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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Total 1642 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Meta-Analysis Women's Health / Infertility

Endocrine Modulation Effect of Herbal Medicine Treatment for Female Hormonal Imbalance: A Meta-Analysis

최유진, 신하늘, 홍서영, et al.

Phytotherapy Research (2023)

24 studies Analyzed studies
2,018 patients Total participants
Normalized Hormone ratio changes

Herbal medicine treatment is effective for endocrine axis modulation of female hormonal imbalance and contributes to fundamental improvement of various gynecological symptoms.

View Source 2023
Meta-Analysis Women's Health / Infertility

Endocrine Modulation Effect of Herbal Medicine Treatment for Female Hormonal Imbalance: A Meta-Analysis

최유진, 신하늘, 홍서영, et al. Phytotherapy Research (2023)
24 studies Analyzed studies
2,018 patients Total participants
Normalized Hormone ratio changes

Summary

A meta-analysis of 24 RCTs (2,018 patients) evaluating endocrine modulation effects of herbal medicine treatment in women with hormonal imbalance (estrogen-progesterone ratio abnormalities). The herbal medicine administration group showed normalizing tendency in estrogen/progesterone ratio, with also significantly improved FSH and LH levels. Improvement rates of menstrual cycle-related symptoms were also high.

Key Conclusion

Herbal medicine treatment is effective for endocrine axis modulation of female hormonal imbalance and contributes to fundamental improvement of various gynecological symptoms.

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Cohort Study Women's Health / Infertility

Effect of Herbal Medicine (Modified Changchul) Treatment on Insulin Resistance in PCOS Women: A Cohort Study

구서현, 남지윤, 탁예은, et al.

Journal of Alternative and Complementary Medicine (2024)

32% HOMA-IR reduction rate
118 patients Study population
Low Gastrointestinal side effects

Herbal medicine treatment shows effects similar to metformin for insulin resistance improvement in PCOS comorbid patients with fewer gastrointestinal side effects, favoring tolerability.

View Source 2024
Cohort Study Women's Health / Infertility

Effect of Herbal Medicine (Modified Changchul) Treatment on Insulin Resistance in PCOS Women: A Cohort Study

구서현, 남지윤, 탁예은, et al. Journal of Alternative and Complementary Medicine (2024)
32% HOMA-IR reduction rate
118 patients Study population
Low Gastrointestinal side effects

Summary

A cohort study comparing herbal medicine (modified Changchul) administration and metformin administration groups in 118 women with PCOS comorbid with insulin resistance. After 16 weeks of treatment, HOMA-IR decreased by an average of 32% in the herbal medicine group, showing similar improvement to the metformin group (38%). Gastrointestinal side effects were markedly fewer in the herbal medicine group.

Key Conclusion

Herbal medicine treatment shows effects similar to metformin for insulin resistance improvement in PCOS comorbid patients with fewer gastrointestinal side effects, favoring tolerability.

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Systematic Review Women's Health / Infertility

Pregnancy Rate Improvement Effect of Korean Medicine Treatment for Endometriosis-Related Infertility: A Systematic Review

허다인, 양서윤, 전채린, et al.

Reproductive BioMedicine Online (2023)

34.2% Natural pregnancy rate
12 studies Analyzed studies
15.5%p Pregnancy rate difference

Korean medicine treatment improves natural pregnancy rates of endometriosis-related infertility and contributes to disease activity reduction.

View Source 2023
Systematic Review Women's Health / Infertility

Pregnancy Rate Improvement Effect of Korean Medicine Treatment for Endometriosis-Related Infertility: A Systematic Review

허다인, 양서윤, 전채린, et al. Reproductive BioMedicine Online (2023)
34.2% Natural pregnancy rate
12 studies Analyzed studies
15.5%p Pregnancy rate difference

Summary

Twelve studies (986 patients) evaluating effects of Korean medicine treatment for endometriosis-related infertile women were systematically reviewed. Natural pregnancy rate in the combined herbal medicine and acupuncture group was 34.2%, significantly higher than expected management group (18.7%). CA-125 level reduction and endometriosis lesion size reduction were also observed.

