금맥한의원
Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

Research Papers
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Total 1642 papers

RCT Digestive Disorders

Treatment Effect of Banhasasim-tang for Reflux Esophagitis: A Randomized Controlled Trial

Lee SJ, Kim NK, Baek NI, et al.

Journal of Ethnopharmacology (2022)

79% Symptom Improvement Rate
70 subjects Number of Participants

Banhasasim-tang demonstrates effects similar to PPIs in mild-to-moderate reflux esophagitis and may serve as a safe alternative.

RCT Digestive Disorders

Treatment Effect of Banhasasim-tang for Reflux Esophagitis: A Randomized Controlled Trial

Lee SJ, Kim NK, Baek NI, et al. Journal of Ethnopharmacology (2022)
79% Symptom Improvement Rate
70 subjects Number of Participants

Summary

Seventy patients with reflux esophagitis (LA classification grades A-B) were divided into a Banhasasim-tang group and a PPI control group and treated for 8 weeks. The symptom improvement rate of the Banhasasim-tang group (79%) showed no statistically significant difference from the PPI group (83%).

Key Conclusion

Banhasasim-tang demonstrates effects similar to PPIs in mild-to-moderate reflux esophagitis and may serve as a safe alternative.

Meta-Analysis Digestive Disorders

Systematic Review and Meta-Analysis of Herbal Medicine Treatment for Irritable Bowel Syndrome

Choi JY, Ko SJ, Park JW, et al.

BMC Complementary Medicine and Therapies (2024)

OR 2.56 Odds Ratio
21 studies Number of Reviewed RCTs

Herbal medicine demonstrates significant effects compared to Western medicine for IBS symptom improvement, with particularly pronounced effects in diarrhea-predominant and mixed types.

Meta-Analysis Digestive Disorders

Systematic Review and Meta-Analysis of Herbal Medicine Treatment for Irritable Bowel Syndrome

Choi JY, Ko SJ, Park JW, et al. BMC Complementary Medicine and Therapies (2024)
OR 2.56 Odds Ratio
21 studies Number of Reviewed RCTs

Summary

The effect of herbal medicine treatment for irritable bowel syndrome (IBS) was meta-analyzed across 21 RCTs. The overall symptom improvement rate of the herbal medicine group was significantly higher than the Western medicine control group at OR 2.56 (95% CI: 1.87-3.51).

Key Conclusion

Herbal medicine demonstrates significant effects compared to Western medicine for IBS symptom improvement, with particularly pronounced effects in diarrhea-predominant and mixed types.

RCT Digestive Disorders

Effect of Acupuncture on Functional Dyspepsia: A Randomized Controlled Trial

Kim JH, Lee TY, Park YC, et al.

Evidence-Based Complementary and Alternative Medicine (2023)

52% Symptom Improvement Rate
90 subjects Number of Participants

Acupuncture is effective for symptom improvement in functional dyspepsia and shows significant superiority compared to sham treatment.

RCT Digestive Disorders

Effect of Acupuncture on Functional Dyspepsia: A Randomized Controlled Trial

Kim JH, Lee TY, Park YC, et al. Evidence-Based Complementary and Alternative Medicine (2023)
52% Symptom Improvement Rate
90 subjects Number of Participants

Summary

Ninety patients with functional dyspepsia (Rome IV criteria) were divided into an acupuncture treatment group and a sham acupuncture group and treated for 8 weeks. The acupuncture treatment group showed a 52% improvement in dyspepsia symptom scores (NDI), demonstrating a significant difference from the sham group (21%).

Key Conclusion

Acupuncture is effective for symptom improvement in functional dyspepsia and shows significant superiority compared to sham treatment.

Systematic Review Geum! Maek! Capsule Diet

Systematic Review of Korean Medicine Diet Effects on Cardiovascular Risk Factors

Oh HW, Sung AD, Min SY, et al.

Evidence-Based Complementary and Alternative Medicine (2025)

19 studies Number of Reviewed Studies
4 Improved Risk Factors

Korean medicine diet comprehensively reduces cardiovascular risk beyond weight loss.

Systematic Review Geum! Maek! Capsule Diet

Systematic Review of Korean Medicine Diet Effects on Cardiovascular Risk Factors

Oh HW, Sung AD, Min SY, et al. Evidence-Based Complementary and Alternative Medicine (2025)
19 studies Number of Reviewed Studies
4 Improved Risk Factors

Summary

The effect of Korean medicine diet on cardiovascular risk factors (blood pressure, blood glucose, lipids, waist circumference) was systematically analyzed across 19 studies. Significant improvements were confirmed in all 4 risk factors in the Korean medicine treatment group.

