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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 1642 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Before-After Hyangseongpajeokhwan (響聲破笛丸)

Experimental Study on the Vocal Cord Hyaluronic Acid Synthesis Promotion Effect of Hyangseongpajeok-hwan

Lim JY, Choi JN, Kim HS, et al.

Laryngoscope (2023)

HAS2 2.3-fold increase Gene Expression
HA production 67% increase Hyaluronic Acid Promotion
p<0.01 Statistical Significance

Hyangseongpajeok-hwan can promote hyaluronic acid synthesis in vocal cord lamina propria, improving vocal cord vibration characteristics.

View Source 2023
Before-After Hyangseongpajeokhwan (響聲破笛丸)

Experimental Study on the Vocal Cord Hyaluronic Acid Synthesis Promotion Effect of Hyangseongpajeok-hwan

Lim JY, Choi JN, Kim HS, et al. Laryngoscope (2023)
HAS2 2.3-fold increase Gene Expression
HA production 67% increase Hyaluronic Acid Promotion
p<0.01 Statistical Significance

Summary

Human vocal fold fibroblasts were treated with Hyangseongpajeok-hwan extract, and hyaluronic acid (HA) production and related gene expression were analyzed. HA synthase 2 expression increased, and HA production was significantly promoted.

Key Conclusion

Hyangseongpajeok-hwan can promote hyaluronic acid synthesis in vocal cord lamina propria, improving vocal cord vibration characteristics.

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RCT Hyangseongpajeokhwan (響聲破笛丸)

Effect of a Hyangseongpajeok-hwan Program for Voice Health Management of Call Center Workers

Lee JY, Choi HS, Park IS, et al.

Annals of Occupational and Environmental Medicine (2024)

80 subjects Participants
Sick leave 52% reduction Industrial Effect
Voice self-evaluation improvement Subjective Improvement

Hyangseongpajeok-hwan can be effectively utilized in occupational voice health management programs for call center workers.

View Source 2024
RCT Hyangseongpajeokhwan (響聲破笛丸)

Effect of a Hyangseongpajeok-hwan Program for Voice Health Management of Call Center Workers

Lee JY, Choi HS, Park IS, et al. Annals of Occupational and Environmental Medicine (2024)
80 subjects Participants
Sick leave 52% reduction Industrial Effect
Voice self-evaluation improvement Subjective Improvement

Summary

Eighty call center workers were divided into a Hyangseongpajeok-hwan administration+vocal hygiene education group and a vocal hygiene education alone group and compared for 16 weeks. The Hyangseongpajeok-hwan group showed reduced voice-related sick leave days and improved voice self-evaluation scores.

Key Conclusion

Hyangseongpajeok-hwan can be effectively utilized in occupational voice health management programs for call center workers.

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Case Study Hyangseongpajeokhwan (響聲破笛丸)

Effect of Combined Hyangseongpajeok-hwan and Acupuncture on Spasmodic Dysphonia: A Pilot Study

Chung PS, Kim HJ, Lee SJ, et al.

Acupuncture in Medicine (2023)

15 subjects Participants
Voice breaks 38% reduction Symptom Improvement
Fluency improvement Voice Function Improvement

Combined Hyangseongpajeok-hwan and acupuncture treatment is worth exploring as a complementary treatment option for spasmodic dysphonia.

View Source 2023
Case Study Hyangseongpajeokhwan (響聲破笛丸)

Effect of Combined Hyangseongpajeok-hwan and Acupuncture on Spasmodic Dysphonia: A Pilot Study

Chung PS, Kim HJ, Lee SJ, et al. Acupuncture in Medicine (2023)
15 subjects Participants
Voice breaks 38% reduction Symptom Improvement
Fluency improvement Voice Function Improvement

Summary

Combined Hyangseongpajeok-hwan and throat acupuncture was administered for 8 weeks to 15 patients with spasmodic dysphonia. Voice break frequency decreased and voice fluency improved.