Key Conclusion

Korean medicine treatment improves natural pregnancy rates of endometriosis-related infertility and contributes to disease activity reduction.

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Before-After Women's Health / Infertility

Kupperman Index Improvement with Korean Medicine Combination Treatment for Comprehensive Menopausal Symptoms: A Pre-Post Comparison Study

도예린, 안소율, 길수현, et al.

Maturitas (2024)

60.5% Kupperman Index reduction rate
84 patients Study population
10/11 Improved sub-items

Korean medicine combination treatment is effective for comprehensive improvement of menopausal comprehensive symptoms and shows significant improvement in most sub-domains of Kupperman Index.

View Source 2024
Before-After Women's Health / Infertility

Kupperman Index Improvement with Korean Medicine Combination Treatment for Comprehensive Menopausal Symptoms: A Pre-Post Comparison Study

도예린, 안소율, 길수현, et al. Maturitas (2024)
60.5% Kupperman Index reduction rate
84 patients Study population
10/11 Improved sub-items

Summary

A pre-post comparison study performing combined herbal medicine (Gamisoyo-san), acupuncture, and moxibustion therapy for 12 weeks in 84 women with moderate-to-severe menopausal symptoms (Kupperman Index 25 or higher). After treatment, Kupperman Index decreased 60.5% from an average of 32.4 to 12.8, with significant improvements observed in 10 of 11 sub-items.

Key Conclusion

Korean medicine combination treatment is effective for comprehensive improvement of menopausal comprehensive symptoms and shows significant improvement in most sub-domains of Kupperman Index.

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Narrative Review Women's Health / Infertility

Effect of Herbal Medicine (Modified Soyo-san) Treatment for Breast Benign Diseases: A Narrative Review

문유진, 채서현, 위예림, et al.

Breast Care (2023)

Multiple Positive studies
Mass reduction Main effect
Liver qi stagnation Core pattern

Modified Soyo-san is a promising treatment for breast benign disease mass reduction and symptom relief, with liver qi stagnation resolution as the key mechanism.

View Source 2023
Narrative Review Women's Health / Infertility

Effect of Herbal Medicine (Modified Soyo-san) Treatment for Breast Benign Diseases: A Narrative Review

문유진, 채서현, 위예림, et al. Breast Care (2023)
Multiple Positive studies
Mass reduction Main effect
Liver qi stagnation Core pattern

Summary

A narrative review comprehensively examining literature on treatment effects of modified Soyo-san for breast benign diseases (fibroadenoma, fibrocystic changes). Many studies were reported showing positive results of Soyo-san on breast mass size reduction, mastalgia relief, and breast density reduction. Liver qi stagnation pattern was presented as the key mechanism.

Key Conclusion

Modified Soyo-san is a promising treatment for breast benign disease mass reduction and symptom relief, with liver qi stagnation resolution as the key mechanism.

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RCT Women's Health / Infertility

Effect of Combined Acupuncture and Herbal Medicine for Uterine Fibroid-Related Menorrhagia: A Randomized Controlled Trial

장다은, 고채영, 남서윤, et al.

Gynecologic and Obstetric Investigation (2024)

52% Menstrual volume reduction rate
102 patients Study population
18.3% Fibroid volume reduction

Combined acupuncture and herbal medicine shows effects equivalent to tranexamic acid for bleeding reduction in uterine fibroid-related menorrhagia, with additional benefit of fibroid size reduction.

View Source 2024
RCT Women's Health / Infertility

Effect of Combined Acupuncture and Herbal Medicine for Uterine Fibroid-Related Menorrhagia: A Randomized Controlled Trial

장다은, 고채영, 남서윤, et al. Gynecologic and Obstetric Investigation (2024)
52% Menstrual volume reduction rate
102 patients Study population
18.3% Fibroid volume reduction

Summary

An RCT comparing combined acupuncture and herbal medicine (Gyejibokryeong-hwan combined with Goonggwigyoae-tang) with tranexamic acid in 102 women with menorrhagia due to uterine fibroids. After 6 months of treatment, menstrual volume decreased by 52% in the Korean medicine treatment group, showing similar effects to the tranexamic acid group (44%). Fibroid volume significantly decreased only in the Korean medicine group (18.3%).

