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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 1642 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
RCT Gwanjeoldan (關節丹)

Effect of Modified Samgieum on Pain and Functional Improvement in Osteoarthritis: A Randomized Controlled Trial

Choi JH, Lee HJ, Kim KW, et al.

Journal of Korean Medicine Rehabilitation (2023)

52% WOMAC Pain Reduction
18° ROM Increase
12 weeks Treatment Period

Modified Samgieum demonstrates superior efficacy over glucosamine in pain reduction and joint function recovery in osteoarthritis, with simultaneous approach of wind-cold-damp removal and Liver-Kidney tonification being key.

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RCT Gwanjeoldan (關節丹)

Effect of Modified Samgieum on Pain and Functional Improvement in Osteoarthritis: A Randomized Controlled Trial

Choi JH, Lee HJ, Kim KW, et al. Journal of Korean Medicine Rehabilitation (2023)
52% WOMAC Pain Reduction
18° ROM Increase
12 weeks Treatment Period

Summary

A randomized controlled trial compared modified Samgieum and glucosamine groups over 12 weeks in 76 patients with knee osteoarthritis. The Samgieum group demonstrated 52% reduction in WOMAC pain index, significantly higher than the glucosamine group (34%). Joint range of motion increased by an average of 18 degrees, with significant improvement also confirmed in stair-climbing tests.

Key Conclusion

Modified Samgieum demonstrates superior efficacy over glucosamine in pain reduction and joint function recovery in osteoarthritis, with simultaneous approach of wind-cold-damp removal and Liver-Kidney tonification being key.

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Meta-Analysis Gwanjeoldan (關節丹)

Systematic Review and Meta-analysis of Wind-Damp-Dispelling Herbal Medicine for Arthritis

Zhang Y, Liu W, Chen H, et al.

Evidence-Based Complementary and Alternative Medicine (2022)

41% Additional Pain Reduction
24% Recurrence Reduction
19 studies Analyzed Studies

Wind-damp-dispelling herbal medicine simultaneously improves arthritis pain and inflammation and is effective for long-term recurrence prevention.

View Source 2022
Meta-Analysis Gwanjeoldan (關節丹)

Systematic Review and Meta-analysis of Wind-Damp-Dispelling Herbal Medicine for Arthritis

Zhang Y, Liu W, Chen H, et al. Evidence-Based Complementary and Alternative Medicine (2022)
41% Additional Pain Reduction
24% Recurrence Reduction
19 studies Analyzed Studies

Summary

Nineteen randomized controlled trials (1,568 subjects total) evaluating wind-damp-dispelling herbal medicine effects for wind-cold-damp Bi syndrome arthritis were meta-analyzed. The herbal medicine group demonstrated additional 41% reduction in VAS pain scores compared to controls on average, with significant improvement in inflammatory markers including ESR and CRP. At 6-month follow-up, recurrence rates were 24% lower.

Key Conclusion

Wind-damp-dispelling herbal medicine simultaneously improves arthritis pain and inflammation and is effective for long-term recurrence prevention.

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Cohort Study Gwanjeoldan (關節丹)

Inflammatory Marker and Joint Function Improvement Effect of Herbal Pills for Rheumatoid Arthritis Patients: A Cohort Study

Lee SY, Park JH, Won SJ, et al.

Rheumatology International (2023)

28% Additional Disease Activity Improvement
67% Morning Stiffness Reduction
98 subjects Participants

Combined herbal pill treatment additionally lowers disease activity in rheumatoid arthritis and is particularly effective for morning stiffness and joint swelling improvement.

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Cohort Study Gwanjeoldan (關節丹)

Inflammatory Marker and Joint Function Improvement Effect of Herbal Pills for Rheumatoid Arthritis Patients: A Cohort Study

Lee SY, Park JH, Won SJ, et al. Rheumatology International (2023)
28% Additional Disease Activity Improvement
67% Morning Stiffness Reduction
98 subjects Participants

Summary

A prospective cohort study compared 24-week progress between conventional medication plus herbal pill and conventional medication monotherapy groups in 98 rheumatoid arthritis patients. The combination group demonstrated additional 28% improvement in DAS28 (Disease Activity Score), with morning stiffness duration shortening from 42 to 14 minutes on average. Joint swelling indices also significantly decreased.

