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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 92 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Meta-Analysis Women's Health / Infertility

Effect of Combined Acupuncture During In Vitro Fertilization (IVF) on Clinical Pregnancy Rates: A Meta-Analysis

이미선, 김하영, 정수빈, et al.

Fertility and Sterility (2024)

43.2% Acupuncture group pregnancy rate
32 studies Analyzed RCTs
4,128 patients Total participants

Acupuncture significantly improves clinical pregnancy rates of IVF procedures, with optimal effects particularly when performed before and after embryo transfer.

View Source 2024
Meta-Analysis Women's Health / Infertility

Effect of Combined Acupuncture During In Vitro Fertilization (IVF) on Clinical Pregnancy Rates: A Meta-Analysis

이미선, 김하영, 정수빈, et al. Fertility and Sterility (2024)
43.2% Acupuncture group pregnancy rate
32 studies Analyzed RCTs
4,128 patients Total participants

Summary

A meta-analysis was performed on 32 RCTs (total 4,128 patients) combining acupuncture before and after IVF procedures. Clinical pregnancy rate of the acupuncture combination group was 43.2%, significantly higher than controls (33.8%), with also improved endometrial receptivity-related indicators on embryo transfer day.

Key Conclusion

Acupuncture significantly improves clinical pregnancy rates of IVF procedures, with optimal effects particularly when performed before and after embryo transfer.

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RCT Women's Health / Infertility

Semen Parameter Improvement Effect of Korean Medicine Combination Treatment for Male Infertility: A Randomized Controlled Trial

최영호, 장세원, 한동길, et al.

Integrative Medicine Research (2023)

52% Post-treatment sperm motility
94 patients Study population
14%p Motility increase

Korean medicine combination treatment significantly improves semen parameters of male infertility and contributes to enhancing fertilization ability through reducing sperm oxidative stress.

View Source 2023
RCT Women's Health / Infertility

Semen Parameter Improvement Effect of Korean Medicine Combination Treatment for Male Infertility: A Randomized Controlled Trial

최영호, 장세원, 한동길, et al. Integrative Medicine Research (2023)
52% Post-treatment sperm motility
94 patients Study population
14%p Motility increase

Summary

An RCT evaluating the effect of combined herbal medicine (modified Ojayeonjong-hwan) and acupuncture therapy in 94 patients with male infertility. After 12 weeks of treatment, sperm motility increased from 38% to 52%, with significantly improved sperm concentration and normal morphology rates. Reactive oxygen species (ROS) levels, an oxidative stress indicator, also markedly decreased.

Key Conclusion

Korean medicine combination treatment significantly improves semen parameters of male infertility and contributes to enhancing fertilization ability through reducing sperm oxidative stress.

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Cohort Study Women's Health / Infertility

Cohort Study of Moxibustion Treatment for Menopausal Insomnia

Noh HM, Park MJ, Yun YG, et al.

Climacteric (2023)

5.8 points PSQI Reduction
100 subjects Participants
12 weeks Follow-up Period

Moxibustion treatment safely improves menopausal insomnia and accompanying symptoms.

View Source 2023
Cohort Study Women's Health / Infertility

Cohort Study of Moxibustion Treatment for Menopausal Insomnia

Noh HM, Park MJ, Yun YG, et al. Climacteric (2023)
5.8 points PSQI Reduction
100 subjects Participants
12 weeks Follow-up Period

Summary

One hundred menopausal insomnia women were followed for 12 weeks, divided into moxibustion treatment and non-treatment groups. PSQI decreased by 5.8 points and menopausal symptoms also simultaneously improved in the moxibustion group.

Key Conclusion

Moxibustion treatment safely improves menopausal insomnia and accompanying symptoms.

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RCT Women's Health / Infertility

Randomized Double-Blind Trial of Gamisoyo-san for Menopausal Depression and Anxiety

Yoo JH, Ahn YJ, Kim DI, et al.

Menopause (2024)

44% Anxiety Reduction
38% Depression Reduction
Double-blind Study Design

Gamisoyo-san is an effective herbal treatment for menopausal depression and anxiety.

View Source 2024
RCT Women's Health / Infertility

Randomized Double-Blind Trial of Gamisoyo-san for Menopausal Depression and Anxiety

Yoo JH, Ahn YJ, Kim DI, et al. Menopause (2024)
44% Anxiety Reduction
38% Depression Reduction
Double-blind Study Design

Summary

One hundred women with menopausal depressive and anxiety symptoms were double-blind compared between Gamisoyo-san and placebo groups for 12 weeks. HADS anxiety (-44%) and depression (-38%) scores decreased significantly in the Gamisoyo-san group.

Key Conclusion

Gamisoyo-san is an effective herbal treatment for menopausal depression and anxiety.

