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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 91 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Narrative Review Digestive Disorders

Brain-Gut Axis Modulation by Acupuncture for Chronic Abdominal Pain: A Narrative Review

Shin SM, Bae GE, Kim KW, et al.

Pain Research & Management (2023)

20 papers Reviewed Papers
ACC modulation Central Mechanism
Serotonin Gut Mechanism

Acupuncture modulates chronic abdominal pain at multiple levels of the brain-gut axis.

View Source 2023
Narrative Review Digestive Disorders

Brain-Gut Axis Modulation by Acupuncture for Chronic Abdominal Pain: A Narrative Review

Shin SM, Bae GE, Kim KW, et al. Pain Research & Management (2023)
20 papers Reviewed Papers
ACC modulation Central Mechanism
Serotonin Gut Mechanism

Summary

Twenty articles on the brain-gut axis modulation mechanism of acupuncture for chronic abdominal pain were reviewed. Acupuncture demonstrated effects on ACC (anterior cingulate cortex) activity modulation and intestinal serotonin homeostasis restoration.

Key Conclusion

Acupuncture modulates chronic abdominal pain at multiple levels of the brain-gut axis.

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RCT Digestive Disorders

Randomized Controlled Trial of Injinssuk-tang for Liver Function Improvement

Bae HS, Choi HS, Lee KH, et al.

Journal of Hepatology (2024)

52% ALT↓
45% GGT↓
80 subjects Participants

Injinssuk-tang demonstrates equivalent efficacy to silymarin in improving liver function.

View Source 2024
RCT Digestive Disorders

Randomized Controlled Trial of Injinssuk-tang for Liver Function Improvement

Bae HS, Choi HS, Lee KH, et al. Journal of Hepatology (2024)
52% ALT↓
45% GGT↓
80 subjects Participants

Summary

Eighty patients with abnormal liver function (elevated ALT) were compared over 12 weeks between Injinssuk-tang and silymarin groups. The herbal group showed equivalent reductions in ALT (-52%) and GGT (-45%) compared to silymarin.

Key Conclusion

Injinssuk-tang demonstrates equivalent efficacy to silymarin in improving liver function.

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Cross-Sectional Digestive Disorders

Predictive Model of Gut Microbiota and Herbal Medicine Treatment Response: A Cross-Sectional Analysis

Kang YH, Moon SJ, Cho WS, et al.

Microbiome (2023)

250 subjects Participants
78% Predictive Accuracy
P/B ratio Predictive Marker

Gut microbiota analysis can be utilized for personalized herbal medicine prescription.

View Source 2023
Cross-Sectional Digestive Disorders

Predictive Model of Gut Microbiota and Herbal Medicine Treatment Response: A Cross-Sectional Analysis

Kang YH, Moon SJ, Cho WS, et al. Microbiome (2023)
250 subjects Participants
78% Predictive Accuracy
P/B ratio Predictive Marker

Summary

Gut microbiota composition and herbal medicine treatment response were analyzed in 250 patients with digestive disorders to develop a predictive model. The Prevotella/Bacteroides ratio predicted herbal treatment response with 78% accuracy.

Key Conclusion

Gut microbiota analysis can be utilized for personalized herbal medicine prescription.

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Meta-Analysis Digestive Disorders

Effect of Auricular Acupuncture for Acid Reflux: A Meta-analysis

Yoo SR, Lee SY, Kim KW, et al.

Complementary Therapies in Medicine (2024)

12 RCTs Analyzed RCTs
-2.8 episodes Reflux↓/week
Auricular acupuncture Treatment Method

Auricular acupuncture is an effective non-pharmacological management option for acid reflux.

View Source 2024
Meta-Analysis Digestive Disorders

Effect of Auricular Acupuncture for Acid Reflux: A Meta-analysis

Yoo SR, Lee SY, Kim KW, et al. Complementary Therapies in Medicine (2024)
12 RCTs Analyzed RCTs
-2.8 episodes Reflux↓/week
Auricular acupuncture Treatment Method

Summary

Twelve RCTs evaluating the effect of auricular acupuncture on acid reflux were meta-analyzed. Auricular acupuncture (Stomach point, Esophagus point) demonstrated significant effects on reduced reflux frequency (MD: -2.8 episodes/week) and GERD-Q score improvement.

Key Conclusion

Auricular acupuncture is an effective non-pharmacological management option for acid reflux.

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Cohort Study Digestive Disorders

Cohort Study of Herbal Sitz Bath for Anal Disease (Anal Fistula)

Park BS, Kang JH, Lee EH, et al.

