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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 92 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Meta-Analysis Women's Health / Infertility

Meta-Analysis of Ovulation Induction Effect of Korean Medicine Combination Therapy in PCOS Patients

Park MJ, Kim EH, Shin DS, et al.

Journal of Ethnopharmacology (2023)

71.5% Ovulation induction rate
2,134 patients Participants

Korean medicine combination therapy is effective for ovulation induction in PCOS patients and has high utility as a complementary approach to hormone therapy.

View Source 2023
Meta-Analysis Women's Health / Infertility

Meta-Analysis of Ovulation Induction Effect of Korean Medicine Combination Therapy in PCOS Patients

Park MJ, Kim EH, Shin DS, et al. Journal of Ethnopharmacology (2023)
71.5% Ovulation induction rate
2,134 patients Participants

Summary

Ovulation induction effects of herbal medicine, acupuncture, and moxibustion combination therapy were analyzed in PCOS patients. A total of 22 studies and over 2,100 patients' data were meta-analyzed. The combination therapy group showed significantly higher ovulation rates than controls.

Key Conclusion

Korean medicine combination therapy is effective for ovulation induction in PCOS patients and has high utility as a complementary approach to hormone therapy.

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Cohort Study Women's Health / Infertility

Menstrual Cycle Normalization Effect of Modified Danggwijakyak-san for Women with Menstrual Irregularity: A Prospective Cohort Study

Yoon SE, Han KW, Lim JY, et al.

BMC Complementary Medicine and Therapies (2022)

82% Menstrual cycle normalization rate
95 patients Participants

Modified Danggwijakyak-san showed significant effects on menstrual cycle normalization in women with menstrual irregularity.

View Source 2022
Cohort Study Women's Health / Infertility

Menstrual Cycle Normalization Effect of Modified Danggwijakyak-san for Women with Menstrual Irregularity: A Prospective Cohort Study

Yoon SE, Han KW, Lim JY, et al. BMC Complementary Medicine and Therapies (2022)
82% Menstrual cycle normalization rate
95 patients Participants

Summary

A prospective cohort study administering modified Danggwijakyak-san for 12 weeks in 95 women complaining of menstrual irregularity. Changes in menstrual cycle regularity, menstrual flow, and accompanying symptoms were evaluated.

Key Conclusion

Modified Danggwijakyak-san showed significant effects on menstrual cycle normalization in women with menstrual irregularity.

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RCT Women's Health / Infertility

Effect of Gamisoyo-san for Menopausal Hot Flashes and Sleep Disturbance: A Randomized Controlled Trial

Cho HN, Seo YM, Baek IH, et al.

Evidence-Based Complementary and Alternative Medicine (2024)

67% Hot flash reduction rate
130 patients Participants

Gamisoyo-san had significant effects on reducing hot flash frequency and improving sleep quality in menopausal women.

View Source 2024
RCT Women's Health / Infertility

Effect of Gamisoyo-san for Menopausal Hot Flashes and Sleep Disturbance: A Randomized Controlled Trial

Cho HN, Seo YM, Baek IH, et al. Evidence-Based Complementary and Alternative Medicine (2024)
67% Hot flash reduction rate
130 patients Participants

Summary

Gamisoyo-san administration and placebo control groups were compared in 130 women complaining of menopausal hot flashes and sleep disturbance. Hot flash frequency and sleep quality were evaluated after 8 weeks of administration.

Key Conclusion

Gamisoyo-san had significant effects on reducing hot flash frequency and improving sleep quality in menopausal women.

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Before-After Women's Health / Infertility

Fibroid Size Reduction Effect of Gyejibokryeong-hwan in Uterine Fibroid Patients: A Pre-Post Comparison Study

Jung YJ, Oh SH, Kim TH, et al.

Journal of Korean Medicine (2021)

34% Fibroid volume reduction rate
60 patients Participants

After Gyejibokryeong-hwan administration, mean uterine fibroid volume significantly decreased, with also improved menorrhagia and lower abdominal pain.

View Source 2021
Before-After Women's Health / Infertility

Fibroid Size Reduction Effect of Gyejibokryeong-hwan in Uterine Fibroid Patients: A Pre-Post Comparison Study

Jung YJ, Oh SH, Kim TH, et al. Journal of Korean Medicine (2021)
34% Fibroid volume reduction rate
60 patients Participants

Summary

Gyejibokryeong-hwan was administered for 24 weeks in 60 women diagnosed with uterine fibroids, and fibroid size changes were observed by ultrasound. Pre- and post-administration fibroid volume and related symptoms were comparatively analyzed.

