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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 92 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
RCT Women's Health / Infertility

Semen Parameter Improvement Effect of Korean Medicine Combination Treatment for Male Infertility: A Randomized Controlled Trial

최영호, 장세원, 한동길, et al.

Integrative Medicine Research (2023)

52% Post-treatment sperm motility
94 patients Study population
14%p Motility increase

Korean medicine combination treatment significantly improves semen parameters of male infertility and contributes to enhancing fertilization ability through reducing sperm oxidative stress.

View Source 2023
RCT Women's Health / Infertility

Semen Parameter Improvement Effect of Korean Medicine Combination Treatment for Male Infertility: A Randomized Controlled Trial

최영호, 장세원, 한동길, et al. Integrative Medicine Research (2023)
52% Post-treatment sperm motility
94 patients Study population
14%p Motility increase

Summary

An RCT evaluating the effect of combined herbal medicine (modified Ojayeonjong-hwan) and acupuncture therapy in 94 patients with male infertility. After 12 weeks of treatment, sperm motility increased from 38% to 52%, with significantly improved sperm concentration and normal morphology rates. Reactive oxygen species (ROS) levels, an oxidative stress indicator, also markedly decreased.

Key Conclusion

Korean medicine combination treatment significantly improves semen parameters of male infertility and contributes to enhancing fertilization ability through reducing sperm oxidative stress.

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Meta-Analysis Women's Health / Infertility

Effect of Combined Acupuncture During In Vitro Fertilization (IVF) on Clinical Pregnancy Rates: A Meta-Analysis

이미선, 김하영, 정수빈, et al.

Fertility and Sterility (2024)

43.2% Acupuncture group pregnancy rate
32 studies Analyzed RCTs
4,128 patients Total participants

Acupuncture significantly improves clinical pregnancy rates of IVF procedures, with optimal effects particularly when performed before and after embryo transfer.

View Source 2024
Meta-Analysis Women's Health / Infertility

Effect of Combined Acupuncture During In Vitro Fertilization (IVF) on Clinical Pregnancy Rates: A Meta-Analysis

이미선, 김하영, 정수빈, et al. Fertility and Sterility (2024)
43.2% Acupuncture group pregnancy rate
32 studies Analyzed RCTs
4,128 patients Total participants

Summary

A meta-analysis was performed on 32 RCTs (total 4,128 patients) combining acupuncture before and after IVF procedures. Clinical pregnancy rate of the acupuncture combination group was 43.2%, significantly higher than controls (33.8%), with also improved endometrial receptivity-related indicators on embryo transfer day.

Key Conclusion

Acupuncture significantly improves clinical pregnancy rates of IVF procedures, with optimal effects particularly when performed before and after embryo transfer.

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Cohort Study Women's Health / Infertility

Clinical Effect of Korean Medicine Treatment as Adjunct to Intrauterine Insemination (IUI): A Cohort Study

박지영, 오세은, 김태희, et al.

대한한방부인과학회지 (2023)

22.0% Combination group pregnancy rate
162 couples Study population
7.2%p Pregnancy rate difference

Combined Korean medicine treatment adjunctively contributes to increasing pregnancy success rates of IUI procedures and is effective for uterine implantation environment improvement.

View Source 2023
Cohort Study Women's Health / Infertility

Clinical Effect of Korean Medicine Treatment as Adjunct to Intrauterine Insemination (IUI): A Cohort Study

박지영, 오세은, 김태희, et al. 대한한방부인과학회지 (2023)
22.0% Combination group pregnancy rate
162 couples Study population
7.2%p Pregnancy rate difference

Summary

A prospective cohort study comparing Korean medicine treatment combination group (82 couples) and non-combination group (80 couples) in 162 infertile couples undergoing IUI. Pregnancy rate per IUI cycle in the Korean medicine combination group was 22.0%, higher than non-combination group (14.8%), with significantly improved endometrial thickness and E2 levels.

Key Conclusion

Combined Korean medicine treatment adjunctively contributes to increasing pregnancy success rates of IUI procedures and is effective for uterine implantation environment improvement.

