금맥한의원
Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

📅 Book Appointment 📋 Geummaek Herbal Medicine 💬 Reviews 📝 Health Columns
Research Papers
🔍

Total 91 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Narrative Review Digestive Disorders

Review of Pharmacological Mechanisms of Prescriptions Used in Korean Medicine Digestive Treatment

Kang WC, Oh JH, Lee KJ, et al.

Journal of Ethnopharmacology (2020)

10 Number of Reviewed Prescriptions
4 Major Mechanisms

Korean medicine digestive prescriptions comprehensively treat digestive diseases through multiple pharmacological mechanisms.

View Source 2020
Narrative Review Digestive Disorders

Review of Pharmacological Mechanisms of Prescriptions Used in Korean Medicine Digestive Treatment

Kang WC, Oh JH, Lee KJ, et al. Journal of Ethnopharmacology (2020)
10 Number of Reviewed Prescriptions
4 Major Mechanisms

Summary

The pharmacological mechanisms of 10 frequently used prescriptions in Korean medicine digestive treatment were systematically reviewed. Four major mechanisms were identified: gastrointestinal motility promotion, gastric acid secretion regulation, anti-inflammation, and intestinal barrier function strengthening.

Key Conclusion

Korean medicine digestive prescriptions comprehensively treat digestive diseases through multiple pharmacological mechanisms.

View Full Paper
RCT Digestive Disorders

Effect of Combined Acupuncture and Moxibustion for Stress-Related Dyspepsia: A Randomized Controlled Trial

Cho KL, Yoon SH, Han JM, et al.

BMC Complementary Medicine and Therapies (2023)

64% Symptom Improvement Rate
72 subjects Number of Participants

Combined acupuncture and moxibustion simultaneously improves digestive symptoms and psychological stress in stress-related dyspepsia.

View Source 2023
RCT Digestive Disorders

Effect of Combined Acupuncture and Moxibustion for Stress-Related Dyspepsia: A Randomized Controlled Trial

Cho KL, Yoon SH, Han JM, et al. BMC Complementary Medicine and Therapies (2023)
64% Symptom Improvement Rate
72 subjects Number of Participants

Summary

Seventy-two patients with stress-related functional dyspepsia were divided into an acupuncture-moxibustion combined group, an acupuncture monotherapy group, and a waiting control group, and treated for 6 weeks. The combined group showed significant improvement in both dyspepsia symptoms and stress scores.

Key Conclusion

Combined acupuncture and moxibustion simultaneously improves digestive symptoms and psychological stress in stress-related dyspepsia.

View Full Paper
RCT Digestive Disorders

Eradication Effect of Combined Herbal Medicine and Triple Therapy for H. pylori-Positive Gastritis

Min BJ, Lee DH, Cho YK, et al.

Phytomedicine (2023)

91% Eradication Success Rate
80 subjects Number of Participants

Combined herbal medicine increases the eradication success rate of H. pylori triple therapy and reduces side effects.

View Source 2023
RCT Digestive Disorders

Eradication Effect of Combined Herbal Medicine and Triple Therapy for H. pylori-Positive Gastritis

Min BJ, Lee DH, Cho YK, et al. Phytomedicine (2023)
91% Eradication Success Rate
80 subjects Number of Participants

Summary

Eighty patients with H. pylori-positive gastritis were divided into a triple therapy monotherapy group and a triple therapy-herbal medicine combined group and treated. The eradication success rate of the combined group was 91%, significantly higher than the monotherapy group (72%), with fewer side effects.

Key Conclusion

Combined herbal medicine increases the eradication success rate of H. pylori triple therapy and reduces side effects.

View Full Paper
Systematic Review Digestive Disorders

Systematic Review of Pharmacopuncture Treatment for Gastrointestinal Diseases

Son MJ, Park JY, Choi SM, et al.

Evidence-Based Complementary and Alternative Medicine (2022)

13 studies Number of Reviewed Studies
85% Positive Result Rate

Pharmacopuncture treatment is an effective treatment option for symptom improvement in various gastrointestinal diseases.

View Source 2022
Systematic Review Digestive Disorders

Systematic Review of Pharmacopuncture Treatment for Gastrointestinal Diseases

Son MJ, Park JY, Choi SM, et al. Evidence-Based Complementary and Alternative Medicine (2022)
13 studies Number of Reviewed Studies
85% Positive Result Rate

Summary

The pharmacopuncture treatment effect for gastrointestinal diseases (dyspepsia, gastritis, IBS, GERD) was systematically analyzed across 13 clinical studies. Most studies showed significant effects of pharmacopuncture treatment for symptom improvement compared to controls.

Key Conclusion

Pharmacopuncture treatment is an effective treatment option for symptom improvement in various gastrointestinal diseases.

