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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 91 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
RCT Digestive Disorders

Treatment Effect of Banhasasim-tang for Reflux Esophagitis: A Randomized Controlled Trial

Lee SJ, Kim NK, Baek NI, et al.

Journal of Ethnopharmacology (2022)

79% Symptom Improvement Rate
70 subjects Number of Participants

Banhasasim-tang demonstrates effects similar to PPIs in mild-to-moderate reflux esophagitis and may serve as a safe alternative.

View Source 2022
RCT Digestive Disorders

Treatment Effect of Banhasasim-tang for Reflux Esophagitis: A Randomized Controlled Trial

Lee SJ, Kim NK, Baek NI, et al. Journal of Ethnopharmacology (2022)
79% Symptom Improvement Rate
70 subjects Number of Participants

Summary

Seventy patients with reflux esophagitis (LA classification grades A-B) were divided into a Banhasasim-tang group and a PPI control group and treated for 8 weeks. The symptom improvement rate of the Banhasasim-tang group (79%) showed no statistically significant difference from the PPI group (83%).

Key Conclusion

Banhasasim-tang demonstrates effects similar to PPIs in mild-to-moderate reflux esophagitis and may serve as a safe alternative.

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Meta-Analysis Digestive Disorders

Systematic Review and Meta-Analysis of Herbal Medicine Treatment for Irritable Bowel Syndrome

Choi JY, Ko SJ, Park JW, et al.

BMC Complementary Medicine and Therapies (2024)

OR 2.56 Odds Ratio
21 studies Number of Reviewed RCTs

Herbal medicine demonstrates significant effects compared to Western medicine for IBS symptom improvement, with particularly pronounced effects in diarrhea-predominant and mixed types.

View Source 2024
Meta-Analysis Digestive Disorders

Systematic Review and Meta-Analysis of Herbal Medicine Treatment for Irritable Bowel Syndrome

Choi JY, Ko SJ, Park JW, et al. BMC Complementary Medicine and Therapies (2024)
OR 2.56 Odds Ratio
21 studies Number of Reviewed RCTs

Summary

The effect of herbal medicine treatment for irritable bowel syndrome (IBS) was meta-analyzed across 21 RCTs. The overall symptom improvement rate of the herbal medicine group was significantly higher than the Western medicine control group at OR 2.56 (95% CI: 1.87-3.51).

Key Conclusion

Herbal medicine demonstrates significant effects compared to Western medicine for IBS symptom improvement, with particularly pronounced effects in diarrhea-predominant and mixed types.

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RCT Digestive Disorders

Effect of Acupuncture on Functional Dyspepsia: A Randomized Controlled Trial

Kim JH, Lee TY, Park YC, et al.

Evidence-Based Complementary and Alternative Medicine (2023)

52% Symptom Improvement Rate
90 subjects Number of Participants

Acupuncture is effective for symptom improvement in functional dyspepsia and shows significant superiority compared to sham treatment.

View Source 2023
RCT Digestive Disorders

Effect of Acupuncture on Functional Dyspepsia: A Randomized Controlled Trial

Kim JH, Lee TY, Park YC, et al. Evidence-Based Complementary and Alternative Medicine (2023)
52% Symptom Improvement Rate
90 subjects Number of Participants

Summary

Ninety patients with functional dyspepsia (Rome IV criteria) were divided into an acupuncture treatment group and a sham acupuncture group and treated for 8 weeks. The acupuncture treatment group showed a 52% improvement in dyspepsia symptom scores (NDI), demonstrating a significant difference from the sham group (21%).

Key Conclusion

Acupuncture is effective for symptom improvement in functional dyspepsia and shows significant superiority compared to sham treatment.

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RCT Digestive Disorders

Effect of Combined Acupuncture and Western Medicine for Reflux Esophagitis

Zhu JJ, Liu S, Chen WG, et al.

BMC Gastroenterology (2023)

68% Symptom Score Reduction
2 times PPI Reduction Success Rate
6 weeks Treatment Duration

Combined acupuncture and PPI is effective as an integrated treatment strategy that strengthens symptom relief in reflux esophagitis and reduces PPI dependence.