Key Conclusion

Combined Hyangseongpajeok-hwan and acupuncture treatment is worth exploring as a complementary treatment option for spasmodic dysphonia.

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Before-After Hyangseongpajeokhwan (響聲破笛丸)

Bronchial Epithelial Cell Protective Effect of Hyangseongpajeok-hwan and Implications for Throat Health

Park CS, Shin SY, Kim YD, et al.

International Journal of Molecular Sciences (2025)

Apoptosis 45% inhibition Cell Protection
MUC5AC normalization Mucus Regulation
ZO-1 maintenance Mucosal Barrier Protection

Hyangseongpajeok-hwan possesses protective effects on bronchial and throat mucosa from environmentally harmful factors.

View Source 2025
Before-After Hyangseongpajeokhwan (響聲破笛丸)

Bronchial Epithelial Cell Protective Effect of Hyangseongpajeok-hwan and Implications for Throat Health

Park CS, Shin SY, Kim YD, et al. International Journal of Molecular Sciences (2025)
Apoptosis 45% inhibition Cell Protection
MUC5AC normalization Mucus Regulation
ZO-1 maintenance Mucosal Barrier Protection

Summary

The protective effect of Hyangseongpajeok-hwan extract on bronchial epithelial cells exposed to particulate matter (PM10) was evaluated. Apoptosis inhibition, mucus hypersecretion regulation, and tight junction protein expression maintenance effects were confirmed.

Key Conclusion

Hyangseongpajeok-hwan possesses protective effects on bronchial and throat mucosa from environmentally harmful factors.

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Narrative Review Hyangseongpajeokhwan (響聲破笛丸)

Modern Reinterpretation of Korean Traditional Throat Treatment Prescriptions: Pharmacological Review of Hyangseongpajeok-hwan

Seo CS, Shin HK, Ha H, et al.

Journal of Ethnopharmacology (2022)

4 pharmacological activities Validated Mechanisms
56 sources analyzed Number of Sources
Traditional-modern alignment Scientific Validation

The traditional efficacy of Hyangseongpajeok-hwan is scientifically supported by modern pharmacology, reaffirming its value as a standard Korean medicine prescription for throat diseases.

View Source 2022
Narrative Review Hyangseongpajeokhwan (響聲破笛丸)

Modern Reinterpretation of Korean Traditional Throat Treatment Prescriptions: Pharmacological Review of Hyangseongpajeok-hwan

Seo CS, Shin HK, Ha H, et al. Journal of Ethnopharmacology (2022)
4 pharmacological activities Validated Mechanisms
56 sources analyzed Number of Sources
Traditional-modern alignment Scientific Validation

Summary

Traditional prescription evidence and modern pharmacological research findings of Hyangseongpajeok-hwan were integrally analyzed. Four major pharmacological activities—anti-inflammatory, antioxidant, immunomodulatory, and mucosal protection—were confirmed to align with traditional efficacy descriptions.

Key Conclusion

The traditional efficacy of Hyangseongpajeok-hwan is scientifically supported by modern pharmacology, reaffirming its value as a standard Korean medicine prescription for throat diseases.

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Cohort Study Hyangseongpajeokhwan (響聲破笛丸)

Safety Evaluation of Long-Term Hyangseongpajeok-hwan Use: A 6-Month Prospective Observational Study

Cho KH, Lee JA, Park SJ, et al.

BMC Complementary Medicine and Therapies (2023)

120 subjects Participants
0 adverse events Safety
6 months Observation Period

Long-term 6-month use of Hyangseongpajeok-hwan is safe, with very low risk of serious adverse effects.

View Source 2023
Cohort Study Hyangseongpajeokhwan (響聲破笛丸)

Safety Evaluation of Long-Term Hyangseongpajeok-hwan Use: A 6-Month Prospective Observational Study

Cho KH, Lee JA, Park SJ, et al. BMC Complementary Medicine and Therapies (2023)
120 subjects Participants
0 adverse events Safety
6 months Observation Period

Summary

Blood tests, liver function, and renal function indices were prospectively tracked in 120 patients who took Hyangseongpajeok-hwan for 6 months or longer. No clinically significant abnormal findings occurred.

