금맥한의원
Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

Research Papers
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Total 84 papers

Systematic Review Men's Health / Urology

Effect of Korean Medicine Interventions for Male Vitality Enhancement: A Systematic Review

Bae CH, Jung IH, Li X, et al.

Sexual Medicine Reviews (2023)

45 studies Included Studies
12 RCTs Number of RCTs
73% Positive Results Rate

Korean medicine interventions show multifaceted effects in improving male sexual function, but additional high-quality large-scale RCTs are needed.

Systematic Review Men's Health / Urology

Effect of Korean Medicine Interventions for Male Vitality Enhancement: A Systematic Review

Bae CH, Jung IH, Li X, et al. Sexual Medicine Reviews (2023)
45 studies Included Studies
12 RCTs Number of RCTs
73% Positive Results Rate

Summary

Forty-five studies on Korean medicine interventions (herbal medicine, acupuncture, moxibustion) aimed at enhancing male vitality were systematically reviewed. Twelve RCTs, 15 cohort studies, and 18 pre-post comparisons were included.

Key Conclusion

Korean medicine interventions show multifaceted effects in improving male sexual function, but additional high-quality large-scale RCTs are needed.

RCT Men's Health / Urology

Effect of Modified Ssanghwa-tang on Male Climacteric Fatigue: A Double-Blind Randomized Controlled Trial

Kwon JY, Moon SH, Lee DW, et al.

Journal of Ginseng Research (2025)

90 subjects Participants
41% Fatigue Reduction Rate
12 weeks Treatment Period

Modified Ssanghwa-tang is effective for improving male climacteric fatigue and shows excellent safety.

RCT Men's Health / Urology

Effect of Modified Ssanghwa-tang on Male Climacteric Fatigue: A Double-Blind Randomized Controlled Trial

Kwon JY, Moon SH, Lee DW, et al. Journal of Ginseng Research (2025)
90 subjects Participants
41% Fatigue Reduction Rate
12 weeks Treatment Period

Summary

Ninety men complaining of male climacteric fatigue symptoms were compared with modified Ssanghwa-tang and placebo for 12 weeks. Fatigue Severity Scale (FSS) and Aging Males Symptoms (AMS) scores improved significantly.

Key Conclusion

Modified Ssanghwa-tang is effective for improving male climacteric fatigue and shows excellent safety.

Before-After Men's Health / Urology

Effect of Acupuncture Treatment on Oxidative Stress Markers in Male Infertility Patients

Hong SK, Park YH, Yamamoto K, et al.

Andrologia (2022)

60 subjects Participants
38% ROS Reduction Rate
p<0.05 Statistical Significance

Acupuncture treatment can contribute to improving sperm quality by reducing oxidative stress in semen of male infertility patients.

Before-After Men's Health / Urology

Effect of Acupuncture Treatment on Oxidative Stress Markers in Male Infertility Patients

Hong SK, Park YH, Yamamoto K, et al. Andrologia (2022)
60 subjects Participants
38% ROS Reduction Rate
p<0.05 Statistical Significance

Summary

Acupuncture treatment was administered for 8 weeks to 60 male infertility patients, and oxidative stress markers in semen (ROS, TAC) were measured. After acupuncture treatment, ROS significantly decreased and TAC increased.

Key Conclusion

Acupuncture treatment can contribute to improving sperm quality by reducing oxidative stress in semen of male infertility patients.

RCT Men's Health / Urology

Effect of Combined Herbal Medicine and Acupuncture Treatment for Prostatitis: A Multicenter Randomized Controlled Trial

Shin MJ, Lee KS, Chen W, et al.

Phytomedicine (2024)

200 subjects Participants
72.5% Symptom Improvement Rate
4 institutions Multicenter Participation

Combined herbal medicine and acupuncture treatment demonstrated superior effects over standard treatment in symptom relief and quality of life improvement for chronic prostatitis.

RCT Men's Health / Urology

Effect of Combined Herbal Medicine and Acupuncture Treatment for Prostatitis: A Multicenter Randomized Controlled Trial

Shin MJ, Lee KS, Chen W, et al. Phytomedicine (2024)
200 subjects Participants
72.5% Symptom Improvement Rate
4 institutions Multicenter Participation

Summary

Two hundred chronic prostatitis patients were recruited from 4 Korean medicine hospitals, and combined herbal medicine and acupuncture treatment was compared with standard antibiotic treatment. After 12 weeks, NIH-CPSI scores were significantly superior in the combined treatment group.

Key Conclusion

Combined herbal medicine and acupuncture treatment demonstrated superior effects over standard treatment in symptom relief and quality of life improvement for chronic prostatitis.