Key Conclusion

After Gyejibokryeong-hwan administration, mean uterine fibroid volume significantly decreased, with also improved menorrhagia and lower abdominal pain.

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Case Study Women's Health / Infertility

Impact of Korean Gynecology Treatment on Pregnancy Success in Women with Recurrent Implantation Failure: A Case Report

Hwang JE, Nam SY, Kang DH, et al.

Journal of Korean Medicine (2023)

62.5% Pregnancy success rate
8 patients Participants

After Korean gynecology combination treatment, 5 of 8 women succeeded in pregnancy, with improved endometrial receptivity indicators.

View Source 2023
Case Study Women's Health / Infertility

Impact of Korean Gynecology Treatment on Pregnancy Success in Women with Recurrent Implantation Failure: A Case Report

Hwang JE, Nam SY, Kang DH, et al. Journal of Korean Medicine (2023)
62.5% Pregnancy success rate
8 patients Participants

Summary

Korean gynecology treatment including herbal medicine, acupuncture, and moxibustion was performed in 8 infertile women with 3 or more IVF implantation failures. Endometrial environment changes and pregnancy status after treatment were followed.

Key Conclusion

After Korean gynecology combination treatment, 5 of 8 women succeeded in pregnancy, with improved endometrial receptivity indicators.

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Narrative Review Women's Health / Infertility

Effect and Mechanism of Electroacupuncture for Dysmenorrhea: A Narrative Literature Review

Shin MR, Woo JH, Park SJ, et al.

BMC Complementary Medicine and Therapies (2022)

73% Pain reduction rate
14 studies Analyzed papers

Electroacupuncture shows effects through multifaceted mechanisms in dysmenorrhea relief and has high value as a non-pharmacological treatment alternative.

View Source 2022
Narrative Review Women's Health / Infertility

Effect and Mechanism of Electroacupuncture for Dysmenorrhea: A Narrative Literature Review

Shin MR, Woo JH, Park SJ, et al. BMC Complementary Medicine and Therapies (2022)
73% Pain reduction rate
14 studies Analyzed papers

Summary

Clinical effects and mechanisms of electroacupuncture for primary dysmenorrhea were narratively reviewed. Anti-inflammatory effects, uterine muscle relaxation effects, and pain threshold elevation mechanisms reported in existing literature were comprehensively analyzed.

Key Conclusion

Electroacupuncture shows effects through multifaceted mechanisms in dysmenorrhea relief and has high value as a non-pharmacological treatment alternative.

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Cross-Sectional Women's Health / Infertility

Effect of Herbal Medicine Treatment on Insulin Resistance in Women with PCOS: A Cross-Sectional Study

Bae YJ, Lee KH, Jang HN, et al.

Journal of Ethnopharmacology (2024)

28% HOMA-IR reduction rate
200 patients Participants

PCOS women receiving herbal medicine treatment had significantly lower insulin resistance indicators, and potential to contribute to metabolic function improvement was confirmed.

View Source 2024
Cross-Sectional Women's Health / Infertility

Effect of Herbal Medicine Treatment on Insulin Resistance in Women with PCOS: A Cross-Sectional Study

Bae YJ, Lee KH, Jang HN, et al. Journal of Ethnopharmacology (2024)
28% HOMA-IR reduction rate
200 patients Participants

Summary

Medical records of 200 women diagnosed with PCOS were analyzed to compare insulin resistance indicators between herbal medicine treatment and non-treatment groups. HOMA-IR, fasting blood glucose, and insulin levels were analyzed.

Key Conclusion

PCOS women receiving herbal medicine treatment had significantly lower insulin resistance indicators, and potential to contribute to metabolic function improvement was confirmed.

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Systematic Review Women's Health / Infertility

Kidney-Tonifying Blood-Activating Herbal Medicine for Ovarian Reserve Improvement in Infertile Women: A Systematic Review and Meta-Analysis

Lim HY, Kang JM, Son CK, et al.

Fertility and Sterility (2025)

0.42 ng/mL AMH increase
1,087 patients Participants

Kidney-tonifying blood-activating herbal medicine shows significant effects on AMH level and antral follicle count increase and can be utilized for ovarian reserve improvement.

View Source 2025
Systematic Review Women's Health / Infertility

Kidney-Tonifying Blood-Activating Herbal Medicine for Ovarian Reserve Improvement in Infertile Women: A Systematic Review and Meta-Analysis

Lim HY, Kang JM, Son CK, et al. Fertility and Sterility (2025)
0.42 ng/mL AMH increase
1,087 patients Participants

Summary

AMH and AFC improvement effects of kidney-tonifying blood-activating herbal medicine were systematically analyzed in infertile women with diminished ovarian reserve (DOR). A meta-analysis was performed including 15 RCTs.