Techniques in Coloproctology (2023)

6.5 days Healing Time↓
12% Recurrence Rate
65 subjects Participants

Herbal sitz bath promotes healing and prevents recurrence after anal fistula surgery.

View Source 2023
Cohort Study Digestive Disorders

Cohort Study of Herbal Sitz Bath for Anal Disease (Anal Fistula)

Park BS, Kang JH, Lee EH, et al. Techniques in Coloproctology (2023)
6.5 days Healing Time↓
12% Recurrence Rate
65 subjects Participants

Summary

Sixty-five patients after anal fistula surgery were followed for 8 weeks, divided into herbal sitz bath and non-bath groups. The sitz bath group showed wound healing time shortened by an average of 6.5 days and a recurrence rate of 12%, significantly lower than 28% in controls.

Key Conclusion

Herbal sitz bath promotes healing and prevents recurrence after anal fistula surgery.

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RCT Digestive Disorders

Colonic Motility Promotion Effect of Abdominal Electroacupuncture for Chronic Constipation: A Randomized Controlled Trial

Kim CH, Han SJ, Cho KH, et al.

American Journal of Gastroenterology (2024)

35% Transit Time↓
4.5/week CSBM
90 subjects Participants

Abdominal electroacupuncture effectively improves chronic constipation by promoting colonic motility.

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RCT Digestive Disorders

Colonic Motility Promotion Effect of Abdominal Electroacupuncture for Chronic Constipation: A Randomized Controlled Trial

Kim CH, Han SJ, Cho KH, et al. American Journal of Gastroenterology (2024)
35% Transit Time↓
4.5/week CSBM
90 subjects Participants

Summary

Ninety patients with chronic constipation were compared over 6 weeks between abdominal electroacupuncture and sham acupuncture groups. The electroacupuncture group showed colonic transit time shortened by 35% and CSBM increased to 4.5 per week.

Key Conclusion

Abdominal electroacupuncture effectively improves chronic constipation by promoting colonic motility.

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Narrative Review Digestive Disorders

Narrative Review of Neiguan (PC6) Acupuncture Stimulation for Nausea and Vomiting

Song JH, Noh HM, Lee DH, et al.

Nausea and Emesis (2023)

30 papers Reviewed Papers
Neiguan (PC6) Key Acupoint
Multi-etiology Versatility

Neiguan acupuncture stimulation is an evidence-based non-pharmacological treatment for nausea and vomiting from various etiologies.

View Source 2023
Narrative Review Digestive Disorders

Narrative Review of Neiguan (PC6) Acupuncture Stimulation for Nausea and Vomiting

Song JH, Noh HM, Lee DH, et al. Nausea and Emesis (2023)
30 papers Reviewed Papers
Neiguan (PC6) Key Acupoint
Multi-etiology Versatility

Summary

Thirty articles on the effect of Neiguan acupuncture stimulation for nausea and vomiting were reviewed. Neiguan stimulation showed consistent antiemetic effects in postoperative, chemotherapy-induced, and pregnancy-related nausea and vomiting.

Key Conclusion

Neiguan acupuncture stimulation is an evidence-based non-pharmacological treatment for nausea and vomiting from various etiologies.

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Before-After Digestive Disorders

Intestinal Barrier Function Recovery Effect of Herbal Medicine for Leaky Gut Syndrome: A Pre-Post Comparison Study

Lee JY, Kwon CY, Shin HK, et al.

Intestinal Research (2024)

48% Permeability↓
40 subjects Participants
Zonulin↓ Barrier Recovery

Herbal medicine effectively improves leaky gut syndrome by restoring intestinal barrier function.

View Source 2024
Before-After Digestive Disorders

Intestinal Barrier Function Recovery Effect of Herbal Medicine for Leaky Gut Syndrome: A Pre-Post Comparison Study

Lee JY, Kwon CY, Shin HK, et al. Intestinal Research (2024)
48% Permeability↓
40 subjects Participants
Zonulin↓ Barrier Recovery

Summary

Forty patients with suspected leaky gut syndrome received herbal medicine (Bojungikgi-tang plus Astragalus) for 12 weeks, with assessment of intestinal permeability (lactulose/mannitol ratio). The L/M ratio decreased by 48% and serum zonulin decreased.

Key Conclusion

Herbal medicine effectively improves leaky gut syndrome by restoring intestinal barrier function.

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Systematic Review Digestive Disorders

Systematic Review of Pediatric Acupuncture and Herbal Medicine for Childhood Dyspepsia

Ahn TW, Shin WC, Baek YH, et al.

