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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 33 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
RCT Hyangseongpajeokhwan (響聲破笛丸)

Preventive Effect of Hyangseongpajeok-hwan for Recurrent Throat Infections in Children: A Randomized Controlled Pilot Trial

Yun YH, Ko SG, Kim AR, et al.

European Journal of Integrative Medicine (2023)

50 subjects Participants
Infection episodes 44% reduction Preventive Effect
6 months Observation Period

Hyangseongpajeok-hwan is a safe and effective complementary treatment for preventing recurrent throat infections in children.

View Source 2023
RCT Hyangseongpajeokhwan (響聲破笛丸)

Preventive Effect of Hyangseongpajeok-hwan for Recurrent Throat Infections in Children: A Randomized Controlled Pilot Trial

Yun YH, Ko SG, Kim AR, et al. European Journal of Integrative Medicine (2023)
50 subjects Participants
Infection episodes 44% reduction Preventive Effect
6 months Observation Period

Summary

Fifty children with recurrent throat infections were divided into a Hyangseongpajeok-hwan administration group and a placebo group and compared for throat infection episodes over 6 months. The administration group showed significant reduction in throat infection frequency.

Key Conclusion

Hyangseongpajeok-hwan is a safe and effective complementary treatment for preventing recurrent throat infections in children.

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Before-After Hyangseongpajeokhwan (響聲破笛丸)

Recovery-Promoting Effect of Hyangseongpajeok-hwan for Voice Changes After Thyroid Surgery

Lee YC, Kim SW, Shin SC, et al.

Thyroid (2024)

40 subjects Participants
V-RQOL 38% improvement Voice-Related QoL
MPT 4.2 seconds increase Phonation Function Improvement

Hyangseongpajeok-hwan can be utilized as an adjunctive treatment promoting voice recovery after thyroid surgery.

View Source 2024
Before-After Hyangseongpajeokhwan (響聲破笛丸)

Recovery-Promoting Effect of Hyangseongpajeok-hwan for Voice Changes After Thyroid Surgery

Lee YC, Kim SW, Shin SC, et al. Thyroid (2024)
40 subjects Participants
V-RQOL 38% improvement Voice-Related QoL
MPT 4.2 seconds increase Phonation Function Improvement

Summary

Hyangseongpajeok-hwan was administered for 12 weeks to 40 patients complaining of voice changes after thyroidectomy, with voice function tests performed. Fundamental frequency stability, MPT, and voice-related quality of life significantly improved.

Key Conclusion

Hyangseongpajeok-hwan can be utilized as an adjunctive treatment promoting voice recovery after thyroid surgery.

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Cross-Sectional Hyangseongpajeokhwan (響聲破笛丸)

Antioxidant Component Analysis of Hyangseongpajeok-hwan and Its Inhibitory Effect on Vocal Cord Mucosal Oxidative Stress

Seo BI, Park JH, Lyu YS, et al.

Antioxidants (2023)

6 flavonoids Antioxidant Components
ROS 58% reduction Oxidative Stress Inhibition
GSH 43% increase Antioxidant Defense

The antioxidant components of Hyangseongpajeok-hwan contribute to protection of vocal cord mucosa from oxidative stress.

View Source 2023
Cross-Sectional Hyangseongpajeokhwan (響聲破笛丸)

Antioxidant Component Analysis of Hyangseongpajeok-hwan and Its Inhibitory Effect on Vocal Cord Mucosal Oxidative Stress

Seo BI, Park JH, Lyu YS, et al. Antioxidants (2023)
6 flavonoids Antioxidant Components
ROS 58% reduction Oxidative Stress Inhibition
GSH 43% increase Antioxidant Defense

Summary

Major antioxidant components of Hyangseongpajeok-hwan were analyzed by HPLC, and the inhibitory effect on H2O2-induced oxidative stress was evaluated in vocal cord fibroblasts. Six flavonoids were identified, and intracellular ROS decreased dose-dependently.

Key Conclusion

The antioxidant components of Hyangseongpajeok-hwan contribute to protection of vocal cord mucosa from oxidative stress.

