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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 91 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Before-After Digestive Disorders

Ghrelin Modulation Effect of Hyangsayukgunja-tang for Anorexia: A Pre-Post Comparison

Chung SH, Roh JD, Min BW, et al.

Appetite (2023)

35% Ghrelin↑
45 subjects Participants
Food intake↑ Appetite Improvement

Hyangsayukgunja-tang effectively improves appetite by promoting ghrelin secretion.

View Source 2023
Before-After Digestive Disorders

Ghrelin Modulation Effect of Hyangsayukgunja-tang for Anorexia: A Pre-Post Comparison

Chung SH, Roh JD, Min BW, et al. Appetite (2023)
35% Ghrelin↑
45 subjects Participants
Food intake↑ Appetite Improvement

Summary

Forty-five patients with anorexia received Hyangsayukgunja-tang for 6 weeks, with assessment of serum ghrelin and appetite. Ghrelin levels increased by 35% and food intake increased significantly.

Key Conclusion

Hyangsayukgunja-tang effectively improves appetite by promoting ghrelin secretion.

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Cohort Study Digestive Disorders

Mucosal Healing Effect of Combined Herbal Medicine and PPI for Gastric Ulcer: A Cohort Study

Cha YR, Woo HS, Nam DH, et al.

European Journal of Gastroenterology & Hepatology (2024)

88% Healing Rate
95 subjects Participants
PPI Combination Treatment Strategy

Combined herbal medicine and PPI improves the healing rate of gastric ulcers.

View Source 2024
Cohort Study Digestive Disorders

Mucosal Healing Effect of Combined Herbal Medicine and PPI for Gastric Ulcer: A Cohort Study

Cha YR, Woo HS, Nam DH, et al. European Journal of Gastroenterology & Hepatology (2024)
88% Healing Rate
95 subjects Participants
PPI Combination Treatment Strategy

Summary

Ninety-five patients with gastric ulcer were followed for 8 weeks, divided into PPI plus herbal medicine (Hwangnyeonhaedok-tang) and PPI-alone groups. The combined group showed an ulcer healing rate of 88%, significantly higher than 72% in the monotherapy group.

Key Conclusion

Combined herbal medicine and PPI improves the healing rate of gastric ulcers.

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RCT Digestive Disorders

Randomized Controlled Trial of Herbal Sitz Bath and Topical Agents for Hemorrhoids

Go GY, Han SH, Park BS, et al.

Diseases of the Colon & Rectum (2023)

62% Bleeding↓
55% Pain↓
70 subjects Participants

Herbal sitz bath and topical agents are effective non-surgical treatments for early-stage hemorrhoids.

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RCT Digestive Disorders

Randomized Controlled Trial of Herbal Sitz Bath and Topical Agents for Hemorrhoids

Go GY, Han SH, Park BS, et al. Diseases of the Colon & Rectum (2023)
62% Bleeding↓
55% Pain↓
70 subjects Participants

Summary

Seventy patients with internal hemorrhoids (Grade I-II) were compared over 6 weeks between herbal sitz bath plus topical and suppository groups. The Korean medicine group showed equivalent improvement in bleeding frequency (-62%) and pain (-55%) compared to suppositories.

Key Conclusion

Herbal sitz bath and topical agents are effective non-surgical treatments for early-stage hemorrhoids.

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Case Study Digestive Disorders

Case Report of Daesiho-tang for Gallstone Disease

Lim JH, Shin BC, Kim CH, et al.

Journal of Hepato-Biliary-Pancreatic Sciences (2024)

8 cases Case Number
3 cleared Gallstone Removal
16 weeks Treatment Period

Daesiho-tang may contribute to size reduction and disappearance of small gallstones.

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Case Study Digestive Disorders

Case Report of Daesiho-tang for Gallstone Disease

Lim JH, Shin BC, Kim CH, et al. Journal of Hepato-Biliary-Pancreatic Sciences (2024)
8 cases Case Number
3 cleared Gallstone Removal
16 weeks Treatment Period

Summary

Eight patients with gallstones received Daesiho-tang for 16 weeks in a reported case series. Five patients showed gallstone size reduction of 30% or more, and three patients had complete gallstone disappearance.

Key Conclusion

Daesiho-tang may contribute to size reduction and disappearance of small gallstones.

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RCT Digestive Disorders

Randomized Controlled Trial of Sogeonjung-tang for Pediatric Constipation

Son HY, Kim MJ, Park EJ, et al.

