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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 83 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Before-After Skin Conditions

Effect of Herbal Bath Therapy on Autonomic Nervous System and Skin Health in Chronic Stress Patients: A Pre-Post Comparison Study

Roh JD, Kang YH, Lee EJ, et al.

Complementary Therapies in Clinical Practice (2024)

31% Parasympathetic activity increase
45 patients Participants
8 weeks Application period

Herbal bath therapy is an effective wellness treatment for autonomic balance recovery and skin health improvement.

View Source 2024
Before-After Skin Conditions

Effect of Herbal Bath Therapy on Autonomic Nervous System and Skin Health in Chronic Stress Patients: A Pre-Post Comparison Study

Roh JD, Kang YH, Lee EJ, et al. Complementary Therapies in Clinical Practice (2024)
31% Parasympathetic activity increase
45 patients Participants
8 weeks Application period

Summary

Herbal bath (based on Artemisia, Angelica, Cnidium) was applied twice weekly for 8 weeks to 45 adults complaining of chronic stress. HRV analysis showed 31% increase in parasympathetic activity, with significantly improved skin hydration and elasticity.

Key Conclusion

Herbal bath therapy is an effective wellness treatment for autonomic balance recovery and skin health improvement.

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Cross-Sectional Skin Conditions

Correlation Between Korean Medicine Pattern Differentiation and Psychological Stress in Skin Disease Patients: A Cross-Sectional Analysis

Go YH, Shin MJ, et al.

Psychodermatology (2024)

300 patients Analysis population
4 types Disease groups
r=0.58 Stress correlation

Korean medicine pattern differentiation in skin diseases is significantly associated with psychological stress, and mind-body integrated treatment is needed.

View Source 2024
Cross-Sectional Skin Conditions

Correlation Between Korean Medicine Pattern Differentiation and Psychological Stress in Skin Disease Patients: A Cross-Sectional Analysis

Go YH, Shin MJ, et al. Psychodermatology (2024)
300 patients Analysis population
4 types Disease groups
r=0.58 Stress correlation

Summary

A cross-sectional analysis of correlations between Korean medicine pattern types and psychological stress (PSS, DASS-21) in 300 patients with various skin diseases (atopy, psoriasis, acne, urticaria). Psychological stress was significantly higher in fire-heat and liver-stagnation patterns.

Key Conclusion

Korean medicine pattern differentiation in skin diseases is significantly associated with psychological stress, and mind-body integrated treatment is needed.

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RCT Skin Conditions

Th2 Immune Response Suppression Effect of Herbal Medicine in Atopic Dermatitis Patients: An RCT

Lee KH, Song YM, Zhao X, et al.

Clinical and Experimental Allergy (2024)

70 patients Participants
42% IL-4 reduction
12 weeks Treatment duration

Herbal medicine acts on immunological mechanisms of atopic dermatitis through Th2 immune response suppression.

View Source 2024
RCT Skin Conditions

Th2 Immune Response Suppression Effect of Herbal Medicine in Atopic Dermatitis Patients: An RCT

Lee KH, Song YM, Zhao X, et al. Clinical and Experimental Allergy (2024)
70 patients Participants
42% IL-4 reduction
12 weeks Treatment duration

Summary

Seventy patients with moderate atopic dermatitis were randomly assigned to herbal medicine or placebo groups and compared over 12 weeks, with blood IL-4, IL-13, and IgE measured. The herbal medicine group showed EASI score reduction along with significant decreases in Th2 cytokines.

Key Conclusion

Herbal medicine acts on immunological mechanisms of atopic dermatitis through Th2 immune response suppression.

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Systematic Review Skin Conditions

Optimal Treatment Strategy of Combined Oral and Topical Herbal Medicine in Eczema Patients: A Systematic Review

Moon DK, Woo SH, et al.

Dermatologic Therapy (2022)

18 studies Included studies
14 studies Combination superiority
Moderate-High Evidence level

Combined oral and topical herbal medicine shows superior effects to monotherapy in eczema treatment.

View Source 2022
Systematic Review Skin Conditions

Optimal Treatment Strategy of Combined Oral and Topical Herbal Medicine in Eczema Patients: A Systematic Review

Moon DK, Woo SH, et al. Dermatologic Therapy (2022)
18 studies Included studies
14 studies Combination superiority
Moderate-High Evidence level

Summary

Eighteen studies on optimal strategies for combined oral and topical herbal medicine treatment for eczema were systematically reviewed. Combined oral and topical use showed superior efficacy to monotherapy.