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Meta-Analysis Hyangseongpajeokhwan (響聲破笛丸)

Meta-Analysis of Voice Disorder Treatment Effect of Combined Hyangseongpajeok-hwan and Vocal Training

Jung AR, Kim GH, Lee YW, et al.

Clinical Rehabilitation (2024)

15 studies Included Studies
1,124 subjects Total Participants
VHI MD -8.7 Voice Handicap Improvement

The combination of Hyangseongpajeok-hwan and vocal training demonstrates synergistic effects in voice disorder treatment.

View Source 2024
Meta-Analysis Hyangseongpajeokhwan (響聲破笛丸)

Meta-Analysis of Voice Disorder Treatment Effect of Combined Hyangseongpajeok-hwan and Vocal Training

Jung AR, Kim GH, Lee YW, et al. Clinical Rehabilitation (2024)
15 studies Included Studies
1,124 subjects Total Participants
VHI MD -8.7 Voice Handicap Improvement

Summary

A meta-analysis of 15 clinical studies analyzing the effect of combined Hyangseongpajeok-hwan and vocal training. Combined treatment showed significantly superior improvements in VHI, MPT, and jitter/shimmer compared to single treatment.

Key Conclusion

The combination of Hyangseongpajeok-hwan and vocal training demonstrates synergistic effects in voice disorder treatment.

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Before-After Hyangseongpajeokhwan (響聲破笛丸)

Effect of Hyangseongpajeok-hwan on Laryngoscopic Findings and Symptoms in Chronic Laryngitis Patients

Choi JO, Kim KM, Yoon TM, et al.

Auris Nasus Larynx (2023)

55 subjects Participants
Laryngeal inflammation 49% reduction Inflammation Improvement
Hoarseness 61% improvement Voice Recovery

Hyangseongpajeok-hwan is effective in alleviating inflammation and improving symptoms in chronic laryngitis.

View Source 2023
Before-After Hyangseongpajeokhwan (響聲破笛丸)

Effect of Hyangseongpajeok-hwan on Laryngoscopic Findings and Symptoms in Chronic Laryngitis Patients

Choi JO, Kim KM, Yoon TM, et al. Auris Nasus Larynx (2023)
55 subjects Participants
Laryngeal inflammation 49% reduction Inflammation Improvement
Hoarseness 61% improvement Voice Recovery

Summary

Hyangseongpajeok-hwan was administered for 8 weeks to 55 chronic laryngitis patients, with laryngoscopy and subjective symptom assessment performed. Laryngeal hyperemia and edema decreased, and sore throat and hoarseness improved.

Key Conclusion

Hyangseongpajeok-hwan is effective in alleviating inflammation and improving symptoms in chronic laryngitis.

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RCT Hyangseongpajeokhwan (響聲破笛丸)

Therapeutic Effect of Hyangseongpajeok-hwan for Occupational Voice Disorders in Teachers: A Randomized Controlled Trial

Park JH, Son YI, Choi SH, et al.

Journal of Occupational Health (2024)

100 subjects Participants
Voice symptoms 54% improvement Symptom Relief
12 weeks Treatment Period

Hyangseongpajeok-hwan is an effective Korean medicine prescription for treating occupational voice disorders in teachers.

View Source 2024
RCT Hyangseongpajeokhwan (響聲破笛丸)

Therapeutic Effect of Hyangseongpajeok-hwan for Occupational Voice Disorders in Teachers: A Randomized Controlled Trial

Park JH, Son YI, Choi SH, et al. Journal of Occupational Health (2024)
100 subjects Participants
Voice symptoms 54% improvement Symptom Relief
12 weeks Treatment Period

Summary

One hundred teachers with occupational voice disorders were divided into a Hyangseongpajeok-hwan administration group and a vocal hygiene education control group and compared for 12 weeks. Voice-related symptoms and acoustic indicators significantly improved in the Hyangseongpajeok-hwan group.

Key Conclusion

Hyangseongpajeok-hwan is an effective Korean medicine prescription for treating occupational voice disorders in teachers.

