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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 1642 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
RCT Digestive Disorders

Comparison of Herbal Medicine Treatment and Low-FODMAP Diet for IBS Patients: A Randomized Controlled Trial

Kim SY, Chung WS, Jang JG, et al.

BMC Complementary Medicine and Therapies (2024)

178 points Combined Group IBS-SSS Reduction
100 subjects Number of Participants

The combination of herbal medicine and Low-FODMAP diet is the most effective strategy for IBS symptom management.

View Source 2024
RCT Digestive Disorders

Comparison of Herbal Medicine Treatment and Low-FODMAP Diet for IBS Patients: A Randomized Controlled Trial

Kim SY, Chung WS, Jang JG, et al. BMC Complementary Medicine and Therapies (2024)
178 points Combined Group IBS-SSS Reduction
100 subjects Number of Participants

Summary

One hundred IBS patients were divided into a herbal medicine group, a Low-FODMAP diet group, and a combined group, and treatment effects were compared over 8 weeks. The IBS-SSS reduction in the combined group (-178 points) was significantly greater than the herbal medicine monotherapy (-132 points) and diet monotherapy (-118 points) groups.

Key Conclusion

The combination of herbal medicine and Low-FODMAP diet is the most effective strategy for IBS symptom management.

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Cross-Sectional Digestive Disorders

Analysis of Treatment Effect Differences by Korean Medicine Constitution in Functional Dyspepsia

Baek YH, Lee SW, Jang ES, et al.

Journal of Korean Medicine (2023)

86% Soeumin Response Rate
120 subjects Number of Participants

The effect of Korean medicine treatment for dyspepsia varies by Sasang constitution, and a constitutional tailored approach is important.

View Source 2023
Cross-Sectional Digestive Disorders

Analysis of Treatment Effect Differences by Korean Medicine Constitution in Functional Dyspepsia

Baek YH, Lee SW, Jang ES, et al. Journal of Korean Medicine (2023)
86% Soeumin Response Rate
120 subjects Number of Participants

Summary

One hundred twenty patients with functional dyspepsia were classified by Sasang constitution and received constitutional tailored herbal medicine treatment. The treatment response rate was highest at 86% in Soeumin and relatively low at 71% in Taeyangin.

Key Conclusion

The effect of Korean medicine treatment for dyspepsia varies by Sasang constitution, and a constitutional tailored approach is important.

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Meta-Analysis Digestive Disorders

Efficacy and Safety of Korean Medicine Treatment Compared to Western Medicine for Reflux Esophagitis: A Meta-Analysis

Woo CH, Ahn TW, Shin HK, et al.

Evidence-Based Complementary and Alternative Medicine (2025)

RR 0.97 Efficacy Comparison
18 studies Number of Reviewed RCTs

Korean medicine treatment shows similar efficacy to PPI in GERD with significantly fewer side effects.

View Source 2025
Meta-Analysis Digestive Disorders

Efficacy and Safety of Korean Medicine Treatment Compared to Western Medicine for Reflux Esophagitis: A Meta-Analysis

Woo CH, Ahn TW, Shin HK, et al. Evidence-Based Complementary and Alternative Medicine (2025)
RR 0.97 Efficacy Comparison
18 studies Number of Reviewed RCTs

Summary

The efficacy of Korean medicine treatment and Western medicine (PPI) treatment for GERD was meta-analyzed across 18 RCTs. The effect of Korean medicine treatment was similar to PPI (RR 0.97), and the adverse event incidence was significantly lower (RR 0.34).

Key Conclusion

Korean medicine treatment shows similar efficacy to PPI in GERD with significantly fewer side effects.

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Before-After Digestive Disorders

Quality of Life and Mental Health Changes After Korean Medicine Treatment in Digestive Disease Patients

Ha IH, Cho WS, Im JY, et al.

Complementary Therapies in Medicine (2021)

38% Quality of Life Improvement
85 subjects Number of Participants

Korean medicine digestive treatment comprehensively improves quality of life and mental health along with digestive symptom improvement.

View Source 2021
Before-After Digestive Disorders

Quality of Life and Mental Health Changes After Korean Medicine Treatment in Digestive Disease Patients

Ha IH, Cho WS, Im JY, et al. Complementary Therapies in Medicine (2021)
38% Quality of Life Improvement
85 subjects Number of Participants

Summary

Changes in SF-36 quality of life scores and PHQ-9 depression scores were evaluated after 12 weeks of Korean medicine treatment in 85 patients with chronic digestive diseases. SF-36 total scores improved by 38%, and PHQ-9 scores also decreased significantly.

