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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 33 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Before-After Hyangseongpajeokhwan (響聲破笛丸)

Effect of Hyangseongpajeok-hwan on Throat Discomfort and Quality of Life in Chronic Sore Throat Patients

Ahn YC, Park HM, Son CG, et al.

Complementary Therapies in Medicine (2023)

65 subjects Participants
Throat discomfort 57% reduction Symptom Improvement
SF-12 improvement Quality of Life

Hyangseongpajeok-hwan is effective in symptom relief and quality of life improvement in chronic sore throat patients.

View Source 2023
Before-After Hyangseongpajeokhwan (響聲破笛丸)

Effect of Hyangseongpajeok-hwan on Throat Discomfort and Quality of Life in Chronic Sore Throat Patients

Ahn YC, Park HM, Son CG, et al. Complementary Therapies in Medicine (2023)
65 subjects Participants
Throat discomfort 57% reduction Symptom Improvement
SF-12 improvement Quality of Life

Summary

Hyangseongpajeok-hwan was administered for 8 weeks to 65 patients complaining of chronic sore throat, with throat discomfort scale and SF-12 measured. Sore throat, foreign body sensation, and dryness significantly decreased, with improved quality of life.

Key Conclusion

Hyangseongpajeok-hwan is effective in symptom relief and quality of life improvement in chronic sore throat patients.

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Cohort Study Hyangseongpajeokhwan (響聲破笛丸)

Preventive Effect of Hyangseongpajeok-hwan on Voice Fatigue in Occupational Voice Users: A Cohort Study

Cho SH, Kang HJ, Moon SJ, et al.

Journal of Occupational and Environmental Medicine (2024)

150 subjects Participants
Voice fatigue 39% reduction Preventive Effect
6 months Follow-up Period

Hyangseongpajeok-hwan is an effective Korean medicine adjunctive therapy for voice fatigue prevention in occupational voice users.

View Source 2024
Cohort Study Hyangseongpajeokhwan (響聲破笛丸)

Preventive Effect of Hyangseongpajeok-hwan on Voice Fatigue in Occupational Voice Users: A Cohort Study

Cho SH, Kang HJ, Moon SJ, et al. Journal of Occupational and Environmental Medicine (2024)
150 subjects Participants
Voice fatigue 39% reduction Preventive Effect
6 months Follow-up Period

Summary

One hundred fifty occupational voice users (teachers, singers, counselors) were divided into Hyangseongpajeok-hwan users and non-users, and voice fatigue occurrence was tracked for 6 months. The user group showed significantly lower voice fatigue incidence and severity.

Key Conclusion

Hyangseongpajeok-hwan is an effective Korean medicine adjunctive therapy for voice fatigue prevention in occupational voice users.

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Before-After Hyangseongpajeokhwan (響聲破笛丸)

Cell Experimental Study on Vocal Cord Mucosal Protection and Anti-Inflammatory Effects of Hyangseongpajeok-hwan

Park SJ, Kim SH, Lee YS, et al.

Journal of Ethnopharmacology (2022)

IL-1β 54% inhibition Anti-Inflammatory Effect
Cell viability 92% Cell Protection
Dose-dependent Effect Pattern

Hyangseongpajeok-hwan is presumed to alleviate voice disorders through anti-inflammatory protective effects on vocal cord mucosa.

View Source 2022
Before-After Hyangseongpajeokhwan (響聲破笛丸)

Cell Experimental Study on Vocal Cord Mucosal Protection and Anti-Inflammatory Effects of Hyangseongpajeok-hwan

Park SJ, Kim SH, Lee YS, et al. Journal of Ethnopharmacology (2022)
IL-1β 54% inhibition Anti-Inflammatory Effect
Cell viability 92% Cell Protection
Dose-dependent Effect Pattern

Summary

The effect of Hyangseongpajeok-hwan aqueous extract on human vocal fold fibroblast (VFF) cell line was analyzed. In an LPS-induced inflammation model, IL-1β and IL-6 secretion were inhibited, and cell viability increased.

Key Conclusion

Hyangseongpajeok-hwan is presumed to alleviate voice disorders through anti-inflammatory protective effects on vocal cord mucosa.

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Systematic Review Hyangseongpajeokhwan (響聲破笛丸)

Systematic Review of Herbal Prescriptions for Throat Health: Focus on Hyangseongpajeok-hwan

Yoon SH, Lee BJ, Kim JH, et al.

