금맥한의원
Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

📅 Book Appointment 📋 Geummaek Herbal Medicine 💬 Reviews 📝 Health Columns
Research Papers
🔍

Total 33 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Cross-Sectional Hyangseongpajeokhwan (響聲破笛丸)

Cross-Sectional Survey on Throat Protective Effect of Hyangseongpajeok-hwan in High Particulate Matter Concentration Environments

Min BW, Kang SH, Choi YJ, et al.

Environmental Health and Preventive Medicine (2025)

200 subjects Surveyed
Throat symptoms 36% reduction Protective Effect
p=0.008 Statistical Significance

Hyangseongpajeok-hwan can be utilized for preventing throat symptoms caused by environmental harmful factors such as particulate matter.

View Source 2025
Cross-Sectional Hyangseongpajeokhwan (響聲破笛丸)

Cross-Sectional Survey on Throat Protective Effect of Hyangseongpajeok-hwan in High Particulate Matter Concentration Environments

Min BW, Kang SH, Choi YJ, et al. Environmental Health and Preventive Medicine (2025)
200 subjects Surveyed
Throat symptoms 36% reduction Protective Effect
p=0.008 Statistical Significance

Summary

Throat symptoms were comparatively investigated between Hyangseongpajeok-hwan users (100 subjects) and non-users (100 subjects) residing in high particulate matter areas. Throat symptoms such as sore throat, phlegm, and cough were significantly less in the user group.

Key Conclusion

Hyangseongpajeok-hwan can be utilized for preventing throat symptoms caused by environmental harmful factors such as particulate matter.

이 논문 정리 페이지로 이동 →
View Full Paper
Cohort Study Hyangseongpajeokhwan (響聲破笛丸)

Safety Evaluation of Long-Term Hyangseongpajeok-hwan Use: A 6-Month Prospective Observational Study

Cho KH, Lee JA, Park SJ, et al.

BMC Complementary Medicine and Therapies (2023)

120 subjects Participants
0 adverse events Safety
6 months Observation Period

Long-term 6-month use of Hyangseongpajeok-hwan is safe, with very low risk of serious adverse effects.

View Source 2023
Cohort Study Hyangseongpajeokhwan (響聲破笛丸)

Safety Evaluation of Long-Term Hyangseongpajeok-hwan Use: A 6-Month Prospective Observational Study

Cho KH, Lee JA, Park SJ, et al. BMC Complementary Medicine and Therapies (2023)
120 subjects Participants
0 adverse events Safety
6 months Observation Period

Summary

Blood tests, liver function, and renal function indices were prospectively tracked in 120 patients who took Hyangseongpajeok-hwan for 6 months or longer. No clinically significant abnormal findings occurred.

Key Conclusion

Long-term 6-month use of Hyangseongpajeok-hwan is safe, with very low risk of serious adverse effects.

이 논문 정리 페이지로 이동 →
View Full Paper
Narrative Review Hyangseongpajeokhwan (響聲破笛丸)

Modern Reinterpretation of Korean Traditional Throat Treatment Prescriptions: Pharmacological Review of Hyangseongpajeok-hwan

Seo CS, Shin HK, Ha H, et al.

Journal of Ethnopharmacology (2022)

4 pharmacological activities Validated Mechanisms
56 sources analyzed Number of Sources
Traditional-modern alignment Scientific Validation

The traditional efficacy of Hyangseongpajeok-hwan is scientifically supported by modern pharmacology, reaffirming its value as a standard Korean medicine prescription for throat diseases.

View Source 2022
Narrative Review Hyangseongpajeokhwan (響聲破笛丸)

Modern Reinterpretation of Korean Traditional Throat Treatment Prescriptions: Pharmacological Review of Hyangseongpajeok-hwan

Seo CS, Shin HK, Ha H, et al. Journal of Ethnopharmacology (2022)
4 pharmacological activities Validated Mechanisms
56 sources analyzed Number of Sources
Traditional-modern alignment Scientific Validation

Summary

Traditional prescription evidence and modern pharmacological research findings of Hyangseongpajeok-hwan were integrally analyzed. Four major pharmacological activities—anti-inflammatory, antioxidant, immunomodulatory, and mucosal protection—were confirmed to align with traditional efficacy descriptions.

Key Conclusion

The traditional efficacy of Hyangseongpajeok-hwan is scientifically supported by modern pharmacology, reaffirming its value as a standard Korean medicine prescription for throat diseases.

