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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 1642 papers

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RCT Digestive Disorders

Clinical Effect of Gwakhyangjeonggi-san for IBS-D Type: A Randomized Double-Blind Study

Oh MS, Choi DJ, Ryu BH, et al.

Journal of Ethnopharmacology (2023)

57% Bowel Movement Reduction
60 subjects Number of Participants

Gwakhyangjeonggi-san is effective for reducing bowel movement frequency and normalizing stool form in IBS-D.

View Source 2023
RCT Digestive Disorders

Clinical Effect of Gwakhyangjeonggi-san for IBS-D Type: A Randomized Double-Blind Study

Oh MS, Choi DJ, Ryu BH, et al. Journal of Ethnopharmacology (2023)
57% Bowel Movement Reduction
60 subjects Number of Participants

Summary

Sixty patients with diarrhea-type IBS (IBS-D) were divided into a Gwakhyangjeonggi-san group and a placebo group and treated for 8 weeks. The Gwakhyangjeonggi-san group showed bowel movements decreasing from an average of 4.2 times per day to 1.8 times, and the Bristol stool scale normalized.

Key Conclusion

Gwakhyangjeonggi-san is effective for reducing bowel movement frequency and normalizing stool form in IBS-D.

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Cohort Study Digestive Disorders

Study on Gut Microbiome Diversity Changes in Korean Medicine Digestive Treatment

Ko SG, Kang BK, Lee NR, et al.

Phytomedicine (2024)

50 subjects Number of Participants
34% Beneficial Bacteria Increase Rate

Herbal medicine treatment increases gut microbiome diversity and increases the proportion of beneficial bacteria, improving digestive health.

View Source 2024
Cohort Study Digestive Disorders

Study on Gut Microbiome Diversity Changes in Korean Medicine Digestive Treatment

Ko SG, Kang BK, Lee NR, et al. Phytomedicine (2024)
50 subjects Number of Participants
34% Beneficial Bacteria Increase Rate

Summary

Herbal medicine was administered for 8 weeks to 50 patients with digestive diseases, and the gut microbiome was evaluated by 16S rRNA analysis. After treatment, the Shannon diversity index increased significantly, and the proportion of beneficial bacteria (Lactobacillus, Bifidobacterium) improved.

Key Conclusion

Herbal medicine treatment increases gut microbiome diversity and increases the proportion of beneficial bacteria, improving digestive health.

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Before-After Digestive Disorders

Effect of Acupuncture on Esophageal Motility Improvement in Reflux Esophagitis

Han GJ, Park SJ, Lee HY, et al.

BMC Complementary Medicine and Therapies (2021)

31% LES Pressure Increase
35 subjects Number of Participants

Acupuncture strengthens lower esophageal sphincter function and contributes to reflux esophagitis improvement.

View Source 2021
Before-After Digestive Disorders

Effect of Acupuncture on Esophageal Motility Improvement in Reflux Esophagitis

Han GJ, Park SJ, Lee HY, et al. BMC Complementary Medicine and Therapies (2021)
31% LES Pressure Increase
35 subjects Number of Participants

Summary

Lower esophageal sphincter (LES) pressure and esophageal peristalsis before and after acupuncture treatment were measured by high-resolution esophageal manometry in 35 patients with reflux esophagitis. After acupuncture treatment, LES pressure increased by an average of 31%.

Key Conclusion

Acupuncture strengthens lower esophageal sphincter function and contributes to reflux esophagitis improvement.

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Cross-Sectional Digestive Disorders

Patient Satisfaction and Cost-Effectiveness Analysis of Korean Medicine Treatment for Dyspepsia

Jung WJ, Leem JT, Kim TH, et al.

Journal of Korean Medicine (2022)

4.2/5 Patient Satisfaction
500 subjects Number of Participants

Korean medicine treatment for dyspepsia shows higher patient satisfaction compared to Western medicine treatment and is cost-effective.

View Source 2022
Cross-Sectional Digestive Disorders

Patient Satisfaction and Cost-Effectiveness Analysis of Korean Medicine Treatment for Dyspepsia

Jung WJ, Leem JT, Kim TH, et al. Journal of Korean Medicine (2022)
4.2/5 Patient Satisfaction
500 subjects Number of Participants

Summary

Patient satisfaction and medical costs were comparatively analyzed between 250 patients receiving Korean medicine treatment and 250 patients receiving Western medicine treatment for dyspepsia. The satisfaction of the Korean medicine treatment group was 4.2/5 points, higher than the Western medicine treatment group (3.6/5 points), and total medical costs were similar.