Key Conclusion

Combined acupuncture and herbal medicine shows effects equivalent to tranexamic acid for bleeding reduction in uterine fibroid-related menorrhagia, with additional benefit of fibroid size reduction.

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Cross-Sectional Women's Health / Infertility

Effect of Herbal Medicine (Yongdamsagan-tang) Sitz Bath Treatment for Chronic Vaginitis: A Cross-Sectional Study

위채린, 진서영, 우예은, et al.

대한한방부인과학회지 (2023)

2.1/year Sitz bath group recurrence count
156 patients Study population
2.7 times Recurrence count difference

Yongdamsagan-tang sitz bath shows positive association with reducing recurrence frequency of chronic vaginitis and maintaining vaginal health.

View Source 2023
Cross-Sectional Women's Health / Infertility

Effect of Herbal Medicine (Yongdamsagan-tang) Sitz Bath Treatment for Chronic Vaginitis: A Cross-Sectional Study

위채린, 진서영, 우예은, et al. 대한한방부인과학회지 (2023)
2.1/year Sitz bath group recurrence count
156 patients Study population
2.7 times Recurrence count difference

Summary

A cross-sectional study comparing vaginitis recurrence patterns and vaginal health indicators between Yongdamsagan-tang sitz bath experience and non-experience groups in 156 women with chronic recurrent vaginitis. Annual vaginitis recurrence count was significantly fewer in the sitz bath experience group (2.1 vs 4.8 times), with also higher vaginal health self-assessment scores.

Key Conclusion

Yongdamsagan-tang sitz bath shows positive association with reducing recurrence frequency of chronic vaginitis and maintaining vaginal health.

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Cohort Study Women's Health / Infertility

Hemoglobin Improvement Effect of Herbal Medicine (Sipjeondaebo-tang) Treatment for Pregnancy Anemia: A Cohort Study

탁서연, 피지현, 도하영, et al.

Journal of Perinatal Medicine (2024)

2.4 g/dL Hb increase (herbal)
88 patients Study population
0.8 g/dL Superiority over iron

Sipjeondaebo-tang is more effective than iron supplements for hemoglobin improvement of pregnancy anemia, with excellent gastrointestinal tolerability.

View Source 2024
Cohort Study Women's Health / Infertility

Hemoglobin Improvement Effect of Herbal Medicine (Sipjeondaebo-tang) Treatment for Pregnancy Anemia: A Cohort Study

탁서연, 피지현, 도하영, et al. Journal of Perinatal Medicine (2024)
2.4 g/dL Hb increase (herbal)
88 patients Study population
0.8 g/dL Superiority over iron

Summary

A cohort study comparing Sipjeondaebo-tang administration group (44 patients) and iron supplement alone group (44 patients) in 88 pregnant women with mid-pregnancy anemia (Hb less than 10 g/dL). After 8 weeks, hemoglobin increased by an average of 2.4 g/dL in the herbal medicine combination group, superior to the iron supplement alone group (1.6 g/dL). Gastrointestinal side effects including dyspepsia were also fewer in the herbal medicine group.

Key Conclusion

Sipjeondaebo-tang is more effective than iron supplements for hemoglobin improvement of pregnancy anemia, with excellent gastrointestinal tolerability.

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Cross-Sectional Women's Health / Infertility

Psychological Satisfaction and Stress Reduction Effect of Korean Medicine Treatment for Infertile Couples: A Cross-Sectional Study

길예진, 안다솜, 류서현, et al.

Human Reproduction (2023)

246 couples Study population
Significant Stress reduction
High Treatment satisfaction

Combined Korean medicine treatment reduces psychological stress of infertile couples and increases treatment satisfaction, improving overall experience of assisted reproductive technology process.

