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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 91 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
RCT Digestive Disorders

Randomized Controlled Trial of Sogeonjung-tang for Pediatric Constipation

Son HY, Kim MJ, Park EJ, et al.

Journal of Pediatric Gastroenterology and Nutrition (2023)

5.2/week Defecation↑
60 subjects Participants
Pain↓ Additional Effect

Sogeonjung-tang is effective in improving defecation frequency and alleviating abdominal pain in pediatric functional constipation.

View Source 2023
RCT Digestive Disorders

Randomized Controlled Trial of Sogeonjung-tang for Pediatric Constipation

Son HY, Kim MJ, Park EJ, et al. Journal of Pediatric Gastroenterology and Nutrition (2023)
5.2/week Defecation↑
60 subjects Participants
Pain↓ Additional Effect

Summary

Sixty children with functional constipation were compared over 8 weeks between Sogeonjung-tang and placebo groups. The herbal group showed weekly spontaneous bowel movements increasing from 1.8 to 5.2, with reduced abdominal pain.

Key Conclusion

Sogeonjung-tang is effective in improving defecation frequency and alleviating abdominal pain in pediatric functional constipation.

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Case Study Digestive Disorders

Case Report of Daesiho-tang for Gallstone Disease

Lim JH, Shin BC, Kim CH, et al.

Journal of Hepato-Biliary-Pancreatic Sciences (2024)

8 cases Case Number
3 cleared Gallstone Removal
16 weeks Treatment Period

Daesiho-tang may contribute to size reduction and disappearance of small gallstones.

View Source 2024
Case Study Digestive Disorders

Case Report of Daesiho-tang for Gallstone Disease

Lim JH, Shin BC, Kim CH, et al. Journal of Hepato-Biliary-Pancreatic Sciences (2024)
8 cases Case Number
3 cleared Gallstone Removal
16 weeks Treatment Period

Summary

Eight patients with gallstones received Daesiho-tang for 16 weeks in a reported case series. Five patients showed gallstone size reduction of 30% or more, and three patients had complete gallstone disappearance.

Key Conclusion

Daesiho-tang may contribute to size reduction and disappearance of small gallstones.

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RCT Digestive Disorders

Randomized Controlled Trial of Herbal Sitz Bath and Topical Agents for Hemorrhoids

Go GY, Han SH, Park BS, et al.

Diseases of the Colon & Rectum (2023)

62% Bleeding↓
55% Pain↓
70 subjects Participants

Herbal sitz bath and topical agents are effective non-surgical treatments for early-stage hemorrhoids.

View Source 2023
RCT Digestive Disorders

Randomized Controlled Trial of Herbal Sitz Bath and Topical Agents for Hemorrhoids

Go GY, Han SH, Park BS, et al. Diseases of the Colon & Rectum (2023)
62% Bleeding↓
55% Pain↓
70 subjects Participants

Summary

Seventy patients with internal hemorrhoids (Grade I-II) were compared over 6 weeks between herbal sitz bath plus topical and suppository groups. The Korean medicine group showed equivalent improvement in bleeding frequency (-62%) and pain (-55%) compared to suppositories.

Key Conclusion

Herbal sitz bath and topical agents are effective non-surgical treatments for early-stage hemorrhoids.

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Cohort Study Digestive Disorders

Mucosal Healing Effect of Combined Herbal Medicine and PPI for Gastric Ulcer: A Cohort Study

Cha YR, Woo HS, Nam DH, et al.

European Journal of Gastroenterology & Hepatology (2024)

88% Healing Rate
95 subjects Participants
PPI Combination Treatment Strategy

Combined herbal medicine and PPI improves the healing rate of gastric ulcers.

View Source 2024
Cohort Study Digestive Disorders

Mucosal Healing Effect of Combined Herbal Medicine and PPI for Gastric Ulcer: A Cohort Study

Cha YR, Woo HS, Nam DH, et al. European Journal of Gastroenterology & Hepatology (2024)
88% Healing Rate
95 subjects Participants
PPI Combination Treatment Strategy

Summary

Ninety-five patients with gastric ulcer were followed for 8 weeks, divided into PPI plus herbal medicine (Hwangnyeonhaedok-tang) and PPI-alone groups. The combined group showed an ulcer healing rate of 88%, significantly higher than 72% in the monotherapy group.

Key Conclusion

Combined herbal medicine and PPI improves the healing rate of gastric ulcers.

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Before-After Digestive Disorders

Ghrelin Modulation Effect of Hyangsayukgunja-tang for Anorexia: A Pre-Post Comparison

Chung SH, Roh JD, Min BW, et al.