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Systematic Review Women's Health / Infertility

Safety and Efficacy of Acupuncture Treatment for Postpartum Depression: A Systematic Review

Noh HM, Yoon JY, Park JE, et al.

Archives of Womens Mental Health (2024)

12 studies Analyzed Studies
EPDS reduction Main Effect
Breastfeeding safe Safety

Acupuncture treatment is a safe and effective non-pharmacological treatment option for postpartum depression.

View Source 2024
Systematic Review Women's Health / Infertility

Safety and Efficacy of Acupuncture Treatment for Postpartum Depression: A Systematic Review

Noh HM, Yoon JY, Park JE, et al. Archives of Womens Mental Health (2024)
12 studies Analyzed Studies
EPDS reduction Main Effect
Breastfeeding safe Safety

Summary

Twelve studies evaluating the effect of acupuncture treatment for postpartum depression were systematically reviewed. Acupuncture treatment showed significant effects on EPDS score reduction and was confirmed to be safely applicable during breastfeeding.

Key Conclusion

Acupuncture treatment is a safe and effective non-pharmacological treatment option for postpartum depression.

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Meta-Analysis Women's Health / Infertility

Impact of Combined Tonifying Prescription and Exercise on Bone Density in Women with Pre-Osteoporosis: A Meta-Analysis

Yoon HJ, Choi SY, Kim EH, et al.

Osteoporosis International (2023)

14 RCTs Analyzed RCTs
Lumbar BMD +0.034 Bone density improvement
Osteopenic women Target

Combined tonifying herbal medicine and exercise effectively improves bone density in osteopenic women and contributes to osteoporosis prevention.

View Source 2023
Meta-Analysis Women's Health / Infertility

Impact of Combined Tonifying Prescription and Exercise on Bone Density in Women with Pre-Osteoporosis: A Meta-Analysis

Yoon HJ, Choi SY, Kim EH, et al. Osteoporosis International (2023)
14 RCTs Analyzed RCTs
Lumbar BMD +0.034 Bone density improvement
Osteopenic women Target

Summary

Fourteen RCTs evaluating the combined effect of tonifying herbal medicine and exercise in osteopenic women were meta-analyzed. The combination group showed significant additional improvements compared to exercise alone in lumbar bone density (MD: 0.034 g/cm²) and femoral bone density (MD: 0.021 g/cm²).

Key Conclusion

Combined tonifying herbal medicine and exercise effectively improves bone density in osteopenic women and contributes to osteoporosis prevention.

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RCT Women's Health / Infertility

Effect of Gamisoyo-san on Menopausal Depression in Middle-Aged Women: An RCT

Woo JK, Ahn MH, et al.

Menopause (2025)

100 subjects Participants
57% BDI Improvement Rate
12 weeks Treatment Period

Gamisoyo-san effectively alleviates menopausal depressive symptoms and accompanying menopausal symptoms.

View Source 2025
RCT Women's Health / Infertility

Effect of Gamisoyo-san on Menopausal Depression in Middle-Aged Women: An RCT

Woo JK, Ahn MH, et al. Menopause (2025)
100 subjects Participants
57% BDI Improvement Rate
12 weeks Treatment Period

Summary

One hundred middle-aged women complaining of menopausal depressive symptoms were randomly assigned to Gamisoyo-san and placebo groups and compared for 12 weeks. BDI and menopausal symptom scores improved significantly in the Gamisoyo-san group.

Key Conclusion

Gamisoyo-san effectively alleviates menopausal depressive symptoms and accompanying menopausal symptoms.

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Cohort Study Women's Health / Infertility

Effect of Korean Medicine Treatment for Postpartum Depression: A Prospective Cohort Study

Yun SH, Kim EJ, Li Y, et al.

Journal of Affective Disorders (2023)

80 subjects Participants
61% EPDS Improvement Rate
12 weeks Follow-up Period

Korean medicine treatment is effective for postpartum depression management and is a safe treatment option compatible with breastfeeding.

View Source 2023
Cohort Study Women's Health / Infertility

Effect of Korean Medicine Treatment for Postpartum Depression: A Prospective Cohort Study

Yun SH, Kim EJ, Li Y, et al. Journal of Affective Disorders (2023)
80 subjects Participants
61% EPDS Improvement Rate
12 weeks Follow-up Period

Summary

A cohort study following 80 women with postpartum depression for 12 weeks, divided into combined herbal medicine-acupuncture and general management groups. EPDS scores decreased significantly in the Korean medicine treatment group, with higher breastfeeding continuation rates.

Key Conclusion

Korean medicine treatment is effective for postpartum depression management and is a safe treatment option compatible with breastfeeding.

