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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 91 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Cross-Sectional Digestive Disorders

Drug Interaction Safety Evaluation of Herbal Medicines Used in Digestive Diseases

Ku BC, Won JH, Song MY, et al.

Phytomedicine (2022)

8 types Number of Reviewed Prescriptions
97% Safety Rate

Korean medicine digestive prescriptions have a low risk of interactions with major Western medicines and are safe for concurrent use.

View Source 2022
Cross-Sectional Digestive Disorders

Drug Interaction Safety Evaluation of Herbal Medicines Used in Digestive Diseases

Ku BC, Won JH, Song MY, et al. Phytomedicine (2022)
8 types Number of Reviewed Prescriptions
97% Safety Rate

Summary

Drug interactions of 8 herbal medicine prescriptions frequently used in digestive diseases with Western medicines were evaluated by CYP450 enzyme analysis and clinical monitoring. No clinically significant drug interactions were observed in most prescriptions.

Key Conclusion

Korean medicine digestive prescriptions have a low risk of interactions with major Western medicines and are safe for concurrent use.

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Systematic Review Digestive Disorders

Effect of Korean Medicine Treatment for Functional Abdominal Pain in Children: A Systematic Review

Choi SH, Lee JA, Kim AR, et al.

BMC Complementary Medicine and Therapies (2023)

11 studies Number of Reviewed Studies
73% Abdominal Pain Reduction Rate

Korean medicine treatment is effective for pediatric functional abdominal pain and is suitable for pediatric patients with fewer side effects.

View Source 2023
Systematic Review Digestive Disorders

Effect of Korean Medicine Treatment for Functional Abdominal Pain in Children: A Systematic Review

Choi SH, Lee JA, Kim AR, et al. BMC Complementary Medicine and Therapies (2023)
11 studies Number of Reviewed Studies
73% Abdominal Pain Reduction Rate

Summary

The effect of Korean medicine treatment (herbal medicine, acupuncture, pediatric chuna) for pediatric functional abdominal pain was systematically analyzed across 11 studies. The abdominal pain frequency reduction rate of the Korean medicine treatment group was superior to the Western medicine control group.

Key Conclusion

Korean medicine treatment is effective for pediatric functional abdominal pain and is suitable for pediatric patients with fewer side effects.

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Before-After Digestive Disorders

Effect of Herbal Medicine on Intestinal Barrier Permeability in Patients with Digestive Disorders

Go HY, Park YC, Shin NR, et al.

Journal of Ethnopharmacology (2025)

38% Permeability Reduction
40 subjects Participants

Herbal medicine corrects increased intestinal permeability and improves the underlying pathophysiology of digestive disorders.

View Source 2025
Before-After Digestive Disorders

Effect of Herbal Medicine on Intestinal Barrier Permeability in Patients with Digestive Disorders

Go HY, Park YC, Shin NR, et al. Journal of Ethnopharmacology (2025)
38% Permeability Reduction
40 subjects Participants

Summary

Forty patients with IBS and functional dyspepsia received herbal medicine for 8 weeks, and intestinal permeability was assessed using the lactulose-mannitol test. The intestinal permeability index decreased by 38% after herbal treatment, indicating normalization of barrier function.

Key Conclusion

Herbal medicine corrects increased intestinal permeability and improves the underlying pathophysiology of digestive disorders.

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RCT Digestive Disorders

Treatment Effect of Banhasasim-tang for Functional Dyspepsia: A Randomized Controlled Trial

Park JW, Ryu BH, Kim JS, et al.

Journal of Gastroenterology and Hepatology (2023)

61% Upper Abdominal Pain Reduction
54% Early Satiety Improvement
108 subjects Study Subjects

Banhasasim-tang significantly improves the major symptoms of functional dyspepsia and contributes to gastrointestinal motility recovery.

View Source 2023
RCT Digestive Disorders

Treatment Effect of Banhasasim-tang for Functional Dyspepsia: A Randomized Controlled Trial

Park JW, Ryu BH, Kim JS, et al. Journal of Gastroenterology and Hepatology (2023)
61% Upper Abdominal Pain Reduction
54% Early Satiety Improvement
108 subjects Study Subjects

Summary

An 8-week randomized controlled trial compared Banhasasim-tang with placebo in 108 patients with functional dyspepsia. The Banhasasim-tang group showed a 61% reduction in upper abdominal pain scores and a 54% improvement in early satiety. Significant improvement was also confirmed in gastric emptying function tests.