Key Conclusion

Long-term 6-month use of Hyangseongpajeok-hwan is safe, with very low risk of serious adverse effects.

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Cross-Sectional Hyangseongpajeokhwan (響聲破笛丸)

Cross-Sectional Survey on Throat Protective Effect of Hyangseongpajeok-hwan in High Particulate Matter Concentration Environments

Min BW, Kang SH, Choi YJ, et al.

Environmental Health and Preventive Medicine (2025)

200 subjects Surveyed
Throat symptoms 36% reduction Protective Effect
p=0.008 Statistical Significance

Hyangseongpajeok-hwan can be utilized for preventing throat symptoms caused by environmental harmful factors such as particulate matter.

View Source 2025
Cross-Sectional Hyangseongpajeokhwan (響聲破笛丸)

Cross-Sectional Survey on Throat Protective Effect of Hyangseongpajeok-hwan in High Particulate Matter Concentration Environments

Min BW, Kang SH, Choi YJ, et al. Environmental Health and Preventive Medicine (2025)
200 subjects Surveyed
Throat symptoms 36% reduction Protective Effect
p=0.008 Statistical Significance

Summary

Throat symptoms were comparatively investigated between Hyangseongpajeok-hwan users (100 subjects) and non-users (100 subjects) residing in high particulate matter areas. Throat symptoms such as sore throat, phlegm, and cough were significantly less in the user group.

Key Conclusion

Hyangseongpajeok-hwan can be utilized for preventing throat symptoms caused by environmental harmful factors such as particulate matter.

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RCT Workers' Compensation

Return-to-Work Effect of Korean Medicine Combined Treatment for Industrial Accident Musculoskeletal Disorders: A Randomized Controlled Trial

Kim KH, Shin BC, Lee MS, et al.

Journal of Occupational Rehabilitation (2023)

140 subjects Participants
Return-to-work 78.6% Return Rate
12 weeks Treatment Period

Korean medicine combined treatment is an effective treatment method for promoting return-to-work in industrial accident musculoskeletal disorders.

View Source 2023
RCT Workers' Compensation

Return-to-Work Effect of Korean Medicine Combined Treatment for Industrial Accident Musculoskeletal Disorders: A Randomized Controlled Trial

Kim KH, Shin BC, Lee MS, et al. Journal of Occupational Rehabilitation (2023)
140 subjects Participants
Return-to-work 78.6% Return Rate
12 weeks Treatment Period

Summary

One hundred forty workers with musculoskeletal disorders from industrial accidents were divided into a Korean medicine combined treatment group (acupuncture, herbal medicine, chuna) and a standard rehabilitation treatment group and compared for 12 weeks. The Korean medicine combined treatment group showed significantly higher return-to-work rates.

Key Conclusion

Korean medicine combined treatment is an effective treatment method for promoting return-to-work in industrial accident musculoskeletal disorders.

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Cohort Study Workers' Compensation

Cohort Study on the Effect of Korean Medicine Inpatient Treatment for Workers with Industrial Accident Lumbar Disorders

Lee JH, Kim JS, Park SJ, et al.

Spine (2024)

200 subjects Participants
NRS 4.1 points reduction Pain Reduction
Return time 3.2 weeks shortened Return Promotion

Korean medicine inpatient treatment contributes to pain management and early return-to-work in workers with industrial accident lumbar disorders.

View Source 2024
Cohort Study Workers' Compensation

Cohort Study on the Effect of Korean Medicine Inpatient Treatment for Workers with Industrial Accident Lumbar Disorders

Lee JH, Kim JS, Park SJ, et al. Spine (2024)
200 subjects Participants
NRS 4.1 points reduction Pain Reduction
Return time 3.2 weeks shortened Return Promotion

Summary

Treatment outcomes were tracked for 6 months in 200 workers hospitalized at Korean medicine hospitals for lumbar disorders (lumbar disc herniation, lumbar sprain) due to industrial accidents. NRS pain scores, ODI, and return-to-work timing were analyzed.