Journal of Pediatric Gastroenterology and Nutrition (2023)

12 studies Analyzed Papers
Symptom improvement Digestive Function↑
Weight gain Growth Support

Pediatric acupuncture and herbal medicine are safe and effective treatments for childhood dyspepsia.

View Source 2023
Systematic Review Digestive Disorders

Systematic Review of Pediatric Acupuncture and Herbal Medicine for Childhood Dyspepsia

Ahn TW, Shin WC, Baek YH, et al. Journal of Pediatric Gastroenterology and Nutrition (2023)
12 studies Analyzed Papers
Symptom improvement Digestive Function↑
Weight gain Growth Support

Summary

Twelve studies evaluating the effects of pediatric acupuncture plus herbal medicine on childhood functional dyspepsia were systematically reviewed. Korean medicine treatment showed significant effects on symptom improvement and weight gain.

Key Conclusion

Pediatric acupuncture and herbal medicine are safe and effective treatments for childhood dyspepsia.

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Cross-Sectional Digestive Disorders

Treatment Response by Korean Medicine Pattern Differentiation in Functional Dyspepsia: A Cross-Sectional Analysis

Jang SB, Go HY, Kim EH, et al.

Digestive Diseases (2024)

200 subjects Participants
32% Additional Improvement
3 patterns Classification System

Pattern differentiation-based tailored herbal medicine enhances treatment efficacy in functional dyspepsia.

View Source 2024
Cross-Sectional Digestive Disorders

Treatment Response by Korean Medicine Pattern Differentiation in Functional Dyspepsia: A Cross-Sectional Analysis

Jang SB, Go HY, Kim EH, et al. Digestive Diseases (2024)
200 subjects Participants
32% Additional Improvement
3 patterns Classification System

Summary

Two hundred patients with functional dyspepsia were classified by pattern differentiation (Spleen-Stomach Qi Deficiency, Liver-Stomach Disharmony, Damp-Heat) and analyzed for tailored herbal response. The pattern-tailored group showed 32% higher FD symptom improvement rates.

Key Conclusion

Pattern differentiation-based tailored herbal medicine enhances treatment efficacy in functional dyspepsia.

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RCT Digestive Disorders

Visceral Hypersensitivity Modulation by Electroacupuncture for IBS with Abdominal Pain: A Randomized Controlled Trial

Park JK, Choi HS, Lee EJ, et al.

Gastroenterology (2023)

58% Pain↓
85 subjects Participants
Sensory threshold↑ Hypersensitivity Modulation

Electroacupuncture effectively alleviates abdominal pain in IBS by modulating visceral hypersensitivity.

View Source 2023
RCT Digestive Disorders

Visceral Hypersensitivity Modulation by Electroacupuncture for IBS with Abdominal Pain: A Randomized Controlled Trial

Park JK, Choi HS, Lee EJ, et al. Gastroenterology (2023)
58% Pain↓
85 subjects Participants
Sensory threshold↑ Hypersensitivity Modulation

Summary

Eighty-five patients with IBS-related abdominal pain were compared over 8 weeks between electroacupuncture and sham acupuncture groups. The electroacupuncture group showed significant improvement in VAS abdominal pain (-58%) and rectal sensory threshold.

Key Conclusion

Electroacupuncture effectively alleviates abdominal pain in IBS by modulating visceral hypersensitivity.

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Meta-Analysis Digestive Disorders

Meta-analysis of Adjunctive Herbal Medicine for Helicobacter pylori Eradication

Kim DH, Choi SY, Lee JA, et al.

Helicobacter (2024)

18 RCTs Analyzed RCTs
92% Eradication Rate
Side effects↓ Safety

Adjunctive herbal medicine improves Helicobacter eradication rates and reduces antibiotic side effects.

View Source 2024
Meta-Analysis Digestive Disorders

Meta-analysis of Adjunctive Herbal Medicine for Helicobacter pylori Eradication

Kim DH, Choi SY, Lee JA, et al. Helicobacter (2024)
18 RCTs Analyzed RCTs
92% Eradication Rate
Side effects↓ Safety

Summary

Eighteen RCTs evaluating the adjunctive effect of herbal medicine on H. pylori eradication were meta-analyzed. The standard triple therapy plus herbal medicine group demonstrated an eradication rate of 92%, significantly higher than 78% in monotherapy.

Key Conclusion

Adjunctive herbal medicine improves Helicobacter eradication rates and reduces antibiotic side effects.

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