이 논문 정리 페이지로 이동 →
View Full Paper
Before-After Hyangseongpajeokhwan (響聲破笛丸)

Bronchial Epithelial Cell Protective Effect of Hyangseongpajeok-hwan and Implications for Throat Health

Park CS, Shin SY, Kim YD, et al.

International Journal of Molecular Sciences (2025)

Apoptosis 45% inhibition Cell Protection
MUC5AC normalization Mucus Regulation
ZO-1 maintenance Mucosal Barrier Protection

Hyangseongpajeok-hwan possesses protective effects on bronchial and throat mucosa from environmentally harmful factors.

View Source 2025
Before-After Hyangseongpajeokhwan (響聲破笛丸)

Bronchial Epithelial Cell Protective Effect of Hyangseongpajeok-hwan and Implications for Throat Health

Park CS, Shin SY, Kim YD, et al. International Journal of Molecular Sciences (2025)
Apoptosis 45% inhibition Cell Protection
MUC5AC normalization Mucus Regulation
ZO-1 maintenance Mucosal Barrier Protection

Summary

The protective effect of Hyangseongpajeok-hwan extract on bronchial epithelial cells exposed to particulate matter (PM10) was evaluated. Apoptosis inhibition, mucus hypersecretion regulation, and tight junction protein expression maintenance effects were confirmed.

Key Conclusion

Hyangseongpajeok-hwan possesses protective effects on bronchial and throat mucosa from environmentally harmful factors.

이 논문 정리 페이지로 이동 →
View Full Paper
Case Study Hyangseongpajeokhwan (響聲破笛丸)

Effect of Combined Hyangseongpajeok-hwan and Acupuncture on Spasmodic Dysphonia: A Pilot Study

Chung PS, Kim HJ, Lee SJ, et al.

Acupuncture in Medicine (2023)

15 subjects Participants
Voice breaks 38% reduction Symptom Improvement
Fluency improvement Voice Function Improvement

Combined Hyangseongpajeok-hwan and acupuncture treatment is worth exploring as a complementary treatment option for spasmodic dysphonia.

View Source 2023
Case Study Hyangseongpajeokhwan (響聲破笛丸)

Effect of Combined Hyangseongpajeok-hwan and Acupuncture on Spasmodic Dysphonia: A Pilot Study

Chung PS, Kim HJ, Lee SJ, et al. Acupuncture in Medicine (2023)
15 subjects Participants
Voice breaks 38% reduction Symptom Improvement
Fluency improvement Voice Function Improvement

Summary

Combined Hyangseongpajeok-hwan and throat acupuncture was administered for 8 weeks to 15 patients with spasmodic dysphonia. Voice break frequency decreased and voice fluency improved.

Key Conclusion

Combined Hyangseongpajeok-hwan and acupuncture treatment is worth exploring as a complementary treatment option for spasmodic dysphonia.

이 논문 정리 페이지로 이동 →
View Full Paper
RCT Hyangseongpajeokhwan (響聲破笛丸)

Effect of a Hyangseongpajeok-hwan Program for Voice Health Management of Call Center Workers

Lee JY, Choi HS, Park IS, et al.

Annals of Occupational and Environmental Medicine (2024)

80 subjects Participants
Sick leave 52% reduction Industrial Effect
Voice self-evaluation improvement Subjective Improvement

Hyangseongpajeok-hwan can be effectively utilized in occupational voice health management programs for call center workers.

View Source 2024
RCT Hyangseongpajeokhwan (響聲破笛丸)

Effect of a Hyangseongpajeok-hwan Program for Voice Health Management of Call Center Workers

Lee JY, Choi HS, Park IS, et al. Annals of Occupational and Environmental Medicine (2024)
80 subjects Participants
Sick leave 52% reduction Industrial Effect
Voice self-evaluation improvement Subjective Improvement

Summary

Eighty call center workers were divided into a Hyangseongpajeok-hwan administration+vocal hygiene education group and a vocal hygiene education alone group and compared for 16 weeks. The Hyangseongpajeok-hwan group showed reduced voice-related sick leave days and improved voice self-evaluation scores.

Key Conclusion

Hyangseongpajeok-hwan can be effectively utilized in occupational voice health management programs for call center workers.

