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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 71 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Cohort Study Respiratory Conditions

Effect of Herbal Medicine Preventive Treatment on COPD Acute Exacerbation Frequency: A 2-Year Cohort

Yoo BK, Min SH, Park KS, et al.

COPD: Journal of Chronic Obstructive Pulmonary Disease (2023)

200 patients Participants
38% Exacerbation reduction
2 years Follow-up period

Herbal medicine preventive treatment combination is effective in reducing acute exacerbation frequency in COPD patients.

View Source 2023
Cohort Study Respiratory Conditions

Effect of Herbal Medicine Preventive Treatment on COPD Acute Exacerbation Frequency: A 2-Year Cohort

Yoo BK, Min SH, Park KS, et al. COPD: Journal of Chronic Obstructive Pulmonary Disease (2023)
200 patients Participants
38% Exacerbation reduction
2 years Follow-up period

Summary

Two hundred COPD patients were divided into a herbal medicine preventive treatment combination group and a standard treatment group, and acute exacerbation frequency was followed for 2 years. The herbal medicine combination group had significantly lower annual acute exacerbation frequency.

Key Conclusion

Herbal medicine preventive treatment combination is effective in reducing acute exacerbation frequency in COPD patients.

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RCT Respiratory Conditions

Effect of Maekmundong-tang for Post-Cold Chronic Cough: A Randomized Controlled Trial

Han JK, Lee GH, et al.

Chest (2024)

100 patients Participants
Non-inferiority confirmed Primary outcome
4 weeks Treatment duration

Maekmundong-tang shows efficacy equivalent to codeine in managing post-cold chronic cough with fewer side effects.

View Source 2024
RCT Respiratory Conditions

Effect of Maekmundong-tang for Post-Cold Chronic Cough: A Randomized Controlled Trial

Han JK, Lee GH, et al. Chest (2024)
100 patients Participants
Non-inferiority confirmed Primary outcome
4 weeks Treatment duration

Summary

One hundred patients with chronic cough lasting more than 8 weeks after a cold were randomly assigned to a Maekmundong-tang or codeine group and compared over 4 weeks. Cough frequency reduction in the Maekmundong-tang group was equivalent to codeine, with significantly fewer drowsiness side effects.

Key Conclusion

Maekmundong-tang shows efficacy equivalent to codeine in managing post-cold chronic cough with fewer side effects.

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Systematic Review Respiratory Conditions

Airway Inflammation-Modulating Effects of Acupuncture in Asthma Patients: A Systematic Review

Shin YS, Kim AY, Chen H, et al.

Allergy, Asthma & Immunology Research (2023)

18 studies Included studies
12 studies Positive results
Moderate Evidence level

Acupuncture can be utilized as adjunctive therapy for airway inflammation modulation in asthma, though additional research is needed.

View Source 2023
Systematic Review Respiratory Conditions

Airway Inflammation-Modulating Effects of Acupuncture in Asthma Patients: A Systematic Review

Shin YS, Kim AY, Chen H, et al. Allergy, Asthma & Immunology Research (2023)
18 studies Included studies
12 studies Positive results
Moderate Evidence level

Summary

Eighteen studies evaluating airway inflammation-modulating effects of acupuncture in asthma patients were systematically reviewed. Decreasing trends in eosinophil counts, FeNO, and IgE were reported in the acupuncture group.

Key Conclusion

Acupuncture can be utilized as adjunctive therapy for airway inflammation modulation in asthma, though additional research is needed.

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Before-After Respiratory Conditions

Anti-Inflammatory and Antipyretic Effects of Eungyo-san for Acute Bronchitis: A Pre-Post Comparison Study

Jung MH, Yoo SH, et al.

Journal of Ethnopharmacology (2022)

60 patients Participants
82% Symptom improvement rate
5 days Treatment duration

Eungyo-san is effective for rapid symptom relief in acute bronchitis.

View Source 2022
Before-After Respiratory Conditions

Anti-Inflammatory and Antipyretic Effects of Eungyo-san for Acute Bronchitis: A Pre-Post Comparison Study

Jung MH, Yoo SH, et al. Journal of Ethnopharmacology (2022)
60 patients Participants
82% Symptom improvement rate
5 days Treatment duration

Summary

Eungyo-san was administered for 5 days to 60 patients with acute bronchitis, and body temperature, CRP, cough frequency, and sputum volume were evaluated. Symptoms significantly improved from day 3 of treatment.