Key Conclusion

Combined herbal pill treatment additionally lowers disease activity in rheumatoid arthritis and is particularly effective for morning stiffness and joint swelling improvement.

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RCT Mental Health

Randomized Controlled Trial of Guibi-tang for Anxiety Disorder Treatment

Park YC, Kim SH, Jo HG, et al.

Journal of Affective Disorders (2023)

52% Anxiety Index Reduction
67% Insomnia Improvement Rate
12 weeks Treatment Period

Guibi-tang shows significant treatment effects on anxiety symptoms and accompanying insomnia in generalized anxiety disorder and also contributes to autonomic balance recovery.

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RCT Mental Health

Randomized Controlled Trial of Guibi-tang for Anxiety Disorder Treatment

Park YC, Kim SH, Jo HG, et al. Journal of Affective Disorders (2023)
52% Anxiety Index Reduction
67% Insomnia Improvement Rate
12 weeks Treatment Period

Summary

A randomized controlled trial comparing 12 weeks of Guibi-tang administration with placebo in 84 generalized anxiety disorder patients. The Guibi-tang group showed an average 52% reduction in HAM-A (Hamilton Anxiety Rating Scale) scores, with 67% improvement rate in accompanying insomnia symptoms. Heart rate variability (HRV) analysis showed significant increase in parasympathetic activity.

Key Conclusion

Guibi-tang shows significant treatment effects on anxiety symptoms and accompanying insomnia in generalized anxiety disorder and also contributes to autonomic balance recovery.

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Meta-Analysis Mental Health

Treatment Effect of Acupuncture for Depression: A Systematic Review and Meta-Analysis

Smith CA, Armour M, Lee MS, et al.

Journal of Clinical Medicine (2022)

72% Treatment Response Rate
29 studies Analyzed Studies
2,268 subjects Total Participants

Acupuncture shows significant effects as adjunctive treatment for depression and can contribute to drug side effect reduction and treatment adherence improvement.

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Meta-Analysis Mental Health

Treatment Effect of Acupuncture for Depression: A Systematic Review and Meta-Analysis

Smith CA, Armour M, Lee MS, et al. Journal of Clinical Medicine (2022)
72% Treatment Response Rate
29 studies Analyzed Studies
2,268 subjects Total Participants

Summary

A meta-analysis of 29 randomized controlled trials (total 2,268 subjects) evaluating the depression treatment effect of acupuncture. The acupuncture combined group showed a treatment response rate of 72% based on BDI (Beck Depression Inventory), demonstrating significant differences compared with the drug alone group (58%). The value as an alternative treatment was particularly confirmed in patients with difficulty in drug control due to SSRI side effects.

Key Conclusion

Acupuncture shows significant effects as adjunctive treatment for depression and can contribute to drug side effect reduction and treatment adherence improvement.

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Before-After Mental Health

Pre-Post Comparison Study of Korean Medicine Combined Treatment for Panic Disorder Symptom Relief

Chung SY, Kim JH, Park JH, et al.

BMC Complementary Medicine and Therapies (2023)

58% Symptom Severity Reduction
81% Attack Frequency Reduction
56 subjects Study Participants

Korean medicine combined treatment significantly reduces the frequency and severity of panic disorder attacks and can be utilized as an adjunctive treatment strategy to reduce drug dependence.

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Before-After Mental Health

Pre-Post Comparison Study of Korean Medicine Combined Treatment for Panic Disorder Symptom Relief

Chung SY, Kim JH, Park JH, et al. BMC Complementary Medicine and Therapies (2023)
58% Symptom Severity Reduction
81% Attack Frequency Reduction
56 subjects Study Participants

Summary

A pre-post comparison study in which Korean medicine combined treatment combining acupuncture, herbal medicine, and relaxation therapy was administered for 8 weeks to 56 panic disorder patients. PDSS (Panic Disorder Severity Scale) decreased by 58% compared with pre-treatment, and panic attack frequency decreased from 4.2 to 0.8 times per week.