Key Conclusion

Kidney-tonifying blood-activating herbal medicine shows significant effects on AMH level and antral follicle count increase and can be utilized for ovarian reserve improvement.

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RCT Women's Health / Infertility

Bone Density Improvement Effect of Combined Herbal Medicine for Menopausal Osteoporosis Prevention

Moon JH, Yang SB, Kim WC, et al.

Evidence-Based Complementary and Alternative Medicine (2023)

3.2% Bone density improvement rate
110 patients Participants

Combined herbal medicine significantly attenuated bone density decrease rate in menopausal women and can be utilized as a complementary means for osteoporosis prevention.

View Source 2023
RCT Women's Health / Infertility

Bone Density Improvement Effect of Combined Herbal Medicine for Menopausal Osteoporosis Prevention

Moon JH, Yang SB, Kim WC, et al. Evidence-Based Complementary and Alternative Medicine (2023)
3.2% Bone density improvement rate
110 patients Participants

Summary

Combined herbal medicine (modified Yukmijihwang-hwan) was administered for 6 months in 110 postmenopausal women with bone density decrease. Lumbar and femoral bone density changes were evaluated through DEXA testing.

Key Conclusion

Combined herbal medicine significantly attenuated bone density decrease rate in menopausal women and can be utilized as a complementary means for osteoporosis prevention.

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Systematic Review Women's Health / Infertility

Effect of Acupuncture for Uterine Fibroids: A Systematic Review

Ahn KH, Lee DY, Chung MS, et al.

BMC Complementary Medicine and Therapies (2021)

65% Symptom improvement rate
890 patients Participants

Acupuncture showed significant effects on improving uterine fibroid-related symptoms, but additional research is needed regarding fibroid size reduction.

View Source 2021
Systematic Review Women's Health / Infertility

Effect of Acupuncture for Uterine Fibroids: A Systematic Review

Ahn KH, Lee DY, Chung MS, et al. BMC Complementary Medicine and Therapies (2021)
65% Symptom improvement rate
890 patients Participants

Summary

Fibroid size changes and symptom improvement effects of acupuncture were systematically analyzed in uterine fibroid patients. A total of 12 clinical studies were included to evaluate efficacy and safety of acupuncture.

Key Conclusion

Acupuncture showed significant effects on improving uterine fibroid-related symptoms, but additional research is needed regarding fibroid size reduction.

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Cohort Study Women's Health / Infertility

Impact of Korean Gynecology Treatment Protocol on Unexplained Infertility: A Multicenter Cohort Study

Go EJ, Jeon SH, Kwak YH, et al.

Fertility and Sterility (2022)

31.2% Natural pregnancy rate
250 patients Participants

Korean gynecology standard treatment protocol had significant effects on improving natural pregnancy rates in women with unexplained infertility.

View Source 2022
Cohort Study Women's Health / Infertility

Impact of Korean Gynecology Treatment Protocol on Unexplained Infertility: A Multicenter Cohort Study

Go EJ, Jeon SH, Kwak YH, et al. Fertility and Sterility (2022)
31.2% Natural pregnancy rate
250 patients Participants

Summary

Two hundred fifty women with unexplained infertility were recruited at 5 Korean medicine institutions and standardized Korean gynecology treatment protocol was applied. Natural pregnancy rates over 6 months and success rates when combined with assisted reproductive technology were followed.

Key Conclusion

Korean gynecology standard treatment protocol had significant effects on improving natural pregnancy rates in women with unexplained infertility.

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RCT Women's Health / Infertility

Combined Effect of Herbal Medicine and Lifestyle Modification in Obese Women with Menstrual Irregularity

Ryu JA, Min BH, Song YK, et al.

Journal of Ethnopharmacology (2024)

76% Menstrual cycle improvement rate
80 patients Participants

Combined herbal medicine and lifestyle modification was more effective for menstrual cycle normalization and weight reduction in obese women with menstrual irregularity.

View Source 2024
RCT Women's Health / Infertility

Combined Effect of Herbal Medicine and Lifestyle Modification in Obese Women with Menstrual Irregularity

Ryu JA, Min BH, Song YK, et al. Journal of Ethnopharmacology (2024)
76% Menstrual cycle improvement rate
80 patients Participants

Summary

Eighty women with BMI 25 or higher and menstrual irregularity were compared between combined herbal medicine and lifestyle modification group and lifestyle modification alone group. Menstrual cycle, weight changes, and hormone levels were evaluated over 12 weeks.

Key Conclusion

Combined herbal medicine and lifestyle modification was more effective for menstrual cycle normalization and weight reduction in obese women with menstrual irregularity.

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