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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 92 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
RCT Women's Health / Infertility

Effect of Electroacupuncture Treatment for Female Urinary Incontinence: A Randomized Controlled Trial

이나연, 김소율, 박다인, et al.

Neurourology and Urodynamics (2024)

71% Urinary incontinence frequency reduction
92 patients Study population
23%p Superiority over Kegel

Electroacupuncture treatment is more effective than pelvic floor exercise for symptom improvement of stress urinary incontinence and contributes to pelvic floor muscle function strengthening.

View Source 2024
RCT Women's Health / Infertility

Effect of Electroacupuncture Treatment for Female Urinary Incontinence: A Randomized Controlled Trial

이나연, 김소율, 박다인, et al. Neurourology and Urodynamics (2024)
71% Urinary incontinence frequency reduction
92 patients Study population
23%p Superiority over Kegel

Summary

An RCT comparing pelvic floor electroacupuncture treatment (PC1, CV3, CV4) and pelvic floor exercise (Kegel exercise) in 92 women with stress urinary incontinence. After 8 weeks of treatment, urinary incontinence frequency decreased 71% from 14.2 to 4.1 times per week in the electroacupuncture group, superior to the Kegel group (48% reduction). One-hour pad test weight also significantly decreased.

Key Conclusion

Electroacupuncture treatment is more effective than pelvic floor exercise for symptom improvement of stress urinary incontinence and contributes to pelvic floor muscle function strengthening.

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Before-After Women's Health / Infertility

Effect of Combined Chuna and Acupuncture Therapy for Pelvic Floor Weakness: A Pre-Post Comparison Study

황서윤, 진예은, 우다현, et al.

한방재활의학과학회지 (2023)

3.8 Post-treatment MOS grade
48 patients Study population
81% MOS improvement rate

Combined Chuna and acupuncture therapy is effective for muscle strength recovery of postpartum pelvic floor weakness and contributes to improvement of comorbid urinary incontinence symptoms.

View Source 2023
Before-After Women's Health / Infertility

Effect of Combined Chuna and Acupuncture Therapy for Pelvic Floor Weakness: A Pre-Post Comparison Study

황서윤, 진예은, 우다현, et al. 한방재활의학과학회지 (2023)
3.8 Post-treatment MOS grade
48 patients Study population
81% MOS improvement rate

Summary

A 12-week pre-post comparison study performing Chuna and acupuncture treatment in 48 women with pelvic floor weakness (MOS grade 3 or below) postpartum. After treatment, pelvic floor muscle strength improved from MOS average 2.1 to 3.8, with vaginal pressure measurements also significantly increased. Improvements were observed even in patients with comorbid urinary incontinence symptoms.

Key Conclusion

Combined Chuna and acupuncture therapy is effective for muscle strength recovery of postpartum pelvic floor weakness and contributes to improvement of comorbid urinary incontinence symptoms.

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Narrative Review Women's Health / Infertility

TSH Normalization Effect of Herbal Medicine Treatment for Female Hypothyroidism: A Narrative Review

도유진, 안서현, 길채영, et al.

Thyroid Research (2024)

Multiple Positive study reports
TSH normalization Main result
Dose reduction Combination effect

Herbal medicine treatment is promising for adjunctive management of female hypothyroidism and can contribute to optimizing thyroid hormone preparation doses.

View Source 2024
Narrative Review Women's Health / Infertility

TSH Normalization Effect of Herbal Medicine Treatment for Female Hypothyroidism: A Narrative Review

도유진, 안서현, 길채영, et al. Thyroid Research (2024)
Multiple Positive study reports
TSH normalization Main result
Dose reduction Combination effect

Summary

A narrative review comprehensively examining literature on effects of herbal medicine treatment for female hypothyroidism. Studies were reported showing positive results on TSH normalization and fT4 level improvement with qi-tonifying blood-nourishing prescriptions such as Bojungikgi-tang and Palmul-tang. Potential for dose reduction was also suggested when combined with thyroid hormone preparations.

Key Conclusion

Herbal medicine treatment is promising for adjunctive management of female hypothyroidism and can contribute to optimizing thyroid hormone preparation doses.

