-group Significance

Combined intranasal pharmacopuncture and herbal medicine demonstrated superior therapeutic effects over herbal medicine monotherapy in chronic sinusitis patients.

View Source 2023
RCT ENT Disorders

Randomized Controlled Trial of Combined Intranasal Pharmacopuncture and Herbal Medicine for Chronic Sinusitis

Yang JC, Lee SH, Moon JY, et al. BMC Complementary Medicine and Therapies (2023)
84.3% Combination Group Improvement Rate
102 subjects Participants
p=0.003 Inter-group Significance

Summary

One hundred two patients with chronic sinusitis were randomized to pharmacopuncture plus herbal medicine combination (51) or herbal medicine monotherapy (51) groups for 8 weeks. The combination group demonstrated significantly greater improvements in Lund-Mackay CT scores and SNOT-22 scores.

Key Conclusion

Combined intranasal pharmacopuncture and herbal medicine demonstrated superior therapeutic effects over herbal medicine monotherapy in chronic sinusitis patients.

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Cross-Sectional ENT Disorders

Cross-Sectional Study on Mucociliary Function Recovery Effect of Herbal Medicine Treatment for Sinusitis

Shin JW, Ko SG, Choi SM, et al.

Complementary Therapies in Medicine (2020)

34.2% Ciliary Transport Time Reduction
236 subjects Total Subjects
p=0.008 Statistical Significance

Herbal medicine treatment exerts a positive influence on mucociliary function recovery in sinusitis patients.

View Source 2020
Cross-Sectional ENT Disorders

Cross-Sectional Study on Mucociliary Function Recovery Effect of Herbal Medicine Treatment for Sinusitis

Shin JW, Ko SG, Choi SM, et al. Complementary Therapies in Medicine (2020)
34.2% Ciliary Transport Time Reduction
236 subjects Total Subjects
p=0.008 Statistical Significance

Summary

Mucociliary transport time was comparatively analyzed between 156 sinusitis patients receiving herbal medicine treatment and 80 untreated controls. The herbal treatment group demonstrated significantly shorter saccharin test times.

Key Conclusion

Herbal medicine treatment exerts a positive influence on mucociliary function recovery in sinusitis patients.

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Case Study ENT Disorders

Personalized Herbal Treatment Case Series for Allergic Rhinitis in Soyangin Constitution

Heo J, Ahn HY, Shin YC, et al.

Explore (2022)

15 cases Number of Cases
TNSS 58% reduction Nasal Symptom Improvement
12 weeks Treatment Period

Soyangin constitution-tailored herbal prescriptions are an effective approach for managing allergic rhinitis symptoms.

View Source 2022
Case Study ENT Disorders

Personalized Herbal Treatment Case Series for Allergic Rhinitis in Soyangin Constitution

Heo J, Ahn HY, Shin YC, et al. Explore (2022)
15 cases Number of Cases
TNSS 58% reduction Nasal Symptom Improvement
12 weeks Treatment Period

Summary

Fifteen patients with allergic rhinitis diagnosed as Soyangin constitution received constitution-tailored herbal medicine, and symptom changes were observed for 12 weeks. Total Nasal Symptom Score (TNSS) and nasal endoscopy findings showed overall improvement.

Key Conclusion

Soyangin constitution-tailored herbal prescriptions are an effective approach for managing allergic rhinitis symptoms.

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Before-After ENT Disorders

Effect of Imyeongumheo-tang Administration for Noise-Induced Hearing Loss Prevention: A Pre-Post Comparison Study

Kim TH, Jung SY, Bae HS, et al.

대한한방이비인후피부과학회지 (2024)

7.2 dB Hearing Threshold Improvement
34%→19% Tinnitus Comorbidity Reduction
58 subjects Participants

Imyeongumheo-tang may contribute to delaying the progression of noise-induced hearing loss and reducing accompanying tinnitus occurrence.

View Source 2024
Before-After ENT Disorders

Effect of Imyeongumheo-tang Administration for Noise-Induced Hearing Loss Prevention: A Pre-Post Comparison Study

Kim TH, Jung SY, Bae HS, et al. 대한한방이비인후피부과학회지 (2024)
7.2 dB Hearing Threshold Improvement
34%→19% Tinnitus Comorbidity Reduction
58 subjects Participants

Summary

Fifty-eight workers in noise-exposed environments received Imyeongumheo-tang for 12 weeks, with pre- and post-treatment pure tone audiometry compared. Hearing thresholds improved by an average of 7.2 dB in high-frequency ranges (4 kHz, 8 kHz), and the rate of accompanying tinnitus decreased from 34% to 19%.

Key Conclusion

Imyeongumheo-tang may contribute to delaying the progression of noise-induced hearing loss and reducing accompanying tinnitus occurrence.

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Systematic Review Men's Health / Urology

Effect of Herbal Medicine Treatment on Semen Parameter Improvement in Male Infertility Patients: A Systematic Review and Meta-Analysis

김동현, 이재훈, 박성민, et al.

Journal of Ethnopharmacology (2024)

67.3% Sperm Motility Improvement Rate
1.8 fold Sperm Concentration Increase
p<0.001 Statistical Significance

Herbal medicine treatment significantly improves semen parameters in male infertility patients and can contribute to pregnancy rate improvement when combined with assisted reproductive technology.

View Source 2024
Systematic Review Men's Health / Urology

Effect of Herbal Medicine Treatment on Semen Parameter Improvement in Male Infertility Patients: A Systematic Review and Meta-Analysis

김동현, 이재훈, 박성민, et al. Journal of Ethnopharmacology (2024)
67.3% Sperm Motility Improvement Rate
1.8 fold Sperm Concentration Increase
p<0.001 Statistical Significance

Summary

A systematic review and meta-analysis analyzing the effect of herbal medicine treatment on semen parameter improvement in 1,247 male infertility patients. Twenty-three randomized controlled trials were included, and the herbal medicine administration group showed significant improvements in sperm concentration, motility, and normal morphology rate. The highest effect size was observed in Ojayeonjong-hwan-based prescriptions.

