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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Total 1642 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Narrative Review Digestive Disorders

Brain-Gut Axis Modulation by Acupuncture for Chronic Abdominal Pain: A Narrative Review

Shin SM, Bae GE, Kim KW, et al.

Pain Research & Management (2023)

20 papers Reviewed Papers
ACC modulation Central Mechanism
Serotonin Gut Mechanism

Acupuncture modulates chronic abdominal pain at multiple levels of the brain-gut axis.

View Source 2023
Narrative Review Digestive Disorders

Brain-Gut Axis Modulation by Acupuncture for Chronic Abdominal Pain: A Narrative Review

Shin SM, Bae GE, Kim KW, et al. Pain Research & Management (2023)
20 papers Reviewed Papers
ACC modulation Central Mechanism
Serotonin Gut Mechanism

Summary

Twenty articles on the brain-gut axis modulation mechanism of acupuncture for chronic abdominal pain were reviewed. Acupuncture demonstrated effects on ACC (anterior cingulate cortex) activity modulation and intestinal serotonin homeostasis restoration.

Key Conclusion

Acupuncture modulates chronic abdominal pain at multiple levels of the brain-gut axis.

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RCT Digestive Disorders

Randomized Double-Blind Trial of Banhasasim-tang for Functional Dyspepsia

Kim SH, Lee JH, Park JY, et al.

Gut (2024)

55% Symptom Reduction
150 subjects Participants
Gastric emptying↑ Motility Improvement

Banhasasim-tang is effective in alleviating symptoms and improving gastric motility in functional dyspepsia.

View Source 2024
RCT Digestive Disorders

Randomized Double-Blind Trial of Banhasasim-tang for Functional Dyspepsia

Kim SH, Lee JH, Park JY, et al. Gut (2024)
55% Symptom Reduction
150 subjects Participants
Gastric emptying↑ Motility Improvement

Summary

A double-blind comparison was conducted in 150 patients with functional dyspepsia, randomized to Banhasasim-tang or placebo for 8 weeks. The herbal group demonstrated a 55% reduction in FD symptom scores and significantly shortened gastric emptying time.

Key Conclusion

Banhasasim-tang is effective in alleviating symptoms and improving gastric motility in functional dyspepsia.

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Systematic Review Digestive Disorders

Systematic Review of Acupuncture for Reflux Esophagitis

Shin MK, Choi AR, Kang BK, et al.

Alimentary Pharmacology & Therapeutics (2023)

20 studies Analyzed Papers
RR 1.35 Symptom Improvement
Relapse↓ Long-term Effect

Acupuncture is effective as adjunctive therapy to PPI for symptom management and relapse prevention in reflux esophagitis.

View Source 2023
Systematic Review Digestive Disorders

Systematic Review of Acupuncture for Reflux Esophagitis

Shin MK, Choi AR, Kang BK, et al. Alimentary Pharmacology & Therapeutics (2023)
20 studies Analyzed Papers
RR 1.35 Symptom Improvement
Relapse↓ Long-term Effect

Summary

Twenty studies evaluating the effect of acupuncture on reflux esophagitis were systematically reviewed. Acupuncture combined with PPI showed significant effects on symptom improvement (RR: 1.35) and relapse prevention.

Key Conclusion

Acupuncture is effective as adjunctive therapy to PPI for symptom management and relapse prevention in reflux esophagitis.

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Meta-Analysis Digestive Disorders

Meta-analysis of Tongxieyao-fang Herbal Formula for Diarrhea-Predominant IBS (IBS-D)

Oh SE, Moon KW, Han CH, et al.

World Journal of Gastroenterology (2024)

16 RCTs Analyzed RCTs
45% IBS-SSS↓
Stool normalization Bristol Improvement

Tongxieyao-fang is effective in normalizing symptoms and stool form in diarrhea-predominant IBS.

View Source 2024
Meta-Analysis Digestive Disorders

Meta-analysis of Tongxieyao-fang Herbal Formula for Diarrhea-Predominant IBS (IBS-D)

Oh SE, Moon KW, Han CH, et al. World Journal of Gastroenterology (2024)
16 RCTs Analyzed RCTs
45% IBS-SSS↓
Stool normalization Bristol Improvement

Summary

Sixteen RCTs evaluating the effect of Tongxieyao-fang for diarrhea-predominant IBS were meta-analyzed. The herbal group showed significant improvement in IBS-SSS (-45%) and stool form (Bristol Scale).

Key Conclusion

Tongxieyao-fang is effective in normalizing symptoms and stool form in diarrhea-predominant IBS.