View Source 2023
Cross-Sectional Women's Health / Infertility

Psychological Satisfaction and Stress Reduction Effect of Korean Medicine Treatment for Infertile Couples: A Cross-Sectional Study

길예진, 안다솜, 류서현, et al. Human Reproduction (2023)
246 couples Study population
Significant Stress reduction
High Treatment satisfaction

Summary

A cross-sectional study evaluating psychological satisfaction, stress levels, and quality of life in 246 infertile couples undergoing combined Korean medicine treatment with assisted reproductive technology. The Korean medicine combination group showed significantly lower infertility-related stress (FPI) scores, higher treatment process satisfaction, and improved marital relationship satisfaction.

Key Conclusion

Combined Korean medicine treatment reduces psychological stress of infertile couples and increases treatment satisfaction, improving overall experience of assisted reproductive technology process.

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RCT Digestive Disorders

Randomized Controlled Trial of Transcutaneous Electrical Stimulation at Neiguan for Motion Sickness

Go JH, Park HJ, Lee SH, et al.

Aviation, Space and Environmental Medicine (2024)

62% Symptoms↓
50 subjects Participants
Gastric rhythm normalization Mechanism

Transcutaneous electrical stimulation at Neiguan is effective in preventing motion sickness.

View Source 2024
RCT Digestive Disorders

Randomized Controlled Trial of Transcutaneous Electrical Stimulation at Neiguan for Motion Sickness

Go JH, Park HJ, Lee SH, et al. Aviation, Space and Environmental Medicine (2024)
62% Symptoms↓
50 subjects Participants
Gastric rhythm normalization Mechanism

Summary

Fifty adults with motion sickness tendency were compared between Neiguan transcutaneous stimulation and placebo groups. The stimulation group demonstrated a 62% reduction in motion sickness symptom scores and normalized gastric dysrhythmia.

Key Conclusion

Transcutaneous electrical stimulation at Neiguan is effective in preventing motion sickness.

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Cohort Study Digestive Disorders

Correlation Between Stress and Gut Symptoms in IBS Patients: An Acupuncture Effect Cohort

Hwang MS, Yoo JH, Cho HJ, et al.

Psychosomatic Medicine (2023)

35% Stress↓
42% IBS-SSS↓
110 subjects Participants

Acupuncture improves IBS by interrupting the vicious cycle of stress and gut symptoms.

View Source 2023
Cohort Study Digestive Disorders

Correlation Between Stress and Gut Symptoms in IBS Patients: An Acupuncture Effect Cohort

Hwang MS, Yoo JH, Cho HJ, et al. Psychosomatic Medicine (2023)
35% Stress↓
42% IBS-SSS↓
110 subjects Participants

Summary

One hundred ten IBS patients were followed for 12 weeks, divided into acupuncture and non-treatment groups. The acupuncture group demonstrated significant reductions in PSS stress (-35%) and IBS-SSS (-42%).

Key Conclusion

Acupuncture improves IBS by interrupting the vicious cycle of stress and gut symptoms.

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Systematic Review Digestive Disorders

Updated Systematic Review of Moxibustion for Digestive Symptoms

Cho AR, Park MJ, Kim DI, et al.

BMC Complementary Medicine (2023)

28 studies Analyzed Papers
Multi-symptom application Versatility
Whole digestive system Application Scope

Moxibustion is an effective treatment universally applicable to various digestive symptoms.

View Source 2023
Systematic Review Digestive Disorders

Updated Systematic Review of Moxibustion for Digestive Symptoms

Cho AR, Park MJ, Kim DI, et al. BMC Complementary Medicine (2023)
28 studies Analyzed Papers
Multi-symptom application Versatility
Whole digestive system Application Scope

Summary

Twenty-eight studies evaluating the effect of moxibustion on digestive symptoms were systematically reviewed. Moxibustion demonstrated significant improvement effects on dyspepsia, abdominal pain, constipation, and diarrhea.

Key Conclusion

Moxibustion is an effective treatment universally applicable to various digestive symptoms.

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