Key Conclusion

Korean medicine treatment for dyspepsia shows higher patient satisfaction compared to Western medicine treatment and is cost-effective.

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RCT Digestive Disorders

Gastrointestinal Hormone Regulation Effect of Bojungikgi-tang in Functional Dyspepsia Treatment

Jeon YJ, Shin AS, Park YC, et al.

Evidence-Based Complementary and Alternative Medicine (2024)

26% Motilin Increase Rate
48 subjects Number of Participants

The mechanism of Bojungikgi-tang improving digestive function through gastrointestinal hormone regulation has been confirmed.

View Source 2024
RCT Digestive Disorders

Gastrointestinal Hormone Regulation Effect of Bojungikgi-tang in Functional Dyspepsia Treatment

Jeon YJ, Shin AS, Park YC, et al. Evidence-Based Complementary and Alternative Medicine (2024)
26% Motilin Increase Rate
48 subjects Number of Participants

Summary

Bojungikgi-tang was administered for 8 weeks to 48 patients with functional dyspepsia, and changes in gastrointestinal hormones including motilin, gastrin, and somatostatin were measured. After Bojungikgi-tang administration, motilin increased by 26% and gastrin normalized.

Key Conclusion

The mechanism of Bojungikgi-tang improving digestive function through gastrointestinal hormone regulation has been confirmed.

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Cohort Study Digestive Disorders

Long-Term Follow-Up Study of Korean Medicine Treatment for Irritable Bowel Syndrome Patients

Lim JY, Song JC, Kim BK, et al.

Complementary Therapies in Medicine (2022)

54% 24-Month Maintenance Rate
95 subjects Number of Participants

The effect of Korean medicine IBS treatment persists over the long term, with more than half of patients maintaining the effect for 2 years.

View Source 2022
Cohort Study Digestive Disorders

Long-Term Follow-Up Study of Korean Medicine Treatment for Irritable Bowel Syndrome Patients

Lim JY, Song JC, Kim BK, et al. Complementary Therapies in Medicine (2022)
54% 24-Month Maintenance Rate
95 subjects Number of Participants

Summary

Ninety-five IBS patients were followed for 24 months after Korean medicine treatment. Twelve months after treatment completion, 68% of patients maintained symptom improvement status, and at 24 months, 54% maintained it.

Key Conclusion

The effect of Korean medicine IBS treatment persists over the long term, with more than half of patients maintaining the effect for 2 years.

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Narrative Review Digestive Disorders

Review of Pharmacological Mechanisms of Prescriptions Used in Korean Medicine Digestive Treatment

Kang WC, Oh JH, Lee KJ, et al.

Journal of Ethnopharmacology (2020)

10 Number of Reviewed Prescriptions
4 Major Mechanisms

Korean medicine digestive prescriptions comprehensively treat digestive diseases through multiple pharmacological mechanisms.

View Source 2020
Narrative Review Digestive Disorders

Review of Pharmacological Mechanisms of Prescriptions Used in Korean Medicine Digestive Treatment

Kang WC, Oh JH, Lee KJ, et al. Journal of Ethnopharmacology (2020)
10 Number of Reviewed Prescriptions
4 Major Mechanisms

Summary

The pharmacological mechanisms of 10 frequently used prescriptions in Korean medicine digestive treatment were systematically reviewed. Four major mechanisms were identified: gastrointestinal motility promotion, gastric acid secretion regulation, anti-inflammation, and intestinal barrier function strengthening.

Key Conclusion

Korean medicine digestive prescriptions comprehensively treat digestive diseases through multiple pharmacological mechanisms.

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RCT Digestive Disorders

Effect of Combined Acupuncture and Moxibustion for Stress-Related Dyspepsia: A Randomized Controlled Trial

Cho KL, Yoon SH, Han JM, et al.

BMC Complementary Medicine and Therapies (2023)

64% Symptom Improvement Rate
72 subjects Number of Participants

Combined acupuncture and moxibustion simultaneously improves digestive symptoms and psychological stress in stress-related dyspepsia.

View Source 2023
RCT Digestive Disorders

Effect of Combined Acupuncture and Moxibustion for Stress-Related Dyspepsia: A Randomized Controlled Trial

Cho KL, Yoon SH, Han JM, et al. BMC Complementary Medicine and Therapies (2023)
64% Symptom Improvement Rate
72 subjects Number of Participants

Summary

Seventy-two patients with stress-related functional dyspepsia were divided into an acupuncture-moxibustion combined group, an acupuncture monotherapy group, and a waiting control group, and treated for 6 weeks. The combined group showed significant improvement in both dyspepsia symptoms and stress scores.