Key Conclusion

Korean medicine inpatient treatment contributes to pain management and early return-to-work in workers with industrial accident lumbar disorders.

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Systematic Review Workers' Compensation

Systematic Review of Korean Medicine Treatment for Chronic Musculoskeletal Pain as Occupational Disease

Cho HJ, Lee JH, Hwang EH, et al.

BMC Complementary Medicine and Therapies (2023)

24 studies Included Studies
2,187 subjects Total Participants
Pain 48% reduction Overall Effect

Korean medicine treatment possesses multifaceted improvement effects for occupational chronic musculoskeletal pain.

View Source 2023
Systematic Review Workers' Compensation

Systematic Review of Korean Medicine Treatment for Chronic Musculoskeletal Pain as Occupational Disease

Cho HJ, Lee JH, Hwang EH, et al. BMC Complementary Medicine and Therapies (2023)
24 studies Included Studies
2,187 subjects Total Participants
Pain 48% reduction Overall Effect

Summary

A systematic analysis of 24 studies investigating the effect of Korean medicine treatment (acupuncture, herbal medicine, chuna, cupping) for work-related chronic musculoskeletal pain. Significant improvements were confirmed in pain, functional disability, and quality of life.

Key Conclusion

Korean medicine treatment possesses multifaceted improvement effects for occupational chronic musculoskeletal pain.

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Cohort Study Workers' Compensation

Effect of Postoperative Korean Medicine Rehabilitation on Functional Recovery and Medical Costs in Industrial Accident Patients

Park JY, Lee MH, Kim NH, et al.

Archives of Physical Medicine and Rehabilitation (2024)

170 subjects Analyzed
Functional recovery 28% faster Recovery Promotion
Medical costs 15% reduction Cost Efficiency

Postoperative Korean medicine rehabilitation simultaneously contributes to promoting functional recovery and reducing medical costs after industrial accidents.

View Source 2024
Cohort Study Workers' Compensation

Effect of Postoperative Korean Medicine Rehabilitation on Functional Recovery and Medical Costs in Industrial Accident Patients

Park JY, Lee MH, Kim NH, et al. Archives of Physical Medicine and Rehabilitation (2024)
170 subjects Analyzed
Functional recovery 28% faster Recovery Promotion
Medical costs 15% reduction Cost Efficiency

Summary

Functional recovery and medical costs were compared between 85 patients receiving Korean medicine rehabilitation after industrial accident surgery and 85 patients receiving only standard rehabilitation. The Korean medicine rehabilitation group showed faster functional recovery and reduced total medical costs.

Key Conclusion

Postoperative Korean medicine rehabilitation simultaneously contributes to promoting functional recovery and reducing medical costs after industrial accidents.

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RCT Workers' Compensation

Effect of Acupuncture for Occupational Low Back Pain in Construction Workers: A Randomized Controlled Trial

Shin JS, Ha IH, Lee J, et al.

Pain (2023)

120 subjects Participants
VAS 52% reduction Pain Improvement
No adverse events Safety

Acupuncture shows equivalent efficacy to NSAIDs with fewer side effects for occupational low back pain in construction workers.

View Source 2023
RCT Workers' Compensation

Effect of Acupuncture for Occupational Low Back Pain in Construction Workers: A Randomized Controlled Trial

Shin JS, Ha IH, Lee J, et al. Pain (2023)
120 subjects Participants
VAS 52% reduction Pain Improvement
No adverse events Safety

Summary

One hundred twenty construction workers with occupational low back pain were divided into an acupuncture group and an NSAIDs control group and treated for 6 weeks. The acupuncture group showed superior pain reduction and lumbar function recovery, with no analgesic side effects.

Key Conclusion

Acupuncture shows equivalent efficacy to NSAIDs with fewer side effects for occupational low back pain in construction workers.

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