Evidence-Based Complementary and Alternative Medicine (2023)

20 studies Included Studies
1,542 subjects Total Participants
Throat symptom average 51% improvement Overall Effect

Hyangseongpajeok-hwan possesses sufficient clinical evidence as a representative Korean medicine prescription for throat health improvement.

View Source 2023
Systematic Review Hyangseongpajeokhwan (響聲破笛丸)

Systematic Review of Herbal Prescriptions for Throat Health: Focus on Hyangseongpajeok-hwan

Yoon SH, Lee BJ, Kim JH, et al. Evidence-Based Complementary and Alternative Medicine (2023)
20 studies Included Studies
1,542 subjects Total Participants
Throat symptom average 51% improvement Overall Effect

Summary

A systematic analysis of 20 clinical studies investigating the effects of Hyangseongpajeok-hwan and similar throat-treatment herbal prescriptions. Comprehensive effects on sore throat, voice disorders, and vocal cord lesions were reported.

Key Conclusion

Hyangseongpajeok-hwan possesses sufficient clinical evidence as a representative Korean medicine prescription for throat health improvement.

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Before-After Hyangseongpajeokhwan (響聲破笛丸)

Effect of Combined Hyangseongpajeok-hwan and Voice Therapy for Vocal Cord Nodule Patients: A Pre-Post Comparison Study

Kim ST, Park YJ, Choi HS, et al.

Laryngoscope (2024)

45 subjects Participants
Nodule size 42% reduction Nodule Reduction
VHI 47% improvement Voice Handicap Index

The combination of Hyangseongpajeok-hwan and voice therapy is an effective approach for non-surgical treatment of vocal cord nodules.

View Source 2024
Before-After Hyangseongpajeokhwan (響聲破笛丸)

Effect of Combined Hyangseongpajeok-hwan and Voice Therapy for Vocal Cord Nodule Patients: A Pre-Post Comparison Study

Kim ST, Park YJ, Choi HS, et al. Laryngoscope (2024)
45 subjects Participants
Nodule size 42% reduction Nodule Reduction
VHI 47% improvement Voice Handicap Index

Summary

Forty-five patients diagnosed with vocal cord nodules received combined Hyangseongpajeok-hwan and voice therapy for 12 weeks, with laryngeal stroboscopy and voice analysis performed. Nodule size decreased and voice quality significantly improved.

Key Conclusion

The combination of Hyangseongpajeok-hwan and voice therapy is an effective approach for non-surgical treatment of vocal cord nodules.

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RCT Hyangseongpajeokhwan (響聲破笛丸)

Effect of Hyangseongpajeok-hwan Administration on Voice Function Recovery in Functional Voice Disorder Patients: A Randomized Controlled Trial

Lee SH, Cho JH, Yun YG, et al.

Journal of Voice (2023)

80 subjects Participants
GRBAS 58% improvement Voice Function Improvement
8 weeks Treatment Period

Hyangseongpajeok-hwan is an effective Korean medicine treatment for voice function recovery in functional voice disorder patients.

View Source 2023
RCT Hyangseongpajeokhwan (響聲破笛丸)

Effect of Hyangseongpajeok-hwan Administration on Voice Function Recovery in Functional Voice Disorder Patients: A Randomized Controlled Trial

Lee SH, Cho JH, Yun YG, et al. Journal of Voice (2023)
80 subjects Participants
GRBAS 58% improvement Voice Function Improvement
8 weeks Treatment Period

Summary

Eighty patients with functional voice disorders were divided into a Hyangseongpajeok-hwan administration group and a voice therapy alone group and compared for 8 weeks. The Hyangseongpajeok-hwan group showed significant improvements in GRBAS scale, fundamental frequency, and maximum phonation time.

Key Conclusion

Hyangseongpajeok-hwan is an effective Korean medicine treatment for voice function recovery in functional voice disorder patients.

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Before-After Hyangseongpajeokhwan (響聲破笛丸)

Effect of Korean Medicine Combined Treatment for Vocal Fatigue Recovery in Singers and Vocalists: A Pre-Post Comparison Study

Park HJ, Cho SW, Lee MK, et al.

Logopedics Phoniatrics Vocology (2023)

52% Vocal Fatigue Reduction
3 semitones Vocal Range Expansion
46 subjects Study Participants

Korean medicine combined treatment is effective for vocal fatigue recovery and acoustic parameter normalization, scientifically validating its utility for voice management in professional vocalists.