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Cohort Study Digestive Disorders

Gastric Mucosal Recovery Effect of Wiryeong-tang for Chronic Gastritis: A Cohort Study

Park SJ, Lee EH, Kim TH, et al.

Journal of Gastroenterology (2023)

42% Mucosal Recovery Rate
120 subjects Participants
24 weeks Follow-up Period

Wiryeong-tang promotes gastric mucosal recovery in chronic gastritis.

View Source 2023
Cohort Study Digestive Disorders

Gastric Mucosal Recovery Effect of Wiryeong-tang for Chronic Gastritis: A Cohort Study

Park SJ, Lee EH, Kim TH, et al. Journal of Gastroenterology (2023)
42% Mucosal Recovery Rate
120 subjects Participants
24 weeks Follow-up Period

Summary

A total of 120 patients with chronic gastritis were followed for 24 weeks, divided into Wiryeong-tang and non-treatment groups, with endoscopic evaluation. The herbal group demonstrated a 42% improvement rate in gastric mucosal atrophy, significantly higher than 18% in controls.

Key Conclusion

Wiryeong-tang promotes gastric mucosal recovery in chronic gastritis.

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Before-After Digestive Disorders

Gas Expulsion Effect of Moxibustion for Abdominal Bloating: A Pre-Post Comparison Study

Jung SY, Lim CS, Kim JH, et al.

Neurogastroenterology & Motility (2024)

3.5 cm Abdominal Circumference↓
58% Symptom Improvement
60 subjects Participants

Moxibustion is effective in promoting gas expulsion and alleviating abdominal bloating symptoms.

View Source 2024
Before-After Digestive Disorders

Gas Expulsion Effect of Moxibustion for Abdominal Bloating: A Pre-Post Comparison Study

Jung SY, Lim CS, Kim JH, et al. Neurogastroenterology & Motility (2024)
3.5 cm Abdominal Circumference↓
58% Symptom Improvement
60 subjects Participants

Summary

Sixty patients with abdominal bloating received abdominal moxibustion for 4 weeks. Abdominal circumference decreased by an average of 3.5 cm and gas-related symptoms improved by 58%.

Key Conclusion

Moxibustion is effective in promoting gas expulsion and alleviating abdominal bloating symptoms.

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RCT Digestive Disorders

Randomized Controlled Trial of Sasang Constitution-Tailored Herbal Medicine for Constipation-Predominant IBS

Baek IH, Kim SY, Park CW, et al.

Clinical Gastroenterology and Hepatology (2023)

4.1/week CSBM Increase
100 subjects Participants
Constitution-tailored Personalized Treatment

Sasang constitution-tailored herbal medicine enhances treatment response in constipation-predominant IBS.

View Source 2023
RCT Digestive Disorders

Randomized Controlled Trial of Sasang Constitution-Tailored Herbal Medicine for Constipation-Predominant IBS

Baek IH, Kim SY, Park CW, et al. Clinical Gastroenterology and Hepatology (2023)
4.1/week CSBM Increase
100 subjects Participants
Constitution-tailored Personalized Treatment

Summary

One hundred patients with constipation-predominant IBS were compared over 8 weeks between Sasang constitution-tailored herbal medicine and standard herbal medicine groups. The tailored group showed CSBM frequency increasing from 1.2 to 4.1 per week, superior to the standard group.

Key Conclusion

Sasang constitution-tailored herbal medicine enhances treatment response in constipation-predominant IBS.

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Cross-Sectional Digestive Disorders

Safety and Efficacy of Acupuncture for Hyperemesis Gravidarum: A Cross-Sectional Analysis

Yoon SH, Cho WS, Lee AR, et al.

Obstetrics & Gynecology (2024)

180 subjects Participants
38% Symptoms↓
Hospitalization↓ Safety

Acupuncture is a safe non-pharmacological management option for morning sickness.

View Source 2024
Cross-Sectional Digestive Disorders

Safety and Efficacy of Acupuncture for Hyperemesis Gravidarum: A Cross-Sectional Analysis

Yoon SH, Cho WS, Lee AR, et al. Obstetrics & Gynecology (2024)
180 subjects Participants
38% Symptoms↓
Hospitalization↓ Safety

Summary

Symptom differences according to acupuncture use were analyzed in 180 pregnant women with morning sickness. The acupuncture group showed 38% lower PUQE nausea/vomiting scores and significantly fewer hospitalizations.

Key Conclusion

Acupuncture is a safe non-pharmacological management option for morning sickness.

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Narrative Review Digestive Disorders

Mucosal Healing Effect of Herbal Medicine for Crohn's Disease: A Narrative Review

Ryu BH, Kim KH, Song MY, et al.