Key Conclusion

Korean medicine digestive treatment comprehensively improves quality of life and mental health along with digestive symptom improvement.

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RCT Digestive Disorders

Effect of Fermented Herbal Medicine Extract on Gastrointestinal Function Improvement: Preclinical and Clinical Studies

Ryu KH, Song JY, Lee MK, et al.

Journal of Ethnopharmacology (2024)

35% Fermentation Superiority Effect
30 subjects Number of Clinical Participants

Fermented herbal medicine extracts show superior effects compared to existing extracts for digestive function improvement.

View Source 2024
RCT Digestive Disorders

Effect of Fermented Herbal Medicine Extract on Gastrointestinal Function Improvement: Preclinical and Clinical Studies

Ryu KH, Song JY, Lee MK, et al. Journal of Ethnopharmacology (2024)
35% Fermentation Superiority Effect
30 subjects Number of Clinical Participants

Summary

The gastrointestinal function improvement effect of fermented herbal medicine extract (fermented Yukgunja-tang) was evaluated in animal experiments and clinical trials (30 subjects). The fermented extract showed 35% greater gastrointestinal motility promotion effect compared to non-fermented, with improved absorption rate.

Key Conclusion

Fermented herbal medicine extracts show superior effects compared to existing extracts for digestive function improvement.

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Case Study Digestive Disorders

Effect of Herbal Medicine Conversion Treatment in Long-Term PPI Users: A Case Study

Lee BJ, Kim JE, Yim MH, et al.

Journal of Korean Medicine (2020)

80% PPI Discontinuation Success Rate
10 subjects Number of Participants

Conversion to herbal medicine is possible in long-term PPI users, and most patients succeeded in symptom management.

View Source 2020
Case Study Digestive Disorders

Effect of Herbal Medicine Conversion Treatment in Long-Term PPI Users: A Case Study

Lee BJ, Kim JE, Yim MH, et al. Journal of Korean Medicine (2020)
80% PPI Discontinuation Success Rate
10 subjects Number of Participants

Summary

A stepwise conversion to herbal medicine was attempted in 10 GERD patients who had been taking PPIs for more than 1 year. Eight patients succeeded in PPI discontinuation, and at 6-month follow-up, 7 patients managed symptoms with herbal medicine alone.

Key Conclusion

Conversion to herbal medicine is possible in long-term PPI users, and most patients succeeded in symptom management.

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Cross-Sectional Digestive Disorders

Drug Interaction Safety Evaluation of Herbal Medicines Used in Digestive Diseases

Ku BC, Won JH, Song MY, et al.

Phytomedicine (2022)

8 types Number of Reviewed Prescriptions
97% Safety Rate

Korean medicine digestive prescriptions have a low risk of interactions with major Western medicines and are safe for concurrent use.

View Source 2022
Cross-Sectional Digestive Disorders

Drug Interaction Safety Evaluation of Herbal Medicines Used in Digestive Diseases

Ku BC, Won JH, Song MY, et al. Phytomedicine (2022)
8 types Number of Reviewed Prescriptions
97% Safety Rate

Summary

Drug interactions of 8 herbal medicine prescriptions frequently used in digestive diseases with Western medicines were evaluated by CYP450 enzyme analysis and clinical monitoring. No clinically significant drug interactions were observed in most prescriptions.

Key Conclusion

Korean medicine digestive prescriptions have a low risk of interactions with major Western medicines and are safe for concurrent use.

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Systematic Review Digestive Disorders

Effect of Korean Medicine Treatment for Functional Abdominal Pain in Children: A Systematic Review

Choi SH, Lee JA, Kim AR, et al.

BMC Complementary Medicine and Therapies (2023)

11 studies Number of Reviewed Studies
73% Abdominal Pain Reduction Rate

Korean medicine treatment is effective for pediatric functional abdominal pain and is suitable for pediatric patients with fewer side effects.

View Source 2023
Systematic Review Digestive Disorders

Effect of Korean Medicine Treatment for Functional Abdominal Pain in Children: A Systematic Review

Choi SH, Lee JA, Kim AR, et al. BMC Complementary Medicine and Therapies (2023)
11 studies Number of Reviewed Studies
73% Abdominal Pain Reduction Rate

Summary

The effect of Korean medicine treatment (herbal medicine, acupuncture, pediatric chuna) for pediatric functional abdominal pain was systematically analyzed across 11 studies. The abdominal pain frequency reduction rate of the Korean medicine treatment group was superior to the Western medicine control group.

Key Conclusion

Korean medicine treatment is effective for pediatric functional abdominal pain and is suitable for pediatric patients with fewer side effects.