Key Conclusion

Combined oral and topical herbal medicine shows superior effects to monotherapy in eczema treatment.

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Cohort Study Skin Conditions

Long-Term Follow-Up of Korean Medicine Treatment in Psoriasis Patients: A 3-Year Cohort Study

Seo HY, Park JW, Kim SH, et al.

Psoriasis: Targets and Therapy (2023)

150 patients Participants
65% 3-year PASI-50 maintenance
3 years Follow-up period

Korean medicine treatment is effective for long-term management of psoriasis, and continued treatment is important for recurrence prevention.

View Source 2023
Cohort Study Skin Conditions

Long-Term Follow-Up of Korean Medicine Treatment in Psoriasis Patients: A 3-Year Cohort Study

Seo HY, Park JW, Kim SH, et al. Psoriasis: Targets and Therapy (2023)
150 patients Participants
65% 3-year PASI-50 maintenance
3 years Follow-up period

Summary

One hundred fifty psoriasis patients who received Korean medicine treatment were followed for 3 years to evaluate long-term effects, recurrence rates, and quality of life. PASI-50 maintenance rate after 3 years was 65%.

Key Conclusion

Korean medicine treatment is effective for long-term management of psoriasis, and continued treatment is important for recurrence prevention.

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RCT Skin Conditions

Effect of Korean Medicine Combination Therapy on Quality of Life in Atopic Dermatitis Patients: An RCT

Noh TY, Lee KM, et al.

Quality of Life Research (2025)

100 patients Participants
6.8 points DLQI improvement
12 weeks Treatment duration

Korean medicine combination therapy comprehensively improves quality of life in atopic dermatitis patients.

View Source 2025
RCT Skin Conditions

Effect of Korean Medicine Combination Therapy on Quality of Life in Atopic Dermatitis Patients: An RCT

Noh TY, Lee KM, et al. Quality of Life Research (2025)
100 patients Participants
6.8 points DLQI improvement
12 weeks Treatment duration

Summary

One hundred atopic dermatitis patients were randomly assigned to Korean medicine combination therapy or standard moisturizing care groups, and DLQI, SCORAD, and sleep quality were compared over 12 weeks. The Korean medicine treatment group showed significant improvements in all three indicators.

Key Conclusion

Korean medicine combination therapy comprehensively improves quality of life in atopic dermatitis patients.

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Narrative Review Skin Conditions

Transdermal Absorption Characteristics of Topical Preparations in Korean Medicine Skin Treatment: Experimental Review

Jung MH, Cho SJ, Pham V, et al.

Pharmaceutical Research (2024)

3 types Topical preparation types
Franz cell Experimental method
15 studies Reviewed papers

Active components of Korean medicine topical preparations show appropriate transdermal absorption rates, providing scientific evidence for skin disease treatment.

View Source 2024
Narrative Review Skin Conditions

Transdermal Absorption Characteristics of Topical Preparations in Korean Medicine Skin Treatment: Experimental Review

Jung MH, Cho SJ, Pham V, et al. Pharmaceutical Research (2024)
3 types Topical preparation types
Franz cell Experimental method
15 studies Reviewed papers

Summary

Transdermal absorption characteristics of major components of Korean medicine topical preparations (Jaungo, Hwanglyeon ointment, Lonicera lotion) were analyzed by Franz diffusion cell, and related clinical studies were reviewed.

Key Conclusion

Active components of Korean medicine topical preparations show appropriate transdermal absorption rates, providing scientific evidence for skin disease treatment.

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Case Study Skin Conditions

Korean Medicine De-Steroidization Protocol for Steroid-Dependent Dermatitis: A Case Series

Ahn BY, Kang SJ, et al.

Dermatitis (2021)

10 patients Cases
80% De-steroidization success
16 weeks Average duration

The Korean medicine de-steroidization protocol helps safe steroid discontinuation in steroid-dependent dermatitis patients.

View Source 2021
Case Study Skin Conditions

Korean Medicine De-Steroidization Protocol for Steroid-Dependent Dermatitis: A Case Series

Ahn BY, Kang SJ, et al. Dermatitis (2021)
10 patients Cases
80% De-steroidization success
16 weeks Average duration

Summary

A case report applying a Korean medicine stepwise de-steroidization protocol in 10 patients with steroid-dependent dermatitis due to long-term topical steroid use. Eight patients successfully discontinued steroids.