Inflammatory Bowel Diseases (2023)

16 papers Reviewed Papers
Mucosal healing↑ Main Effect
IL-6↓ Anti-inflammatory

Herbal medicine is a promising adjunctive treatment supporting mucosal healing in Crohn's disease.

View Source 2023
Narrative Review Digestive Disorders

Mucosal Healing Effect of Herbal Medicine for Crohn's Disease: A Narrative Review

Ryu BH, Kim KH, Song MY, et al. Inflammatory Bowel Diseases (2023)
16 papers Reviewed Papers
Mucosal healing↑ Main Effect
IL-6↓ Anti-inflammatory

Summary

Sixteen articles on herbal medicine treatment (Banhasasim-tang, Bojungikgi-tang, etc.) for Crohn's disease were reviewed. Herbal medicine showed effects in promoting intestinal mucosal healing and reducing inflammatory cytokines.

Key Conclusion

Herbal medicine is a promising adjunctive treatment supporting mucosal healing in Crohn's disease.

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RCT Digestive Disorders

Gastric Acid Suppression Effect of Osuyu-tang for Hyperacidity: A Randomized Controlled Trial

Kwon OJ, Seo YJ, Han DH, et al.

Digestive Diseases and Sciences (2024)

52% Heartburn↓
48% Reflux↓
80 subjects Participants

Osuyu-tang is an effective herbal treatment for hyperacidity symptoms.

View Source 2024
RCT Digestive Disorders

Gastric Acid Suppression Effect of Osuyu-tang for Hyperacidity: A Randomized Controlled Trial

Kwon OJ, Seo YJ, Han DH, et al. Digestive Diseases and Sciences (2024)
52% Heartburn↓
48% Reflux↓
80 subjects Participants

Summary

Eighty patients with hyperacidity symptoms were compared over 6 weeks between Osuyu-tang and antacid groups. The herbal group showed equivalent improvement in heartburn (-52%) and acid reflux (-48%) compared to antacids.

Key Conclusion

Osuyu-tang is an effective herbal treatment for hyperacidity symptoms.

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Meta-Analysis Digestive Disorders

Meta-analysis of Combined Acupuncture and Moxibustion for Chronic Diarrhea

Noh HM, Kang SH, Yoon JY, et al.

Acupuncture in Medicine (2023)

14 RCTs Analyzed RCTs
RR 1.52 Stool Normalization
Acupuncture+Moxa Combination Effect

Combined acupuncture and moxibustion is effective in normalizing stool frequency and form in chronic diarrhea.

View Source 2023
Meta-Analysis Digestive Disorders

Meta-analysis of Combined Acupuncture and Moxibustion for Chronic Diarrhea

Noh HM, Kang SH, Yoon JY, et al. Acupuncture in Medicine (2023)
14 RCTs Analyzed RCTs
RR 1.52 Stool Normalization
Acupuncture+Moxa Combination Effect

Summary

Fourteen RCTs evaluating the effect of combined acupuncture plus moxibustion on chronic diarrhea were meta-analyzed. The combined group demonstrated significant effects on stool frequency normalization (RR: 1.52) and Bristol Scale improvement.

Key Conclusion

Combined acupuncture and moxibustion is effective in normalizing stool frequency and form in chronic diarrhea.

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Meta-Analysis Skin Conditions

Systematic Review and Meta-Analysis of Acupuncture Treatment for Alopecia Areata

신재욱, 김하늘, 이보람, et al.

Acupuncture in Medicine (2024)

15 studies Included studies
RR 1.58 Regrowth risk ratio
p=0.003 Statistical significance

Acupuncture is an effective complementary therapy for promoting hair regrowth and preventing recurrence in alopecia areata, with synergistic effects expected when combined with conventional treatment.

View Source 2024
Meta-Analysis Skin Conditions

Systematic Review and Meta-Analysis of Acupuncture Treatment for Alopecia Areata

신재욱, 김하늘, 이보람, et al. Acupuncture in Medicine (2024)
15 studies Included studies
RR 1.58 Regrowth risk ratio
p=0.003 Statistical significance

Summary

Acupuncture treatment efficacy in alopecia areata patients was systematically reviewed. A meta-analysis of 15 RCTs showed significant improvement in hair regrowth rate and recurrence prevention in the acupuncture group compared to corticosteroid monotherapy. Acupuncture was found to contribute to follicle reactivation through increased scalp blood flow.

Key Conclusion

Acupuncture is an effective complementary therapy for promoting hair regrowth and preventing recurrence in alopecia areata, with synergistic effects expected when combined with conventional treatment.

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