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Before-After Digestive Disorders

Effect of Herbal Medicine on Intestinal Barrier Permeability in Patients with Digestive Disorders

Go HY, Park YC, Shin NR, et al.

Journal of Ethnopharmacology (2025)

38% Permeability Reduction
40 subjects Participants

Herbal medicine corrects increased intestinal permeability and improves the underlying pathophysiology of digestive disorders.

View Source 2025
Before-After Digestive Disorders

Effect of Herbal Medicine on Intestinal Barrier Permeability in Patients with Digestive Disorders

Go HY, Park YC, Shin NR, et al. Journal of Ethnopharmacology (2025)
38% Permeability Reduction
40 subjects Participants

Summary

Forty patients with IBS and functional dyspepsia received herbal medicine for 8 weeks, and intestinal permeability was assessed using the lactulose-mannitol test. The intestinal permeability index decreased by 38% after herbal treatment, indicating normalization of barrier function.

Key Conclusion

Herbal medicine corrects increased intestinal permeability and improves the underlying pathophysiology of digestive disorders.

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Meta-Analysis ENT Disorders

Systematic Review and Meta-analysis of Korean Medicine Rhinitis Treatment Focused on Socheongryong-tang

Kim SH, Park JW, Lee MK, et al.

Evidence-Based Complementary and Alternative Medicine (2023)

82.3% Symptom Improvement Rate
1420 subjects Participants
18 papers Analyzed Papers

Socheongryong-tang is effective in improving major symptoms of allergic rhinitis and can be utilized as a safe treatment with low adverse event rates.

View Source 2023
Meta-Analysis ENT Disorders

Systematic Review and Meta-analysis of Korean Medicine Rhinitis Treatment Focused on Socheongryong-tang

Kim SH, Park JW, Lee MK, et al. Evidence-Based Complementary and Alternative Medicine (2023)
82.3% Symptom Improvement Rate
1420 subjects Participants
18 papers Analyzed Papers

Summary

A systematic review including 18 RCTs was conducted to evaluate the efficacy of Socheongryong-tang for allergic rhinitis. Analysis of 1,420 patients showed significant improvements in major symptoms including nasal congestion, sneezing, and rhinorrhea in the Socheongryong-tang group.

Key Conclusion

Socheongryong-tang is effective in improving major symptoms of allergic rhinitis and can be utilized as a safe treatment with low adverse event rates.

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RCT ENT Disorders

Randomized Controlled Clinical Trial of Modified Changija-san for Sinusitis Patients

Choi YJ, Seo BK, Han CH, et al.

Complementary Therapies in Medicine (2024)

76.5% Symptom Improvement Rate
96 subjects Participants
8 weeks Treatment Period

Modified Changija-san is an effective Korean medicine treatment for symptom and quality-of-life improvement in chronic sinusitis patients.

View Source 2024
RCT ENT Disorders

Randomized Controlled Clinical Trial of Modified Changija-san for Sinusitis Patients

Choi YJ, Seo BK, Han CH, et al. Complementary Therapies in Medicine (2024)
76.5% Symptom Improvement Rate
96 subjects Participants
8 weeks Treatment Period

Summary

Ninety-six patients with chronic sinusitis were compared over 8 weeks between modified Changija-san and placebo groups. Nasal endoscopic findings and SNOT-22 scores significantly improved in the treatment group. Side effects were limited to 3 cases of mild gastrointestinal disturbance.

Key Conclusion

Modified Changija-san is an effective Korean medicine treatment for symptom and quality-of-life improvement in chronic sinusitis patients.

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Before-After ENT Disorders

Pre-Post Comparison Study of Korean Medicine Combined Treatment for Pediatric Otitis Media

Lee JH, Kim YS, Hwang DS, et al.

Journal of Korean Medicine (2022)

71.1% Tympanic Membrane Improvement Rate
45 subjects Participants
12 weeks Treatment Period

Korean medicine combined treatment can reduce recurrence frequency and contribute to hearing improvement in pediatric recurrent otitis media.

View Source 2022
Before-After ENT Disorders

Pre-Post Comparison Study of Korean Medicine Combined Treatment for Pediatric Otitis Media

Lee JH, Kim YS, Hwang DS, et al. Journal of Korean Medicine (2022)
71.1% Tympanic Membrane Improvement Rate
45 subjects Participants
12 weeks Treatment Period

Summary

Forty-five pediatric patients with recurrent otitis media received combined acupuncture and herbal medicine treatment for 12 weeks. Significant improvements were observed in tympanic membrane findings and audiometric tests after treatment.

Key Conclusion

Korean medicine combined treatment can reduce recurrence frequency and contribute to hearing improvement in pediatric recurrent otitis media.

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