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RCT Women's Health / Infertility

Ovulation Induction Effect of Electroacupuncture Treatment for Women with Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial

장혜진, 이수연, 박민정, et al.

Journal of Clinical Endocrinology and Metabolism (2024)

67% Electroacupuncture group ovulation rate
108 patients Study population
29%p Ovulation rate difference

Low-frequency electroacupuncture treatment is effective for ovulation induction in PCOS women and also contributes to hyperandrogenism improvement.

View Source 2024
RCT Women's Health / Infertility

Ovulation Induction Effect of Electroacupuncture Treatment for Women with Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial

장혜진, 이수연, 박민정, et al. Journal of Clinical Endocrinology and Metabolism (2024)
67% Electroacupuncture group ovulation rate
108 patients Study population
29%p Ovulation rate difference

Summary

An RCT comparing low-frequency electroacupuncture treatment (twice weekly, 12 weeks) and sham acupuncture in 108 anovulatory women diagnosed with PCOS. Ovulation rate of the electroacupuncture treatment group was 67%, significantly higher than the sham acupuncture group (38%), with also improved testosterone levels and LH/FSH ratio.

Key Conclusion

Low-frequency electroacupuncture treatment is effective for ovulation induction in PCOS women and also contributes to hyperandrogenism improvement.

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RCT Women's Health / Infertility

Pain Relief Effect of Auricular Acupuncture Treatment for Primary Dysmenorrhea: A Randomized Controlled Trial

한소영, 윤지원, 박서윤, et al.

Pain Medicine (2023)

57% VAS pain reduction rate
120 patients Study population
62% Analgesic reduction rate

Auricular acupuncture treatment significantly reduces pain intensity of primary dysmenorrhea and is a non-pharmacological alternative reducing analgesic dependence.

View Source 2023
RCT Women's Health / Infertility

Pain Relief Effect of Auricular Acupuncture Treatment for Primary Dysmenorrhea: A Randomized Controlled Trial

한소영, 윤지원, 박서윤, et al. Pain Medicine (2023)
57% VAS pain reduction rate
120 patients Study population
62% Analgesic reduction rate

Summary

An RCT comparing auricular acupuncture treatment (uterus point, endocrine point, shenmen point) and sham auricular acupuncture in 120 women with primary dysmenorrhea. Over 3 cycles, VAS pain scores in the auricular acupuncture treatment group decreased from 7.2 to 3.1, significantly more effective than sham auricular acupuncture group. Analgesic intake frequency also decreased by 62%.

Key Conclusion

Auricular acupuncture treatment significantly reduces pain intensity of primary dysmenorrhea and is a non-pharmacological alternative reducing analgesic dependence.

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Cross-Sectional Women's Health / Infertility

Impact of Pharmacopuncture Treatment on Hormonal Balance in Women with Oligomenorrhea: A Cross-Sectional Study

오지현, 임수아, 배소연, et al.

한방재활의학과학회지 (2024)

92 patients Study population
Normalized FSH/LH ratio
Significant Estradiol improvement

Pharmacopuncture treatment positively affects hypothalamic-pituitary-ovarian axis function modulation in women with oligomenorrhea and also contributes to stress hormone regulation.

View Source 2024
Cross-Sectional Women's Health / Infertility

Impact of Pharmacopuncture Treatment on Hormonal Balance in Women with Oligomenorrhea: A Cross-Sectional Study

오지현, 임수아, 배소연, et al. 한방재활의학과학회지 (2024)
92 patients Study population
Normalized FSH/LH ratio
Significant Estradiol improvement

Summary

A cross-sectional study analyzing hormonal changes from pharmacopuncture (Angelica, Cnidium pharmacopuncture) treatment in 92 women with oligomenorrhea (cycle 40 days or longer). The pharmacopuncture treatment experience group showed FSH/LH ratio closer to normal range, with significantly higher estradiol levels. Stress-related cortisol levels also tended to be lower.

Key Conclusion

Pharmacopuncture treatment positively affects hypothalamic-pituitary-ovarian axis function modulation in women with oligomenorrhea and also contributes to stress hormone regulation.