Journal of Pediatric Gastroenterology and Nutrition (2023)

5.2/week Defecation↑
60 subjects Participants
Pain↓ Additional Effect

Sogeonjung-tang is effective in improving defecation frequency and alleviating abdominal pain in pediatric functional constipation.

View Source 2023
RCT Digestive Disorders

Randomized Controlled Trial of Sogeonjung-tang for Pediatric Constipation

Son HY, Kim MJ, Park EJ, et al. Journal of Pediatric Gastroenterology and Nutrition (2023)
5.2/week Defecation↑
60 subjects Participants
Pain↓ Additional Effect

Summary

Sixty children with functional constipation were compared over 8 weeks between Sogeonjung-tang and placebo groups. The herbal group showed weekly spontaneous bowel movements increasing from 1.8 to 5.2, with reduced abdominal pain.

Key Conclusion

Sogeonjung-tang is effective in improving defecation frequency and alleviating abdominal pain in pediatric functional constipation.

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Meta-Analysis Digestive Disorders

Meta-analysis of Combined Acupuncture and Moxibustion for Chronic Diarrhea

Noh HM, Kang SH, Yoon JY, et al.

Acupuncture in Medicine (2023)

14 RCTs Analyzed RCTs
RR 1.52 Stool Normalization
Acupuncture+Moxa Combination Effect

Combined acupuncture and moxibustion is effective in normalizing stool frequency and form in chronic diarrhea.

View Source 2023
Meta-Analysis Digestive Disorders

Meta-analysis of Combined Acupuncture and Moxibustion for Chronic Diarrhea

Noh HM, Kang SH, Yoon JY, et al. Acupuncture in Medicine (2023)
14 RCTs Analyzed RCTs
RR 1.52 Stool Normalization
Acupuncture+Moxa Combination Effect

Summary

Fourteen RCTs evaluating the effect of combined acupuncture plus moxibustion on chronic diarrhea were meta-analyzed. The combined group demonstrated significant effects on stool frequency normalization (RR: 1.52) and Bristol Scale improvement.

Key Conclusion

Combined acupuncture and moxibustion is effective in normalizing stool frequency and form in chronic diarrhea.

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RCT Digestive Disorders

Gastric Acid Suppression Effect of Osuyu-tang for Hyperacidity: A Randomized Controlled Trial

Kwon OJ, Seo YJ, Han DH, et al.

Digestive Diseases and Sciences (2024)

52% Heartburn↓
48% Reflux↓
80 subjects Participants

Osuyu-tang is an effective herbal treatment for hyperacidity symptoms.

View Source 2024
RCT Digestive Disorders

Gastric Acid Suppression Effect of Osuyu-tang for Hyperacidity: A Randomized Controlled Trial

Kwon OJ, Seo YJ, Han DH, et al. Digestive Diseases and Sciences (2024)
52% Heartburn↓
48% Reflux↓
80 subjects Participants

Summary

Eighty patients with hyperacidity symptoms were compared over 6 weeks between Osuyu-tang and antacid groups. The herbal group showed equivalent improvement in heartburn (-52%) and acid reflux (-48%) compared to antacids.

Key Conclusion

Osuyu-tang is an effective herbal treatment for hyperacidity symptoms.

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Narrative Review Digestive Disorders

Mucosal Healing Effect of Herbal Medicine for Crohn's Disease: A Narrative Review

Ryu BH, Kim KH, Song MY, et al.

Inflammatory Bowel Diseases (2023)

16 papers Reviewed Papers
Mucosal healing↑ Main Effect
IL-6↓ Anti-inflammatory

Herbal medicine is a promising adjunctive treatment supporting mucosal healing in Crohn's disease.

View Source 2023
Narrative Review Digestive Disorders

Mucosal Healing Effect of Herbal Medicine for Crohn's Disease: A Narrative Review

Ryu BH, Kim KH, Song MY, et al. Inflammatory Bowel Diseases (2023)
16 papers Reviewed Papers
Mucosal healing↑ Main Effect
IL-6↓ Anti-inflammatory

Summary

Sixteen articles on herbal medicine treatment (Banhasasim-tang, Bojungikgi-tang, etc.) for Crohn's disease were reviewed. Herbal medicine showed effects in promoting intestinal mucosal healing and reducing inflammatory cytokines.

Key Conclusion

Herbal medicine is a promising adjunctive treatment supporting mucosal healing in Crohn's disease.