Key Conclusion

Korean medicine combined treatment significantly reduces the frequency and severity of panic disorder attacks and can be utilized as an adjunctive treatment strategy to reduce drug dependence.

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RCT Skin Conditions

Effect of Herbal Medicine Treatment for Atopic Dermatitis: A Randomized Controlled Trial

Choi IH, Kim S, Kim Y, et al.

Annals of Dermatology (2023)

48% SCORAD index reduction
55% Pruritus improvement
12 weeks Treatment duration

Herbal medicine treatment significantly improves skin lesions and pruritus in atopic dermatitis and may contribute to reducing steroid use.

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RCT Skin Conditions

Effect of Herbal Medicine Treatment for Atopic Dermatitis: A Randomized Controlled Trial

Choi IH, Kim S, Kim Y, et al. Annals of Dermatology (2023)
48% SCORAD index reduction
55% Pruritus improvement
12 weeks Treatment duration

Summary

Seventy-two patients with moderate atopic dermatitis were compared between herbal medicine and placebo groups for 12 weeks. The herbal medicine group showed an average 48% reduction in SCORAD index and 55% improvement in pruritus VAS. Serum IgE levels also significantly decreased, confirming immunomodulatory effects.

Key Conclusion

Herbal medicine treatment significantly improves skin lesions and pruritus in atopic dermatitis and may contribute to reducing steroid use.

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Systematic Review Skin Conditions

Systematic Review of Acupuncture Treatment for Chronic Urticaria

Lee HJ, Park YC, Kim KS, et al.

European Journal of Integrative Medicine (2022)

37% Additional symptom reduction
29% Recurrence reduction
11 studies Analyzed studies

Acupuncture as adjunctive treatment for chronic urticaria shows significant effects on symptom control and recurrence prevention.

View Source 2022
Systematic Review Skin Conditions

Systematic Review of Acupuncture Treatment for Chronic Urticaria

Lee HJ, Park YC, Kim KS, et al. European Journal of Integrative Medicine (2022)
37% Additional symptom reduction
29% Recurrence reduction
11 studies Analyzed studies

Summary

Eleven RCTs evaluating acupuncture treatment for chronic spontaneous urticaria were systematically analyzed. The acupuncture combination group showed an additional 37% reduction in UAS7 (urticaria activity score) compared to antihistamines alone, with 29% lower recurrence rates at 6-month follow-up.

Key Conclusion

Acupuncture as adjunctive treatment for chronic urticaria shows significant effects on symptom control and recurrence prevention.

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Cohort Study Skin Conditions

Effect of Korean Medicine Combination Therapy in Psoriasis Patients: A Prospective Cohort Study

Yun YH, Choi JE, Kim KJ, et al.

Journal of Alternative and Complementary Medicine (2023)

41% PASI 75 achievement rate
62% Quality of life improvement
98 patients Study population

Korean medicine combination therapy contributes to reducing skin lesions and improving quality of life in psoriasis, with expected synergistic effects when combined with conventional treatment.

View Source 2023
Cohort Study Skin Conditions

Effect of Korean Medicine Combination Therapy in Psoriasis Patients: A Prospective Cohort Study

Yun YH, Choi JE, Kim KJ, et al. Journal of Alternative and Complementary Medicine (2023)
41% PASI 75 achievement rate
62% Quality of life improvement
98 patients Study population

Summary

A cohort study observing PASI score changes after 16 weeks of Korean medicine combination therapy combining herbal medicine and acupuncture in 98 patients with mild-to-moderate psoriasis. PASI 75 achievement rate was 41%, and patient-reported outcomes (DLQI) showed an average 62% improvement in quality of life.

Key Conclusion

Korean medicine combination therapy contributes to reducing skin lesions and improving quality of life in psoriasis, with expected synergistic effects when combined with conventional treatment.