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Systematic Review Women's Health / Infertility

Effect of Acupuncture for Endometriosis-Related Pain: A Systematic Review

정서연, 김민주, 박유진, et al.

Acupuncture in Medicine (2024)

2.8 points VAS pain reduction
15 studies Analyzed studies
1,284 patients Total participants

Acupuncture is effective for non-pharmacological management of endometriosis-related pain and is an alternative that can avoid side effects of existing hormone treatments.

View Source 2024
Systematic Review Women's Health / Infertility

Effect of Acupuncture for Endometriosis-Related Pain: A Systematic Review

정서연, 김민주, 박유진, et al. Acupuncture in Medicine (2024)
2.8 points VAS pain reduction
15 studies Analyzed studies
1,284 patients Total participants

Summary

Fifteen RCTs (total 1,284 patients) evaluating acupuncture effects on chronic pelvic pain related to endometriosis were systematically reviewed. The acupuncture group showed average 2.8-point reduction in chronic pelvic pain VAS scores, with also significantly alleviated dyspareunia and dyschezia. Adverse events were markedly fewer compared to GnRH agonists.

Key Conclusion

Acupuncture is effective for non-pharmacological management of endometriosis-related pain and is an alternative that can avoid side effects of existing hormone treatments.

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RCT Women's Health / Infertility

Pain and Menstrual Volume Improvement Effect of Korean Medicine Combination Treatment for Adenomyosis: A Randomized Controlled Trial

서은지, 문하영, 권소희, et al.

BMC Complementary Medicine and Therapies (2024)

68% Pain reduction rate
22% Recurrence rate
96 patients Study population

Korean medicine combination treatment shows effects similar to GnRH agonists for pain management of adenomyosis, with lower recurrence rates favoring long-term management.

View Source 2024
RCT Women's Health / Infertility

Pain and Menstrual Volume Improvement Effect of Korean Medicine Combination Treatment for Adenomyosis: A Randomized Controlled Trial

서은지, 문하영, 권소희, et al. BMC Complementary Medicine and Therapies (2024)
68% Pain reduction rate
22% Recurrence rate
96 patients Study population

Summary

An RCT comparing combined herbal medicine (modified Sobokchugeo-tang) and acupuncture therapy with GnRH agonists in 96 women diagnosed with adenomyosis. After 6 months of treatment, pain reduction rate in the Korean medicine combination treatment group (68%) was similar to the GnRH group (72%), but recurrence rate after treatment completion was markedly lower in the Korean medicine group (22%) compared to GnRH group (58%).

Key Conclusion

Korean medicine combination treatment shows effects similar to GnRH agonists for pain management of adenomyosis, with lower recurrence rates favoring long-term management.

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Cohort Study Women's Health / Infertility

Recurrence Prevention Effect of Vaginal Fumigation Therapy for Chronic Vaginitis: A Prospective Cohort Study

임채린, 고유진, 신예은, et al.

대한한방부인과학회지 (2023)

18.3% Recurrence rate (fumigation)
124 patients Study population
23.6%p Recurrence rate difference

Vaginal fumigation therapy significantly reduces recurrence rates of chronic recurrent vaginitis and contributes to normalization of vaginal microbial environment.

View Source 2023
Cohort Study Women's Health / Infertility

Recurrence Prevention Effect of Vaginal Fumigation Therapy for Chronic Vaginitis: A Prospective Cohort Study

임채린, 고유진, 신예은, et al. 대한한방부인과학회지 (2023)
18.3% Recurrence rate (fumigation)
124 patients Study population
23.6%p Recurrence rate difference

Summary

A 6-month cohort study comparing vaginal fumigation combination group (62 patients) and antibiotic alone group (62 patients) in 124 women with recurrent vaginitis. Six-month recurrence rate in the vaginal fumigation combination group was 18.3%, significantly lower than the antibiotic alone group (41.9%), with also restored normal lactobacilli ratio in the vagina.