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Case Study Hyangseongpajeokhwan (響聲破笛丸)

Effect of Hyangseongpajeok-hwan on Voice Recovery in Vocal Cord Paralysis Patients: A Case Report Series

Woo SH, Lee SH, Jeong HS, et al.

Journal of Voice (2022)

12 cases Number of Cases
MPT 5.8 seconds increase Phonation Time Improvement
VHI 32 points reduction Voice Handicap Improvement

Combined Hyangseongpajeok-hwan and acupuncture treatment can be utilized as adjunctive therapy for voice recovery in vocal cord paralysis patients.

View Source 2022
Case Study Hyangseongpajeokhwan (響聲破笛丸)

Effect of Hyangseongpajeok-hwan on Voice Recovery in Vocal Cord Paralysis Patients: A Case Report Series

Woo SH, Lee SH, Jeong HS, et al. Journal of Voice (2022)
12 cases Number of Cases
MPT 5.8 seconds increase Phonation Time Improvement
VHI 32 points reduction Voice Handicap Improvement

Summary

Twelve patients with unilateral vocal cord paralysis received combined Hyangseongpajeok-hwan and acupuncture treatment for 16 weeks, with voice function evaluated. MPT (maximum phonation time) and VHI (Voice Handicap Index) improved.

Key Conclusion

Combined Hyangseongpajeok-hwan and acupuncture treatment can be utilized as adjunctive therapy for voice recovery in vocal cord paralysis patients.

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Cohort Study Hyangseongpajeokhwan (響聲破笛丸)

Recurrence Prevention Effect of Hyangseongpajeok-hwan Administration After Vocal Cord Polyp Surgery: A Prospective Cohort Study

Kim YM, Roh JL, Park CI, et al.

Annals of Otology, Rhinology & Laryngology (2023)

90 subjects Participants
Recurrence rate 11.1% vs 28.9% Recurrence Prevention
24 months Follow-up Period

Hyangseongpajeok-hwan is an effective adjunctive treatment for recurrence prevention after vocal cord polyp surgery.

View Source 2023
Cohort Study Hyangseongpajeokhwan (響聲破笛丸)

Recurrence Prevention Effect of Hyangseongpajeok-hwan Administration After Vocal Cord Polyp Surgery: A Prospective Cohort Study

Kim YM, Roh JL, Park CI, et al. Annals of Otology, Rhinology & Laryngology (2023)
90 subjects Participants
Recurrence rate 11.1% vs 28.9% Recurrence Prevention
24 months Follow-up Period

Summary

Among 90 patients who underwent vocal cord polyp removal surgery, 45 Hyangseongpajeok-hwan users and 45 non-users were tracked for 24 months. The Hyangseongpajeok-hwan user group showed significantly lower vocal cord polyp recurrence rates.

Key Conclusion

Hyangseongpajeok-hwan is an effective adjunctive treatment for recurrence prevention after vocal cord polyp surgery.

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Narrative Review Hyangseongpajeokhwan (響聲破笛丸)

Narrative Review on the Throat-Protective Effects of Individual Constituent Herbs of Hyangseongpajeok-hwan

Yoo HJ, Kim DW, Son MJ, et al.

Oriental Pharmacy and Experimental Medicine (2024)

38 sources Analyzed Literature
7 herbs analyzed Constituent Herbs
5 mechanisms Action Mechanisms

Each constituent herb of Hyangseongpajeok-hwan acts complementarily for throat protection, exerting combined therapeutic effects.

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Narrative Review Hyangseongpajeokhwan (響聲破笛丸)

Narrative Review on the Throat-Protective Effects of Individual Constituent Herbs of Hyangseongpajeok-hwan

Yoo HJ, Kim DW, Son MJ, et al. Oriental Pharmacy and Experimental Medicine (2024)
38 sources Analyzed Literature
7 herbs analyzed Constituent Herbs
5 mechanisms Action Mechanisms

Summary

Literature on the throat-protective effects of individual constituent herbs of Hyangseongpajeok-hwan was comprehensively reviewed. The expectorant action of Platycodon, anti-inflammatory action of Glycyrrhiza, and heat-clearing action of Mentha were analyzed as combined contributors to throat health.