Key Conclusion

Eungyo-san is effective for rapid symptom relief in acute bronchitis.

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RCT Respiratory Conditions

Effect of Combination Herbal Medicine on FVC and FEV1 Improvement in Patients with Reduced Pulmonary Function: An RCT

Cho SJ, Park BH, Li M, et al.

Phytomedicine (2025)

80 patients Participants
8.5% FVC improvement
16 weeks Treatment duration

Combination herbal medicine is effective for improving respiratory function in patients with reduced pulmonary function.

View Source 2025
RCT Respiratory Conditions

Effect of Combination Herbal Medicine on FVC and FEV1 Improvement in Patients with Reduced Pulmonary Function: An RCT

Cho SJ, Park BH, Li M, et al. Phytomedicine (2025)
80 patients Participants
8.5% FVC improvement
16 weeks Treatment duration

Summary

Eighty patients with restrictive lung disease were randomized to a combination herbal medicine or placebo group and compared over 16 weeks. The herbal medicine group showed significant improvements in FVC and FEV1.

Key Conclusion

Combination herbal medicine is effective for improving respiratory function in patients with reduced pulmonary function.

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Cohort Study Respiratory Conditions

Exercise Tolerance Improvement Effect of Bopye-tang in Stable COPD Patients: A Prospective Cohort

Kim DH, Song MJ, et al.

International Journal of Chronic Obstructive Pulmonary Disease (2024)

100 patients Participants
42 m 6-min walk improvement
6 months Follow-up period

Bopye-tang combination improves exercise tolerance and quality of life in stable COPD patients.

View Source 2024
Cohort Study Respiratory Conditions

Exercise Tolerance Improvement Effect of Bopye-tang in Stable COPD Patients: A Prospective Cohort

Kim DH, Song MJ, et al. International Journal of Chronic Obstructive Pulmonary Disease (2024)
100 patients Participants
42 m 6-min walk improvement
6 months Follow-up period

Summary

One hundred patients with GOLD 2-3 stage COPD were followed for 6 months, divided into a Bopye-tang combination group and a standard treatment group. The Bopye-tang group showed significant improvements in 6-minute walk distance and SGRQ scores.

Key Conclusion

Bopye-tang combination improves exercise tolerance and quality of life in stable COPD patients.

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Meta-Analysis Respiratory Conditions

Effect of Korean Medicine Treatment for Chronic Cough: A Systematic Review and Meta-Analysis

Lee SY, Choi HK, Watanabe K, et al.

Pulmonary Pharmacology & Therapeutics (2023)

14 studies Included studies
1,180 patients Total participants
WMD 3.2 LCQ improvement

Herbal medicine shows significant efficacy in reducing chronic cough frequency and improving quality of life.

View Source 2023
Meta-Analysis Respiratory Conditions

Effect of Korean Medicine Treatment for Chronic Cough: A Systematic Review and Meta-Analysis

Lee SY, Choi HK, Watanabe K, et al. Pulmonary Pharmacology & Therapeutics (2023)
14 studies Included studies
1,180 patients Total participants
WMD 3.2 LCQ improvement

Summary

Fourteen RCTs (total 1,180 patients) evaluating herbal medicine treatment for chronic cough lasting more than 8 weeks were meta-analyzed. The herbal medicine group showed significant improvements in cough frequency and LCQ scores.

Key Conclusion

Herbal medicine shows significant efficacy in reducing chronic cough frequency and improving quality of life.

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RCT Respiratory Conditions

Airway Hyperresponsiveness Improvement Effect of Socheongryong-tang for Bronchial Asthma: A Double-Blind RCT

Park HS, Kim JM, Lee WK, et al.

Respiratory Medicine (2024)

120 patients Participants
23% FEV1 improvement
12 weeks Treatment duration

Socheongryong-tang is effective for improving airway hyperresponsiveness and pulmonary function in asthma patients.

View Source 2024
RCT Respiratory Conditions

Airway Hyperresponsiveness Improvement Effect of Socheongryong-tang for Bronchial Asthma: A Double-Blind RCT

Park HS, Kim JM, Lee WK, et al. Respiratory Medicine (2024)
120 patients Participants
23% FEV1 improvement
12 weeks Treatment duration

Summary

A double-blind randomized trial comparing Socheongryong-tang versus placebo over 12 weeks in 120 patients with mild-to-moderate asthma. The Socheongryong-tang group showed significant improvements in PC20 methacholine, FEV1, and ACT scores.