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RCT Digestive Disorders

Treatment Effect of Banhasasim-tang for Functional Dyspepsia: A Randomized Controlled Trial

Park JW, Ryu BH, Kim JS, et al.

Journal of Gastroenterology and Hepatology (2023)

61% Upper Abdominal Pain Reduction
54% Early Satiety Improvement
108 subjects Study Subjects

Banhasasim-tang significantly improves the major symptoms of functional dyspepsia and contributes to gastrointestinal motility recovery.

View Source 2023
RCT Digestive Disorders

Treatment Effect of Banhasasim-tang for Functional Dyspepsia: A Randomized Controlled Trial

Park JW, Ryu BH, Kim JS, et al. Journal of Gastroenterology and Hepatology (2023)
61% Upper Abdominal Pain Reduction
54% Early Satiety Improvement
108 subjects Study Subjects

Summary

An 8-week randomized controlled trial compared Banhasasim-tang with placebo in 108 patients with functional dyspepsia. The Banhasasim-tang group showed a 61% reduction in upper abdominal pain scores and a 54% improvement in early satiety. Significant improvement was also confirmed in gastric emptying function tests.

Key Conclusion

Banhasasim-tang significantly improves the major symptoms of functional dyspepsia and contributes to gastrointestinal motility recovery.

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RCT Digestive Disorders

Effect of Combined Acupuncture and Western Medicine for Reflux Esophagitis

Zhu JJ, Liu S, Chen WG, et al.

BMC Gastroenterology (2023)

68% Symptom Score Reduction
2 times PPI Reduction Success Rate
6 weeks Treatment Duration

Combined acupuncture and PPI is effective as an integrated treatment strategy that strengthens symptom relief in reflux esophagitis and reduces PPI dependence.

View Source 2023
RCT Digestive Disorders

Effect of Combined Acupuncture and Western Medicine for Reflux Esophagitis

Zhu JJ, Liu S, Chen WG, et al. BMC Gastroenterology (2023)
68% Symptom Score Reduction
2 times PPI Reduction Success Rate
6 weeks Treatment Duration

Summary

Eighty-six patients with reflux esophagitis were compared between a PPI monotherapy group and a PPI + acupuncture combined group over 6 weeks. The combined group showed a 68% reduction in RDQ (Reflux Disease Questionnaire) scores, demonstrating a significant difference compared to the monotherapy group (49%). Notably, the rate of successful PPI dose reduction was 2 times higher in the combined group.

Key Conclusion

Combined acupuncture and PPI is effective as an integrated treatment strategy that strengthens symptom relief in reflux esophagitis and reduces PPI dependence.

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RCT ENT Disorders

Therapeutic Effect of Socheongryong-tang on Allergic Rhinitis: A Randomized Controlled Trial

Jung JW, Kang HR, Kim MH, et al.

Allergy, Asthma & Immunology Research (2023)

57% Nasal symptom reduction
94 patients Study population
4 weeks Treatment duration

Socheongryong-tang demonstrates symptom relief efficacy comparable to antihistamines for allergic rhinitis with fewer side effects, serving as a safe alternative treatment option.

View Source 2023
RCT ENT Disorders

Therapeutic Effect of Socheongryong-tang on Allergic Rhinitis: A Randomized Controlled Trial

Jung JW, Kang HR, Kim MH, et al. Allergy, Asthma & Immunology Research (2023)
57% Nasal symptom reduction
94 patients Study population
4 weeks Treatment duration

Summary

A randomized controlled trial comparing 4 weeks of Socheongryong-tang versus cetirizine alone in 94 patients with seasonal allergic rhinitis. The Socheongryong-tang group showed a 57% reduction in Total Nasal Symptom Score (TNSS), comparable to cetirizine (51%), while having significantly fewer side effects including drowsiness.

Key Conclusion

Socheongryong-tang demonstrates symptom relief efficacy comparable to antihistamines for allergic rhinitis with fewer side effects, serving as a safe alternative treatment option.

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