Key Conclusion

The Korean medicine de-steroidization protocol helps safe steroid discontinuation in steroid-dependent dermatitis patients.

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RCT Skin Conditions

Comparison of Acupotomy and Microneedling for Acne Scars: An RCT

Choi BK, Lee HJ, et al.

Journal of Cosmetic and Laser Therapy (2023)

60 patients Participants
Equivalent effect Primary outcome
3 months Treatment duration

Acupotomy is a Korean medicine procedure that shows effects equivalent to microneedling for atrophic acne scar improvement.

View Source 2023
RCT Skin Conditions

Comparison of Acupotomy and Microneedling for Acne Scars: An RCT

Choi BK, Lee HJ, et al. Journal of Cosmetic and Laser Therapy (2023)
60 patients Participants
Equivalent effect Primary outcome
3 months Treatment duration

Summary

Sixty patients with atrophic acne scars were randomly assigned to acupotomy or microneedling groups, and scar improvement was compared after 6 sessions (3 months) of treatment. Both groups showed similar effects.

Key Conclusion

Acupotomy is a Korean medicine procedure that shows effects equivalent to microneedling for atrophic acne scar improvement.

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Systematic Review Skin Conditions

Systematic Review of Korean Medicine Treatment for Chronic Urticaria

Oh JY, Min KS, et al.

Allergy, Asthma & Clinical Immunology (2024)

22 studies Included studies
18 studies Positive results
Moderate Evidence level

Korean medicine treatment is an effective complementary treatment option for chronic urticaria management.

View Source 2024
Systematic Review Skin Conditions

Systematic Review of Korean Medicine Treatment for Chronic Urticaria

Oh JY, Min KS, et al. Allergy, Asthma & Clinical Immunology (2024)
22 studies Included studies
18 studies Positive results
Moderate Evidence level

Summary

Twenty-two studies on Korean medicine treatment for chronic urticaria were systematically reviewed. Both herbal medicine and acupuncture treatment showed positive results in UAS7 reduction and quality of life improvement.

Key Conclusion

Korean medicine treatment is an effective complementary treatment option for chronic urticaria management.

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Before-After Skin Conditions

Effect of Herbal Medicine Treatment on TNF-α and IL-17 Pathways in Psoriasis Patients

Song WH, Kim JK, et al.

Cytokine (2023)

60 patients Participants
35% IL-17A reduction
12 weeks Treatment duration

Cheongyeoljihwang-tang directly acts on immunological mechanisms of psoriasis by suppressing TNF-α and IL-17 pathways.

View Source 2023
Before-After Skin Conditions

Effect of Herbal Medicine Treatment on TNF-α and IL-17 Pathways in Psoriasis Patients

Song WH, Kim JK, et al. Cytokine (2023)
60 patients Participants
35% IL-17A reduction
12 weeks Treatment duration

Summary

Cheongyeoljihwang-tang was administered for 12 weeks to 60 patients with moderate psoriasis, and changes in blood TNF-α, IL-17A, and IL-23 were tracked. All three cytokines significantly decreased and showed positive correlation with PASI scores.

Key Conclusion

Cheongyeoljihwang-tang directly acts on immunological mechanisms of psoriasis by suppressing TNF-α and IL-17 pathways.

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Meta-Analysis Skin Conditions

Recurrence Prevention Effect of Korean Medicine Treatment for Atopic Dermatitis: A Meta-Analysis

Kwon SH, Lee AR, Huang Y, et al.

Annals of Dermatology (2025)

12 studies Included studies
1,050 patients Total participants
OR 0.48 Recurrence risk reduction

Korean medicine treatment shows superior long-term effects to steroid treatment in atopic dermatitis recurrence prevention.

View Source 2025
Meta-Analysis Skin Conditions

Recurrence Prevention Effect of Korean Medicine Treatment for Atopic Dermatitis: A Meta-Analysis

Kwon SH, Lee AR, Huang Y, et al. Annals of Dermatology (2025)
12 studies Included studies
1,050 patients Total participants
OR 0.48 Recurrence risk reduction

Summary

Twelve RCTs (total 1,050 patients) evaluating recurrence prevention effects of Korean medicine treatment for atopic dermatitis were meta-analyzed. The Korean medicine treatment group showed significantly lower 6-month recurrence rates.

Key Conclusion

Korean medicine treatment shows superior long-term effects to steroid treatment in atopic dermatitis recurrence prevention.

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