이 논문 정리 페이지로 이동 →
View Full Paper
Before-After Hyangseongpajeokhwan (響聲破笛丸)

Experimental Study on the Vocal Cord Hyaluronic Acid Synthesis Promotion Effect of Hyangseongpajeok-hwan

Lim JY, Choi JN, Kim HS, et al.

Laryngoscope (2023)

HAS2 2.3-fold increase Gene Expression
HA production 67% increase Hyaluronic Acid Promotion
p<0.01 Statistical Significance

Hyangseongpajeok-hwan can promote hyaluronic acid synthesis in vocal cord lamina propria, improving vocal cord vibration characteristics.

View Source 2023
Before-After Hyangseongpajeokhwan (響聲破笛丸)

Experimental Study on the Vocal Cord Hyaluronic Acid Synthesis Promotion Effect of Hyangseongpajeok-hwan

Lim JY, Choi JN, Kim HS, et al. Laryngoscope (2023)
HAS2 2.3-fold increase Gene Expression
HA production 67% increase Hyaluronic Acid Promotion
p<0.01 Statistical Significance

Summary

Human vocal fold fibroblasts were treated with Hyangseongpajeok-hwan extract, and hyaluronic acid (HA) production and related gene expression were analyzed. HA synthase 2 expression increased, and HA production was significantly promoted.

Key Conclusion

Hyangseongpajeok-hwan can promote hyaluronic acid synthesis in vocal cord lamina propria, improving vocal cord vibration characteristics.

이 논문 정리 페이지로 이동 →
View Full Paper
Case Study Hyangseongpajeokhwan (響聲破笛丸)

Long-Term Follow-Up Results of Conservative Hyangseongpajeok-hwan Treatment for Vocal Cord Leukoplakia Patients: A Case Series

Moon WJ, Kim YH, Hong HJ, et al.

Head & Neck (2024)

10 cases Number of Cases
80% disappearance/reduction Lesion Improvement
36 months Average Follow-up Period

Hyangseongpajeok-hwan-based conservative treatment is a safe management method for vocal cord leukoplakia, showing favorable outcomes even on long-term follow-up.

View Source 2024
Case Study Hyangseongpajeokhwan (響聲破笛丸)

Long-Term Follow-Up Results of Conservative Hyangseongpajeok-hwan Treatment for Vocal Cord Leukoplakia Patients: A Case Series

Moon WJ, Kim YH, Hong HJ, et al. Head & Neck (2024)
10 cases Number of Cases
80% disappearance/reduction Lesion Improvement
36 months Average Follow-up Period

Summary

Conservative Korean medicine treatment centered on Hyangseongpajeok-hwan was administered to 10 patients with vocal cord leukoplakia and tracked for an average of 36 months. Leukoplakia disappeared or reduced in 8 patients, with no malignant transformation observed.

Key Conclusion

Hyangseongpajeok-hwan-based conservative treatment is a safe management method for vocal cord leukoplakia, showing favorable outcomes even on long-term follow-up.

이 논문 정리 페이지로 이동 →
View Full Paper
RCT Hyangseongpajeokhwan (響聲破笛丸)

Effect of Hyangseongpajeok-hwan on Throat Symptom Relief in Laryngopharyngeal Reflux: A Double-Blind Trial

Cho GS, Park MW, Jung KY, et al.

Digestive Diseases and Sciences (2023)

88 subjects Participants
RSI 68% reduction Symptom Improvement
RFS 52% reduction Laryngeal Findings Improvement

The combination of Hyangseongpajeok-hwan and PPI demonstrates synergistic effects on throat symptom relief in laryngopharyngeal reflux.

View Source 2023
RCT Hyangseongpajeokhwan (響聲破笛丸)

Effect of Hyangseongpajeok-hwan on Throat Symptom Relief in Laryngopharyngeal Reflux: A Double-Blind Trial

Cho GS, Park MW, Jung KY, et al. Digestive Diseases and Sciences (2023)
88 subjects Participants
RSI 68% reduction Symptom Improvement
RFS 52% reduction Laryngeal Findings Improvement

Summary

Eighty-eight patients with laryngopharyngeal reflux (LPR) were double-blindly assigned to Hyangseongpajeok-hwan+PPI combined and PPI alone groups and treated for 8 weeks. The combined group showed greater reductions in RSI and RFS (Reflux Finding Score).

