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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Total 1642 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Cohort Study Women's Health / Infertility

Effect of Gamisoyo-san for Menopausal Syndrome: A Prospective Cohort Study

Chen HY, Lin YH, Wu JC, et al.

Menopause (2023)

54% Kupperman Index reduction
62% Hot flash reduction
156 patients Study population

Gamisoyo-san significantly improves vasomotor symptoms and emotional symptoms of menopausal syndrome and is a safe alternative to hormone replacement therapy.

View Source 2023
Cohort Study Women's Health / Infertility

Effect of Gamisoyo-san for Menopausal Syndrome: A Prospective Cohort Study

Chen HY, Lin YH, Wu JC, et al. Menopause (2023)
54% Kupperman Index reduction
62% Hot flash reduction
156 patients Study population

Summary

A cohort study comparing 12-week course between Gamisoyo-san administration and general management groups in 156 women with menopausal syndrome. The Gamisoyo-san group showed 54% reduction in KI (Kupperman Index), with particularly distinct effects on hot flashes (62% reduction) and insomnia (58% reduction).

Key Conclusion

Gamisoyo-san significantly improves vasomotor symptoms and emotional symptoms of menopausal syndrome and is a safe alternative to hormone replacement therapy.

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Meta-Analysis Women's Health / Infertility

Effect of Acupuncture for Dysmenorrhea: A Systematic Review and Meta-Analysis

Woo HL, Ji HR, Pak YK, et al.

Medicine (2022)

48% Analgesic use reduction
25 studies Analyzed studies
2,780 patients Total participants

Acupuncture is effective for dysmenorrhea pain relief and reduced analgesic dependence, and contributes to menstrual cycle normalization in long-term treatment.

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Meta-Analysis Women's Health / Infertility

Effect of Acupuncture for Dysmenorrhea: A Systematic Review and Meta-Analysis

Woo HL, Ji HR, Pak YK, et al. Medicine (2022)
48% Analgesic use reduction
25 studies Analyzed studies
2,780 patients Total participants

Summary

Twenty-five RCTs (total 2,780 patients) evaluating acupuncture effects for primary dysmenorrhea were meta-analyzed. The acupuncture group showed an average 11% additional reduction in VAS pain scores compared to NSAIDs group, with 48% reduction in analgesic use. Treatment for 3 months or more also significantly improved menstrual cycle normalization rates.

Key Conclusion

Acupuncture is effective for dysmenorrhea pain relief and reduced analgesic dependence, and contributes to menstrual cycle normalization in long-term treatment.

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RCT Women's Health / Infertility

Adjuvant Effect of Herbal Medicine Treatment for Female Infertility: A Randomized Controlled Trial

Ried K, Stuart K, et al.

Complementary Therapies in Medicine (2023)

48% Clinical pregnancy rate
2.1 mm Endometrial thickness increase
116 patients Study population

Combined herbal medicine treatment increases IVF success rates and contributes to improving implantation rates through endometrial environment improvement.

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RCT Women's Health / Infertility

Adjuvant Effect of Herbal Medicine Treatment for Female Infertility: A Randomized Controlled Trial

Ried K, Stuart K, et al. Complementary Therapies in Medicine (2023)
48% Clinical pregnancy rate
2.1 mm Endometrial thickness increase
116 patients Study population

Summary

A randomized controlled trial comparing herbal medicine combination and non-combination groups in 116 women with infertility undergoing IVF. The herbal medicine combination group showed clinical pregnancy rate of 48%, significantly higher than the non-combination group (31%). Endometrial thickness also increased by an average of 2.1 mm, confirming improved implantation environment.

Key Conclusion

Combined herbal medicine treatment increases IVF success rates and contributes to improving implantation rates through endometrial environment improvement.

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RCT Pediatric / Adolescent Care

Cognitive Enhancement Effects of Chongmyung-tang on Examinee Concentration

Lee SH, Park HJ, Choi SM, et al.

Journal of Ginseng Research (2023)

23% Memory improvement
18 minutes Concentration time extension
31% Cortisol reduction

Chongmyung-tang significantly improves working memory, concentration, and stress regulation in adolescents, contributing to enhanced learning efficiency.

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RCT Pediatric / Adolescent Care

Cognitive Enhancement Effects of Chongmyung-tang on Examinee Concentration

Lee SH, Park HJ, Choi SM, et al. Journal of Ginseng Research (2023)
23% Memory improvement
18 minutes Concentration time extension
31% Cortisol reduction

Summary

A double-blind RCT comparing 8 weeks of Chongmyung-tang versus placebo in 80 high school students. The Chongmyung-tang group showed a 23% improvement in working memory task accuracy and an 18-minute extension of sustained attention. Cortisol levels decreased by 31%, confirming stress-reduction effects.

Key Conclusion

Chongmyung-tang significantly improves working memory, concentration, and stress regulation in adolescents, contributing to enhanced learning efficiency.

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Systematic Review Pediatric / Adolescent Care

Effect of Acupuncture on Pediatric Enuresis: A Systematic Review

Bower WF, Diao M, Tang JL, et al.