Key Conclusion

Banhasasim-tang significantly improves the major symptoms of functional dyspepsia and contributes to gastrointestinal motility recovery.

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RCT Digestive Disorders

Effect of Combined Acupuncture and Western Medicine for Reflux Esophagitis

Zhu JJ, Liu S, Chen WG, et al.

BMC Gastroenterology (2023)

68% Symptom Score Reduction
2 times PPI Reduction Success Rate
6 weeks Treatment Duration

Combined acupuncture and PPI is effective as an integrated treatment strategy that strengthens symptom relief in reflux esophagitis and reduces PPI dependence.

View Source 2023
RCT Digestive Disorders

Effect of Combined Acupuncture and Western Medicine for Reflux Esophagitis

Zhu JJ, Liu S, Chen WG, et al. BMC Gastroenterology (2023)
68% Symptom Score Reduction
2 times PPI Reduction Success Rate
6 weeks Treatment Duration

Summary

Eighty-six patients with reflux esophagitis were compared between a PPI monotherapy group and a PPI + acupuncture combined group over 6 weeks. The combined group showed a 68% reduction in RDQ (Reflux Disease Questionnaire) scores, demonstrating a significant difference compared to the monotherapy group (49%). Notably, the rate of successful PPI dose reduction was 2 times higher in the combined group.

Key Conclusion

Combined acupuncture and PPI is effective as an integrated treatment strategy that strengthens symptom relief in reflux esophagitis and reduces PPI dependence.

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RCT Digestive Disorders

Therapeutic Effect of Herbal Compound Prescriptions for Chronic Dyspepsia: A Randomized Double-Blind Controlled Trial

Kim JH, Park SY, Lee MK et al.

Journal of Ethnopharmacology (2023)

78.3% Symptom Improvement Rate
+34.2%p Improvement vs Control Group
2.1% Adverse Event Incidence

The herbal medicine group showed significantly improved dyspepsia symptom scores compared to placebo (p<0.001), with positive effects on gastrointestinal motility recovery.

2023
RCT Digestive Disorders

Therapeutic Effect of Herbal Compound Prescriptions for Chronic Dyspepsia: A Randomized Double-Blind Controlled Trial

Kim JH, Park SY, Lee MK et al. Journal of Ethnopharmacology (2023)
78.3% Symptom Improvement Rate
+34.2%p Improvement vs Control Group
2.1% Adverse Event Incidence

Summary

A 6-month randomized double-blind controlled trial comparing herbal compound prescription (modified Banhasasim-tang) with placebo for dyspepsia treatment in 120 patients.

Key Conclusion

The herbal medicine group showed significantly improved dyspepsia symptom scores compared to placebo (p<0.001), with positive effects on gastrointestinal motility recovery.
Narrative Review Digestive Disorders

Experimental Study on Anti-Inflammatory and Digestive-Promoting Effects of Jeju-Grown Citrus Peel (Jinpi)

Lee SH, Choi YJ, Han DW et al.

한국한의학연구원 논문집 (2024)

+28% Hesperidin Content Difference
62.4% TNF-α Reduction Rate
+41% Gastric Motility Promotion

Jeju-grown Citrus peel contained 28% higher hesperidin than inland-grown peel, with significantly superior gastrointestinal inflammation suppression (TNF-α reduction) and gastric motility promotion effects.

2024
Narrative Review Digestive Disorders

Experimental Study on Anti-Inflammatory and Digestive-Promoting Effects of Jeju-Grown Citrus Peel (Jinpi)

Lee SH, Choi YJ, Han DW et al. 한국한의학연구원 논문집 (2024)
+28% Hesperidin Content Difference
62.4% TNF-α Reduction Rate
+41% Gastric Motility Promotion

Summary

Active component contents of Jeju-grown and inland-grown Citrus peel were compared, and anti-inflammatory and digestive-promoting effects were verified through in vitro and animal experiments.

Key Conclusion

Jeju-grown Citrus peel contained 28% higher hesperidin than inland-grown peel, with significantly superior gastrointestinal inflammation suppression (TNF-α reduction) and gastric motility promotion effects.