Narrative Review Men's Health / Urology

Effect of Bojungikgi-tang on Male Vitality Enhancement: A Literature Review

Yoon TH, Kim GR, et al.

Korean Journal of Oriental Medicine (2021)

32 sources Analyzed Literature
85% Positive Results Rate

Bojungikgi-tang contributes to sexual function improvement in qi-deficient men through various mechanisms, and additional large-scale clinical studies are needed.

Narrative Review Men's Health / Urology

Effect of Bojungikgi-tang on Male Vitality Enhancement: A Literature Review

Yoon TH, Kim GR, et al. Korean Journal of Oriental Medicine (2021)
32 sources Analyzed Literature
85% Positive Results Rate

Summary

A literature review was conducted on the male sexual function and vitality enhancement effects of Bojungikgi-tang. Thirty-two related studies were retrieved and analyzed from domestic and international databases.

Key Conclusion

Bojungikgi-tang contributes to sexual function improvement in qi-deficient men through various mechanisms, and additional large-scale clinical studies are needed.

Before-After Men's Health / Urology

Effect of Deer Antler Combined Formula on Testosterone Level Improvement in Male Climacteric Syndrome

Choi WK, Seo BN, Lee HJ, et al.

Journal of Ethnopharmacology (2023)

100 subjects Participants
23.4% Testosterone Increase Rate
p<0.001 Statistical Significance

Deer antler combined formula can contribute to improving hormone levels and quality of life in male climacteric syndrome patients.

Before-After Men's Health / Urology

Effect of Deer Antler Combined Formula on Testosterone Level Improvement in Male Climacteric Syndrome

Choi WK, Seo BN, Lee HJ, et al. Journal of Ethnopharmacology (2023)
100 subjects Participants
23.4% Testosterone Increase Rate
p<0.001 Statistical Significance

Summary

A pre-post comparison study in which a deer antler combined formula was administered for 24 weeks to 100 men aged 40-65 diagnosed with male climacteric syndrome. Blood total testosterone and free testosterone levels increased significantly.

Key Conclusion

Deer antler combined formula can contribute to improving hormone levels and quality of life in male climacteric syndrome patients.

RCT Men's Health / Urology

Effect of Acupuncture Treatment on Chronic Prostatitis/Pelvic Pain Syndrome

Lee SWH, Liong ML, Yuen KH, et al.

Urology (2023)

52% Symptom Index Reduction
24 weeks Effect Duration
74 subjects Study Participants

Acupuncture treatment significantly improves pain and urinary symptoms of chronic prostatitis/pelvic pain syndrome, with confirmed long-term efficacy.

RCT Men's Health / Urology

Effect of Acupuncture Treatment on Chronic Prostatitis/Pelvic Pain Syndrome

Lee SWH, Liong ML, Yuen KH, et al. Urology (2023)
52% Symptom Index Reduction
24 weeks Effect Duration
74 subjects Study Participants

Summary

A randomized controlled trial comparing 10 weeks of acupuncture treatment with sham acupuncture in 74 patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). The acupuncture treatment group showed a 52% reduction in NIH-CPSI (Chronic Prostatitis Symptom Index), demonstrating significant differences from the sham acupuncture group (23%). Effects were maintained at 24-week follow-up.

Key Conclusion

Acupuncture treatment significantly improves pain and urinary symptoms of chronic prostatitis/pelvic pain syndrome, with confirmed long-term efficacy.

Systematic Review Men's Health / Urology

Systematic Review of Herbal Medicine Treatment for Male Infertility

Xu C, Peng Y, Zhao X, et al.

Andrologia (2022)

33% Sperm Concentration Increase
29% Motility Improvement
22% Natural Pregnancy Rate

Herbal medicine treatment significantly improves quantitative and qualitative sperm indicators and is recommended as an adjunctive treatment for male infertility.

Systematic Review Men's Health / Urology

Systematic Review of Herbal Medicine Treatment for Male Infertility

Xu C, Peng Y, Zhao X, et al. Andrologia (2022)
33% Sperm Concentration Increase
29% Motility Improvement
22% Natural Pregnancy Rate

Summary

A systematic review of 17 randomized controlled trials (total 1,386 subjects) evaluating the effect of herbal medicine treatment on male infertility. The herbal medicine administration group showed an average 33% increase in sperm concentration and 29% improvement in sperm motility. The natural pregnancy rate of partners was significantly higher in the herbal medicine group at 22% compared with the control group at 12%.

Key Conclusion

Herbal medicine treatment significantly improves quantitative and qualitative sperm indicators and is recommended as an adjunctive treatment for male infertility.