Key Conclusion

Korean medicine diet comprehensively reduces cardiovascular risk beyond weight loss.

Case Study Geum! Maek! Capsule Diet

Adipocyte Differentiation Inhibition Mechanism of Herbal Medicine Extract: An in vitro Study

Roh SS, Jung AY, Kwon DY, et al.

Journal of Ethnopharmacology (2021)

68% Differentiation Inhibition Rate
3 types Major Herbal Materials

Herbal medicine extracts effectively block adipocyte differentiation through inhibition of key transcription factors.

Case Study Geum! Maek! Capsule Diet

Adipocyte Differentiation Inhibition Mechanism of Herbal Medicine Extract: An in vitro Study

Roh SS, Jung AY, Kwon DY, et al. Journal of Ethnopharmacology (2021)
68% Differentiation Inhibition Rate
3 types Major Herbal Materials

Summary

The 3T3-L1 preadipocyte differentiation inhibition effect of a combined herbal medicine extract (Astragalus, Atractylodes, Alisma) was evaluated. The herbal medicine extract inhibited adipocyte differentiation by 68% by suppressing PPARγ and C/EBPα expression.

Key Conclusion

Herbal medicine extracts effectively block adipocyte differentiation through inhibition of key transcription factors.

Cross-Sectional Geum! Maek! Capsule Diet

Korean Medicine Treatment Satisfaction and Quality of Life Changes in Obese Patients: A Multicenter Cross-Sectional Study

Ha NY, Shin JY, Choi WJ, et al.

Journal of Korean Medicine (2019)

4.1/5 Treatment Satisfaction
350 subjects Number of Participants

Korean medicine obesity treatment contributes to high patient satisfaction along with quality of life improvement.

Cross-Sectional Geum! Maek! Capsule Diet

Korean Medicine Treatment Satisfaction and Quality of Life Changes in Obese Patients: A Multicenter Cross-Sectional Study

Ha NY, Shin JY, Choi WJ, et al. Journal of Korean Medicine (2019)
4.1/5 Treatment Satisfaction
350 subjects Number of Participants

Summary

Treatment satisfaction and SF-36 quality of life scores were analyzed in 350 patients receiving Korean medicine obesity treatment at 8 Korean medicine clinics. Overall satisfaction was 4.1/5 points, with significant improvements in physical function and mental health domains.

Key Conclusion

Korean medicine obesity treatment contributes to high patient satisfaction along with quality of life improvement.

Cohort Study Geum! Maek! Capsule Diet

Effect of Maintenance Program for Yo-Yo Effect Prevention After Korean Medicine Obesity Treatment

Cho YJ, Kim TH, Sung HK, et al.

Complementary Therapies in Medicine (2024)

1.2kg Participant Group Regain
200 subjects Number of Participants

Korean medicine maintenance programs effectively prevent the yo-yo effect after obesity treatment.

Cohort Study Geum! Maek! Capsule Diet

Effect of Maintenance Program for Yo-Yo Effect Prevention After Korean Medicine Obesity Treatment

Cho YJ, Kim TH, Sung HK, et al. Complementary Therapies in Medicine (2024)
1.2kg Participant Group Regain
200 subjects Number of Participants

Summary

One hundred patients participating in a weight maintenance program (monthly acupuncture + herbal tea) and 100 non-participants were compared for 6 months after Korean medicine obesity treatment. Weight regain in the maintenance program participants was 1.2 kg, significantly less than the non-participant group (4.8 kg).

Key Conclusion

Korean medicine maintenance programs effectively prevent the yo-yo effect after obesity treatment.

RCT Geum! Maek! Capsule Diet

Metabolic Improvement Effect of Moxibustion for Obesity: A Randomized Controlled Trial

Jang MK, Park HJ, Lee SD, et al.

BMC Complementary Medicine and Therapies (2020)

19% HOMA-IR Reduction
50 subjects Number of Participants

Moxibustion has comprehensive effects on improving metabolic indicators in obese patients.

RCT Geum! Maek! Capsule Diet

Metabolic Improvement Effect of Moxibustion for Obesity: A Randomized Controlled Trial

Jang MK, Park HJ, Lee SD, et al. BMC Complementary Medicine and Therapies (2020)
19% HOMA-IR Reduction
50 subjects Number of Participants

Summary

Fifty obese patients were divided into a moxibustion treatment group and a control group, and metabolic indicators were compared after 8 weeks of treatment. The moxibustion treatment group showed reductions in fasting blood glucose by 8%, triglycerides by 14%, and HOMA-IR by 19%.