Key Conclusion

Socheongryong-tang is effective for improving airway hyperresponsiveness and pulmonary function in asthma patients.

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Cohort Study Respiratory Conditions

Effect of Korean Medicine Combination Therapy on Asthma Attack Prevention in Children: A Cohort Study

Kim EJ, Lee SH, Yoon HJ, et al.

Pediatric Allergy and Immunology (2023)

67% Acute exacerbation reduction
38% Steroid use reduction
124 patients Study population

Korean medicine combination therapy is effective as adjunctive treatment for reducing acute exacerbation frequency and lowering steroid dependence in pediatric asthma.

View Source 2023
Cohort Study Respiratory Conditions

Effect of Korean Medicine Combination Therapy on Asthma Attack Prevention in Children: A Cohort Study

Kim EJ, Lee SH, Yoon HJ, et al. Pediatric Allergy and Immunology (2023)
67% Acute exacerbation reduction
38% Steroid use reduction
124 patients Study population

Summary

A 2-year cohort study following 124 pediatric asthma patients. The herbal medicine plus acupuncture combination group showed annual acute exacerbation frequency decreased from 1.8 to 0.6 episodes (67% reduction) and average 38% reduction in inhaled steroid use. Pulmonary function tests (FEV1) also showed significant improvement.

Key Conclusion

Korean medicine combination therapy is effective as adjunctive treatment for reducing acute exacerbation frequency and lowering steroid dependence in pediatric asthma.

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Systematic Review Respiratory Conditions

Systematic Review of Herbal Medicine Treatment for Chronic Cough

Jiang M, Lu C, Zhang C, et al.

Journal of Ethnopharmacology (2022)

63% Cough frequency reduction
14 studies Analyzed studies
8+ weeks Target cough duration

Herbal medicine treatment shows significant efficacy for chronic cough, particularly intractable cough of unknown origin, making it suitable for patients unresponsive to conventional treatments.

View Source 2022
Systematic Review Respiratory Conditions

Systematic Review of Herbal Medicine Treatment for Chronic Cough

Jiang M, Lu C, Zhang C, et al. Journal of Ethnopharmacology (2022)
63% Cough frequency reduction
14 studies Analyzed studies
8+ weeks Target cough duration

Summary

Fourteen clinical studies on herbal medicine treatment for chronic cough lasting more than 8 weeks were systematically reviewed. The herbal medicine group showed an average 63% reduction in cough frequency with significant improvement in cough-related quality of life (LCQ) scores. The efficacy was particularly notable in chronic cough of unknown origin.

Key Conclusion

Herbal medicine treatment shows significant efficacy for chronic cough, particularly intractable cough of unknown origin, making it suitable for patients unresponsive to conventional treatments.

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RCT Respiratory Conditions

Pulmonary Function-Improving Effect of Bopyeikgi-tang for Chronic Obstructive Pulmonary Disease (COPD): A Randomized Controlled Trial

이동원, 김상혁, 정민영

대한한방내과학회지 (2022)

14.2% FEV1 improvement
41% Acute exacerbation reduction
78 patients Study population

Bopyeikgi-tang is effective for improving pulmonary function and preventing acute exacerbations in COPD patients, with synergistic effects observed when combined with conventional Western medicine.

View Source 2022
RCT Respiratory Conditions

Pulmonary Function-Improving Effect of Bopyeikgi-tang for Chronic Obstructive Pulmonary Disease (COPD): A Randomized Controlled Trial

이동원, 김상혁, 정민영 대한한방내과학회지 (2022)
14.2% FEV1 improvement
41% Acute exacerbation reduction
78 patients Study population
12 weeks Treatment duration

Summary

In 78 COPD patients, comparison between a Bopyeikgi-tang treatment group and a control group showed significant improvement in FEV1 (forced expiratory volume in 1 second) after 12 weeks of treatment, with reduced frequency of acute exacerbations.

Key Conclusion

Bopyeikgi-tang is effective for improving pulmonary function and preventing acute exacerbations in COPD patients, with synergistic effects observed when combined with conventional Western medicine.

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