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Meta-Analysis Women's Health / Infertility

Effect of Personalized Herbal Prescriptions on Menopausal Syndrome: A Systematic Review and Meta-Analysis

Choi JE, Lee HW, Kim YI, et al.

Maturitas (2023)

21 studies Included Studies
1,847 subjects Total Participants
KI score 38% reduction Symptom Improvement

Personalized herbal prescriptions effectively alleviate overall symptoms of menopausal syndrome and can serve as a complement to hormone replacement therapy.

View Source 2023
Meta-Analysis Women's Health / Infertility

Effect of Personalized Herbal Prescriptions on Menopausal Syndrome: A Systematic Review and Meta-Analysis

Choi JE, Lee HW, Kim YI, et al. Maturitas (2023)
21 studies Included Studies
1,847 subjects Total Participants
KI score 38% reduction Symptom Improvement

Summary

A meta-analysis of 21 clinical studies investigating the efficacy of personalized herbal medicine for menopausal syndrome. Kupperman Index and hot flash frequency significantly decreased.

Key Conclusion

Personalized herbal prescriptions effectively alleviate overall symptoms of menopausal syndrome and can serve as a complement to hormone replacement therapy.

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RCT Women's Health / Infertility

Effect of Personalized Herbal Prescription Combined with Acupuncture on Dysmenorrhea Improvement

Jang JB, Kim DC, Park KM, et al.

Journal of Alternative and Complementary Medicine (2023)

80 subjects Participants
VAS 62% reduction Pain Improvement
3 cycles Observation Period

The combination of personalized herbal medicine and acupuncture demonstrates synergistic effects in managing dysmenorrhea.

View Source 2023
RCT Women's Health / Infertility

Effect of Personalized Herbal Prescription Combined with Acupuncture on Dysmenorrhea Improvement

Jang JB, Kim DC, Park KM, et al. Journal of Alternative and Complementary Medicine (2023)
80 subjects Participants
VAS 62% reduction Pain Improvement
3 cycles Observation Period

Summary

Eighty women with primary dysmenorrhea were divided into herbal medicine alone, acupuncture alone, herbal medicine+acupuncture combined, and analgesic control groups and observed for 3 menstrual cycles. The combined group showed the greatest reduction in VAS pain scores.

Key Conclusion

The combination of personalized herbal medicine and acupuncture demonstrates synergistic effects in managing dysmenorrhea.

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Cross-Sectional Women's Health / Infertility

Differences in Treatment Response by Korean Medicine Pattern Type in Menopausal Syndrome: A Multicenter Cross-Sectional Study

Noh YJ, Song KH, Kim BM, et al.

Journal of Korean Medicine (2022)

74% Tailored treatment efficacy rate
400 patients Participants

Tailored treatment by pattern type showed significant differences in symptom improvement of menopausal syndrome, presenting evidence for personalized treatment.

View Source 2022
Cross-Sectional Women's Health / Infertility

Differences in Treatment Response by Korean Medicine Pattern Type in Menopausal Syndrome: A Multicenter Cross-Sectional Study

Noh YJ, Song KH, Kim BM, et al. Journal of Korean Medicine (2022)
74% Tailored treatment efficacy rate
400 patients Participants

Summary

Four hundred women with menopausal syndrome were recruited at 5 Korean medicine hospitals, with Korean medicine pattern differentiation performed and Kupperman Index changes by pattern type analyzed. Patterns were classified into liver-kidney yin deficiency, heart-spleen yang deficiency, liver qi stagnation, etc.

Key Conclusion

Tailored treatment by pattern type showed significant differences in symptom improvement of menopausal syndrome, presenting evidence for personalized treatment.

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Cohort Study Women's Health / Infertility

Cost-Effectiveness Analysis of Combined Korean and Western Medicine Treatment Model for Infertile Couples

Jin HW, Yoo SY, Lim DK, et al.

Fertility and Sterility (2023)

23% Cost reduction rate
300 couples Participating couples

The integrative treatment model showed high pregnancy success rates per cost compared to Western medicine alone, confirming economic superiority.

View Source 2023
Cohort Study Women's Health / Infertility

Cost-Effectiveness Analysis of Combined Korean and Western Medicine Treatment Model for Infertile Couples

Jin HW, Yoo SY, Lim DK, et al. Fertility and Sterility (2023)
23% Cost reduction rate
300 couples Participating couples

Summary

Cost versus pregnancy success rates were analyzed between combined Korean and Western medicine treatment and Western medicine alone groups in 300 infertile couples. Economic evaluation including direct medical costs, indirect costs, and time to delivery was performed.

Key Conclusion

The integrative treatment model showed high pregnancy success rates per cost compared to Western medicine alone, confirming economic superiority.

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