Appetite (2023)

35% Ghrelin↑
45 subjects Participants
Food intake↑ Appetite Improvement

Hyangsayukgunja-tang effectively improves appetite by promoting ghrelin secretion.

View Source 2023
Before-After Digestive Disorders

Ghrelin Modulation Effect of Hyangsayukgunja-tang for Anorexia: A Pre-Post Comparison

Chung SH, Roh JD, Min BW, et al. Appetite (2023)
35% Ghrelin↑
45 subjects Participants
Food intake↑ Appetite Improvement

Summary

Forty-five patients with anorexia received Hyangsayukgunja-tang for 6 weeks, with assessment of serum ghrelin and appetite. Ghrelin levels increased by 35% and food intake increased significantly.

Key Conclusion

Hyangsayukgunja-tang effectively improves appetite by promoting ghrelin secretion.

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Meta-Analysis Digestive Disorders

Meta-analysis of Adjunctive Herbal Medicine for Helicobacter pylori Eradication

Kim DH, Choi SY, Lee JA, et al.

Helicobacter (2024)

18 RCTs Analyzed RCTs
92% Eradication Rate
Side effects↓ Safety

Adjunctive herbal medicine improves Helicobacter eradication rates and reduces antibiotic side effects.

View Source 2024
Meta-Analysis Digestive Disorders

Meta-analysis of Adjunctive Herbal Medicine for Helicobacter pylori Eradication

Kim DH, Choi SY, Lee JA, et al. Helicobacter (2024)
18 RCTs Analyzed RCTs
92% Eradication Rate
Side effects↓ Safety

Summary

Eighteen RCTs evaluating the adjunctive effect of herbal medicine on H. pylori eradication were meta-analyzed. The standard triple therapy plus herbal medicine group demonstrated an eradication rate of 92%, significantly higher than 78% in monotherapy.

Key Conclusion

Adjunctive herbal medicine improves Helicobacter eradication rates and reduces antibiotic side effects.

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RCT Digestive Disorders

Visceral Hypersensitivity Modulation by Electroacupuncture for IBS with Abdominal Pain: A Randomized Controlled Trial

Park JK, Choi HS, Lee EJ, et al.

Gastroenterology (2023)

58% Pain↓
85 subjects Participants
Sensory threshold↑ Hypersensitivity Modulation

Electroacupuncture effectively alleviates abdominal pain in IBS by modulating visceral hypersensitivity.

View Source 2023
RCT Digestive Disorders

Visceral Hypersensitivity Modulation by Electroacupuncture for IBS with Abdominal Pain: A Randomized Controlled Trial

Park JK, Choi HS, Lee EJ, et al. Gastroenterology (2023)
58% Pain↓
85 subjects Participants
Sensory threshold↑ Hypersensitivity Modulation

Summary

Eighty-five patients with IBS-related abdominal pain were compared over 8 weeks between electroacupuncture and sham acupuncture groups. The electroacupuncture group showed significant improvement in VAS abdominal pain (-58%) and rectal sensory threshold.

Key Conclusion

Electroacupuncture effectively alleviates abdominal pain in IBS by modulating visceral hypersensitivity.

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Cross-Sectional Digestive Disorders

Treatment Response by Korean Medicine Pattern Differentiation in Functional Dyspepsia: A Cross-Sectional Analysis

Jang SB, Go HY, Kim EH, et al.

Digestive Diseases (2024)

200 subjects Participants
32% Additional Improvement
3 patterns Classification System

Pattern differentiation-based tailored herbal medicine enhances treatment efficacy in functional dyspepsia.

View Source 2024
Cross-Sectional Digestive Disorders

Treatment Response by Korean Medicine Pattern Differentiation in Functional Dyspepsia: A Cross-Sectional Analysis

Jang SB, Go HY, Kim EH, et al. Digestive Diseases (2024)
200 subjects Participants
32% Additional Improvement
3 patterns Classification System

Summary

Two hundred patients with functional dyspepsia were classified by pattern differentiation (Spleen-Stomach Qi Deficiency, Liver-Stomach Disharmony, Damp-Heat) and analyzed for tailored herbal response. The pattern-tailored group showed 32% higher FD symptom improvement rates.

Key Conclusion

Pattern differentiation-based tailored herbal medicine enhances treatment efficacy in functional dyspepsia.

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Systematic Review Digestive Disorders

Systematic Review of Pediatric Acupuncture and Herbal Medicine for Childhood Dyspepsia

Ahn TW, Shin WC, Baek YH, et al.