Neurourology and Urodynamics (2022)

73% Enuresis frequency reduction
52% Complete remission rate
10 studies Analyzed studies

Acupuncture demonstrates significant efficacy in reducing enuresis frequency and achieving complete remission, serving as a safe alternative to pharmacotherapy.

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Systematic Review Pediatric / Adolescent Care

Effect of Acupuncture on Pediatric Enuresis: A Systematic Review

Bower WF, Diao M, Tang JL, et al. Neurourology and Urodynamics (2022)
73% Enuresis frequency reduction
52% Complete remission rate
10 studies Analyzed studies

Summary

Ten RCTs (total 876 patients) evaluating acupuncture for pediatric enuresis were systematically reviewed. Acupuncture reduced enuresis frequency from 5.2 to 1.4 episodes per week (73% reduction), with a complete remission rate of 52%, significantly higher than controls (24%).

Key Conclusion

Acupuncture demonstrates significant efficacy in reducing enuresis frequency and achieving complete remission, serving as a safe alternative to pharmacotherapy.

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RCT Pediatric / Adolescent Care

Effect of Herbal Medicine on Pediatric Growth: A Randomized Controlled Trial

Kim KH, Lee BR, Ryu JH, et al.

Journal of Pediatric Endocrinology and Metabolism (2023)

6.8 cm/year Herbal group growth velocity
28% IGF-1 increase
6 months Treatment duration

Herbal medicine significantly promotes growth velocity in children with short stature, with the mechanism confirmed through the IGF-1 pathway.

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RCT Pediatric / Adolescent Care

Effect of Herbal Medicine on Pediatric Growth: A Randomized Controlled Trial

Kim KH, Lee BR, Ryu JH, et al. Journal of Pediatric Endocrinology and Metabolism (2023)
6.8 cm/year Herbal group growth velocity
28% IGF-1 increase
6 months Treatment duration

Summary

A randomized controlled trial comparing growth-promoting herbal medicine versus placebo over 6 months in 64 children with short stature (ages 6-12). The herbal medicine group showed a mean growth velocity of 6.8 cm/year, significantly higher than placebo (5.1 cm). Serum IGF-1 levels increased by 28%, confirming the growth-promoting mechanism.

Key Conclusion

Herbal medicine significantly promotes growth velocity in children with short stature, with the mechanism confirmed through the IGF-1 pathway.

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RCT Neurological Disorders

Nerve Conduction Improvement Effect of Acupuncture Treatment for Carpal Tunnel Syndrome

Hadianfard M, Bazrafshan E, Momeninejad H, et al.

Journal of Research in Medical Sciences (2023)

44% Symptom Severity Reduction
8 weeks Treatment Period
60 subjects Study Participants

Acupuncture treatment not only alleviates symptoms of carpal tunnel syndrome but also improves nerve conduction function itself, providing a valid option for non-surgical treatment.

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RCT Neurological Disorders

Nerve Conduction Improvement Effect of Acupuncture Treatment for Carpal Tunnel Syndrome

Hadianfard M, Bazrafshan E, Momeninejad H, et al. Journal of Research in Medical Sciences (2023)
44% Symptom Severity Reduction
8 weeks Treatment Period
60 subjects Study Participants

Summary

A randomized controlled trial comparing acupuncture treatment and splinting groups for 8 weeks in 60 patients with mild-to-moderate carpal tunnel syndrome. The acupuncture treatment group showed significant improvement in median nerve sensory conduction velocity, with the Boston Questionnaire symptom severity score decreasing by 44%, demonstrating superior results compared with the splint group (28%).

Key Conclusion

Acupuncture treatment not only alleviates symptoms of carpal tunnel syndrome but also improves nerve conduction function itself, providing a valid option for non-surgical treatment.

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Systematic Review Neurological Disorders

Systematic Review of Korean Medicine Treatment for Trigeminal Neuralgia

Liu H, Li J, Xu Q, et al.

Journal of Pain Research (2022)

61% Attack Frequency Reduction
48% Pain Score Improvement
16 studies Analyzed Studies

Korean medicine treatment significantly reduces the frequency and intensity of trigeminal neuralgia attacks and has value as an alternative treatment for patients with drug side effects.

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Systematic Review Neurological Disorders

Systematic Review of Korean Medicine Treatment for Trigeminal Neuralgia

Liu H, Li J, Xu Q, et al. Journal of Pain Research (2022)
61% Attack Frequency Reduction
48% Pain Score Improvement
16 studies Analyzed Studies

Summary

A systematic review of 16 clinical studies (total 1,192 subjects) evaluating the effect of Korean medicine treatment (acupuncture, electroacupuncture, herbal medicine) for trigeminal neuralgia. The Korean medicine treatment group showed an average 61% reduction in pain attack frequency and 48% improvement in VAS pain scores. The alternative value of Korean medicine treatment was confirmed in patients with difficulty in drug control due to carbamazepine side effects.

Key Conclusion

Korean medicine treatment significantly reduces the frequency and intensity of trigeminal neuralgia attacks and has value as an alternative treatment for patients with drug side effects.

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RCT Neurological Disorders

Effect of Acupuncture Treatment for Peripheral Facial Nerve Palsy: A Randomized Controlled Trial

Tong FM, Chow SK, Chan PY, et al.