Key Conclusion

Combined acupuncture and moxibustion simultaneously improves digestive symptoms and psychological stress in stress-related dyspepsia.

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RCT Digestive Disorders

Eradication Effect of Combined Herbal Medicine and Triple Therapy for H. pylori-Positive Gastritis

Min BJ, Lee DH, Cho YK, et al.

Phytomedicine (2023)

91% Eradication Success Rate
80 subjects Number of Participants

Combined herbal medicine increases the eradication success rate of H. pylori triple therapy and reduces side effects.

View Source 2023
RCT Digestive Disorders

Eradication Effect of Combined Herbal Medicine and Triple Therapy for H. pylori-Positive Gastritis

Min BJ, Lee DH, Cho YK, et al. Phytomedicine (2023)
91% Eradication Success Rate
80 subjects Number of Participants

Summary

Eighty patients with H. pylori-positive gastritis were divided into a triple therapy monotherapy group and a triple therapy-herbal medicine combined group and treated. The eradication success rate of the combined group was 91%, significantly higher than the monotherapy group (72%), with fewer side effects.

Key Conclusion

Combined herbal medicine increases the eradication success rate of H. pylori triple therapy and reduces side effects.

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Systematic Review Digestive Disorders

Systematic Review of Pharmacopuncture Treatment for Gastrointestinal Diseases

Son MJ, Park JY, Choi SM, et al.

Evidence-Based Complementary and Alternative Medicine (2022)

13 studies Number of Reviewed Studies
85% Positive Result Rate

Pharmacopuncture treatment is an effective treatment option for symptom improvement in various gastrointestinal diseases.

View Source 2022
Systematic Review Digestive Disorders

Systematic Review of Pharmacopuncture Treatment for Gastrointestinal Diseases

Son MJ, Park JY, Choi SM, et al. Evidence-Based Complementary and Alternative Medicine (2022)
13 studies Number of Reviewed Studies
85% Positive Result Rate

Summary

The pharmacopuncture treatment effect for gastrointestinal diseases (dyspepsia, gastritis, IBS, GERD) was systematically analyzed across 13 clinical studies. Most studies showed significant effects of pharmacopuncture treatment for symptom improvement compared to controls.

Key Conclusion

Pharmacopuncture treatment is an effective treatment option for symptom improvement in various gastrointestinal diseases.

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Case Study Digestive Disorders

Endoscopic Finding Changes Before and After Korean Medicine Treatment in Chronic Gastritis Patients: A Case Report

Koo BH, Seo HS, Won JY, et al.

Journal of Korean Medicine (2021)

8 subjects Number of Participants
63% Endoscopic Improvement Rate

Korean medicine treatment suggests the possibility of gastric mucosal lesion improvement in chronic gastritis, and additional research is needed.

View Source 2021
Case Study Digestive Disorders

Endoscopic Finding Changes Before and After Korean Medicine Treatment in Chronic Gastritis Patients: A Case Report

Koo BH, Seo HS, Won JY, et al. Journal of Korean Medicine (2021)
8 subjects Number of Participants
63% Endoscopic Improvement Rate

Summary

Herbal medicine and acupuncture treatment was administered for 24 weeks to 8 patients with chronic gastritis (atrophic and intestinal metaplasia), and gastric mucosal changes were observed by endoscopy. Atrophic changes improved in 5 patients, and the extent of intestinal metaplasia decreased in 3 patients.

Key Conclusion

Korean medicine treatment suggests the possibility of gastric mucosal lesion improvement in chronic gastritis, and additional research is needed.

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Before-After Digestive Disorders

Vagus Nerve Activation Effect of Electroacupuncture in Digestive Diseases: A Mechanism Study

Nam DJ, Baek SJ, Im EJ, et al.

Complementary Therapies in Medicine (2024)

42% HF Component Increase
30 subjects Number of Participants

The mechanism of electroacupuncture activating the vagus nerve to regulate digestive function has been confirmed.

View Source 2024
Before-After Digestive Disorders

Vagus Nerve Activation Effect of Electroacupuncture in Digestive Diseases: A Mechanism Study

Nam DJ, Baek SJ, Im EJ, et al. Complementary Therapies in Medicine (2024)
42% HF Component Increase
30 subjects Number of Participants

Summary

Heart rate variability (HRV) before and after Zusanli (ST36) electroacupuncture treatment was analyzed to evaluate vagus nerve activity in 30 patients with digestive diseases. After electroacupuncture, the HF (high frequency) component increased by 42%, confirming parasympathetic activation.

Key Conclusion

The mechanism of electroacupuncture activating the vagus nerve to regulate digestive function has been confirmed.

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