Key Conclusion

Moxibustion has comprehensive effects on improving metabolic indicators in obese patients.

Before-After Geum! Maek! Capsule Diet

Satiety Enhancement and Energy Intake Reduction Effect of Herbal Medicine Diet Capsules

Woo JS, Min BJ, Lim CY, et al.

Phytomedicine (2023)

320kcal Daily Intake Reduction
42 subjects Number of Participants

Herbal medicine diet capsules induce natural caloric intake reduction by increasing satiety.

Before-After Geum! Maek! Capsule Diet

Satiety Enhancement and Energy Intake Reduction Effect of Herbal Medicine Diet Capsules

Woo JS, Min BJ, Lim CY, et al. Phytomedicine (2023)
320kcal Daily Intake Reduction
42 subjects Number of Participants

Summary

Herbal medicine diet capsules were administered for 6 weeks to 42 overweight adults, and food diaries and satiety scales were analyzed. After capsule administration, daily caloric intake decreased by an average of 320 kcal, and satiety increased by 35%.

Key Conclusion

Herbal medicine diet capsules induce natural caloric intake reduction by increasing satiety.

Meta-Analysis Geum! Maek! Capsule Diet

Effect of Herbal Medicine Treatment on Inflammatory Markers in Obese Patients: A Meta-Analysis

Park SJ, Hong JM, Kim YS, et al.

Journal of Ethnopharmacology (2025)

SMD -0.89 CRP Reduction Effect
13 studies Number of Reviewed RCTs

Korean herbal medicine obesity treatment significantly reduces systemic inflammation along with weight loss.

Meta-Analysis Geum! Maek! Capsule Diet

Effect of Herbal Medicine Treatment on Inflammatory Markers in Obese Patients: A Meta-Analysis

Park SJ, Hong JM, Kim YS, et al. Journal of Ethnopharmacology (2025)
SMD -0.89 CRP Reduction Effect
13 studies Number of Reviewed RCTs

Summary

The effect of Korean herbal medicine obesity treatment on inflammatory markers (CRP, IL-6, TNF-α) was meta-analyzed across 13 RCTs. The herbal medicine group showed significant reductions in CRP (SMD: -0.89) and IL-6 (SMD: -0.74).

Key Conclusion

Korean herbal medicine obesity treatment significantly reduces systemic inflammation along with weight loss.

Cross-Sectional Geum! Maek! Capsule Diet

Effect of Korean Medicine Diet on Weight Management in Postmenopausal Women: A Cross-Sectional Study

Yoon SH, Kim MJ, Han CH, et al.

Journal of Korean Medicine (2021)

5.4kg Average Weight Loss
72 subjects Number of Participants

Korean medicine diet selectively reduces body fat while preserving bone mineral density in postmenopausal women.

Cross-Sectional Geum! Maek! Capsule Diet

Effect of Korean Medicine Diet on Weight Management in Postmenopausal Women: A Cross-Sectional Study

Yoon SH, Kim MJ, Han CH, et al. Journal of Korean Medicine (2021)
5.4kg Average Weight Loss
72 subjects Number of Participants

Summary

Weight, body fat, and bone mineral density before and after participation in a Korean medicine diet program were comparatively analyzed in 72 postmenopausal obese women. An average weight reduction of 5.4 kg was achieved, with selective body fat reduction without bone mineral density loss.

Key Conclusion

Korean medicine diet selectively reduces body fat while preserving bone mineral density in postmenopausal women.

Cohort Study Geum! Maek! Capsule Diet

Liver Function Safety Evaluation of Korean Medicine Obesity Treatment: A Prospective Monitoring Study

Shin IS, Ko SG, Lee MY, et al.

Evidence-Based Complementary and Alternative Medicine (2022)

97.5% Normal Maintenance Rate
200 subjects Number of Participants

Korean medicine obesity treatment is safe for liver function and shows positive effects on existing fatty liver improvement.

Cohort Study Geum! Maek! Capsule Diet

Liver Function Safety Evaluation of Korean Medicine Obesity Treatment: A Prospective Monitoring Study

Shin IS, Ko SG, Lee MY, et al. Evidence-Based Complementary and Alternative Medicine (2022)
97.5% Normal Maintenance Rate
200 subjects Number of Participants

Summary

Liver function (AST, ALT, GGT) changes were prospectively monitored for 12 weeks in 200 patients receiving Korean medicine obesity treatment. Liver function values remained within the normal range in 97.5% of patients, and the fatty liver index actually improved.

Key Conclusion

Korean medicine obesity treatment is safe for liver function and shows positive effects on existing fatty liver improvement.