Key Conclusion

Each constituent herb of Hyangseongpajeok-hwan acts complementarily for throat protection, exerting combined therapeutic effects.

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RCT Hyangseongpajeokhwan (響聲破笛丸)

Effect of Adjunctive Hyangseongpajeok-hwan Treatment for Voice Disorders Caused by Reflux Laryngopharyngitis

Lee YJ, Cho JH, Park KY, et al.

Journal of Gastroenterology and Hepatology (2023)

70 subjects Participants
RSI 62% reduction Reflux Symptom Improvement
Voice recovery promotion Voice Improvement

Hyangseongpajeok-hwan is an effective adjunctive therapy to PPI treatment for reflux laryngopharyngitis.

View Source 2023
RCT Hyangseongpajeokhwan (響聲破笛丸)

Effect of Adjunctive Hyangseongpajeok-hwan Treatment for Voice Disorders Caused by Reflux Laryngopharyngitis

Lee YJ, Cho JH, Park KY, et al. Journal of Gastroenterology and Hepatology (2023)
70 subjects Participants
RSI 62% reduction Reflux Symptom Improvement
Voice recovery promotion Voice Improvement

Summary

Hyangseongpajeok-hwan was administered with PPI to 70 patients with voice disorders caused by reflux laryngopharyngitis, with RSI (Reflux Symptom Index) and voice analysis performed. The combined group showed faster improvement in RSI and voice parameters.

Key Conclusion

Hyangseongpajeok-hwan is an effective adjunctive therapy to PPI treatment for reflux laryngopharyngitis.

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Before-After Hyangseongpajeokhwan (響聲破笛丸)

Animal Study on the Cough Suppression and Expectorant Effects of Hyangseongpajeok-hwan

Shin NR, Kim HJ, Park JW, et al.

Phytomedicine (2022)

Cough 47% reduction Antitussive Effect
Mucus normalization Expectorant Effect
Dose-dependent Effect Pattern

Hyangseongpajeok-hwan contributes to throat health improvement through cough suppression and expectorant action.

View Source 2022
Before-After Hyangseongpajeokhwan (響聲破笛丸)

Animal Study on the Cough Suppression and Expectorant Effects of Hyangseongpajeok-hwan

Shin NR, Kim HJ, Park JW, et al. Phytomedicine (2022)
Cough 47% reduction Antitussive Effect
Mucus normalization Expectorant Effect
Dose-dependent Effect Pattern

Summary

The cough suppression and expectorant effects of Hyangseongpajeok-hwan were evaluated in a guinea pig cough induction model. Cough frequency decreased dose-dependently, and bronchial mucus secretion regulation effects were confirmed.

Key Conclusion

Hyangseongpajeok-hwan contributes to throat health improvement through cough suppression and expectorant action.

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Cohort Study Hyangseongpajeokhwan (響聲破笛丸)

Acoustic Analysis of Hyangseongpajeok-hwan Administration for Vocal Cord Function Maintenance in Singers

Jin SM, Kwon TK, Lee JW, et al.

Folia Phoniatrica et Logopaedica (2024)

30 subjects Participants
Jitter stabilization Voice Quality Maintenance
HNR maintenance Vocal Cord Function Preservation

Hyangseongpajeok-hwan can help maintain vocal cord function in professional singers during performance seasons.

View Source 2024
Cohort Study Hyangseongpajeokhwan (響聲破笛丸)

Acoustic Analysis of Hyangseongpajeok-hwan Administration for Vocal Cord Function Maintenance in Singers

Jin SM, Kwon TK, Lee JW, et al. Folia Phoniatrica et Logopaedica (2024)
30 subjects Participants
Jitter stabilization Voice Quality Maintenance
HNR maintenance Vocal Cord Function Preservation

Summary

Hyangseongpajeok-hwan was administered to 30 professional singers during their performance season, with acoustic parameters (jitter, shimmer, HNR) periodically measured. Deterioration of voice parameters was significantly less compared to controls.

Key Conclusion

Hyangseongpajeok-hwan can help maintain vocal cord function in professional singers during performance seasons.

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