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RCT Women's Health / Infertility

Antibody Reduction Effect of Combined Acupuncture and Herbal Medicine for Hashimoto's Thyroiditis: A Randomized Controlled Trial

문서진, 장예빈, 곽하은, et al.

Autoimmunity Reviews (2023)

38% TPO-Ab reduction rate
86 patients Study population
31% Tg-Ab reduction rate

Combined acupuncture and herbal medicine is effective for autoantibody reduction in Hashimoto's thyroiditis and contributes to autoimmune response regulation.

View Source 2023
RCT Women's Health / Infertility

Antibody Reduction Effect of Combined Acupuncture and Herbal Medicine for Hashimoto's Thyroiditis: A Randomized Controlled Trial

문서진, 장예빈, 곽하은, et al. Autoimmunity Reviews (2023)
38% TPO-Ab reduction rate
86 patients Study population
31% Tg-Ab reduction rate

Summary

An RCT comparing combined acupuncture and herbal medicine (modified Sihogyeji-tang) with levothyroxine alone in 86 women with Hashimoto's thyroiditis. After 24 weeks of treatment, TPO-Ab decreased by an average of 38% in the combination group, with Tg-Ab also decreasing by 31%. No significant antibody changes occurred in the levothyroxine alone group.

Key Conclusion

Combined acupuncture and herbal medicine is effective for autoantibody reduction in Hashimoto's thyroiditis and contributes to autoimmune response regulation.

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RCT Women's Health / Infertility

Hair Growth Promotion Effect of Pharmacopuncture (Deer Antler Pharmacopuncture) Treatment for Female Pattern Baldness: A Randomized Controlled Trial

이서윤, 김채원, 박소현, et al.

Journal of Dermatological Treatment (2024)

28.4% Hair density increase
78 patients Study population
16%p Anagen hair increase

Deer antler pharmacopuncture is effective for hair density increase and hair growth cycle improvement in female pattern baldness, with scalp blood flow improvement suggested as the mechanism.

View Source 2024
RCT Women's Health / Infertility

Hair Growth Promotion Effect of Pharmacopuncture (Deer Antler Pharmacopuncture) Treatment for Female Pattern Baldness: A Randomized Controlled Trial

이서윤, 김채원, 박소현, et al. Journal of Dermatological Treatment (2024)
28.4% Hair density increase
78 patients Study population
16%p Anagen hair increase

Summary

An RCT comparing deer antler pharmacopuncture and placebo acupuncture in 78 patients with female pattern baldness (Ludwig classification type I-II). After 24 weeks of treatment, hair density increased by an average of 28.4% in the deer antler pharmacopuncture group, with anagen hair ratio also improving from 62% to 78%. Scalp blood flow also significantly increased on ultrasound Doppler.

Key Conclusion

Deer antler pharmacopuncture is effective for hair density increase and hair growth cycle improvement in female pattern baldness, with scalp blood flow improvement suggested as the mechanism.

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Meta-Analysis Women's Health / Infertility

Endocrine Modulation Effect of Herbal Medicine Treatment for Female Hormonal Imbalance: A Meta-Analysis

최유진, 신하늘, 홍서영, et al.

Phytotherapy Research (2023)

24 studies Analyzed studies
2,018 patients Total participants
Normalized Hormone ratio changes

Herbal medicine treatment is effective for endocrine axis modulation of female hormonal imbalance and contributes to fundamental improvement of various gynecological symptoms.

View Source 2023
Meta-Analysis Women's Health / Infertility

Endocrine Modulation Effect of Herbal Medicine Treatment for Female Hormonal Imbalance: A Meta-Analysis

최유진, 신하늘, 홍서영, et al. Phytotherapy Research (2023)
24 studies Analyzed studies
2,018 patients Total participants
Normalized Hormone ratio changes

Summary

A meta-analysis of 24 RCTs (2,018 patients) evaluating endocrine modulation effects of herbal medicine treatment in women with hormonal imbalance (estrogen-progesterone ratio abnormalities). The herbal medicine administration group showed normalizing tendency in estrogen/progesterone ratio, with also significantly improved FSH and LH levels. Improvement rates of menstrual cycle-related symptoms were also high.

Key Conclusion

Herbal medicine treatment is effective for endocrine axis modulation of female hormonal imbalance and contributes to fundamental improvement of various gynecological symptoms.