View Source 2023
RCT Digestive Disorders

Effect of Combined Acupuncture and Western Medicine for Reflux Esophagitis

Zhu JJ, Liu S, Chen WG, et al. BMC Gastroenterology (2023)
68% Symptom Score Reduction
2 times PPI Reduction Success Rate
6 weeks Treatment Duration

Summary

Eighty-six patients with reflux esophagitis were compared between a PPI monotherapy group and a PPI + acupuncture combined group over 6 weeks. The combined group showed a 68% reduction in RDQ (Reflux Disease Questionnaire) scores, demonstrating a significant difference compared to the monotherapy group (49%). Notably, the rate of successful PPI dose reduction was 2 times higher in the combined group.

Key Conclusion

Combined acupuncture and PPI is effective as an integrated treatment strategy that strengthens symptom relief in reflux esophagitis and reduces PPI dependence.

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RCT Digestive Disorders

Treatment Effect of Banhasasim-tang for Functional Dyspepsia: A Randomized Controlled Trial

Park JW, Ryu BH, Kim JS, et al.

Journal of Gastroenterology and Hepatology (2023)

61% Upper Abdominal Pain Reduction
54% Early Satiety Improvement
108 subjects Study Subjects

Banhasasim-tang significantly improves the major symptoms of functional dyspepsia and contributes to gastrointestinal motility recovery.

View Source 2023
RCT Digestive Disorders

Treatment Effect of Banhasasim-tang for Functional Dyspepsia: A Randomized Controlled Trial

Park JW, Ryu BH, Kim JS, et al. Journal of Gastroenterology and Hepatology (2023)
61% Upper Abdominal Pain Reduction
54% Early Satiety Improvement
108 subjects Study Subjects

Summary

An 8-week randomized controlled trial compared Banhasasim-tang with placebo in 108 patients with functional dyspepsia. The Banhasasim-tang group showed a 61% reduction in upper abdominal pain scores and a 54% improvement in early satiety. Significant improvement was also confirmed in gastric emptying function tests.

Key Conclusion

Banhasasim-tang significantly improves the major symptoms of functional dyspepsia and contributes to gastrointestinal motility recovery.

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Narrative Review Digestive Disorders

Experimental Study on Anti-Inflammatory and Digestive-Promoting Effects of Jeju-Grown Citrus Peel (Jinpi)

Lee SH, Choi YJ, Han DW et al.

한국한의학연구원 논문집 (2024)

+28% Hesperidin Content Difference
62.4% TNF-α Reduction Rate
+41% Gastric Motility Promotion

Jeju-grown Citrus peel contained 28% higher hesperidin than inland-grown peel, with significantly superior gastrointestinal inflammation suppression (TNF-α reduction) and gastric motility promotion effects.

2024
Narrative Review Digestive Disorders

Experimental Study on Anti-Inflammatory and Digestive-Promoting Effects of Jeju-Grown Citrus Peel (Jinpi)

Lee SH, Choi YJ, Han DW et al. 한국한의학연구원 논문집 (2024)
+28% Hesperidin Content Difference
62.4% TNF-α Reduction Rate
+41% Gastric Motility Promotion

Summary

Active component contents of Jeju-grown and inland-grown Citrus peel were compared, and anti-inflammatory and digestive-promoting effects were verified through in vitro and animal experiments.

Key Conclusion

Jeju-grown Citrus peel contained 28% higher hesperidin than inland-grown peel, with significantly superior gastrointestinal inflammation suppression (TNF-α reduction) and gastric motility promotion effects.

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RCT Digestive Disorders

Therapeutic Effect of Herbal Compound Prescriptions for Chronic Dyspepsia: A Randomized Double-Blind Controlled Trial

Kim JH, Park SY, Lee MK et al.

Journal of Ethnopharmacology (2023)

78.3% Symptom Improvement Rate
+34.2%p Improvement vs Control Group
2.1% Adverse Event Incidence

The herbal medicine group showed significantly improved dyspepsia symptom scores compared to placebo (p<0.001), with positive effects on gastrointestinal motility recovery.

2023
RCT Digestive Disorders

Therapeutic Effect of Herbal Compound Prescriptions for Chronic Dyspepsia: A Randomized Double-Blind Controlled Trial

Kim JH, Park SY, Lee MK et al. Journal of Ethnopharmacology (2023)
78.3% Symptom Improvement Rate
+34.2%p Improvement vs Control Group
2.1% Adverse Event Incidence

Summary

A 6-month randomized double-blind controlled trial comparing herbal compound prescription (modified Banhasasim-tang) with placebo for dyspepsia treatment in 120 patients.

Key Conclusion

The herbal medicine group showed significantly improved dyspepsia symptom scores compared to placebo (p<0.001), with positive effects on gastrointestinal motility recovery.

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