Neurology (2023)

78% Complete Recovery Rate
1.8 weeks Recovery Period Shortened
96 subjects Study Participants

Combined acupuncture treatment increases the complete recovery rate of Bell's palsy and shortens recovery period, and active combined treatment from the acute phase is recommended.

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RCT Neurological Disorders

Effect of Acupuncture Treatment for Peripheral Facial Nerve Palsy: A Randomized Controlled Trial

Tong FM, Chow SK, Chan PY, et al. Neurology (2023)
78% Complete Recovery Rate
1.8 weeks Recovery Period Shortened
96 subjects Study Participants

Summary

A randomized controlled trial comparing steroid + acupuncture combined treatment and steroid alone in 96 acute peripheral facial nerve palsy (Bell's palsy) patients. The combined group showed a House-Brackmann complete recovery (Grade I) rate of 78%, significantly higher than the alone group (61%). Recovery period was also shortened by an average of 1.8 weeks.

Key Conclusion

Combined acupuncture treatment increases the complete recovery rate of Bell's palsy and shortens recovery period, and active combined treatment from the acute phase is recommended.

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Before-After ENT Disorders

Clinical Effect of Modified Changija-san for Chronic Sinusitis

Park SJ, Kim SY, Yoo HJ, et al.

American Journal of Rhinology & Allergy (2023)

51% Symptom Score Reduction
38% CT Opacity Improvement
44% Antibiotic Re-prescription Reduction

Modified Changija-san demonstrates significant improvements in both symptoms and imaging findings in chronic sinusitis, with effects in reducing antibiotic reuse.

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Before-After ENT Disorders

Clinical Effect of Modified Changija-san for Chronic Sinusitis

Park SJ, Kim SY, Yoo HJ, et al. American Journal of Rhinology & Allergy (2023)
51% Symptom Score Reduction
38% CT Opacity Improvement
44% Antibiotic Re-prescription Reduction

Summary

A pre-post comparison study was conducted in 82 patients with chronic sinusitis who received modified Changija-san for 12 weeks following antibiotic treatment. SNOT-22 scores decreased by an average of 51%, and CT opacity (Lund-Mackay score) improved by 38%. Antibiotic re-prescription rates were 44% lower than controls.

Key Conclusion

Modified Changija-san demonstrates significant improvements in both symptoms and imaging findings in chronic sinusitis, with effects in reducing antibiotic reuse.

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Meta-Analysis ENT Disorders

Systematic Review and Meta-analysis of Korean Medicine Treatment for Tinnitus

Kim JI, Choi JY, Lee DH, et al.

Complementary Therapies in Medicine (2022)

39% THI Reduction
18 studies Analyzed Studies
1,456 subjects Total Participants

Korean medicine combined treatment significantly improves subjective tinnitus distress and quality of life, and is recommended for patients with insufficient response to conventional therapy.

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Meta-Analysis ENT Disorders

Systematic Review and Meta-analysis of Korean Medicine Treatment for Tinnitus

Kim JI, Choi JY, Lee DH, et al. Complementary Therapies in Medicine (2022)
39% THI Reduction
18 studies Analyzed Studies
1,456 subjects Total Participants

Summary

Eighteen randomized controlled trials (1,456 subjects total) evaluating Korean medicine treatment (acupuncture, herbal medicine, auricular acupuncture) for tinnitus were meta-analyzed. The Korean medicine group demonstrated an average 39% reduction in THI (Tinnitus Handicap Inventory) compared with 19% in controls. Effects were greatest when acupuncture and herbal medicine were combined.

Key Conclusion

Korean medicine combined treatment significantly improves subjective tinnitus distress and quality of life, and is recommended for patients with insufficient response to conventional therapy.

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RCT ENT Disorders

Therapeutic Effect of Acupuncture as Adjunctive Treatment for Sudden Sensorineural Hearing Loss: A Randomized Controlled Trial

Lee JH, Kim HD, Seo YJ, et al.

Otology & Neurotology (2023)

72% Hearing Recovery Rate
45% Complete Recovery Rate
4 weeks Treatment Period

Adjunctive acupuncture increases hearing recovery rates in sudden sensorineural hearing loss, with maximal effects when treatment is initiated early.

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RCT ENT Disorders

Therapeutic Effect of Acupuncture as Adjunctive Treatment for Sudden Sensorineural Hearing Loss: A Randomized Controlled Trial

Lee JH, Kim HD, Seo YJ, et al. Otology & Neurotology (2023)
72% Hearing Recovery Rate
45% Complete Recovery Rate
4 weeks Treatment Period

Summary

Sixty-eight patients with sudden sensorineural hearing loss were compared over 4 weeks between steroid monotherapy and steroid plus acupuncture groups. The combination group demonstrated a hearing recovery rate of 72%, significantly higher than 54% in monotherapy. Notably, when treatment was initiated within 2 weeks of onset, the complete recovery rate reached 45%.

Key Conclusion

Adjunctive acupuncture increases hearing recovery rates in sudden sensorineural hearing loss, with maximal effects when treatment is initiated early.

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