RCT Men's Health / Urology

Effect of Herbal Medicine Treatment for Benign Prostatic Hyperplasia: A Randomized Controlled Trial

Kim TH, Lee MS, Kim KH, et al.

Prostate (2023)

46% IPSS Reduction
92 subjects Study Participants
12 weeks Treatment Period

Herbal medicine treatment shows symptom improvement effects equivalent to alpha-blockers for benign prostatic hyperplasia and is suitable for long-term treatment due to fewer side effects.

RCT Men's Health / Urology

Effect of Herbal Medicine Treatment for Benign Prostatic Hyperplasia: A Randomized Controlled Trial

Kim TH, Lee MS, Kim KH, et al. Prostate (2023)
46% IPSS Reduction
92 subjects Study Participants
12 weeks Treatment Period

Summary

A randomized controlled trial comparing 12 weeks of herbal medicine administration with tamsulosin alone in 92 patients with benign prostatic hyperplasia. The herbal medicine group showed a 46% reduction in IPSS (International Prostate Symptom Score), demonstrating efficacy equivalent to the tamsulosin group (42%). Significant results were also observed in residual urine reduction and maximum flow rate improvement.

Key Conclusion

Herbal medicine treatment shows symptom improvement effects equivalent to alpha-blockers for benign prostatic hyperplasia and is suitable for long-term treatment due to fewer side effects.

Systematic Review Men's Health / Urology

Systematic Review of Herbal Medicine Treatment for Androgenetic Alopecia (AGA): Analysis of 32 RCTs

Zhang Y, Liu W, Chen X, et al.

Journal of Ethnopharmacology (2023)

Herbal medicine treatment is effective for increasing hair density and suppressing hair loss progression in androgenetic alopecia, and unlike finasteride, no sexual function-related side effects were reported.

Systematic Review Men's Health / Urology

Systematic Review of Herbal Medicine Treatment for Androgenetic Alopecia (AGA): Analysis of 32 RCTs

Zhang Y, Liu W, Chen X, et al. Journal of Ethnopharmacology (2023)

Summary

Analysis of 32 randomized controlled trials (total 2,876 subjects) showed that combined herbal prescriptions significantly increased hair density in androgenetic alopecia patients, with treatment response rates showing significant differences between the herbal medicine group at 76.3% and the control group at 48.1%.

Key Conclusion

Herbal medicine treatment is effective for increasing hair density and suppressing hair loss progression in androgenetic alopecia, and unlike finasteride, no sexual function-related side effects were reported.

Meta-Analysis Men's Health / Urology

Effect of Combined Herbal Prescriptions on Erectile Dysfunction Improvement: A Systematic Review and Meta-Analysis

Cui T, Lin Y, Gao J, et al.

The Journal of Sexual Medicine (2016)

Herbal medicine treatment has significant effects on improving erectile dysfunction and can be safely used without sexual function-related side effects.

Meta-Analysis Men's Health / Urology

Effect of Combined Herbal Prescriptions on Erectile Dysfunction Improvement: A Systematic Review and Meta-Analysis

Cui T, Lin Y, Gao J, et al. The Journal of Sexual Medicine (2016)

Summary

A meta-analysis analyzing the effect of herbal medicine treatment in patients with erectile dysfunction. The herbal medicine administration group showed significant improvement in IIEF-5 scores, and additional improvement effects were confirmed when combined with PDE5 inhibitors alone.

Key Conclusion

Herbal medicine treatment has significant effects on improving erectile dysfunction and can be safely used without sexual function-related side effects.

Systematic Review Men's Health / Urology

Systematic Review and Meta-Analysis of Herbal Medicine Treatment for Male Climacteric Syndrome (LOH)

Pan C, Zhang L, Zhu Q, et al.

The Aging Male (2020)

Herbal medicine treatment is effective for improving male climacteric symptoms and can be a safe alternative with fewer side effects compared with hormone replacement therapy.

Systematic Review Men's Health / Urology

Systematic Review and Meta-Analysis of Herbal Medicine Treatment for Male Climacteric Syndrome (LOH)

Pan C, Zhang L, Zhu Q, et al. The Aging Male (2020)

Summary

A systematic review analyzing the effect of herbal medicine treatment in patients with male climacteric syndrome (Late-Onset Hypogonadism). The herbal medicine administration group showed significant improvement in Aging Males Symptoms (AMS) scores, and improvement in testosterone levels was also confirmed.

Key Conclusion

Herbal medicine treatment is effective for improving male climacteric symptoms and can be a safe alternative with fewer side effects compared with hormone replacement therapy.