View Full Paper
Case Study Digestive Disorders

Endoscopic Finding Changes Before and After Korean Medicine Treatment in Chronic Gastritis Patients: A Case Report

Koo BH, Seo HS, Won JY, et al.

Journal of Korean Medicine (2021)

8 subjects Number of Participants
63% Endoscopic Improvement Rate

Korean medicine treatment suggests the possibility of gastric mucosal lesion improvement in chronic gastritis, and additional research is needed.

View Source 2021
Case Study Digestive Disorders

Endoscopic Finding Changes Before and After Korean Medicine Treatment in Chronic Gastritis Patients: A Case Report

Koo BH, Seo HS, Won JY, et al. Journal of Korean Medicine (2021)
8 subjects Number of Participants
63% Endoscopic Improvement Rate

Summary

Herbal medicine and acupuncture treatment was administered for 24 weeks to 8 patients with chronic gastritis (atrophic and intestinal metaplasia), and gastric mucosal changes were observed by endoscopy. Atrophic changes improved in 5 patients, and the extent of intestinal metaplasia decreased in 3 patients.

Key Conclusion

Korean medicine treatment suggests the possibility of gastric mucosal lesion improvement in chronic gastritis, and additional research is needed.

View Full Paper
Before-After Digestive Disorders

Vagus Nerve Activation Effect of Electroacupuncture in Digestive Diseases: A Mechanism Study

Nam DJ, Baek SJ, Im EJ, et al.

Complementary Therapies in Medicine (2024)

42% HF Component Increase
30 subjects Number of Participants

The mechanism of electroacupuncture activating the vagus nerve to regulate digestive function has been confirmed.

View Source 2024
Before-After Digestive Disorders

Vagus Nerve Activation Effect of Electroacupuncture in Digestive Diseases: A Mechanism Study

Nam DJ, Baek SJ, Im EJ, et al. Complementary Therapies in Medicine (2024)
42% HF Component Increase
30 subjects Number of Participants

Summary

Heart rate variability (HRV) before and after Zusanli (ST36) electroacupuncture treatment was analyzed to evaluate vagus nerve activity in 30 patients with digestive diseases. After electroacupuncture, the HF (high frequency) component increased by 42%, confirming parasympathetic activation.

Key Conclusion

The mechanism of electroacupuncture activating the vagus nerve to regulate digestive function has been confirmed.

View Full Paper
RCT Digestive Disorders

Comparison of Herbal Medicine Treatment and Low-FODMAP Diet for IBS Patients: A Randomized Controlled Trial

Kim SY, Chung WS, Jang JG, et al.

BMC Complementary Medicine and Therapies (2024)

178 points Combined Group IBS-SSS Reduction
100 subjects Number of Participants

The combination of herbal medicine and Low-FODMAP diet is the most effective strategy for IBS symptom management.

View Source 2024
RCT Digestive Disorders

Comparison of Herbal Medicine Treatment and Low-FODMAP Diet for IBS Patients: A Randomized Controlled Trial

Kim SY, Chung WS, Jang JG, et al. BMC Complementary Medicine and Therapies (2024)
178 points Combined Group IBS-SSS Reduction
100 subjects Number of Participants

Summary

One hundred IBS patients were divided into a herbal medicine group, a Low-FODMAP diet group, and a combined group, and treatment effects were compared over 8 weeks. The IBS-SSS reduction in the combined group (-178 points) was significantly greater than the herbal medicine monotherapy (-132 points) and diet monotherapy (-118 points) groups.

Key Conclusion

The combination of herbal medicine and Low-FODMAP diet is the most effective strategy for IBS symptom management.

View Full Paper
Cross-Sectional Digestive Disorders

Analysis of Treatment Effect Differences by Korean Medicine Constitution in Functional Dyspepsia

Baek YH, Lee SW, Jang ES, et al.

Journal of Korean Medicine (2023)

86% Soeumin Response Rate
120 subjects Number of Participants

The effect of Korean medicine treatment for dyspepsia varies by Sasang constitution, and a constitutional tailored approach is important.

View Source 2023
Cross-Sectional Digestive Disorders

Analysis of Treatment Effect Differences by Korean Medicine Constitution in Functional Dyspepsia

Baek YH, Lee SW, Jang ES, et al. Journal of Korean Medicine (2023)
86% Soeumin Response Rate
120 subjects Number of Participants

Summary

One hundred twenty patients with functional dyspepsia were classified by Sasang constitution and received constitutional tailored herbal medicine treatment. The treatment response rate was highest at 86% in Soeumin and relatively low at 71% in Taeyangin.

Key Conclusion

The effect of Korean medicine treatment for dyspepsia varies by Sasang constitution, and a constitutional tailored approach is important.