Journal of Pediatric Gastroenterology and Nutrition (2023)

12 studies Analyzed Papers
Symptom improvement Digestive Function↑
Weight gain Growth Support

Pediatric acupuncture and herbal medicine are safe and effective treatments for childhood dyspepsia.

View Source 2023
Systematic Review Digestive Disorders

Systematic Review of Pediatric Acupuncture and Herbal Medicine for Childhood Dyspepsia

Ahn TW, Shin WC, Baek YH, et al. Journal of Pediatric Gastroenterology and Nutrition (2023)
12 studies Analyzed Papers
Symptom improvement Digestive Function↑
Weight gain Growth Support

Summary

Twelve studies evaluating the effects of pediatric acupuncture plus herbal medicine on childhood functional dyspepsia were systematically reviewed. Korean medicine treatment showed significant effects on symptom improvement and weight gain.

Key Conclusion

Pediatric acupuncture and herbal medicine are safe and effective treatments for childhood dyspepsia.

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Before-After Digestive Disorders

Intestinal Barrier Function Recovery Effect of Herbal Medicine for Leaky Gut Syndrome: A Pre-Post Comparison Study

Lee JY, Kwon CY, Shin HK, et al.

Intestinal Research (2024)

48% Permeability↓
40 subjects Participants
Zonulin↓ Barrier Recovery

Herbal medicine effectively improves leaky gut syndrome by restoring intestinal barrier function.

View Source 2024
Before-After Digestive Disorders

Intestinal Barrier Function Recovery Effect of Herbal Medicine for Leaky Gut Syndrome: A Pre-Post Comparison Study

Lee JY, Kwon CY, Shin HK, et al. Intestinal Research (2024)
48% Permeability↓
40 subjects Participants
Zonulin↓ Barrier Recovery

Summary

Forty patients with suspected leaky gut syndrome received herbal medicine (Bojungikgi-tang plus Astragalus) for 12 weeks, with assessment of intestinal permeability (lactulose/mannitol ratio). The L/M ratio decreased by 48% and serum zonulin decreased.

Key Conclusion

Herbal medicine effectively improves leaky gut syndrome by restoring intestinal barrier function.

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Narrative Review Digestive Disorders

Narrative Review of Neiguan (PC6) Acupuncture Stimulation for Nausea and Vomiting

Song JH, Noh HM, Lee DH, et al.

Nausea and Emesis (2023)

30 papers Reviewed Papers
Neiguan (PC6) Key Acupoint
Multi-etiology Versatility

Neiguan acupuncture stimulation is an evidence-based non-pharmacological treatment for nausea and vomiting from various etiologies.

View Source 2023
Narrative Review Digestive Disorders

Narrative Review of Neiguan (PC6) Acupuncture Stimulation for Nausea and Vomiting

Song JH, Noh HM, Lee DH, et al. Nausea and Emesis (2023)
30 papers Reviewed Papers
Neiguan (PC6) Key Acupoint
Multi-etiology Versatility

Summary

Thirty articles on the effect of Neiguan acupuncture stimulation for nausea and vomiting were reviewed. Neiguan stimulation showed consistent antiemetic effects in postoperative, chemotherapy-induced, and pregnancy-related nausea and vomiting.

Key Conclusion

Neiguan acupuncture stimulation is an evidence-based non-pharmacological treatment for nausea and vomiting from various etiologies.

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RCT Digestive Disorders

Colonic Motility Promotion Effect of Abdominal Electroacupuncture for Chronic Constipation: A Randomized Controlled Trial

Kim CH, Han SJ, Cho KH, et al.

American Journal of Gastroenterology (2024)

35% Transit Time↓
4.5/week CSBM
90 subjects Participants

Abdominal electroacupuncture effectively improves chronic constipation by promoting colonic motility.

View Source 2024
RCT Digestive Disorders

Colonic Motility Promotion Effect of Abdominal Electroacupuncture for Chronic Constipation: A Randomized Controlled Trial

Kim CH, Han SJ, Cho KH, et al. American Journal of Gastroenterology (2024)
35% Transit Time↓
4.5/week CSBM
90 subjects Participants

Summary

Ninety patients with chronic constipation were compared over 6 weeks between abdominal electroacupuncture and sham acupuncture groups. The electroacupuncture group showed colonic transit time shortened by 35% and CSBM increased to 4.5 per week.

Key Conclusion

Abdominal electroacupuncture effectively improves chronic constipation by promoting colonic motility.

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