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Cohort Study Women's Health / Infertility

Effect of Herbal Medicine (Modified Changchul) Treatment on Insulin Resistance in PCOS Women: A Cohort Study

구서현, 남지윤, 탁예은, et al.

Journal of Alternative and Complementary Medicine (2024)

32% HOMA-IR reduction rate
118 patients Study population
Low Gastrointestinal side effects

Herbal medicine treatment shows effects similar to metformin for insulin resistance improvement in PCOS comorbid patients with fewer gastrointestinal side effects, favoring tolerability.

View Source 2024
Cohort Study Women's Health / Infertility

Effect of Herbal Medicine (Modified Changchul) Treatment on Insulin Resistance in PCOS Women: A Cohort Study

구서현, 남지윤, 탁예은, et al. Journal of Alternative and Complementary Medicine (2024)
32% HOMA-IR reduction rate
118 patients Study population
Low Gastrointestinal side effects

Summary

A cohort study comparing herbal medicine (modified Changchul) administration and metformin administration groups in 118 women with PCOS comorbid with insulin resistance. After 16 weeks of treatment, HOMA-IR decreased by an average of 32% in the herbal medicine group, showing similar improvement to the metformin group (38%). Gastrointestinal side effects were markedly fewer in the herbal medicine group.

Key Conclusion

Herbal medicine treatment shows effects similar to metformin for insulin resistance improvement in PCOS comorbid patients with fewer gastrointestinal side effects, favoring tolerability.

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Systematic Review Women's Health / Infertility

Pregnancy Rate Improvement Effect of Korean Medicine Treatment for Endometriosis-Related Infertility: A Systematic Review

허다인, 양서윤, 전채린, et al.

Reproductive BioMedicine Online (2023)

34.2% Natural pregnancy rate
12 studies Analyzed studies
15.5%p Pregnancy rate difference

Korean medicine treatment improves natural pregnancy rates of endometriosis-related infertility and contributes to disease activity reduction.

View Source 2023
Systematic Review Women's Health / Infertility

Pregnancy Rate Improvement Effect of Korean Medicine Treatment for Endometriosis-Related Infertility: A Systematic Review

허다인, 양서윤, 전채린, et al. Reproductive BioMedicine Online (2023)
34.2% Natural pregnancy rate
12 studies Analyzed studies
15.5%p Pregnancy rate difference

Summary

Twelve studies (986 patients) evaluating effects of Korean medicine treatment for endometriosis-related infertile women were systematically reviewed. Natural pregnancy rate in the combined herbal medicine and acupuncture group was 34.2%, significantly higher than expected management group (18.7%). CA-125 level reduction and endometriosis lesion size reduction were also observed.

Key Conclusion

Korean medicine treatment improves natural pregnancy rates of endometriosis-related infertility and contributes to disease activity reduction.

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Before-After Women's Health / Infertility

Kupperman Index Improvement with Korean Medicine Combination Treatment for Comprehensive Menopausal Symptoms: A Pre-Post Comparison Study

도예린, 안소율, 길수현, et al.

Maturitas (2024)

60.5% Kupperman Index reduction rate
84 patients Study population
10/11 Improved sub-items

Korean medicine combination treatment is effective for comprehensive improvement of menopausal comprehensive symptoms and shows significant improvement in most sub-domains of Kupperman Index.

View Source 2024
Before-After Women's Health / Infertility

Kupperman Index Improvement with Korean Medicine Combination Treatment for Comprehensive Menopausal Symptoms: A Pre-Post Comparison Study

도예린, 안소율, 길수현, et al. Maturitas (2024)
60.5% Kupperman Index reduction rate
84 patients Study population
10/11 Improved sub-items

Summary

A pre-post comparison study performing combined herbal medicine (Gamisoyo-san), acupuncture, and moxibustion therapy for 12 weeks in 84 women with moderate-to-severe menopausal symptoms (Kupperman Index 25 or higher). After treatment, Kupperman Index decreased 60.5% from an average of 32.4 to 12.8, with significant improvements observed in 10 of 11 sub-items.

Key Conclusion

Korean medicine combination treatment is effective for comprehensive improvement of menopausal comprehensive symptoms and shows significant improvement in most sub-domains of Kupperman Index.