View Full Paper
Meta-Analysis Digestive Disorders

Efficacy and Safety of Korean Medicine Treatment Compared to Western Medicine for Reflux Esophagitis: A Meta-Analysis

Woo CH, Ahn TW, Shin HK, et al.

Evidence-Based Complementary and Alternative Medicine (2025)

RR 0.97 Efficacy Comparison
18 studies Number of Reviewed RCTs

Korean medicine treatment shows similar efficacy to PPI in GERD with significantly fewer side effects.

View Source 2025
Meta-Analysis Digestive Disorders

Efficacy and Safety of Korean Medicine Treatment Compared to Western Medicine for Reflux Esophagitis: A Meta-Analysis

Woo CH, Ahn TW, Shin HK, et al. Evidence-Based Complementary and Alternative Medicine (2025)
RR 0.97 Efficacy Comparison
18 studies Number of Reviewed RCTs

Summary

The efficacy of Korean medicine treatment and Western medicine (PPI) treatment for GERD was meta-analyzed across 18 RCTs. The effect of Korean medicine treatment was similar to PPI (RR 0.97), and the adverse event incidence was significantly lower (RR 0.34).

Key Conclusion

Korean medicine treatment shows similar efficacy to PPI in GERD with significantly fewer side effects.

View Full Paper
Before-After Digestive Disorders

Quality of Life and Mental Health Changes After Korean Medicine Treatment in Digestive Disease Patients

Ha IH, Cho WS, Im JY, et al.

Complementary Therapies in Medicine (2021)

38% Quality of Life Improvement
85 subjects Number of Participants

Korean medicine digestive treatment comprehensively improves quality of life and mental health along with digestive symptom improvement.

View Source 2021
Before-After Digestive Disorders

Quality of Life and Mental Health Changes After Korean Medicine Treatment in Digestive Disease Patients

Ha IH, Cho WS, Im JY, et al. Complementary Therapies in Medicine (2021)
38% Quality of Life Improvement
85 subjects Number of Participants

Summary

Changes in SF-36 quality of life scores and PHQ-9 depression scores were evaluated after 12 weeks of Korean medicine treatment in 85 patients with chronic digestive diseases. SF-36 total scores improved by 38%, and PHQ-9 scores also decreased significantly.

Key Conclusion

Korean medicine digestive treatment comprehensively improves quality of life and mental health along with digestive symptom improvement.

View Full Paper
RCT Digestive Disorders

Effect of Fermented Herbal Medicine Extract on Gastrointestinal Function Improvement: Preclinical and Clinical Studies

Ryu KH, Song JY, Lee MK, et al.

Journal of Ethnopharmacology (2024)

35% Fermentation Superiority Effect
30 subjects Number of Clinical Participants

Fermented herbal medicine extracts show superior effects compared to existing extracts for digestive function improvement.

View Source 2024
RCT Digestive Disorders

Effect of Fermented Herbal Medicine Extract on Gastrointestinal Function Improvement: Preclinical and Clinical Studies

Ryu KH, Song JY, Lee MK, et al. Journal of Ethnopharmacology (2024)
35% Fermentation Superiority Effect
30 subjects Number of Clinical Participants

Summary

The gastrointestinal function improvement effect of fermented herbal medicine extract (fermented Yukgunja-tang) was evaluated in animal experiments and clinical trials (30 subjects). The fermented extract showed 35% greater gastrointestinal motility promotion effect compared to non-fermented, with improved absorption rate.

Key Conclusion

Fermented herbal medicine extracts show superior effects compared to existing extracts for digestive function improvement.

View Full Paper
Case Study Digestive Disorders

Effect of Herbal Medicine Conversion Treatment in Long-Term PPI Users: A Case Study

Lee BJ, Kim JE, Yim MH, et al.

Journal of Korean Medicine (2020)

80% PPI Discontinuation Success Rate
10 subjects Number of Participants

Conversion to herbal medicine is possible in long-term PPI users, and most patients succeeded in symptom management.

View Source 2020
Case Study Digestive Disorders

Effect of Herbal Medicine Conversion Treatment in Long-Term PPI Users: A Case Study

Lee BJ, Kim JE, Yim MH, et al. Journal of Korean Medicine (2020)
80% PPI Discontinuation Success Rate
10 subjects Number of Participants

Summary

A stepwise conversion to herbal medicine was attempted in 10 GERD patients who had been taking PPIs for more than 1 year. Eight patients succeeded in PPI discontinuation, and at 6-month follow-up, 7 patients managed symptoms with herbal medicine alone.

Key Conclusion

Conversion to herbal medicine is possible in long-term PPI users, and most patients succeeded in symptom management.

View Full Paper