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Cross-Sectional Digestive Disorders

Safety and Efficacy of Acupuncture for Hyperemesis Gravidarum: A Cross-Sectional Analysis

Yoon SH, Cho WS, Lee AR, et al.

Obstetrics & Gynecology (2024)

180 subjects Participants
38% Symptoms↓
Hospitalization↓ Safety

Acupuncture is a safe non-pharmacological management option for morning sickness.

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Cross-Sectional Digestive Disorders

Safety and Efficacy of Acupuncture for Hyperemesis Gravidarum: A Cross-Sectional Analysis

Yoon SH, Cho WS, Lee AR, et al. Obstetrics & Gynecology (2024)
180 subjects Participants
38% Symptoms↓
Hospitalization↓ Safety

Summary

Symptom differences according to acupuncture use were analyzed in 180 pregnant women with morning sickness. The acupuncture group showed 38% lower PUQE nausea/vomiting scores and significantly fewer hospitalizations.

Key Conclusion

Acupuncture is a safe non-pharmacological management option for morning sickness.

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RCT Digestive Disorders

Randomized Controlled Trial of Sasang Constitution-Tailored Herbal Medicine for Constipation-Predominant IBS

Baek IH, Kim SY, Park CW, et al.

Clinical Gastroenterology and Hepatology (2023)

4.1/week CSBM Increase
100 subjects Participants
Constitution-tailored Personalized Treatment

Sasang constitution-tailored herbal medicine enhances treatment response in constipation-predominant IBS.

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RCT Digestive Disorders

Randomized Controlled Trial of Sasang Constitution-Tailored Herbal Medicine for Constipation-Predominant IBS

Baek IH, Kim SY, Park CW, et al. Clinical Gastroenterology and Hepatology (2023)
4.1/week CSBM Increase
100 subjects Participants
Constitution-tailored Personalized Treatment

Summary

One hundred patients with constipation-predominant IBS were compared over 8 weeks between Sasang constitution-tailored herbal medicine and standard herbal medicine groups. The tailored group showed CSBM frequency increasing from 1.2 to 4.1 per week, superior to the standard group.

Key Conclusion

Sasang constitution-tailored herbal medicine enhances treatment response in constipation-predominant IBS.

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Before-After Digestive Disorders

Gas Expulsion Effect of Moxibustion for Abdominal Bloating: A Pre-Post Comparison Study

Jung SY, Lim CS, Kim JH, et al.

Neurogastroenterology & Motility (2024)

3.5 cm Abdominal Circumference↓
58% Symptom Improvement
60 subjects Participants

Moxibustion is effective in promoting gas expulsion and alleviating abdominal bloating symptoms.

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Before-After Digestive Disorders

Gas Expulsion Effect of Moxibustion for Abdominal Bloating: A Pre-Post Comparison Study

Jung SY, Lim CS, Kim JH, et al. Neurogastroenterology & Motility (2024)
3.5 cm Abdominal Circumference↓
58% Symptom Improvement
60 subjects Participants

Summary

Sixty patients with abdominal bloating received abdominal moxibustion for 4 weeks. Abdominal circumference decreased by an average of 3.5 cm and gas-related symptoms improved by 58%.

Key Conclusion

Moxibustion is effective in promoting gas expulsion and alleviating abdominal bloating symptoms.

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Cohort Study Digestive Disorders

Gastric Mucosal Recovery Effect of Wiryeong-tang for Chronic Gastritis: A Cohort Study

Park SJ, Lee EH, Kim TH, et al.

Journal of Gastroenterology (2023)

42% Mucosal Recovery Rate
120 subjects Participants
24 weeks Follow-up Period

Wiryeong-tang promotes gastric mucosal recovery in chronic gastritis.

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Cohort Study Digestive Disorders

Gastric Mucosal Recovery Effect of Wiryeong-tang for Chronic Gastritis: A Cohort Study

Park SJ, Lee EH, Kim TH, et al. Journal of Gastroenterology (2023)
42% Mucosal Recovery Rate
120 subjects Participants
24 weeks Follow-up Period

Summary

A total of 120 patients with chronic gastritis were followed for 24 weeks, divided into Wiryeong-tang and non-treatment groups, with endoscopic evaluation. The herbal group demonstrated a 42% improvement rate in gastric mucosal atrophy, significantly higher than 18% in controls.

Key Conclusion

Wiryeong-tang promotes gastric mucosal recovery in chronic gastritis.

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