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Narrative Review Women's Health / Infertility

Effect of Herbal Medicine (Modified Soyo-san) Treatment for Breast Benign Diseases: A Narrative Review

문유진, 채서현, 위예림, et al.

Breast Care (2023)

Multiple Positive studies
Mass reduction Main effect
Liver qi stagnation Core pattern

Modified Soyo-san is a promising treatment for breast benign disease mass reduction and symptom relief, with liver qi stagnation resolution as the key mechanism.

View Source 2023
Narrative Review Women's Health / Infertility

Effect of Herbal Medicine (Modified Soyo-san) Treatment for Breast Benign Diseases: A Narrative Review

문유진, 채서현, 위예림, et al. Breast Care (2023)
Multiple Positive studies
Mass reduction Main effect
Liver qi stagnation Core pattern

Summary

A narrative review comprehensively examining literature on treatment effects of modified Soyo-san for breast benign diseases (fibroadenoma, fibrocystic changes). Many studies were reported showing positive results of Soyo-san on breast mass size reduction, mastalgia relief, and breast density reduction. Liver qi stagnation pattern was presented as the key mechanism.

Key Conclusion

Modified Soyo-san is a promising treatment for breast benign disease mass reduction and symptom relief, with liver qi stagnation resolution as the key mechanism.

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RCT Women's Health / Infertility

Effect of Combined Acupuncture and Herbal Medicine for Uterine Fibroid-Related Menorrhagia: A Randomized Controlled Trial

장다은, 고채영, 남서윤, et al.

Gynecologic and Obstetric Investigation (2024)

52% Menstrual volume reduction rate
102 patients Study population
18.3% Fibroid volume reduction

Combined acupuncture and herbal medicine shows effects equivalent to tranexamic acid for bleeding reduction in uterine fibroid-related menorrhagia, with additional benefit of fibroid size reduction.

View Source 2024
RCT Women's Health / Infertility

Effect of Combined Acupuncture and Herbal Medicine for Uterine Fibroid-Related Menorrhagia: A Randomized Controlled Trial

장다은, 고채영, 남서윤, et al. Gynecologic and Obstetric Investigation (2024)
52% Menstrual volume reduction rate
102 patients Study population
18.3% Fibroid volume reduction

Summary

An RCT comparing combined acupuncture and herbal medicine (Gyejibokryeong-hwan combined with Goonggwigyoae-tang) with tranexamic acid in 102 women with menorrhagia due to uterine fibroids. After 6 months of treatment, menstrual volume decreased by 52% in the Korean medicine treatment group, showing similar effects to the tranexamic acid group (44%). Fibroid volume significantly decreased only in the Korean medicine group (18.3%).

Key Conclusion

Combined acupuncture and herbal medicine shows effects equivalent to tranexamic acid for bleeding reduction in uterine fibroid-related menorrhagia, with additional benefit of fibroid size reduction.

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Cross-Sectional Women's Health / Infertility

Effect of Herbal Medicine (Yongdamsagan-tang) Sitz Bath Treatment for Chronic Vaginitis: A Cross-Sectional Study

위채린, 진서영, 우예은, et al.

대한한방부인과학회지 (2023)

2.1/year Sitz bath group recurrence count
156 patients Study population
2.7 times Recurrence count difference

Yongdamsagan-tang sitz bath shows positive association with reducing recurrence frequency of chronic vaginitis and maintaining vaginal health.

View Source 2023
Cross-Sectional Women's Health / Infertility

Effect of Herbal Medicine (Yongdamsagan-tang) Sitz Bath Treatment for Chronic Vaginitis: A Cross-Sectional Study

위채린, 진서영, 우예은, et al. 대한한방부인과학회지 (2023)
2.1/year Sitz bath group recurrence count
156 patients Study population
2.7 times Recurrence count difference

Summary

A cross-sectional study comparing vaginitis recurrence patterns and vaginal health indicators between Yongdamsagan-tang sitz bath experience and non-experience groups in 156 women with chronic recurrent vaginitis. Annual vaginitis recurrence count was significantly fewer in the sitz bath experience group (2.1 vs 4.8 times), with also higher vaginal health self-assessment scores.

Key Conclusion

Yongdamsagan-tang sitz bath shows positive association with reducing recurrence frequency of chronic vaginitis and maintaining vaginal health.

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