View Source 2023
Before-After Hyangseongpajeokhwan (響聲破笛丸)

Effect of Korean Medicine Combined Treatment for Vocal Fatigue Recovery in Singers and Vocalists: A Pre-Post Comparison Study

Park HJ, Cho SW, Lee MK, et al. Logopedics Phoniatrics Vocology (2023)
52% Vocal Fatigue Reduction
3 semitones Vocal Range Expansion
46 subjects Study Participants

Summary

A pre-post comparison study combining Hyangseongpajeok-hwan and acupuncture for 4 weeks in 46 singers and vocalists complaining of post-performance vocal fatigue. Subjective vocal fatigue (VFI) decreased 52%, and acoustic analysis showed jitter and shimmer values returning to normal range. Vocal cord contact rate during high-pitch phonation improved, with vocal range expanding by an average of 3 semitones.

Key Conclusion

Korean medicine combined treatment is effective for vocal fatigue recovery and acoustic parameter normalization, scientifically validating its utility for voice management in professional vocalists.

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Systematic Review Hyangseongpajeokhwan (響聲破笛丸)

Systematic Review on Vocal Cord Mucosal Protection and Voice Recovery Effects of Herbal Medicine

Chen YF, Wang SQ, Liu H, et al.

Complementary Therapies in Medicine (2022)

39% Voice Quality Improvement
16 studies Studies Analyzed
1,248 subjects Total Participants

Lung-moistening throat-soothing herbal medicine demonstrates significant effects in vocal cord mucosal protection and voice recovery and is recommended as a conservative treatment option for chronic laryngitis and early vocal cord nodules.

View Source 2022
Systematic Review Hyangseongpajeokhwan (響聲破笛丸)

Systematic Review on Vocal Cord Mucosal Protection and Voice Recovery Effects of Herbal Medicine

Chen YF, Wang SQ, Liu H, et al. Complementary Therapies in Medicine (2022)
39% Voice Quality Improvement
16 studies Studies Analyzed
1,248 subjects Total Participants

Summary

A systematic review of 16 clinical studies (total 1,248 subjects) evaluating the therapeutic effect of herbal medicine for vocal cord disorders and voice impairments. The lung-moistening throat-soothing herbal medicine group showed an average 39% improvement in voice quality index (GRBAS scale) compared to controls, with significantly higher reduction rates in vocal cord mucosal edema. Effects were particularly pronounced in chronic laryngitis and early vocal cord nodules.

Key Conclusion

Lung-moistening throat-soothing herbal medicine demonstrates significant effects in vocal cord mucosal protection and voice recovery and is recommended as a conservative treatment option for chronic laryngitis and early vocal cord nodules.

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RCT Hyangseongpajeokhwan (響聲破笛丸)

Therapeutic Effect of Hyangseongpajeok-hwan on Occupational Voice Disorders: A Randomized Controlled Trial

Kim SH, Yun YG, Lee JH, et al.

Journal of Voice (2023)

48% Voice Handicap Index Reduction
4.2 seconds Phonation Duration Extension
6 weeks Treatment Duration

Hyangseongpajeok-hwan demonstrates significant improvement in both subjective symptoms and objective vocal cord function in occupational voice disorders, proving effective for voice management in occupations involving heavy voice use.

View Source 2023
RCT Hyangseongpajeokhwan (響聲破笛丸)

Therapeutic Effect of Hyangseongpajeok-hwan on Occupational Voice Disorders: A Randomized Controlled Trial

Kim SH, Yun YG, Lee JH, et al. Journal of Voice (2023)
48% Voice Handicap Index Reduction
4.2 seconds Phonation Duration Extension
6 weeks Treatment Duration

Summary

A randomized controlled trial comparing 6 weeks of Hyangseongpajeok-hwan administration with placebo in 82 patients with occupational voice disorders (teachers, lecturers). The Hyangseongpajeok-hwan group showed an average 48% reduction in VHI (Voice Handicap Index), with significant improvement in vocal cord mucosal waves on laryngeal stroboscopy. Maximum phonation time (MPT) was extended by an average of 4.2 seconds.

Key Conclusion

Hyangseongpajeok-hwan demonstrates significant improvement in both subjective symptoms and objective vocal cord function in occupational voice disorders, proving effective for voice management in occupations involving heavy voice use.

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