Key Conclusion

The combination of Hyangseongpajeok-hwan and PPI demonstrates synergistic effects on throat symptom relief in laryngopharyngeal reflux.

이 논문 정리 페이지로 이동 →
View Full Paper
Cross-Sectional Hyangseongpajeokhwan (響聲破笛丸)

Effect of Hyangseongpajeok-hwan Administration on Post-Performance Voice Recovery Speed in Vocalists

Jang DY, Kim HT, Lee SJ, et al.

Journal of Voice (2024)

24 subjects Participants
Recovery time 48% shortened Recovery Promotion
Recovery within 24 hours Rapid Recovery

Hyangseongpajeok-hwan promotes post-performance voice recovery in vocalists, contributing to vocal cord health maintenance.

View Source 2024
Cross-Sectional Hyangseongpajeokhwan (響聲破笛丸)

Effect of Hyangseongpajeok-hwan Administration on Post-Performance Voice Recovery Speed in Vocalists

Jang DY, Kim HT, Lee SJ, et al. Journal of Voice (2024)
24 subjects Participants
Recovery time 48% shortened Recovery Promotion
Recovery within 24 hours Rapid Recovery

Summary

Voice recovery speed after a 2-hour performance was compared by Hyangseongpajeok-hwan use status in 24 professional vocalists. The Hyangseongpajeok-hwan user group showed voice parameters returning to baseline within 24 hours.

Key Conclusion

Hyangseongpajeok-hwan promotes post-performance voice recovery in vocalists, contributing to vocal cord health maintenance.

이 논문 정리 페이지로 이동 →
View Full Paper
Narrative Review Hyangseongpajeokhwan (響聲破笛丸)

Narrative Review on Korean Medicine Treatment Strategies for Voice Recovery: Role of Hyangseongpajeok-hwan

Kim JH, Lee BJ, Shin HK, et al.

Journal of Korean Medicine (2022)

42 sources Analyzed Literature
4 pattern types Prescription Modifications
Combination strategies presented Clinical Recommendations

Hyangseongpajeok-hwan is a core prescription in Korean medicine treatment of voice disorders, with personalized modifications enhancing treatment effects.

View Source 2022
Narrative Review Hyangseongpajeokhwan (響聲破笛丸)

Narrative Review on Korean Medicine Treatment Strategies for Voice Recovery: Role of Hyangseongpajeok-hwan

Kim JH, Lee BJ, Shin HK, et al. Journal of Korean Medicine (2022)
42 sources Analyzed Literature
4 pattern types Prescription Modifications
Combination strategies presented Clinical Recommendations

Summary

Korean medicine treatment strategies for voice disorders were narratively reviewed, and the role of Hyangseongpajeok-hwan and clinical utilization plans were analyzed. Prescription modification methods according to pattern differentiation and combination strategies with other treatment modalities were presented.

Key Conclusion

Hyangseongpajeok-hwan is a core prescription in Korean medicine treatment of voice disorders, with personalized modifications enhancing treatment effects.

이 논문 정리 페이지로 이동 →
View Full Paper
Before-After Hyangseongpajeokhwan (響聲破笛丸)

Exploratory Study on the Oral and Throat Microbiota Modulation Effect of Hyangseongpajeok-hwan

Han GJ, Song MY, Lee SJ, et al.

Microorganisms (2024)

35 subjects Participants
Pathogens 32% reduction Microbial Modulation
Beneficial bacteria increase Microbiota Improvement

Hyangseongpajeok-hwan may contribute to maintaining a healthy balance of throat microbiota.

View Source 2024
Before-After Hyangseongpajeokhwan (響聲破笛丸)

Exploratory Study on the Oral and Throat Microbiota Modulation Effect of Hyangseongpajeok-hwan

Han GJ, Song MY, Lee SJ, et al. Microorganisms (2024)
35 subjects Participants
Pathogens 32% reduction Microbial Modulation
Beneficial bacteria increase Microbiota Improvement

Summary

Hyangseongpajeok-hwan was administered for 8 weeks to 35 patients with chronic throat discomfort, and throat microbiota changes were analyzed by 16S rRNA sequencing. Pathogenic bacterial proportions decreased and beneficial bacteria increased.

Key Conclusion

Hyangseongpajeok-hwan may contribute to maintaining a healthy balance of throat microbiota.

이 논문 정리 페이지로 이동 →
View Full Paper