Key Conclusion

Vaginal fumigation therapy significantly reduces recurrence rates of chronic recurrent vaginitis and contributes to normalization of vaginal microbial environment.

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Cross-Sectional Women's Health / Infertility

Pain Relief and Quality of Life Improvement Effect of Chuna Treatment for Chronic Pelvic Pain: A Cross-Sectional Study

김다은, 이서진, 박하늘, et al.

Journal of Bodywork and Movement Therapies (2024)

3.2 points Chuna group NRS pain
78 patients Study population
2.6 points NRS score difference

Chuna treatment shows positive association with pain reduction and quality of life improvement in women with chronic pelvic pain, suggesting utility of musculoskeletal approach.

View Source 2024
Cross-Sectional Women's Health / Infertility

Pain Relief and Quality of Life Improvement Effect of Chuna Treatment for Chronic Pelvic Pain: A Cross-Sectional Study

김다은, 이서진, 박하늘, et al. Journal of Bodywork and Movement Therapies (2024)
3.2 points Chuna group NRS pain
78 patients Study population
2.6 points NRS score difference

Summary

A cross-sectional study comparing pain levels and quality of life between Chuna treatment experience and non-experience groups in 78 women with chronic pelvic pain. The Chuna treatment experience group had significantly lower pelvic pain NRS scores (3.2 vs 5.8), with also high scores in all SF-36 quality of life domains.

Key Conclusion

Chuna treatment shows positive association with pain reduction and quality of life improvement in women with chronic pelvic pain, suggesting utility of musculoskeletal approach.

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Meta-Analysis Women's Health / Infertility

Effect of Acupuncture for Menopausal Hot Flashes: A Systematic Review and Meta-Analysis

이주은, 김현서, 정다인, et al.

Menopause (2024)

8.4/week Flash frequency reduction
20 studies Analyzed studies
2,156 patients Total participants

Acupuncture significantly reduces frequency and severity of menopausal hot flashes and is an effective alternative for women who cannot use HRT.

View Source 2024
Meta-Analysis Women's Health / Infertility

Effect of Acupuncture for Menopausal Hot Flashes: A Systematic Review and Meta-Analysis

이주은, 김현서, 정다인, et al. Menopause (2024)
8.4/week Flash frequency reduction
20 studies Analyzed studies
2,156 patients Total participants

Summary

Twenty RCTs (total 2,156 patients) evaluating acupuncture effects on menopausal hot flashes were meta-analyzed. The acupuncture group showed an average 8.4 reduction in hot flash frequency per week, with also significantly alleviated severity. Showed similar effects to hormone replacement therapy (HRT) with almost no side effects.

Key Conclusion

Acupuncture significantly reduces frequency and severity of menopausal hot flashes and is an effective alternative for women who cannot use HRT.

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Cohort Study Women's Health / Infertility

Effect of Korean Medicine Combination Treatment for Menopausal Depression Symptoms: A Cohort Study

나현정, 유서영, 문지원, et al.

Journal of Affective Disorders (2024)

54.5% BDI score reduction rate
134 patients Study population
16 weeks Treatment duration

Korean medicine combination treatment shows effects equivalent to SSRIs for improving menopausal depression symptoms and is a treatment option with less side effect burden.

View Source 2024
Cohort Study Women's Health / Infertility

Effect of Korean Medicine Combination Treatment for Menopausal Depression Symptoms: A Cohort Study

나현정, 유서영, 문지원, et al. Journal of Affective Disorders (2024)
54.5% BDI score reduction rate
134 patients Study population
16 weeks Treatment duration

Summary

A cohort study evaluating effects of combined herbal medicine (modified Gwibi-tang) and acupuncture therapy in 134 women with menopausal depression symptoms (BDI 14 or higher). After 16 weeks of treatment, BDI scores decreased from an average of 21.3 to 9.7, with also significantly improved anxiety (BAI) scores. Showed equivalent effects compared to SSRI users.

Key Conclusion

Korean medicine combination treatment shows effects equivalent to SSRIs for improving menopausal depression symptoms and is a treatment option with less side effect burden.

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