Key Conclusion

Herbal medicine treatment significantly improves semen parameters in male infertility patients and can contribute to pregnancy rate improvement when combined with assisted reproductive technology.

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Systematic Review Men's Health / Urology

Effect of Epimedium-Based Herbal Medicine on Erectile Dysfunction (ED): A Systematic Review

신동혁, 문성환, 박준혁, et al.

Phytomedicine (2023)

5.8 points IIEF-5 Improvement
18 studies Included Studies
p=0.002 Statistical Significance

Epimedium-based herbal medicine is effective for mild-to-moderate erectile dysfunction and promotes corpus cavernosum relaxation through mechanisms similar to PDE5 inhibitors.

View Source 2023
Systematic Review Men's Health / Urology

Effect of Epimedium-Based Herbal Medicine on Erectile Dysfunction (ED): A Systematic Review

신동혁, 문성환, 박준혁, et al. Phytomedicine (2023)
5.8 points IIEF-5 Improvement
18 studies Included Studies
p=0.002 Statistical Significance

Summary

A systematic review analyzing the effect of Epimedium (icariin-containing)-based herbal medicine in erectile dysfunction patients. Eighteen clinical trials were included, and the Epimedium extract administration group showed an average IIEF-5 score improvement of 5.8 points. PDE5 inhibitory activity and NO/cGMP pathway activation were confirmed as main mechanisms.

Key Conclusion

Epimedium-based herbal medicine is effective for mild-to-moderate erectile dysfunction and promotes corpus cavernosum relaxation through mechanisms similar to PDE5 inhibitors.

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Meta-Analysis Men's Health / Urology

Effect of Combined Herbal Medicine and Acupuncture Treatment for Sexual Dysfunction: A Meta-Analysis of Randomized Controlled Trials

이정환, 김도윤, 최병훈, et al.

The Journal of Sexual Medicine (2024)

7.2 points IIEF Total Score Difference
892 subjects Total Subjects
14 RCTs Included RCTs

Combined herbal medicine and acupuncture treatment is effective for multidimensional improvement of male sexual dysfunction, with synergistic effects confirmed compared with single treatments.

View Source 2024
Meta-Analysis Men's Health / Urology

Effect of Combined Herbal Medicine and Acupuncture Treatment for Sexual Dysfunction: A Meta-Analysis of Randomized Controlled Trials

이정환, 김도윤, 최병훈, et al. The Journal of Sexual Medicine (2024)
7.2 points IIEF Total Score Difference
892 subjects Total Subjects
14 RCTs Included RCTs

Summary

A meta-analysis of 14 randomized controlled trials including 892 male sexual dysfunction patients. The combined herbal medicine and acupuncture treatment group showed an average IIEF total score improvement 7.2 points higher than the control group, with significant differences confirmed in all subdomains of libido, erectile function, orgasm, and sexual satisfaction.

Key Conclusion

Combined herbal medicine and acupuncture treatment is effective for multidimensional improvement of male sexual dysfunction, with synergistic effects confirmed compared with single treatments.

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Cohort Study ENT Disorders

Long-Term Effects of Korean Medicine Combination Therapy (Herbal Medicine, Acupuncture, Fumigation) for Chronic Sinusitis: A Cohort Study

박소영, 김재원, 정은지, et al.

대한한방내과학회지 (2023)

48% SNOT-22 improvement rate
98 patients Study population
72% Effect maintenance at 6 months

Korean medicine combination therapy is effective for long-term symptom management of chronic sinusitis and may contribute to recurrence reduction.

View Source 2023
Cohort Study ENT Disorders

Long-Term Effects of Korean Medicine Combination Therapy (Herbal Medicine, Acupuncture, Fumigation) for Chronic Sinusitis: A Cohort Study

박소영, 김재원, 정은지, et al. 대한한방내과학회지 (2023)
48% SNOT-22 improvement rate
98 patients Study population
72% Effect maintenance at 6 months

Summary

A cohort study performing 12 weeks of herbal medicine (modified Changi-san), acupuncture, and Korean medicine fumigation in 98 patients with chronic sinusitis of 1 year or more duration, with 6-month follow-up. SNOT-22 scores improved by average 48% at treatment end, and 72% of improvement was maintained at 6 months.

Key Conclusion

Korean medicine combination therapy is effective for long-term symptom management of chronic sinusitis and may contribute to recurrence reduction.

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Cohort Study Mental Health

Cohort Study of Herbal Medicine (Guibi-tang) for Geriatric Depression

Moon KW, Go JH, Shin BC, et al.

Aging & Mental Health (2024)

41% GDS Reduction
180 subjects Participants
24 weeks Follow-up Period

Guibi-tang is effective for improving geriatric depression and preventing accompanying cognitive decline.

View Source 2024
Cohort Study Mental Health

Cohort Study of Herbal Medicine (Guibi-tang) for Geriatric Depression

Moon KW, Go JH, Shin BC, et al. Aging & Mental Health (2024)
41% GDS Reduction
180 subjects Participants
24 weeks Follow-up Period

Summary

One hundred eighty elderly depression patients aged 65 and older were followed for 24 weeks, divided into Guibi-tang administration and non-administration groups. GDS scores decreased by 41% and cognitive function (MMSE) was significantly maintained in the Guibi-tang group.

Key Conclusion

Guibi-tang is effective for improving geriatric depression and preventing accompanying cognitive decline.

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